Abstract
Sclerosing odontogenic carcinoma is a rare locally destructive neoplasm with many histologic mimics. Here the diagnostic challenges are presented of a case of sclerosing odontogenic carcinoma with variable histologic features, including unusual and unexpected negative immunostaining for CK19.
Similar content being viewed by others
References
El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ. World Health Organization Classification of Head and Neck tumours. 4th ed. Lyon: IARC Press; 2017.
Speight PM, Takata T. New tumour entities in the 4th edition of the World Health Organization Classification of Head and Neck tumours: odontogenic and maxillofacial bone tumours. Virchows Arch. 2018;472:331–39. https://doi.org/10.1007/s00428-017-2182-3.
Tan SH, Yeo JF, Kheem Pang BN, Petersson F. An intraosseous sclerosing odontogenic tumor predominantly composed of epithelial cells: relation to (so-called) sclerosing odontogenic carcinoma and epithelial-rich central odontogenic fibroma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;118:119–25. https://doi.org/10.1016/j.oooo.2014.02.010.
Hussain O, Rendon AT, Orr RL, Speight PM. Sclerosing odontogenic carcinoma in the maxilla: a rare primary intraosseous carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116:283–86. https://doi.org/10.1016/j.oooo.2013.01.018.
Koutlas IG, Allen CM, Warnock GR, Manivel JC. Sclerosing odontogenic carcinoma: a previously unreported variant of a locally aggressive odontogenic neoplasm without apparent metastatic potential. Am J Surg Pathol. 2008;32:1613–19. https://doi.org/10.1097/PAS.0b013e31817a8a58.
Richardson MS, Muller S. Malignant odontogenic tumors: an update on selected tumors. Head Neck Pathol. 2014;8(4):411–20. https://doi.org/10.1007/s12105-014-0584-y.
Hanisch M, Baumhoer D, Elges S, Frohlich LF, Kleinheinz J, Jung S. Sclerosing odontogenic carcinoma: current diagnostic and management considerations concerning a most unusual neoplasm. Int J Oral Maxillofac Surg. 2017;46:1641–49. https://doi.org/10.1016/j.ijom.2017.05.024.
Wood A, Young F, Morrison J, Conn BI. Sclerosing odontogenic carcinoma presenting on the hard palate of a 43 year old female: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122:204–8. https://doi.org/10.1016/j.oooo.2016.07.009.
Ide F, Mishima K, Saito I, Kusama K. Diagnostically challenging epithelial odontogenic tumors: a selective review of 7 jawbone lesions. Head Neck Pathol. 2009;3:18–26. https://doi.org/10.1007/s12105-009-0107-4.
Yancoskie AE, Sreekantaiah C, Jacob J, Rosenberg A, Edelman M, Antonescu CR. EWSR1 and ATF1 rearrangements in clear cell odontogenic carcinoma: presentation of a case. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;118(4):e115-8. https://doi.org/10.1016/j.oooo.2014.02.004.
Irie T, Ogawa I, Takata T, Toyosawa S, Isobe T, Hokazono C. Sclerosing odontogenic carcinoma. Pathol Int. 2012;62:75–6. https://doi.org/10.1111/j.1440-1827.2011.02749.
Saxena S, Kumar S. Sclerosing odontogenic carcinoma: an enigma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;115:840. https://doi.org/10.1016/j.oooo.2013.02.019.
Misra SR, Shankar YU, Rastogi V, Maragathavalli G. Metastatic hepatocellular carcinoma in the maxilla and mandible, an extremely rare presentation. Contemp Clin Dent. 2015;6(Suppl 1):26–31.
Dujardin F, Binh MB, Bouvier C, Gomez-Brouchet A, Larousserie F, Muret AD, et al. MDM2 and CDK4 immunohistochemistry is a valuable tool in the differential diagnosis of low-grade osteosarcomas and other primary fibro-osseous lesions of the bone. Mod Pathol. 2011;24:624–37. https://doi.org/10.1038/modpathol.2010.229.
Kwon IJ, Kim SM, Amponsah EK, Myoung H, Lee JH, Lee SK. Mandibular clear cell odontogenic carcinoma. World J Surg Oncol. 2015;13:284. https://doi.org/10.1186/s12957-015-0693-4.
Bilodeau EA, Weinreb I, Antonescu CR, Zhang L, Dacic S, Muller S. Clear cell odontogenic carcinomas show EWSR1 rearrangements: a novel finding and a biological link to salivary clear cell carcinomas. Am J Surg Pathol. 2013;37:1001–5. https://doi.org/10.1097/PAS.0b013e31828a6727.
Philipsen HP, et al. Calcifying epithelial odontogenic tumour: biological profile based on 181 cases from the literature. Oral Oncol. 2000;36:17–26.
Eversole LR, Leider AS, Strub D. Ameloblastoma with pronounced desmoplasia. J Oral Maxillofac Surg. 1984;42:735–40.
Funding
No associated funding.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
No conflicts of interest to disclose.
Rights and permissions
About this article
Cite this article
Todorovic, E., Berthelet, E., O’Connor, R. et al. Sclerosing Odontogenic Carcinoma with Local Recurrence: Case Report and Review of Literature. Head and Neck Pathol 13, 371–377 (2019). https://doi.org/10.1007/s12105-018-0975-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12105-018-0975-6