Skip to main content

Advertisement

SpringerLink
Log in

Neurodevelopmental and Behavioral Outcome of Very Low Birth Weight Babies at Corrected Age of 2 Years

  • Original Article
  • Published:
The Indian Journal of Pediatrics Aims and scope Submit manuscript

Abstract

Objective

Neurodevelopmental and behavioral assessment of very low birth weight babies (VLBW) at corrected age (CA) of 2 years.

Methods

127, 110, 99 and 101 babies ≤34 weeks and ≤1500 g were followed at CA of 3, 6, 9, 12 months respectively for developmental and neurological assessment. DASII (Developmental assessment scale for Indian infants) was used at CA of 18 months and preschool behavioural checklist (PBCL) at CA 2 years.

Results

Of 101 VLBW babies available for follow up at CA 1 year, 3 (3%) babies had Cerebral Palsy (CP) and 3% (n = 3) had suspect abnormality (mild hypotonia), 11% (n = 11) had gross motor and 8% (n = 8) had language abnormality. Their mean mental (MeDQ) and motor (MoDQ) quotients were 80.4 ± 10.7 and 77.2 ± 13.3 and a score of < 70 was found in 17% (MeDQ) and 25.7% (MoDQ) VLBW babies. High PBCL score (mean 16.8 ± 5.4) was seen in 84%VLBW babies. On subgroup analysis, 2 babies (5%) in subgroup1 ( n = 54, ≤1200 g,) and 1 (1.6%) in subgroup 2 (n = 78, 1201–1500 g) had CP. Twelve (29%) in subgroup 1 had significant language delay (p = 0.004) as compared to 4 (15%) in subgroup 2 at 1 year. BSID and PBCL scores were comparable. Amongst ELBW babies (<1000 g), 6.6% (n = 1) had CP, 25% (n = 3) and 42% (n = 5) had low MeDQ and MoDQ respectively and all of them had high PBCL score. AGA and SGA had similar outcome.

Conclusion

VLBW babies need close and longer follow up due to high risk of neurodevelopmental and behavioral abnormality.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

Abbreviations

VLBW:

Very low birth weight

ELBW:

Extremely low birth weight

DASII:

Developmental assessment scale for Indian infants

DDST:

Denver Development Screening test

PBCL:

Preschool behavioral checklist

CP:

Cerebral Palsy

MeDQ:

Mental developmental quotient

MoDQ:

Motor developmental quotient

AGA:

Appropriate for gestational age

SGA:

Small for gestational age

References

  1. Stevenson DK, Wright LL, Lemons JA, Oh W, Korenes SB, Papile LA, et al. Very low birth weight outcomes of the National Institute of Child Health and Human development Neonatal Research Network, January 1993 through December 1994. Am J Obstet Gynecol. 1998;179:1632–9.

    Article  CAS  PubMed  Google Scholar 

  2. Wilson-Costello D, Friedman H, Minich N, Fanaroff AA, Hack M. Improved survival rates with increased neurodevelopmental disability for extremely low birth weight infants in the 1990s. Pediatrics. 2005;115:997–1003.

    Article  PubMed  Google Scholar 

  3. Wilson-Costello D, Friedman H, Minich N, Siner B, Taylor G, Schluchter M, et al. Improved neurodevelopmental outcomes for extremely low birth weight infants in 2000–2002. Pediatrics. 2007;119:37–45.

    Article  PubMed  Google Scholar 

  4. Vohr BR, Wright LL, Dusick AM, Mele L, Verter J, Steichen JJ, et al. Neurodevelopmental and functional outcomes of extremely low birth weight infants in the National Institute of Child Health and Human development Neonatal Research Network, 1993–1994. Pediatrics. 2000;105:1216–26.

    Article  CAS  PubMed  Google Scholar 

  5. High risk follow-up working group ( Kowloon Region). Neurodevelopmental outcomes of extremely low birth weight infants born between 2001 and 2002. Hong Kong Med J. 2008;14:21–8.

    Google Scholar 

  6. Ho JJ, Amar HS, Mohan AJ, Hon TH. Neurodevelopmental outcome of very low birth weight babies admitted to a Malaysian nursery. J Pediatr Child Health. 1999;35:175–80.

