Skip to main content

Advertisement

SpringerLink
Log in

A Comprehensive Review on the Role of Genetic Factors in the Pathogenesis of Migraine

  • Published:
Journal of Molecular Neuroscience Aims and scope Submit manuscript

A Correction to this article was published on 23 March 2021

This article has been updated

Abstract

Migraine is a common neurovascular condition. This disorder has a complex genetic background. Several single-nucleotide polymorphisms (SNPs) or mutations within genes regulating glutamatergic neurotransmission, cortical excitability, ion channels, and solute carriers have been associated with polygenic and monogenic forms of migraine. SNPs within ACE, DBH, TRPM8, COMT, GABRQ, CALCA, TRPV1, and other genes have been reported to affect the risk of migraine or the associated clinical parameters. The distribution of some HLA alleles within the HLA-DRB1, HLA-DR2, HLA-B, and HLA-C regions have also been found to differ between migraineurs and healthy subjects. In addition, certain mitochondrial DNA changes and polymorphisms in this region have been shown to increase the risk of migraine. A few functional studies have investigated the molecular mechanisms contributing to these genetic factors in the development of migraine. Here we review studies evaluating the role of genetic polymorphisms and mRNA/miRNA dysregulation in migraine.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

Data Availability

The data sets generated and analyzed during the study are available from the corresponding author on reasonable request.

Change history

References

  • Abdolahi M, Jafarieh A, Sarraf P, Sedighiyan M, Yousefi A, Tafakhori A et al (2019) The neuromodulatory effects of ω-3 fatty acids and nano-curcumin on the COX-2/iNOS network in migraines: A clinical trial study from gene expression to clinical symptoms. Endocr Metab Immune Disord Drug Targets (Formerly Current Drug Targets-Immune, Endocrine & Metabolic Disorders) 19(6):874–84

  • Abdolahi M, Sarraf P, Javanbakht MH, Honarvar NM, Hatami M, Soveyd N et al (2018) A novel combination of ω-3 fatty acids and nano-curcumin modulates interleukin-6 gene expression and high sensitivity C-reactive protein serum levels in patients with migraine: a randomized clinical trial study. CNS Neurol Disord Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders) 17(6):430–8

  • Abedin-Do A, Pouriamanesh S, Kamaliyan Z, Mirfakhraie R (2017) Angiotensin-converting enzyme gene rs4343 polymorphism increases susceptibility to migraine. CNS Neurosci Ther 23(8):698

    Article  PubMed  PubMed Central  Google Scholar 

  • An XK, Fang J, Yu ZZ, Lin Q, Lu CX, Qu HL et al (2017a) Multilocus analysis reveals three candidate genes for Chinese migraine susceptibility. Clin Genet 92(2):143–149

  • An X, Fang J, Lin Q, Lu C, Ma Q, Qu H (2017b) New evidence for involvement of ESR1 gene in susceptibility to Chinese migraine. J Neurol 264(1):81–87

  • Andersen HH, Duroux M, Gazerani P (2016) Serum microRNA signatures in migraineurs during attacks and in pain-free periods. Mol Neurobiol 53(3):1494–1500

    Article  CAS  PubMed  Google Scholar 

  • Ansari M, Karkhaneh A, Kheirollahi A, Emamgholipour S, Rafiee MH (2017) The effect of melatonin on gene expression of calcitonin gene-related peptide and some proinflammatory mediators in patients with pure menstrual migraine. Acta Neurol Belg 117(3):677–685

    Article  PubMed  Google Scholar 

  • Atasayar G, Eryilmaz IE, Karli N, Egeli U, Zarifoglu M, Cecener G et al (2016) Association of MDR1, CYP2D6, and CYP2C19 gene polymorphisms with prophylactic migraine treatment response. J Neurol Sci 366:149–154

