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Phosphorylated insulin-like growth factor-1 receptor expression predicts poor prognosis of Chinese patients with gastric cancer

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Abstract

Previous studies have established the role of phosphorylated form of insulin-like growth factor type 1 receptor (p-IGF1R) as a good candidate for tumor biomarker. The aims of this study were to investigate p-IGF1R expression status in gastric cancer (GC) specimens and to clarify its clinical significance. A total of 78 GC patients treated with radical resection were enrolled in this study. Immunohistochemistry was used to detect p-IGF1R and phosphatase and tensin homolog deleted on chromosome ten (PTEN) protein expression in paired tumor and adjacent normal tissues. Results showed a higher level of p-IGF1R protein expression in tumor tissues than that in normal tissues, and the rate of p-IGF1R protein high/moderate expression in GC and normal tissues was 52.6 % (41/78) and 6.4 % (5/78), respectively (p < 0.001). In contrast, PTEN protein expression was downregulated in GC, as compared with normal tissues (negative/low expression 49/78 vs. 8/78, p < 0.001). Moreover, PTEN protein downregulation was consistent with p-IGF1R upregulation. Overexpression of p-IGF1R protein was associated with lymph metastasis, clinical stage, and adverse 3-year progression-free survival (PFS). Survival analysis and Cox proportional hazards model revealed that p-IGF1R overexpression was an independent factor in predicting PFS for GC patients, apart from lymph metastasis. In conclusion, p-IGF1R is highly expressed in GC, which may be a novel biomarker to predict the clinical outcome of GC patients.

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Abbreviations

GC:

Gastric cancer

MAPK:

Mitogen-activated protein kinase

PI3K:

Phosphatidylinositol 3-kinase

PFS:

Progression-free survival

p-IGF1R:

Phosphorylated insulin-like growth factor type 1 receptor

PTEN:

Phosphatase and tensin homolog deleted on chromosome ten

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Acknowledgments

This study was supported by National Natural Science Foundation of China (N0. 81101650). The valuable help from the Departments of Pathology of Henan Cancer Hospital, China, is also greatly appreciated.

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Correspondence to Su-xia Luo or You-wei Zhang.

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Deng, Wy., Li, N., Wan, Xb. et al. Phosphorylated insulin-like growth factor-1 receptor expression predicts poor prognosis of Chinese patients with gastric cancer. Med Oncol 31, 141 (2014). https://doi.org/10.1007/s12032-014-0141-2

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  • DOI: https://doi.org/10.1007/s12032-014-0141-2

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