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Phosphoinositide-specific Phospholipase C β1 gene deletion in bipolar disorder affected patient

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Journal of Cell Communication and Signaling Aims and scope

Abstract

The involvement of phosphoinositides (PI) signal transduction pathway and related molecules, such as the Phosphoinositide-specific Phospholipase C (PI-PLC) enzymes, in the pathophysiology of mood disorders is corroborated by a number of recent evidences. Our previous works identified the deletion of PLCB1 gene, which codifies for the PI-PLC β1 enzyme, in 4 out 15 patients affected with schizophrenia, and no deletion both in major depression affected patients and in normal controls. By using interphase fluorescent in situ hybridization methodology, we analyzed PLCB1 in paraffin embedded samples of orbito-frontal cortex of 15 patients affected with bipolar disorder. Deletion of PLCB1 was identified in one female patient.

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Abbreviations

SSC:

Saline-sodium citrate buffer

DAPI:

4',6-diamino-2-phenylindole dihydrochloride

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Authors and Affiliations

  1. Dipartimento Organi di Senso, Sapienza University of Rome, Rome, Italy

    Vincenza Rita Lo Vasco & Lucia Longo

  2. Dipartimento di Scienze Ginecologiche e della Riproduzione Umana, Padova University Hospital, Padova, Italy

    Patrizia Polonia

  3. Department of Organi di Senso, Faculty of Medicine and Dentistry, University of Rome “Sapienza”, viale del Policlinico, 155-00185, Rome, Italy

    Vincenza Rita Lo Vasco

Authors
  1. Vincenza Rita Lo Vasco
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  2. Lucia Longo
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  3. Patrizia Polonia
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Correspondence to Vincenza Rita Lo Vasco.

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The Corresponding Author, Dr Vincenza Rita Lo Vasco, has the right to grant on behalf of all authors and does grant on behalf of all authors, an exclusive licence (or non exclusive for government employees) on a worldwide basis to permit this article (if accepted) to be published in this journal.

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The AUTHORS, Dr Vincenza Rita Lo Vasco and Dr Patrizia Polonia, declare that:

the submitted work has not been published previously, it is not under consideration for publication elsewhere, its publication is approved by all authors and tacitly or explicitly by the responsible authorities where the work was carried out, and, if accepted, it will not be published elsewhere including electronically in the same form, in English or in any other language, without the written consent of the copyright-holder.

Author contribution

The authors materially participated in the research and/or article preparation. Vincenza Rita Lo Vasco: participated in concept and design of the research; carrying out the experimental work; data analysis and interpretation; writing of the article. Patrizia Polonia and Lucia Longo: participated in data analysis and interpretation; writing of the article.

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Lo Vasco, V.R., Longo, L. & Polonia, P. Phosphoinositide-specific Phospholipase C β1 gene deletion in bipolar disorder affected patient. J. Cell Commun. Signal. 7, 25–29 (2013). https://doi.org/10.1007/s12079-012-0182-2

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  • DOI: https://doi.org/10.1007/s12079-012-0182-2

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