Skip to main content

Advertisement

Log in

Allgrove syndrome

  • Clinical Brief
  • Published:
The Indian Journal of Pediatrics Aims and scope Submit manuscript

Abstract

Allgrove syndrome consists of triad of Adrenal hypoplasia, Achalasia cardia and Alacrimia. Often the first manifestation of adrenal hypoplasia is Addisonian crisis precipitated by infection or trauma. We present case of a 9-year-old boy who presented in shock due to adrenal failure later confirmed to have Allgove syndrome.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Allgrove J, Clayton GS, Grant DB. Familial glucocorticoid deficiency with achalasia and deficient tear production. Lancet 1978; 1: 1284–1286.

    Article  PubMed  CAS  Google Scholar 

  2. Agarwal et al. Physical and sexual growth patteren of Indian affluent children from 5–18 yr of age. Indian Pediatrics 1992; 29: 1203–1282.

    PubMed  CAS  Google Scholar 

  3. Sheppard TH, landing BH, Manson DG. Familial Addison’s disease. Case report of two sisters with corticoid deficiency unassociated with hypoaldosteronism. J Chlid 1959; 97: 154–162.

    Google Scholar 

  4. Migeon CJ, Kenny FM, kowarski A et al. The syndrome of congenital unresponsiveness to ACTH. Report of six cases. Pediatr Res 1968; 2: 501–513.

    Article  PubMed  CAS  Google Scholar 

  5. Thistlewaite D, Darling JAB, Fraser R, Manson PA, Ress LH, Harkness RA. Familial glucocorticoid deficiency. Studies of diagnosis and pathogenesis. Arch Dis Child 1975; 50: 291–297.

    Article  Google Scholar 

  6. Gantz I, Tashiro T, Barcroft C et al. Localization of the gene encoding the melanocortin-2 (adrenocorticotrphic hormone) and melanocortin-3 receptor to chromosome 18p11.2 and 20q13.2–13.3 by fluorescence in situ hybridization. Genomics 1993; 18: 166–167.

    Article  PubMed  CAS  Google Scholar 

  7. Weber A, wienker TF, Jung M et al. Linkage of the gene for Triple A syndrome to chromosome 12q13 near type-II keratin gene cluster. Hum Mol Gen 1996; 5: 2061–2066.

    Article  PubMed  CAS  Google Scholar 

  8. Sratakis CA, Lin JPF, Pras E et al. Segregation of Allgrove (Triple A) syndrome in Puerto Rican kindreds with chromosome 12 (12q13) polymorphic markers. Proc Asso Am Physicians 1997; 109: 478–482.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to V. V. Khadilkar.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kasar, P.A., Khadilkar, V.V. & Tibrewala, V.N. Allgrove syndrome. Indian J Pediatr 74, 959–961 (2007). https://doi.org/10.1007/s12098-007-0179-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12098-007-0179-7

Key words

Navigation