    Article  CAS  PubMed  Google Scholar 

  • Barbanti P, Guadagni F, De Marchis ML, Ialongo C, Egeo G, Fofi L et al (2019) Dopamine-beta-hydroxylase 19-bp insertion/deletion polymorphism affects medication overuse in patients with chronic migraine. Neurol Sci 40(8):1717–1724

    Article  PubMed  Google Scholar 

  • Børte S, Zwart J-A, Skogholt AH, Gabrielsen ME, Thomas LF, Fritsche LG et al (2020) Mitochondrial genome-wide association study of migraine–the HUNT Study. Cephalalgia 40(6):625–634

    Article  PubMed  PubMed Central  Google Scholar 

  • Cacciapuoti F (2017) Migraine homocysteine-related: Old and new mechanisms. Neurol Clin Neurosci 5(5):137–140

    Article  CAS  Google Scholar 

  • Chang X, Pellegrino R, Garifallou J, March M, Snyder J, Mentch F et al (2018) Common variants at 5q33. 1 predispose to migraine in African-American children. J Med Genet 55(12):831–6

  • Chen S-P, Fuh J-L, Chung M-Y, Lin Y-C, Liao Y-C, Wang Y-F et al (2018) Genome-wide association study identifies novel susceptibility loci for migraine in Han Chinese resided in Taiwan. Cephalalgia 38(3):466–475

    Article  PubMed  Google Scholar 

  • Cheng C-Y, Chen S-P, Liao Y-C, Fuh J-L, Wang Y-F, Wang S-J (2018) Elevated circulating endothelial-specific microRNAs in migraine patients: a pilot study. Cephalalgia 38(9):1585–1591

    Article  PubMed  Google Scholar 

  • Christensen AF, Esserlind A-L, Werge T, Stefánsson H, Stefánsson K, Olesen J (2016) The influence of genetic constitution on migraine drug responses. Cephalalgia 36(7):624–639

    Article  PubMed  Google Scholar 

  • Coelho FMS, Pradella-Hallinan M, Abud PC, Predazzoli Neto M, Moreira F, Bittencourt LRA et al (2007) Prevalence of HLA DQB1* 0602 allele in patients with migraine. Arq Neuropsiquiatr 65(4B):1123–1125

    Article  PubMed  Google Scholar 

  • Coşkun S, Varol S, Ozdemir HH, Agacayak E, Aydın B, Kapan O et al (2016a) Association of brain-derived neurotrophic factor and nerve growth factor gene polymorphisms with susceptibility to migraine. Neuropsychiatr Dis Treat 12:1779

  • Coşkun S, Varol S, Özdemir HH, Çelik SB, Balduz M, Camkurt MA et al (2016b) association between sequence variations of the Mediterranean fever gene and the risk of migraine: a case–control study. Neuropsychiatr Dis Treat 12:2225

  • Coşkun S, Yücel Y, Çim A, Cengiz B, Oztuzcu S, Varol S et al (2016c) Contribution of polymorphisms in ESR1, ESR2, FSHR, CYP19A1, SHBG and NRIP1 genes to migraine susceptibility in Turkish population. J Genet 95(1):131–140

  • Deng Y, Huang J, Zhang H, Zhu X, Gong Q (2018) Association of expression of DRD2 rs1800497 polymorphism with migraine risk in Han Chinese individuals. J Pain Res 11:763

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Di Gennaro G, Buzzi M, Ciccarelli O, Santorelli F, Pierelli F, Fortini D et al (2000) Assessing the relative incidence of mitochondrial DNA A3243G in migraine without aura with maternal inheritance. Headache: J Head Face Pain 40(7):568–71.

  • Djalali M, Djalali M, Abdolahi M, Mohammadi H, Heidari H, Hosseini S et al (2020) The Effect of Nano-Curcumin Supplementation on Pentraxin 3 Gene Expression and Serum Level in Migraine Patients. Rep Biochem Mol Biol 9(1):1

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dodick DW (2018) A Phase-by-Phase Review of Migraine Pathophysiology. Headache. May;58 Suppl 1:4–16. PubMed PMID: 29697154. Epub 2018/04/27. eng.