    Article  CAS  Google Scholar 

  7. National Neonatal Perinatal database, report for the year 2000, National Neonatology Forum, India.

  8. National Neonatal Perinatal database, report for the year 2002–3, National Neonatology Forum, India.

  9. Chaudhari S, Kulkarni S, Pajnigar F, Pandit AN, Desmukh S. A longitudinal follow up of development of preterm infants. Indian Pediatr. 1991;28:873–80.

    CAS  PubMed  Google Scholar 

  10. Chaudhari S, Kulkarni S, Barve S, Pandit AN, Sonak U, Sarpotdar N. Neurologic sequelae in high risk infants–a three year follow up. Indian Pediatr. 1996;33:645–53.

    CAS  PubMed  Google Scholar 

  11. Chaudhari S, Bhalerao MR, Chitale A, Pandit AN, Nene U. Pune low birth weight study–a six year follow up. Indian Pediatr. 1999;36:669–76.

    CAS  PubMed  Google Scholar 

  12. Gutbrod T, Wolke D, Soehne B, Ohrt B, Riegel K. Effects of gestation and birth weight on the growth and development of very low birth weight small for gestational age infants: a matched group comparison. Arch Dis Child Fetal Neonatal Ed. 2000;82:F208–14.

    Article  CAS  PubMed  Google Scholar 

  13. Horwood LJ, Mogridge N, Darlow BA. Cognitive, educational and behavioural outcome at 7–8 years in a national very low birth weight cohort. Arch Dis Child Fetal Neonatal Ed. 1998;79:F12–20.

    Article  CAS  PubMed  Google Scholar 

  14. Mukhopadhyay K, Narang A, Mahajan R. Effect of human milk fortification in appropriate for gestation and small for gestation preterm babies: a randomized controlled trial. Indian Pediatr. 2007;44:286–90.

    PubMed  Google Scholar 

  15. Frankenburg WK. The Denver approach to early case finding. In: Frankenburg WK, Emde RN, Sullivan JW, editors. Early identification of children at risk. New York: Plenum; 1985. p. 135–58.

    Google Scholar 

  16. Amiel-Tison C, Grenier A. Neurological assessment during first year of life. New York: Oxford University Press; 1986. p. 46–94.

    Google Scholar 

  17. Misra N, Pathak P. Developmental assessment scales for Indian Infants (DASII): Manual, Baroda, M.S. University of Baroda, 1996.

  18. McGuuire J, Richman N. Screening for behavior problems in nurseries. The reliability and validity of the Pre-School Behavior Checklist. J Child Psychol Psychiatry. 1986;27:7–32.

    Article  Google Scholar 

  19. Lubchenco LO, Hansman C, Dressler M, Boyd E. Intrauterine growth as estimate from live born birth weight data at 24 to 42 weeks of gestation. Pediatrics. 1963;32:793–800.

    CAS  PubMed  Google Scholar 

  20. Platt MJ, Cans C, Johnson A, Surman G, Topp M, Torrioli MG, et al. Trends in cerebral palsy among infants of very low birth weight (<1500 g) or born prematurely (< 32 weeks) in 16 European centers: a database study. Lancet. 2007;369:43–50.

    Article  PubMed  Google Scholar 

Download references

Contributions

KM responsible for protocol development, patient screening, enrollment, outcome assessment, preliminary data analysis and writing the manuscript.

RM helped in collection and compilation of data,

PM primarily responsible for developmental assessment and also contributed to the writing of the manuscripts. AN did the critical review of the manuscript and helped in designing the study.

Conflict of Interest

None

Role of Funding Source

Partial financial support was obtained from PGI Research scheme.

Author information

Authors and Affiliations

  1. Department of Pediatrics, PGIMER, Chandigarh, 160012, India

    Kanya Mukhopadhyay, Prahbhjot Malhi, Rama Mahajan & Anil Narang

Authors
  1. Kanya Mukhopadhyay
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Prahbhjot Malhi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rama Mahajan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Anil Narang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kanya Mukhopadhyay.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mukhopadhyay, K., Malhi, P., Mahajan, R. et al. Neurodevelopmental and Behavioral Outcome of Very Low Birth Weight Babies at Corrected Age of 2 Years. Indian J Pediatr 77, 963–967 (2010). https://doi.org/10.1007/s12098-010-0149-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12098-010-0149-3

Keywords

Search

Navigation