Abstract
A large number of studies have investigated a variety of psychological aspects in people with Amyotrophic Lateral Sclerosis, but there is still considerable uncertainty concerning the actual morbidity, in particular for anxiety. We aim to evaluate depression levels and anxiety disposition in ALS patients and their caregivers, in comparison to healthy controls. We conducted a cross-sectional comparison between people with ALS, their caregivers and a non-clinical control group in order to evaluate anxiety and depression levels. 40 ALS patients, their caregivers and 40 healthy adult subjects completed the Beck Depression Inventory II (BDI-II) and the State-Trait Anxiety Inventory—Y2 scale (STAI). We compared overall and single item scores in order to find differences between the three groups. BDI-II scores were significantly different between groups. Depression scores were higher for patients than for healthy controls, in both somatic and psychological sub-scales. Caregivers presented higher levels of psychological depression in comparison with healthy controls, and lower scores of somatic depression in comparison to patients. No differences were found in trait anxiety levels comparing the three groups. ALS patients and their caregivers developed more depression related symptomatology than the non-clinical sample. However, susceptibility to anxiety for both patients and caregivers seemed to be at a normal level.
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References
American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, D.C.: APA.
Averill, A. J., Kasarskis, E. J., & Segerstrom, S. C. (2007). Psychological health in patients with amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, 8(4), 243–254.
Beck, A. T., Steer, R. A., & Brown, G. K. (1996). Beck depression inventory (2nd ed.). San Antonio: The Psychological Corporation.
Brooks, B. R., Miller, R. G., Swash, M., & Munsat, T. L. (2000). El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, 1(5), 293–299.
Cedarbaum, J. M., Stambler, N., Malta, E., Fuller, C., Hilt, D., Thurmond, B., et al. (1999). The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III). Journal of Neurological Sciences, 169(1–2), 13–21.
Clarke, S., Hickey, A., O’Boyle, C., & Hardiman, O. (2001). Assessing individual quality of life in amyotrophic lateral sclerosis. Quality of Life Research, 10(2), 149–158.
Ganzini, L., Johnston, W. S., McFarland, B. H., Tolle, S. W., & Lee, M. A. (1998). Attitudes of patients with amyotrophic lateral sclerosis and their care givers toward assisted suicide. The New England Journal of Medicine, 339(14), 967–973.
Ganzini, L., Johnston, W. S., & Hoffman, W. F. (1999). Correlates of suffering in amyotrophic lateral sclerosis. Neurology, 52(7), 1434–1440.
Ganzini, L., Silveira, M. J., & Johnston, W. S. (2002). Predictors and correlates of interest in assisted suicide in the final month of life among ALS patients in Oregon and Washington. Journal of Pain and Symptom Management, 24(3), 312–317.
Gauthier, A., Vignola, A., Calvo, A., Cavallo, E., Moglia, C., Sellitti, L., et al. (2007). A longitudinal study on quality of life and depression in ALS patient-caregiver couples. Neurology, 68(12), 923–926.
Kubler, A., Winter, S., Ludolph, A. C., Hautzinger, M., & Birbaumer, N. (2005). Severity of depressive symptoms and quality of life in patients with amyotrophic lateral sclerosis. Neurorehabilitation and Neural Repair, 19(3), 182–193.
Kurt, A., Nijboer, F., Matuz, T., & Kubler, A. (2007). Depression and anxiety in individuals with amyotrophic lateral sclerosis —Epidemiology and management. CNS Drugs, 21(4), 279–291.
Lou, J. S., Reeves, A., Benice, T., & Sexton, G. (2003). Fatigue and depression are associated with poor quality of life in ALS. Neurology, 60(1), 122–123.
Lule, D., Hacker, S., Ludolph, A., Birbaumer, N., & Kubler, A. (2008). Depression and quality of life in patients with amyotrophic lateral sclerosis. Deutsches Ärzteblatt International, 105(23), 397–403.