  • Esserlind A-L, Christensen AF, Steinberg S, Grarup N, Pedersen O, Hansen T et al (2016) The association between candidate migraine susceptibility loci and severe migraine phenotype in a clinical sample. Cephalalgia 36(7):615–623

    Article  PubMed  Google Scholar 

  • Fachal L, Mosquera-Miguel A, Pastor P, Ortega-Cubero S, Lorenzo E, Oterino-Durán A et al (2015) No evidence of association between common European mitochondrial DNA variants in Alzheimer, Parkinson, and migraine in the Spanish population. Am J Med Genet Part B: Neuropsychiatr Genet 168(1):54–65

    Article  CAS  Google Scholar 

  • Fang J, Yuan X, An X, Qu H, Wang C, Hong G et al (2018) Involvement of the Tetraspanin 2 (TSPAN2) gene in migraine: a case-control study in Han Chinese. Front Neurol 9:714

    Article  PubMed  PubMed Central  Google Scholar 

  • Farahani S, Solgi L, Bayat S, Abedin Do A, Zare‐Karizi S, Safarpour Lima B et al (2020) RAR‐related orphan receptor A: One gene with multiple functions related to migraine. CNS Neurosci Ther

  • Fernández-de-Las-Peñas C, Ambite-Quesada S, Florencio LL, Palacios-Ceña M, Ordás-Bandera C, Arendt-Nielsen L (2019) Catechol-O-Methyltransferase Val158Met Polymorphism Is Associated with Anxiety, Depression, and Widespread Pressure Pain Sensitivity in Women with Chronic, but Not Episodic. Migraine Pain Medicine 20(7):1409–1417

    Article  PubMed  Google Scholar 

  • Fernandez FE, Colson NJ, Lea RA, Griffiths LR, Quinlan S, MacMillan J (2009) Association between migraine and a functional polymorphism at the DBH locus

  • Fuh J-L, Chung M-Y, Yao S-C, Chen P-K, Liao Y-C, Hsu C-L et al (2016) Susceptible genes of restless legs syndrome in migraine. Cephalalgia 36(11):1028–1037

    Article  PubMed  Google Scholar 

  • Gallelli L, Cione E, Peltrone F, Siviglia S, Verano A, Chirchiglia D et al (2019) Hsa-miR-34a-5p and hsa-miR-375 as biomarkers for monitoring the effects of drug treatment for migraine pain in children and adolescents: a pilot study. J Clin Med 8(7):928

    Article  CAS  PubMed Central  Google Scholar 

  • García-Martín E, Esguevillas G, Serrador M, Alonso-Navarro H, Navacerrada F, Amo G et al (2018) Gamma-aminobutyric acid (GABA) receptors GABRA4, GABRE, and GABRQ gene polymorphisms and risk for migraine. J Neural Transm 125(4):689–698

    Article  PubMed  CAS  Google Scholar 

  • Geyik S, Ergun S, Kuzudişli S, Şensoy F, Temiz E, Altunışık E et al (2016) Plasma urotensin-2 level and Thr21Met but not Ser89Asn polymorphisms of the urotensin-2 gene are associated with migraines. J Headache Pain 17(1):36

    Article  PubMed  PubMed Central  Google Scholar 

  • Greco R, Demartini C, Zanaboni AM, Tassorelli C (2018) Chronic and intermittent administration of systemic nitroglycerin in the rat induces an increase in the gene expression of CGRP in central areas: potential contribution to pain processing. J Headache Pain 19(1):51

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Greco R, Demartini C, Zanaboni AM, Tumelero E, Icco RD, Sances G et al. (2020) Peripheral changes of endocannabinoid system components in episodic and chronic migraine patients: A pilot study. Cephalalgia 0333102420949201

