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The Role of Gut Microbiota in Blood–Brain Barrier Disruption after Stroke

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Abstract

Growing evidence has proved that alterations in the gut microbiota have been linked to neurological disorders including stroke. Structural and functional disruption of the blood-brain barrier (BBB) is observed after stroke. In this context, there is pioneering evidence supporting that gut microbiota may be involved in the pathogenesis of stroke by regulating the BBB function. However, only a few experimental studies have been performed on stroke models to observe the BBB by altering the structure of gut microbiota, which warrant further exploration. Therefore, in order to provide a novel mechanism for stroke and highlight new insights into BBB modification as a stroke intervention, this review summarizes existing evidence of the relationship between gut microbiota and BBB integrity and discusses the mechanisms of gut microbiota on BBB dysfunction and its role in stroke.

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Acknowledgements

We would like to thank BioRender.com. The figure in this manuscript was created with BioRender.com.

Funding

This work was supported by the Guangdong Basic and Applied Basic Research Foundation (2023A1515030045) and the Presidential Foundation of Zhujiang Hospital, Southern Medical University (yzjj2022ms4).

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Authors and Affiliations

  1. Clinical Biobank Center, Microbiome Medicine Center, Department of Laboratory Medicine, Guangdong Provincial Clinical Research Center for Laboratory Medicine, Zhujiang Hospital, Southern Medical University, 510280, Guangzhou, China

    Meiqin Zeng, Meichang Peng, Jianhao Liang & Haitao Sun

  2. Neurosurgery Center, The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China On Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory On Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China

    Meiqin Zeng, Meichang Peng, Jianhao Liang & Haitao Sun

  3. Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Centre for Brain Science and Brain-Inspired Intelligence, Southern Medical University, Guangzhou, China

    Haitao Sun

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Haitao Sun conceived the topic and designed the outline of this review; Meiqin Zeng drafted the manuscript and contributed to the literature review and manuscript writing; Jianhao Liang prepared the figure; Meichang Peng critically revised the manuscript. All authors read and approved the final manuscript. The work presented here was carried out in collaboration among all authors.

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Zeng, M., Peng, M., Liang, J. et al. The Role of Gut Microbiota in Blood–Brain Barrier Disruption after Stroke. Mol Neurobiol (2023). https://doi.org/10.1007/s12035-023-03512-7

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