Abstract
Lobular breast carcinoma represents 2–20% of infiltrative carcinomas of the breast. The incidence of extrahepatic gastrointestinal (GI) tract metastases observed in necropsy studies varies from 6% to 18% and the most commonly affected organ is the stomach, followed by colon and rectum [1–4]. Reported herein is the case of a 67-year-old woman who was primarily diagnosed and surgically treated for a lobular carcinoma of the breast 15 years ago and is now referred with back pain and right hydronephrosis caused by a metastasis in rectum. Frequently, the absence of specific symptoms of digestive metastases of breast cancer leads to a misdiagnosis of this pathology [5–7]. The treatment will be based on a detailed clinical history and histopathological findings. Metastases from breast cancer in GI tract tumours must be excluded in a patient with previous history of breast carcinoma, as in the case reported herein.
Similar content being viewed by others
References
Gegúndez C, Paz JM, Mata I et al (2005) Obstrucción de intestino delgado por metástasis de carcinoma mamario lobulillar. Cir Esp 77:102–104
Pla V, Safont MJ, Buch E et al (2002) Metastasis de un carcinoma intraductal infiltrante de mama diseminado con cáncer de colon obstructivo. Cir Esp 71:257–258
Cervi G, Vettoreto N, Vinco A et al (2001) Rectal localization of metastatic lobular breast cancer. Dis Colon Rectum 44:453–455
Habertisch R, Tuech JJ, Wilt M, Rodier JF (2005) Anal localization as first manifestation of metastatic ductal breast carcinoma. Tech Coloproctol 9:237–238
Birla R, Mahawar KK, Orizu M et al (2008) Caecal metastasis from breast cancer presenting as intestinal obstruction. World J Surg Oncol 6:47
Schwartz RE, Klimstra DS, Turnbull ADM (1998) Metastatic breast cancer masquerading as gastrointestinal primary. Am J Gastroenterol 93:111–114
Bamias A, Baltayiannis G, Kaminam S et al (2001) Rectal metastases from lobular carcinoma of the breast: report of a case and literature review. Ann Oncol 12:715–718
Doval DC, Bhatia K, Pavithran K et al (2006) Breast carcinoma with metastasis to the gallbladder: an unusual case report with a short review of literature. Hepatobiliary Pancreat Dis 5:305–307
Zagouri F, Sergentanis TN, Koulocheri D et al (2007) Bilateral synchronous breast carcinomas followed by a metastasis to the gallbladder: a case report. World J Surg Oncol 5:101
Signorelli C, Pomponi-Formiconi D, Nelli F, Pollera CF (2005) Single colon metastasis from breast cancer: a clinical case report. Tumori 91:424–427
Santini D, Altomare A, Vincenzi B et al (2006) An increase of CA 19.9 as the first clinical sign of ileocecal valve metastasis from breast cancer. In Vivo 20:165–168
Aurello P, D’Angelo F, Cosenza G et al (2006) Gastric metastasis 14 years after mastectomy for breast lobular carcinoma: a case report and literature review. Am J Surg 72:456–460
Ayantunde AA, Agrawal A, Parsons SL, Welch NT (2007) Esophagogastric cancers secondary to a breast primary tumor do not require resection. World J Surg 31:1597–1601
Werling RW, Yaziji H, Bachi CE, Gown AM (2003) CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin. Am J Surg Pathol 27:303–310
De Lott LB, Morrison C, Suster S et al (2005) CDX2 is a useful marker of intestinal-type differentiation: a tissue microarray-based study of 629 tumors from various sites. Arch Pathol Lab Med 129:1100–1105
Harris M, Howell A, Chrissohou M et al (1984) A comparison of the metastatic pattern of infiltrating lobular carcinoma and infiltrating ductal carcinoma of the breast. Br J Cancer 50:23–30
Lamovec J, Bracko M (1991) Metastatic pattern of infiltrating lobular carcinoma of the breast: an autopsy study. J Surg Oncol 48:28–33
Borst MJ, Ingold JA (1993) Metastatic patterns of invasive lobular versus invasive ductal carcinoma of the breast. Surgery 114:637–641
Fayemi AO, Ali M, Braun EV (1979) Metastatic carcinoma simulating linitis plastica of the colon. A case report. Am J Gastroenterol 71:311–314
Koos L, Field RE (1980) Metastatic carcinoma of breast simulating Crohn’ s disease. Int Surg 65:359–362
Taal BG, den Hartog Jager FCA, Steinmetz R, Peterse H (1992) The spectrum of gastrointestinal metastases of breast carcinoma. Gastrointest Endosc 38:136–141
Van Halteren HK, Peters H, Gerlag PGG (1998) Large bowel mucosal metastases from breast cancer. J Clin Oncol 16:3711–3713
Rabau MY, Alon RJ, Werbin N, Yossipov Y (1988) Colonoic metastases from lobular carcinoma of the breast. Dis Colon Rectum 31:401–402
Vang R, Gown AM, Wu LS et al (2006) Immunohistochemical expression of CDX2 in primary ovarian mucinous tumors and metastatic mucinous carcinomas involving the ovary: comparison with CK20 and correlation with coordinate expression of CK7. Modern Path 19:1421–1428
Ortiz-Rey JA, Alvarez C, San Miguel P et al (2005) Expression of CDX2, cytokeratins 7 and 20 in sinonasal intestinal-type adenocarcinoma. Appl Immunohistochem Mol Morphol 13:142–146
Guarneri V, Giovanelli S, Ficarra G et al (2008) Comparison of HER-2 and hormone receptor expression in primary breast cancers and asynchronous paired metastases: impact on patient management. Oncologist 13:838–844
Alba M, Piedrafita E, Chivite de León A et al (1997) Metástasis gástricas de un carcinoma de mama. Rev Esp Enf Digest 89:647–649
Washington K, McDonagh D (1995) Secondary tumours of the gastrointestinal tract: surgical pathologic findings and comparison with autopsy series. Mod Pathol 8:427–433
Hansen RM, Lewis DJ, Janjan NA, Komorowsky RA (1988) Occult carcinoma of the breast masquerading as primary adenocarcinoma of the small intestine. A case report. J Clin Gastroenterol 10:213–217
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
López Deogracias, M., Flores Jaime, L., Arias-Camisón, I. et al. Rectal metastasis from lobular breast carcinoma 15 years after primary diagnosis. Clin Transl Oncol 12, 150–153 (2010). https://doi.org/10.1007/S12094-010-0481-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/S12094-010-0481-0