  • Guan X, Dong C, Zhu P, Chen C, Wang T, Wu M et al (2020) Association of the cyclooxygenase-2 1759A allele with migraine in Chinese Han individuals. PLoS One 15(9):e0239856

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Guo S, Esserlind AL, Andersson Z, Frederiksen AL, Olesen J, Vissing J et al (2016) Prevalence of migraine in persons with the 3243A> G mutation in mitochondrial DNA. Eur J Neurol 23(1):175–181

    Article  CAS  PubMed  Google Scholar 

  • Haghdoost F, Gharzi M, Faez F, Hosseinzadeh E, Tajaddini M, Rafiei L et al (2016) Association between Ala379Val polymorphism of lipoprotein-associated phospholipase A2 and migraine without aura in Iranian population. Iran J Neurol 15(2):80

    PubMed  PubMed Central  Google Scholar 

  • He W, Long T, Pan Q, Zhang S, Zhang Y, Zhang D et al (2019) Microglial NLRP3 inflammasome activation mediates IL-1β release and contributes to central sensitization in a recurrent nitroglycerin-induced migraine model. J Neuroinflammation 16(1):1–17

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Honkasalo ML, Kaprio J, Winter T, Heikkilä K, Sillanpää M, Koskenvuo M (1995) Migraine and concomitant symptoms among 8167 adult twin pairs. Headache: J Head Face Pain 35(2):70–8

    Article  CAS  Google Scholar 

  • Huang C, Chen S-P, Huang Y-H, Chen H-Y, Wang Y-F, Lee M-H et al (2020) HLA class I alleles are associated with clinic-based migraine and increased risks of chronic migraine and medication overuse. Cephalalgia 40(5):493–502

    Article  CAS  PubMed  Google Scholar 

  • Jeong H, Moye LS, Southey BR, Hernandez AG, Dripps I, Romanova EV et al (2018) Gene network dysregulation in the trigeminal ganglia and nucleus accumbens of a model of chronic migraine-associated hyperalgesia. Front Syst Neurosci 12:63

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kang L, Lee S-T, Im W, Kim SC, Hun KS, Kim B-K et al (2007) Screening of the A11084G polymorphism and scanning of a mitochondrial genome SNP in Korean migraineurs. J Clin Neurol 3(3):127–132

    Article  PubMed  PubMed Central  Google Scholar 

  • Kaur S, Ali A, Pandey AK, Singh B (2018) Association of MTHFR gene polymorphisms with migraine in North Indian population. Neurol Sci 39(4):691–698

    Article  PubMed  Google Scholar 

  • Kaur S, Ali A, Ahmad U, Pandey A, Singh B (2019) rs2651899 variant is associated with risk for migraine without aura from North Indian population. Mol Biol Rep 46(1):1247–1255

    Article  CAS  PubMed  Google Scholar 

  • Kogelman LJ, Falkenberg K, Halldorsson GH, Poulsen LU, Worm J, Ingason A et al (2019) Comparing migraine with and without aura to healthy controls using RNA sequencing. Cephalalgia 39(11):1435–1444

    Article  PubMed  Google Scholar 

  • Körtési T, Tuka B, Nyári A, Vécsei L, Tajti J (2019) The effect of orofacial complete Freund’s adjuvant treatment on the expression of migraine-related molecules. J Headache Pain 20(1):43

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kowalska M, Kapelusiak-Pielok M, Grzelak T, Wypasek E, Kozubski W, Dorszewska J (2018) The new* G29A and G1222A of HCRTR1, 5-HTTLPR of SLC6A4 polymorphisms and hypocretin-1, serotonin concentrations in migraine patients. Front Mol Neurosci 11:191

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lin GY, Lin YK, Liang CS, Lee JT, Tsai CL, Hung KS et al (2020) Association of genetic variants in migraineurs with and without restless legs syndrome. Ann Clin Transl Neurol

