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Relationship Between Worst Pattern of Invasion and Extranodal Extension in Oral Tongue Squamous Cell Carcinomas

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Abstract

Background

Oral tongue squamous cell carcinoma (OTSCC) is a common malignancy of the oral cavity with poor survival rates. The aim of this project is to investigate the relationship between certain histopathological factors such as Worst Pattern of Invasion (WPOI) and Extranodal Extension (ENE) in patients with oral tongue squamous cell carcinoma (OTSCC) who underwent surgical resection at Loyola University Medical Center.

Methods

This was a retrospective cohort study at a tertiary care academic medical center. All patients that underwent primary surgical resection of OTSCC between 1/1/2015 and 1/1/2022 were reviewed. Patients were identified using the Cerner CoPath Laboratory Information System.

Results

A total of 82 patients met inclusion criteria and were included in the study. Higher grades of WPOI (WPOI 5) were not significantly associated with the presence of ENE in our study (P = 0.82), regardless of the presence of major or minor ENE. WPOI 5 was associated with a higher incidence of local recurrence (P = 0.011).

Conclusions

Higher grades of WPOI were not found to correlate with the presence of ENE, a common histopathological factor that is used as an important prognostic indicator in OTSCC. It is important for clinicians to consider these factors separately when determining whether a patient is high-risk and would benefit from aggressive multimodal treatment.

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Data Availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

Code Availability

The software application code used in SPSS for statistical analysis is available from the corresponding author on reasonable request.

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Funding

This study was not supported by any funding.

Author information

Authors and Affiliations

  1. Loyola University Chicago, Stritch School of Medicine, Maywood, IL, USA

    Mayuri Yasuda, Celina Chiodo & Cullen Lilley

  2. Department of Pathology, Loyola University Medical Center, Maywood, IL, USA

    Swati Mehrotra & Vijayalakshmi Ananthanarayanan

  3. Department of Otolaryngology - Head and Neck Surgery, Loyola University Medical Center, Maywood, IL, USA

    Andrea Ziegler & Eric Thorpe

Authors
  1. Mayuri Yasuda
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  2. Celina Chiodo
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  3. Cullen Lilley
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  4. Swati Mehrotra
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  5. Vijayalakshmi Ananthanarayanan
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  6. Andrea Ziegler
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  7. Eric Thorpe
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Contributions

All authors contributed to the study conception and design, material preparation, data collection and analysis. The first draft of the manuscript was written by MY and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Mayuri Yasuda.

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The authors declare that they have no conflicts of interest.

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For this type of study formal consent is not required. The study was given an IRB exemption by the Loyola University Medical Center Institutional Review Board.

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Yasuda, M., Chiodo, C., Lilley, C. et al. Relationship Between Worst Pattern of Invasion and Extranodal Extension in Oral Tongue Squamous Cell Carcinomas. Head and Neck Pathol 17, 460–466 (2023). https://doi.org/10.1007/s12105-023-01531-3

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  • DOI: https://doi.org/10.1007/s12105-023-01531-3

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