Abstract
Objective
To assess the microvascular density (MVD) in juvenile nasopharyngeal angiofibroma (JNA) with CD34 immunostaining and evaluate its relationship with clinico-demographic features.
Methods
This prospective study included patients with JNA undergoing endoscopic excision. The histopathological specimen was stained using CD-34 antibodies to calculate MVD. MVD and clinico-demographic features were correlated.
Results
The study included 12 patients with a median age of 15.5 years. The mean MVD was 39 vessels/high power field (range 5 to 151 vessels). MVD was significantly associated only with the volume of tumour (r = 0.65, p = 0.02). The recurrence occurred in one patient with an MVD of 107. The median follow-up was 38 months.
Conclusion
MVD is significantly associated with tumour volume in JNA, which implies a robust role of angiogenesis in the pathology of the tumour. Also, higher MVD may be a risk factor for recurrence.
Key message
•Juvenile nasopharyngeal angiofibroma (JNA) is currently thought to originate from remnant of first branchial arch.
•Microvascular density (MVD) is a reliable indicator of angiogenesis which can be assessed using CD34 antibodies.
•JNA has high microvascular density for a benign tumour with a mean MVD of 39 micro-vessels/high power field.
•MVD is positively correlated with tumour volume which indicates a significant role of angiogenesis in tumour growth.
•High MVD may be a risk factor for tumour recurrence.
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All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Avinash Shekhar Jaiswal and Rakesh Kumar. The first draft of the manuscript was written by Avinash Shekhar Jaiswal and all authors commented on subsequent versions of the manuscript. All authors read and approved the final manuscript.
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Jaiswal, A.S., Kumar, R., Kakkar, A. et al. Role of CD34-immunopositive Microvascular Density in Juvenile Nasopharyngeal Angiofibroma. Indian J Otolaryngol Head Neck Surg 76, 1503–1508 (2024). https://doi.org/10.1007/s12070-023-04331-x
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DOI: https://doi.org/10.1007/s12070-023-04331-x