  • Lin Q-F, Chen Z-C, Fu X-G, Yang J, Cao L-Y, Yao L-T et al (2017) Migraine susceptibility genes in Han Chinese of Fujian province. J Clin Neurol 13(1):71–6

  • Lu W, Li B, Chen J, Su Y, Dong X, Su X et al (2016) Expression of calcitonin gene-related peptide, adenosine A2a receptor and adenosine A1 receptor in experiment rat migraine models. Biomed Rep 4(3):379–383

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Martelletti P, Lulli P, Morellini M, Mariani B, Pennesi G, Cappellacci S et al (1999) Chromosome 6p-encoded HLA-DR2 determinant discriminates migraine without aura from migraine with aura. Hum Immunol 60(1):69–74

    Article  CAS  PubMed  Google Scholar 

  • Moreno-Mayordomo R, Ruiz M, Pascual J, de la Sacristana MG, Vidriales I, Sobrado M et al (2019) CALCA and TRPV1 genes polymorphisms are related to a good outcome in female chronic migraine patients treated with OnabotulinumtoxinA. J Headache Pain 20(1):39

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mozaffari E, Doosti A, Arshi A, Faghani M (2016) Association of COX-2 Promoter Polymorphisms-765G/C and-1195A/G with Migraine. Iran J Public Health 45(12):1625

    PubMed  PubMed Central  Google Scholar 

  • Mulder EJ, Van Baal C, Gaist D, Kallela M, Kaprio J, Svensson DA et al (2003) Genetic and environmental influences on migraine: a twin study across six countries. Twin research : the official journal of the International Society for Twin Studies. Oct;6(5):422–31. PubMed PMID: 14624726. Epub 2003/11/20. eng.

  • O’Brien J, Hayder H, Zayed Y, Peng C (2018) Overview of microRNA biogenesis, mechanisms of actions, and circulation. Front Endocrinol 9:402

    Article  CAS  Google Scholar 

  • O'Neill BP, Kapur JJ (1979) Good AE. HLA antigens in migraine. Headache: J Head Face Pain 19(2):71–73

  • Orsini A, Sammartino I, Valetto A, Bertini V, Marchese P, Bonuccelli A et al (2018) Methylenetetrahydrofolate reductase polymorphism (MTHFR C677T) and headache in children: a retrospective study from a tertiary level outpatient service. Ital J Pediatr 44(1):106

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Palmirotta R, Barbanti P, Ludovici G, De Marchis ML, Ialongo C, Egeo G et al (2014) Association between migraine and ACE gene (insertion/deletion) polymorphism: the BioBIM study. Pharmacogenomics 15(2):147–155

    Article  CAS  PubMed  Google Scholar 

  • Polderman TJ, Benyamin B, De Leeuw CA, Sullivan PF, Van Bochoven A, Visscher PM et al (2015) Meta-analysis of the heritability of human traits based on fifty years of twin studies. Nat Genet 47(7):702–709

    Article  CAS  PubMed  Google Scholar 

  • Pollock CE, Sutherland HG, Maher BH, Lea RA, Haupt LM, Frith A et al (2018) The NRP1 migraine risk variant shows evidence of association with menstrual migraine. J Headache Pain 19(1):31

    Article  PubMed  PubMed Central  Google Scholar 

  • Quintas M, Neto JL, Sequeiros J, Sousa A, Pereira‐Monteiro J, Lemos C, Alonso I (2020) Going deep into synaptic vesicle machinery genes and migraine susceptibility–A case‐control association study. Headache: J Head Face Pain 60(10):2152–2165

  • Rainero I, Fasano E, Rubino E, Rivoiro C, Valfrè W, Gallone S et al (2005) Association between migraine and HLA–DRB1 gene polymorphisms. J Headache Pain 6(4):185