McElhiney, M. C., Rabkin, J. G., Gordon, P. H., Goetz, R., & Mitsumoto, H. (2009). Prevalence of fatigue and depression in ALS patients and change over time. Journal of Neurology, Neurosurgery & Psychiatry, 80(10), 1146–1149.
McLeod, J. E., & Clarke, D. M. (2007). A review of psychosocial aspects of motor neurone disease. Journal of Neurological Sciences, 258(1–2), 4–10.
Mockford, C., Jenkinson, C., & Fitzpatrick, R. (2006). A review: carers, MND and service provision. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, 7(3), 132–141.
Pagnini, F., Rossi, G., Lunetta, C., Banfi, P., Castelnuovo, G., Corbo, M., et al. (2010). Burden, depression, and anxiety in caregivers of people with amyotrophic lateral sclerosis. Psychology, Health & Medicine, 15(6), 685–693.
Pagnini, F., Lunetta, C., Rossi, G., Banfi, P., Gorni, K., Cellotto, N., et al. (2011). Existential well-being and spirituality of individuals with amyotrophic lateral sclerosis is related to psychological well-being of their caregivers. Amyotrophic Lateral Sclerosis, 12(2), 105–108.
Rabkin, J. G., Wagner, G. J., & Del Bene, M. (2000). Resilience and distress among amyotrophic lateral sclerosis patients and caregivers. Psychosomatic Medicine, 62(2), 271–279.
Roy-Bellina, S., Brunel, H., Almohsen, C., Gely-Nargeot, M. C., Carton, S., & Camu, W. (2008). Alexithymia in amyotrophic lateral sclerosis. A neuropsychological approach. Journal of Neurology, 255, 51–51.
Spielberger, C. D., Gorsuch, R. L., & Lushene, R. E. (1970). Manual for the state-trait anxiety inventory. Palo Alto, CA: Consulting Psychologists Press.
Tedman, B. M., Young, C. A., & Williams, I. R. (1997). Assessment of depression in patients with motor neuron disease and other neurologically disabling illness. Journal of Neurological Science, 152(Suppl 1), S75–S79.
Trail, M., Nelson, N. D., Van, J. N., Appel, S. H., & Lai, E. C. (2003). A study comparing patients with amyotrophic lateral sclerosis and their caregivers on measures of quality of life, depression, and their attitudes toward treatment options. Journal of Neurological Sciences, 209(1–2), 79–85.
Vignola, A., Guzzo, A., Calvo, A., Moglia, C., Pessia, A., Cavallo, E., et al. (2008). Anxiety undermines quality of life in ALS patients and caregivers. European Journal of Neurology, 15(11), 1231–1236.
Wasner, M., Bold, U., Vollmer, T. C., & Borasio, G. D. (2004). Sexuality in patients with amyotrophic lateral sclerosis and their partners. Journal of Neurology, 251(4), 445–448.
Wicks, P., Abrahams, S., Masi, D., Hejda-Forde, S., Leigh, P. N., & Goldstein, L. H. (2007). Prevalence of depression in a 12-month consecutive sample of patients with ALS. European Journal of Neurology, 14(9), 993–1001.
Worms, P. M. (2001). The epidemiology of motor neuron diseases: a review of recent studies. Journal of Neurological Science, 191(1–2), 3–9.
Acknowledgments
The MAPPA DM SLA Project (Modelli di Assistenza (ordinario ed intensivo) Per Persone Affette da Distrofia Muscolare e Sclerosi Laterale Amiotrofica) and IdAQ SLA DM Projects (Impatto dell’assistenza sulla qualità della vita nella Sclerosi Laterale Amiotrofica e nella Distrofia Muscolare) were supported by the “Fondazione Cariplo” Italian private foundation.
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Pagnini, F., Lunetta, C., Banfi, P. et al. Anxiety and Depression in Patients with Amyotrophic Lateral Sclerosis and Their Caregivers. Curr Psychol 31, 79–87 (2012). https://doi.org/10.1007/s12144-012-9132-7
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DOI: https://doi.org/10.1007/s12144-012-9132-7