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Role of vitamin D in targeting cancer and cancer stem cell populations and its therapeutic implications

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Abstract

Cancer is recognized globally as the second-most dominating and leading cause of morbidities. Fighting the global health epidemic threat posed by cancer requires progress and improvements in imaging techniques, surgical techniques, radiotherapy, and chemotherapy. The existence of a small subpopulation of undifferentiated cells known as cancer stem cells has been supported by accumulating evidence and ongoing research. According to clinical data, cancer recurrence, tumor development, and metastasis are thought to be caused by CSCs. Nutritional or dietary supplements can help you to fight against cancer and cope with the treatment side effects. Vitamin D, sometimes known as the sunshine vitamin, is produced in the skin in reaction to sunlight. Vitamin D deficiency is hazardous to any degree, increasing the risk of diseases such as cancer and disorders like osteoporosis. Bioactive vitamin D, or calcitriol, regulates several biological pathways. Many modes of action of Vitamin D might be helpful in protecting somatic stem cells (e.g., DNA damage repair and oxidative stress protection) or restricting cancer stem cell growth (e.g., cell cycle arrest, cell apoptosis). Researchers have recently begun to investigate the inhibitory effects of dietary vitamin D on cancer stem cells. In this review, we investigated the therapeutic impact of vitamin D and its molecular processes to target cancer and cancer stem cells as well.

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Author notes

  1. Jyoti Bharamgoud Marigoudar, Yakubu Magaji Yuguda, and Reem Fawaz Abutayeh have contributed equally and should be considered as first authors.

Authors and Affiliations

  1. MES College of Arts, Commerce, and Science, Bengaluru, Karnataka, 560003, India

    Jyoti Bharamgoud Marigoudar

  2. Department of Microbiology, Ramakrishna Mission Vidyamandira, Belur Math, Haora, West Bengal, 711202, India

    Diptendu Sarkar

  3. Department of Science Laboratory Technology, Faculty of Sciences, Federal Polytechnic, Kaltungo, Gombe State, Nigeria

    Yakubu Magaji Yuguda

  4. Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmacy, Applied Science Private University, Amman, 11931, Jordan

    Reem Fawaz Abutayeh

  5. SGT College of Pharmacy SGT University, Gurgaon, Haryana, 122505, India

    Avneet Kaur

  6. Department of Immunology and Rheumatology (IMS & SUM HOSPITAL), Siksha ‘O’ Anusandhan Deemed to be University, Jagamara, Bhubaneswar, Odisha, 751030, India

    Ankita Pati

  7. Department of Biophysics, Molecular Biology and Bioinformatics, University of Calcutta, Calcutta, 700073, India

    Disha Mitra

  8. Department of Biotechnology School of Life Science and Biotechnology, Adamas University Barasat, Calcutta, 700126, India

    Animikha Ghosh

  9. Department of Biotechnology, Faculty of Science, Atmiya University, “Yogidham Gurukul”, Kalawad Road, Rajkot, Gujarat, 360005, India

    Debashis Banerjee

  10. School of Pharmaceutical Sciences, University of Science and Technology, Baridua, Meghalaya, 793101, India

    Sudarshana Borah, Kamallochan Barman & Bhanita Das

  11. MET’s Institute of Pharmacy, Bhujbal Knowledge City, Nashik, Maharashtra, 422003, India

    Shubham Jagdish Khairnar

  12. Faculty of Health Studies, University of Sarajevo, 71000, Sarajevo, Bosnia and Herzegovina

    Emir Šeherčehajić

  13. School of Biological Science, University of Portsmouth, Portsmouth, PO1 2DY, England

    Shivam Kumar

Authors
  1. Jyoti Bharamgoud Marigoudar
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  2. Diptendu Sarkar
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  3. Yakubu Magaji Yuguda
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  4. Reem Fawaz Abutayeh
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  5. Avneet Kaur
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  6. Ankita Pati
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  7. Disha Mitra
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  8. Animikha Ghosh
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  9. Debashis Banerjee
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  10. Sudarshana Borah
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  11. Kamallochan Barman
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  12. Bhanita Das
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  13. Shubham Jagdish Khairnar
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  14. Emir Šeherčehajić
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  15. Shivam Kumar
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by JBM, DS, YMY, RFA, AK, AP, DM, AG, DB, SB, KB, BD, SJK, and EŠ. The first draft of the manuscript was written by SK and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Shivam Kumar.

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Marigoudar, J.B., Sarkar, D., Yuguda, Y.M. et al. Role of vitamin D in targeting cancer and cancer stem cell populations and its therapeutic implications. Med Oncol 40, 2 (2023). https://doi.org/10.1007/s12032-022-01855-0

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