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ramroodi N, Saboori H, Sanadgol N (2018) Investigation of association between CD40 current gene variants (rs4810485, rs1883832 and rs3765459) and serum CD154 protein levels in Iranian migraineurs. Cell Mol Biol (Noisy-le-grand) 64(14):72–78

    Article  Google Scholar 

  • Rozen TD, Shanske S, Otaegui D, Lu J, Young WB, Bradley K et al (2004) Study of mitochondrial DNA mutations in patients with migraine with prolonged aura. Headache: J Head Face Pain 44(7):674–7

  • Russell M, Diamant M, Nerby S (1997) Genetic heterogeneity of migraine with and without aura in Danes cannot be explained by mutation in mtDNA nucleotide pair 11084. Acta Neurol Scand 96(3):171–173

    Article  CAS  PubMed  Google Scholar 

  • Salehi M, Amin-Beidokhti M, Lima BS, Gholami M, Javadi G-R, Mirfakhraie R (2018) The rs4846049 polymorphism in the 3′ UTR region of the MTHFR gene increases the migraine susceptibility in an Iranian population. J Pain Res 11:145

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sazci A, Sazci G, Sazci B, Ergul E, Idrisoglu HA (2016) Nicotinamide-N-Methyltransferase gene rs694539 variant and migraine risk. J Headache Pain 17(1):93

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Sezer S, Kurt S, Ates O (2016) Analysis of dopamine beta hydroxylase gene polymorphisms in migraine. Clin Neurol Neurosurg 145:96–100

    Article  PubMed  Google Scholar 

  • Sutherland HG, Albury CL, Griffiths LR (2019) Advances in genetics of migraine. J Headache Pain. 2019/06/21;20(1):72

  • Tafuri E, Santovito D, de Nardis V, Marcantonio P, Paganelli C, Affaitati G et al (2015) MicroRNA profiling in migraine without aura: pilot study. Ann Med 47(6):468–473

    Article  PubMed  CAS  Google Scholar 

  • Taheri M, Nicknafs F, Hesami O, Javadi A, Arsang-Jang S, Sayad A et al (2020) Differential Expression of Cytokine-Coding Genes among Migraine Patients with and without Aura and Normal Subjects. J Mol Neurosci 1–8

  • Takeshima T, Fukuhara Y, Adachi Y, Ishizaki K, Kusumi M, Kowa H et al (2001) Leukocyte mitochondrial DNA A to G polymorphism at 11084 is not a risk factor for Japanese migraineurs. Cephalalgia 21(10):987–989

    Article  CAS  PubMed  Google Scholar 

  • Tang L, Wang Y, Wang H, Xu B, Ji H, Xu G et al (2019) Long noncoding-RNA component of mitochondrial RNA processing endoribonuclease is involved in the progression of cholangiocarcinoma by regulating microRNA-217. Cancer Sci 110(7):2166

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Vgontzas A, Renthal W (2020) Migraine-associated gene expression in cell types of the central and peripheral nervous system. Cephalalgia 40(5):517–523

    Article  PubMed  Google Scholar 

  • Wang Q, Ito M, Adams K, Li BU, Klopstock T, Maslim A et al (2004) Mitochondrial DNA control region sequence variation in migraine headache and cyclic vomiting syndrome. Am J Med Genet Part A 131(1):50–58

    Article  PubMed  Google Scholar 

  • Wang X, Zhao H, Liu L, Niu P, Zhai C, Li J et al (2020) Hejie Zhitong prescription promotes sleep and inhibits nociceptive transmission-associated neurotransmitter activity in a rodent migraine model. Chin Med 15(1):1–12

    Article  CAS  Google Scholar 

  • Wu X, Qiu F, Wang Z, Liu B, Qi X (2020) Correlation of 5-HTR6 gene polymorphism with vestibular migraine. J Clin Lab Anal 34(2):e23042

