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Based on Virtual Screening and Simulation Exploring the Mechanism of Plant-Derived Compounds with PINK1 to Postherpetic Neuralgia

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Abstract

Accumulating evidence strongly supports that PINK1 mutation can mediate mitochondrial autophagy dysfunction in dopaminergic neurons. This study was conducted to determine the role of PINK1 in the pathogenesis of postherpetic neuralgia (PHN) and find new targets for its treatment. A rigorous literature review was conducted to identify 2801 compounds from more than 200 plants in Asia. Virtual screening was used to shortlist the compounds into 20 groups based on their binding energies. MM/PBSA was used to further screen the compound dataset, and vitexin, luteoloside, and 2′-deoxyadenosine-5′-monophosphate were found to have a score of − 59.439, − 52.421, and − 47.544 kcal/mol, respectively. Pain behavioral quantification, enzyme-linked immunosorbent assay, quantitative polymerase chain reaction, western blotting, and transmission electron microscopy were used to confirm the effective mechanism. Vitexin had the most significant therapeutic effect on rats with PHN followed by luteoloside; 2′-deoxyadenosine-5′-monophosphate had no significant effect. Our findings suggested that vitexin could alleviate PHN by regulating mitochondrial autophagy through PINK1.

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Funding

This work was financially supported by grants from Shanghai Municipal Commission of Health and Family Planning, NO. ZY (2021–2023)-0208, support project of the Shanghai Science and Technology Commission (14401901400), and the Science and Technology Commission of Shanghai Municipality (Grant No. 23S21900300).

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  1. Engineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Cai Lun Road 1200, Shanghai, 201203, People’s Republic of China

    Wenjing Guo, Bo Zhang, Minchen Liu, Jiquan Zhang & Yi Feng

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  1. Wenjing Guo
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Contributions

Wenjing Guo: conceptualization, methodology, data curation, writing—original draft; Bo Zhang: visualization, investigation; Minchen Liu: visualization, investigation; Jiquan Zhang: visualization, investigation; Yi Feng: data curation, writing—review and editing.

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Correspondence to Jiquan Zhang or Yi Feng.

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The Institutional Animal Care and Use Committee (IACUC) of Shanghai University of Traditional Chinese Medicine approval the protocols of all experiments involving animals (approval number: PZSHUTCM2212080002).

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Guo, W., Zhang, B., Liu, M. et al. Based on Virtual Screening and Simulation Exploring the Mechanism of Plant-Derived Compounds with PINK1 to Postherpetic Neuralgia. Mol Neurobiol (2024). https://doi.org/10.1007/s12035-024-04098-4

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