Abstract
The aim of this study was to evaluate the demographic and clinicopathologic data of salivary gland tumors managed at a tertiary referral medical center in Turkey. The data of 510 patients with salivary gland tumors managed during the period of January 1984 to May 2012, were reviewed. Only primary neoplasms derived from salivary glands were included. Out of 510 neoplasms, 352 (69.0 %) were classified as benign and 158 (31.0 %) were classified as malignant. There was a male predominance and male:female ratio was 1.23 (281/229). The most common location was parotid gland (372/510, 72.9 %) followed by minor salivary glands (97/510, 19.0 %) and submandibular gland (40/510, 7.9 %). The malignancy rates were 21.5, 40.0, and 56.7 % in parotid, submandibular, and minor salivary glands locations, respectively. The most common location for minor salivary gland neoplasms was oral cavity (61/97, 62.9 %). Pleomorphic adenoma (PA) was the most common histopathological type (45.3 %) in the whole study group and also among pediatric patients. The most common malignant neoplasms were adenoid cystic carcinoma (39/510, 7.6 %) and mucoepidermoid carcinoma (5.7 %). Salivary gland tumors are more common in men. The malignancy rate is almost three times higher in neoplasms derived from minor glands when compared to parotid gland. PA is the most common histopathological tumor type in all locations and in all age groups.
Similar content being viewed by others
References
Guzzo M, Locati LD, Prott FJ, Gatta G, McGurk M, Licitra L (2010) Major and minor salivary gland tumors. Crit Rev Oncol Hematol 74:134–148
(2005) Tumors of the salivary glands. In: Barnes L, Eveson JW, Reichart P, Sidransky D (eds) World Health Organization classification of tumors: pathology and genetics of head & neck tumors. IARC Press, Lyon, pp 208–281
Przewoźny T, Stankiewicz C (2004) Neoplasms of the parotid gland in northern Poland, 1991–2000: an epidemiologic study. Eur Arch Otorhinolaryngol 261:369–375
Lukšić I, Virag M, Manojlović S, Macan D (2012) Salivary gland tumours: 25 years of experience from a single institution in Croatia. J Craniomaxillofac Surg 40:e75–e81
Sadetzki S, Chetrit A, Jarus-Hakak A, Cardis E, Deutch Y, Duvdevani S, Zultan A, Novikov I, Freedman L, Wolf M (2008) Cellular phone use and risk of benign and malignant parotid gland tumors—a nationwide case-control study. Am J Epidemiol 167:457–467
Beal KP, Singh B, Kraus D, Yahalom J, Portlock C, Wolden SL (2003) Radiation-induced salivary gland tumors: a report of 18 cases and a review of the literature. Cancer J 9:467–471
Sadetzki S, Oberman B, Mandelzweig L, Chetrit A, Ben-Tal T, Jarus-Hakak A, Duvdevani S, Cardis E, Wolf M (2008) Smoking and risk of parotid gland tumors: a nationwide case-control study. Cancer 112:1974–1982
Westra WH (2007) Diagnostic difficulties in the classification and grading of salivary gland tumors. Int J Radiat Oncol Biol Phys 69:S49–S51
Westra WH, Kronz JD, Eisele DW (2002) The impact of second opinion surgical pathology on the practice of head and neck surgery: a decade experience at a large referral hospital. Head Neck 24:684–693
Tian Z, Li L, Wang L, Hu Y, Li J (2010) Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population. Int J Oral Maxillofac Surg 39:235–242
Li LJ, Li Y, Wen YM, Liu H, Zhao HW (2008) Clinical analysis of salivary gland tumor cases in West China in past 50 years. Oral Oncol 44:187–192
Jones AV, Craig GT, Speight PM, Franklin CD (2008) The range and demographics of salivary gland tumours diagnosed in a UK population. Oral Oncol 44:407–417
