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Comparative modeling of retinol-binding protein-3 and retinal S-antigen in Eales’ disease and prediction of their binding sites using computational methods

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Journal of Ocular Biology, Diseases, and Informatics

Abstract

Retinal S-antigen and interphotoreceptor retinoid-binding protein-3 play a significant role in the etiopathogenesis of Eales' disease. Protein 3D structures are functionally very important and play a significant role in progression of the disease, hence these 3D structures are better target for further drug designing and relative studies. We developed 3D model structure of retinol-binding protein-3 and retinal S-antigen protein of human involved in Eales' disease. Functional site prediction is a very important and related step; hence, in the current course of analysis, we predicted putative functional site residues in the target proteins. Molecular models of these proteins of Eales' disease as documented in this study may provide a valuable aid for designing an inhibitor or better ligand against Eales' disease and could play a significant role in drug design.

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Acknowledgments

We wish to express our acknowledgement to Mr. Aseem Chauhan, Additional President, RBEF parent organization of Amity University Uttar Pradesh (AUUP) and chairman of Amity University Lucknow Campus; Maj. Gen. K.K Ohri, AVSM (Retd.), Director General of AUUP- Lucknow Campus, Asst. Professor Dr. Rajesh K. Tiwari, Deputy Director and Head, Amity Institute of Biotechnology, Lucknow and Professor Shally Awasthi, Dept. of Pediatrics, CSM Medical university, Lucknow, UP for providing their valuable support and encouragement throughout the work.

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Authors and Affiliations

  1. Department of Ophthalmology, CSM Medical University (Erstwhile King George’s Medical University), Lucknow, India

    Anshul Tiwari & Sandeep Saxena

  2. Indian Institute of Toxicological Research, Lucknow, India

    Aditya Bhusan Pant

  3. Amity Institute of Biotechnology, Amity University, Lucknow Campus, Lucknow, India

    Ashish Chandra Trivedi & Prachi Srivastava

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  1. Anshul Tiwari
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  2. Ashish Chandra Trivedi
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  3. Prachi Srivastava
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  4. Aditya Bhusan Pant
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  5. Sandeep Saxena
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Correspondence to Sandeep Saxena.

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Tiwari, A., Trivedi, A.C., Srivastava, P. et al. Comparative modeling of retinol-binding protein-3 and retinal S-antigen in Eales’ disease and prediction of their binding sites using computational methods. j ocul biol dis inform 3, 88–91 (2010). https://doi.org/10.1007/s12177-011-9060-z

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  • DOI: https://doi.org/10.1007/s12177-011-9060-z

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