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The Impact of microRNA SNPs on Breast Cancer: Potential Biomarkers for Disease Detection

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Abstract

Breast cancer is considered a significant health concern worldwide, with genetic predisposition playing a critical role in its etiology. Single nucleotide polymorphisms (SNPs), particularly those within the 3' untranslated regions (3'UTRs) of target genes, are emerging as key factors in breast cancer susceptibility. Specifically, miRNAs have been recognized as possible novel approach for biomarkers discovery for both prognosis and diagnosis due to their direct association with cancer progression. Regional disparities in breast cancer incidence underscore the need for precise interventions, considering socio-cultural and economic factors. This review explores into the differential effects of SNP-miRNA interactions on breast cancer risk, emphasizing both risk-enhancing and protective associations across diverse populations. Furthermore, it explores the clinical implications of these findings, highlighting the potential of personalized approaches in breast cancer management. Additionally, it reviews the evolving therapeutic prospect of microRNAs (miRNAs), extending beyond cancer therapeutics to encompass various diseases, indicative of their versatility as therapeutic agents.

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Abbreviations

SNPs:

Single Nucleotides Polymorphism

SYK:

Spleen Tyrosine Kinase

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  1. Department of Biotechnology, Sharda University, Greater Noida, Uttar Pradesh, India

    Sakshi Chauhan, Runjhun Mathur & Abhimanyu Kumar Jha

  2. Dr APJ Abdul Kalam Technical University, Lucknow, Uttar Pradesh, India

    Runjhun Mathur

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Chauhan, S., Mathur, R. & Jha, A.K. The Impact of microRNA SNPs on Breast Cancer: Potential Biomarkers for Disease Detection. Mol Biotechnol 67, 845–861 (2025). https://doi.org/10.1007/s12033-024-01113-w

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