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Genetic Risk Factors for Intracranial Aneurysm in the Kazakh Population

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Abstract

An intracranial aneurysm (IA) is a weak or thin area on a blood vessel in the brain that balloons as it fills with blood. Genetic factors can influence the risk of developing an aneurism. The purpose of this study was to explore the relationship between single nucleotide polymorphisms (SNPs) and IA in Kazakh population. The patients were genotyped for 60 single nucleotide polymorphisms. Genotyping was performed on the QuantStudio 12K Flex (Life Technologies). A linear regression analysis found 13 SNPs’ significant association with development and rupture of IA: the rs1800956 polymorphism of the ENG gene, rs1756 46 polymorphism of the JDP2 gene, variant rs1800255 of the COL3A1, rs4667622 of the UBR3, rs2374513 of the c12orf75, rs3742321 polymorphism of the StAR, the rs3782356 polymorphism of MLL2 gene, rs3932338 to 214 kilobases downstream of PRDM9, rs7550260 polymorphism of the ARHGEF, rs1504749 polymorphism of the SOX17, the rs173686 polymorphism of CSPG2 gene, rs6460071 located on LIMK1 gene, and the rs4934 polymorphism of SERPINA3. A total of 13 SNPs were identified as potential genetic markers for the development and risk of rupture of aneurysms in the Kazakh population. Similar results were obtained after adjusting for the confounding factors of arterial hypertension and age.

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Acknowledgments

The authors thank Akhmetova Madina for management of this project.

Funding Details

This study was supported by Ministry of Education and Science of the Republic of Kazakhstan (grant no. 0115РК00539).

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Authors and Affiliations

  1. National Center for Biotechnology, 13/5, Korgalzhinskoe Highway, Astana, Kazakhstan

    Elena V. Zholdybayeva, Akbota M. Aitkulova, Yerkebulan A. Talzhanov, Gulmira N. Kulmambetova, Aisha N. Iskakova & Yerlan M. Ramankulov

  2. JSC “National Center of Neurosurgery”, 34/1, Turan Avenue, Astana, Kazakhstan

    Yerkin Z. Medetov, Yerbol T. Makhambetov, Serik K. Akshulakov & Assylbek B. Kaliyev

  3. Al-Farabi Kazakh National University, 71, al-Farabi Ave., Almaty, Kazakhstan

    Akbota M. Aitkulova

  4. School of Science and Technology, Nazarbayev University, 53 Kabanbay Batyr Ave., Astana, Kazakhstan

    Yerlan M. Ramankulov

Authors
  1. Elena V. Zholdybayeva
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  2. Yerkin Z. Medetov
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  3. Akbota M. Aitkulova
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  4. Yerbol T. Makhambetov
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  6. Assylbek B. Kaliyev
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  8. Gulmira N. Kulmambetova
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  9. Aisha N. Iskakova
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Correspondence to Elena V. Zholdybayeva.

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The authors declare that they have no conflicts of interest. The authors alone are responsible for the content and writing of this paper.

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Zholdybayeva, E.V., Medetov, Y.Z., Aitkulova, A.M. et al. Genetic Risk Factors for Intracranial Aneurysm in the Kazakh Population. J Mol Neurosci 66, 135–145 (2018). https://doi.org/10.1007/s12031-018-1134-y

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  • DOI: https://doi.org/10.1007/s12031-018-1134-y

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