    Article  CAS  PubMed  Google Scholar 

  • Yakubova A, Davidyuk Y, Tohka J, Khayrutdinova O, Kudryavtsev I, Nurkhametova D et al (2020) Searching for Predictors of Migraine Chronification: a Pilot Study of 1911A> G Polymorphism of TRPV1 Gene in Episodic Versus Chronic Migraine. J Mol Neurosci 1–7

  • Yao G, Man Y-H, Li A-R, Guo Y, Dai Y, Wang P et al (2020) NO up-regulates migraine-related CGRP via activation of an Akt/GSK-3β/NF-κB signaling cascade in trigeminal ganglion neurons. Aging (Albany NY) 12(7):6370

    Article  CAS  Google Scholar 

  • Yücel Y, Salih Coşkun BC, Özdemir HH, Uzar E, Çim A, Camkurt MA et al (2016) Association of polymorphisms within the serotonin receptor genes 5-HTR1A, 5-HTR1B, 5-HTR2A and 5-HTR2C and migraine susceptibility in a Turkish population. Clin Psychopharmacol Neurosci 14(3):250

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Zabetian CP, Anderson GM, Buxbaum SG, Elston RC, Ichinose H, Nagatsu T et al (2001) A quantitative-trait analysis of human plasma–dopamine β-hydroxylase activity: evidence for a major functional polymorphism at the DBH locus. Am J Hum Genet 68(2):515–522

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zaki EA, Freilinger T, Klopstock T, Baldwin E, Heisner K, Adams K et al (2009) Two common mitochondrial DNA polymorphisms are highly associated with migraine headache and cyclic vomiting syndrome. Cephalalgia 29(7):719–728

    Article  CAS  PubMed  Google Scholar 

  • Zhai Y, Zhu Y (2018) MiR-30a relieves migraine by degrading CALCA. Eur Rev Med Pharmacol Sci 22(7):2022–2028

    CAS  PubMed  Google Scholar 

  • Zhang Y, Kong Q, Chen J, Li L, Wang D, Zhou J (2016) International Classification of Headache Disorders 3rd edition beta-based field testing of vestibular migraine in China: Demographic, clinical characteristics, audiometric findings and diagnosis statues. Cephalalgia 36(3):240–248

    Article  PubMed  Google Scholar 

  • Zhao L-P, Liu L, Pei P, Qu Z-Y, Zhu Y-P, Wang L-P (2017) Electroacupuncture at Fengchi (GB20) inhibits calcitonin gene-related peptide expression in the trigeminovascular system of a rat model of migraine. Neural Regen Res 12(5):804

Download references

Acknowledgements

This study was financially supported by Shahid Beheshti University of Medical Sciences.

Author information

Authors and Affiliations

  1. Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Kaveh Ebahimzadeh & Mohammad Samadian

  2. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Mahdi Gholipour

  3. Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Mohammad Taheri

  4. Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Soudeh Ghafouri-Fard

Authors
  1. Kaveh Ebahimzadeh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mahdi Gholipour
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mohammad Samadian
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mohammad Taheri
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Soudeh Ghafouri-Fard
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

MT and SGF wrote the draft and revised it. KE, MGH and MS collected the data, and designed the tables and figures. All authors contributed equally and read the submission.

Corresponding authors

Correspondence to Mohammad Taheri or Soudeh Ghafouri-Fard.

Ethics declarations

Competing Interests

The authors declare that they have nothing to report.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent forms were obtained from all study participants. The study protocol was approved by the ethical committee of Shahid Beheshti University of Medical Sciences (IR.SBMU.RETECH.REC.1398.304). All methods were performed in accordance with the relevant guidelines and regulations.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ebahimzadeh, K., Gholipour, M., Samadian, M. et al. A Comprehensive Review on the Role of Genetic Factors in the Pathogenesis of Migraine. J Mol Neurosci 71, 1987–2006 (2021). https://doi.org/10.1007/s12031-020-01788-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12031-020-01788-1

Keywords

Search

Navigation