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Inhibition of Protein Phosphatase 2A: Focus on the Glutamatergic System

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Abstract

In a recent review published in Molecular Neurobiology, Kamat and colleagues (Mol Neurobiol. 2014 Dec;50(3):852–65) highlighted the cellular and molecular mechanisms involved in Okadaic acid (OKA)-induced neurotoxicity. In this review, the authors underline a wide range of pathological signaling pathways involved in OKA-induced neurotoxicity; however, the role of glutamate was only briefly described. We believe that the hyperactivation of the glutamatergic system is a key pathophysiological player in OKA-induced neurotoxicity and deserves serious attention. In this commentary, we propose an integrative model linking glutamate and PP2A and put forward some unanswered questions.

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Conflict of Interest

The authors declare that they have no competing interests.

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Authors and Affiliations

  1. Department of Biochemistry, ICBS, Federal University of Rio Grande do Sul (UFRGS), 2600 Ramiro Barcelos Street, 90035-003, Porto Alegre, RS, Brazil

    Eduardo R. Zimmer, Diogo O. Souza & Luis V. Portela

  2. Centre for Alzheimer Research, Division of Translational Alzheimer Neurobiology, Karolinska Institutet, Stockholm, Sweden

    Antoine Leuzy

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  1. Eduardo R. Zimmer
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  2. Antoine Leuzy
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  3. Diogo O. Souza
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  4. Luis V. Portela
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Correspondence to Luis V. Portela.

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Zimmer, E.R., Leuzy, A., Souza, D.O. et al. Inhibition of Protein Phosphatase 2A: Focus on the Glutamatergic System. Mol Neurobiol 53, 3753–3755 (2016). https://doi.org/10.1007/s12035-015-9321-0

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  • DOI: https://doi.org/10.1007/s12035-015-9321-0

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