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Genetic changes in small cell lung carcinoma

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Abstract

Small cell lung carcinoma (SCLC) accounts for approximately 15% of all lung cancer cases. Despite a frequently good response to first-line treatment with chemotherapy and/or radiotherapy, early relapse occurs in the majority of patients and 5-year survival is only about 5%. Therefore, there is a need to develop novel treatments to improve the outcome of patients with SCLC. To fulfil this need, it is critical to gain further understanding on the molecular basis of SCLC and specifically to identify novel therapeutic targets. Clinical trials with molecularly targeted agents have been performed with little success in the past, but recently many promising oncogenic pathways have been discovered and novel targeted therapies are under evaluation. In this review, we summarise the most relevant genetic and signalling pathway alterations reported to date in SCLC and discuss the potential therapeutic implications of such events.

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Authors and Affiliations

  1. Medical Oncology Service, Hospital del Mar, Passeig Maritim, 25-29, ES-08003, Barcelona, Spain

    Edurne Arriola, Israel Cañadas, Ana Rovira & Joan Albanell

  2. Cancer Research Program, IMIM-Hospital del Mar, Barcelona, Spain

    Edurne Arriola, Israel Cañadas, Montse Arumí, Federico Rojo, Ana Rovira & Joan Albanell

  3. Pathology Service, Hospital del Mar, Barcelona, Spain

    Montse Arumí

  4. Pathology Service, Fundación Jiménez Díaz, Madrid, Spain

    Federico Rojo

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  1. Edurne Arriola
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Arriola, E., Cañadas, I., Arumí, M. et al. Genetic changes in small cell lung carcinoma. Clin Transl Oncol 10, 189–197 (2008). https://doi.org/10.1007/s12094-008-0181-1

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