Tilakaratne WM, Jayasooriya PR, Tennakoon TM, Saku T (2009) Epithelial salivary tumors in Sri Lanka: a retrospective study of 713 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108:90–98
de Oliveira FA, Duarte EC, Taveira CT, Máximo AA, de Aquino EC, Alencar Rde C, Vencio EF (2009) Salivary gland tumor: a review of 599 cases in a Brazilian population. Head Neck Pathol 3:271–275
Fonseca FP, de Vasconcelos Carvalho M, de Almeida OP, Rangel AL, Takizawa MC, Bueno AG, Vargas PA (2012) Clinicopathologic analysis of 493 cases of salivary gland tumors in a Southern Brazilian population. Oral Surg Oral Med Oral Pathol Oral Radiol 114:230–239
Vuhahula EA (2004) Salivary gland tumors in Uganda: clinical pathological study. Afr Health Sci 4:15–23
Wang YL, Zhu YX, Chen TZ, Wang Y, Sun GH, Zhang L, Huang CP, Wang ZY, Shen Q, Li DS, Wu Y, Ji QH (2012) Clinicopathologic study of 1176 salivary gland tumors in a Chinese population: experience of one cancer center 1997–2007. Acta Otolaryngol [Epub ahead of print]
Subhashraj K (2008) Salivary gland tumors: a single institution experience in India. Br J Oral Maxillofac Surg 46:635–638
Kara MI, Göze F, Ezirganli S, Polat S, Muderris S, Elagoz S (2010) Neoplasms of the salivary glands in a Turkish adult population. Med Oral Patol Oral Cir Bucal 15:e880–e885
Al-Khateeb TH, Ababneh KT (2007) Salivary tumors in north Jordanians: a descriptive study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:e53–e59
Satko I, Stanko P, Longauerová I (2000) Salivary gland tumours treated in the stomatological clinics in Bratislava. J Craniomaxillofac Surg 28:56–61
Mejía-Velázquez CP, Durán-Padilla MA, Gómez-Apo E, Quezada-Rivera D, Gaitán-Cepeda LA (2012) Tumors of the salivary gland in Mexicans. A retrospective study of 360 cases. Med Oral Patol Oral Cir Bucal 17:e183–e189
Kopeć T, Szyfter W (2006) Deep lobe of parotid gland tumors. Otolaryngol Pol 60:317–324. (abstract)
Musani MA, Sohail Z, Zafar S, Malik S (2008) Morphological pattern of parotid gland tumours. J Coll Physicians Surg Pak 18:274–277
Colella G, Biondi P, Itro A, Compilato D, Campisi G (2010) Warthin’s tumor distribution within the parotid gland. A feasible etiologic source from lymph nodal tissue. Minerva Stomatol 59:245–249, 250–252
Pires FR, Pringle GA, de Almeida OP, Chen SY (2007) Intra-oral minor salivary gland tumors: a clinicopathological study of 546 cases. Oral Oncol 43:463–470
Guzzo M, Ferrari A, Marcon I, Collini P, Gandola L, Pizzi N, Casanova M, Mattavelli F, Scaramellini G (2006) Salivary gland neoplasms in children: the experience of the Istituto Nazionale Tumori of Milan. Pediatr Blood Cancer 47:806–810
Ribeiro Kde C, Kowalski LP, Saba LM, de Camargo B (2002) Epithelial salivary glands neoplasms in children and adolescents: a forty-four-year experience. Med Pediatr Oncol 39:594–600
Liu B, Liu JY, Zhang WF, Jia J (2012) Pediatric parotid tumors: clinical review of 24 cases in a Chinese population. Int J Pediatr Otorhinolaryngol 76:1007–1011
Shapiro NL, Bhattacharyya N (2006) Clinical characteristics and survival for major salivary gland malignancies in children. Otolaryngol Head Neck Surg 134:631–634
Conflict of interest
none.
Financial disclosure
none.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kızıl, Y., Aydil, U., Ekinci, Ö. et al. Salivary Gland Tumors in Turkey: Demographic Features and Histopathological Distribution of 510 Patients. Indian J Otolaryngol Head Neck Surg 65 (Suppl 1), 112–120 (2013). https://doi.org/10.1007/s12070-012-0594-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12070-012-0594-6