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Basal Cell Adenoma and Basal Cell Adenocarcinoma: a 50-year Experience From a Single Institution

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Abstract

Background

Basal cell adenoma (BCA) and adenocarcinoma (BCAd) are two of the least frequent salivary gland tumors. We describe the largest series of these neoplasms, spanning over a period of 50 years (1970–2020), diagnosed and treated in a single Institution.

Methods

Sixty-eight cases were identified. Clinical and pathological data were collected and correlated with outcome.

Results

Forty-one BCA and 27 BCAd were identified. BCA cases had almost pristine prognosis, with only a relapse in a tumor inadequately excised. Ten patients with BCAd developed metastases, and 14 died from the disease. The 2-year and 5-year survival was of 76% and 42%.

Conclusions

The importance of adequate excision is reinforced in BCA, with no recurrences occurring when margins were negative. Contrary to previous reports, BCAd was not associated with a good prognosis. A better understanding of the genetics of these neoplasms may identify therapeutic options when dealing with inoperable or metastatic disease.

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Funding

No funding was received for conducting this study.

Author information

Authors and Affiliations

  1. Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa, R. Prof. Lima Basto, 1099-023, Lisbon, Portugal

    Miguel Rito & Isabel Fonseca

  2. Faculdade de Medicina, Instituto de Anatomia Patológica, Universidade de Lisboa, Lisbon, Portugal

    Miguel Rito & Isabel Fonseca

  3. Unidade de Investigação Clínica, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal

    Susana Esteves

Authors
  1. Miguel Rito
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  2. Susana Esteves
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  3. Isabel Fonseca
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Contributions

MR and IF: Contributed to the study conception and design, reviewed the pathological slides and agreed on the diagnosis. MR: performed the data collection, data analysis and wrote the first draft of the manuscript. Susana Esteves did the statistical analysis. Isabel Fonseca and Susana Esteves reviewed and edited the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Miguel Rito.

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Conflict of interest

The authors have no relevant financial or non-financial interests to disclose.

Ethical Approval

The study was approved by the Institutional board of Instituto Português de Oncologia de Lisboa Francisco Gentil (Lisboa, Portugal), project number UIC/993.

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Rito, M., Esteves, S. & Fonseca, I. Basal Cell Adenoma and Basal Cell Adenocarcinoma: a 50-year Experience From a Single Institution. Head and Neck Pathol 16, 1157–1166 (2022). https://doi.org/10.1007/s12105-022-01484-z

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  • DOI: https://doi.org/10.1007/s12105-022-01484-z

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