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Correlation of LAPTM4B polymorphisms with hepatocellular carcinoma in Chinese patients

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Abstract

Hepatocellular carcinoma (HCC) is the leading cause of cancer mortality in many countries. Evaluation of new susceptibility risk factors is therefore warranted in order to explore means to improve the survival rate. Here, we report on a novel HCC-related gene known as lysosomal protein transmembrane 4 beta (LAPTM4B) that has two alleles designated LAPTM4B*1 and LAPTM4B*2. Allele *1 differs from allele *2 in that it contains one copy of a 19-bp sequence, whereas this sequence is duplicated in allele *2 in exon 1 of LAPTM4B. In this study, we aimed to investigate the relationship between LAPTM4B allelic variation and HCC susceptibility. The LAPTM4B genotype was analyzed in the blood samples from 102 HCC patients and 135 healthy individuals by PCR. The genotypic distribution of LAPTM4B was analyzed using the chi-squared test. The frequencies of allele *2 were 38.24 and 24.07% in the HCC group and control group, respectively, representing a significant difference between these two groups (P < 0.001). Thus, allele *2 of LAPTM4B appears to be associated with genetic susceptibility of HCC and may therefore be considered as a risk factor.

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Authors and Affiliations

  1. Department of Interventional Radiology and Vascular Surgery, Peking University Third Hospital, Beijing, 100191, China

    Guojun Zhai & Xuan Li

  2. Department of Cell Biology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China

    Hua Yang

  3. Department of General Surgery, Peking University Third Hospital, Beijing, 100191, China

    Xiaoxu Ji

  4. Department of Pharmacology, Loma Linda University, Loma Linda, CA, 92354, USA

    Fuxia Xiong

  5. Department of Pathology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China

    Jing Su & Michael A. McNutt

Authors
  1. Guojun Zhai
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  2. Hua Yang
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  3. Xiaoxu Ji
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  4. Fuxia Xiong
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  5. Jing Su
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  6. Michael A. McNutt
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  7. Xuan Li
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Corresponding author

Correspondence to Xuan Li.

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Guojun Zhai and Hua Yang contributed equally to this work.

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Zhai, G., Yang, H., Ji, X. et al. Correlation of LAPTM4B polymorphisms with hepatocellular carcinoma in Chinese patients. Med Oncol 29, 2744–2749 (2012). https://doi.org/10.1007/s12032-011-0139-y

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  • DOI: https://doi.org/10.1007/s12032-011-0139-y

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