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Management of radiation therapy-induced mucositis in head and neck cancer patients. Part I: Clinical significance, pathophysiology and prevention

  • Review
  • Published:
Oncology Reviews

Abstract

Oropharyngeal mucositis is the acute inflammatory and ulcerative reaction of the oral mucosa following radiation therapy to the head and neck region. It is such a common problem that nearly all head and neck cancer patients develop some degree of mucositis. This complication is usually transient in nature but it also represents an important clinical problem as it is a painful, debilitating, dose-dependent side effect for which there is no widely acceptable prophylaxis or effective treatment. As several authoritative groups have recently either undertaken systematic reviews or issued guidelines on the management of mucositis, it is the aim of this review to provide instead an overview of all the possible remedies available, as well as highlighting to researchers the gaps that need to be filled. The first part of this review outlines the clinical significance and pathophysiology of radiation-induced mucositis, and looks into some of the preventive approaches available.

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Authors and Affiliations

  1. Department of Oral & Maxillofacial Surgery, Faculty of Dentistry, University of Malaya, 50603, Kuala Lumpur, Malaysia

    Wei Cheong Ngeow

  2. Department of General Dental Practice and Oral & Maxillofacial Imaging, Faculty of Dentistry, University of Malaya, 50603, Kuala Lumpur, Malaysia

    Wen Lin Chai

  3. Department of Oral Pathology, Oral Medicine and Periodontology, Faculty of Dentistry, University of Malaya, 50603, Kuala Lumpur, Malaysia

    Rosnah Binti Zain

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  1. Wei Cheong Ngeow
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  2. Wen Lin Chai
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Correspondence to Wei Cheong Ngeow.

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Ngeow, W.C., Chai, W.L. & Zain, R.B. Management of radiation therapy-induced mucositis in head and neck cancer patients. Part I: Clinical significance, pathophysiology and prevention. Oncol Rev 2, 102–113 (2008). https://doi.org/10.1007/s12156-008-0064-2

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