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Low-Level Laser Therapy Ameliorates Disease Progression in a Mouse Model of Alzheimer’s Disease

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Abstract

Low–level laser therapy (LLLT) has been used to treat inflammation, tissue healing, and repair processes. We recently reported that LLLT to the bone marrow (BM) led to proliferation of mesenchymal stem cells (MSCs) and their homing in the ischemic heart suggesting its role in regenerative medicine. The aim of the present study was to investigate the ability of LLLT to stimulate MSCs of autologous BM in order to affect neurological behavior and β-amyloid burden in progressive stages of Alzheimer’s disease (AD) mouse model. MSCs from wild-type mice stimulated with LLLT showed to increase their ability to maturate towards a monocyte lineage and to increase phagocytosis activity towards soluble amyloid beta (Aβ). Furthermore, weekly LLLT to BM of AD mice for 2 months, starting at 4 months of age (progressive stage of AD), improved cognitive capacity and spatial learning, as compared to sham-treated AD mice. Histology revealed a significant reduction in Aβ brain burden. Our results suggest the use of LLLT as a therapeutic application in progressive stages of AD and imply its role in mediating MSC therapy in brain amyloidogenic diseases.

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Acknowledgments

This work is supported by grants from the Alzheimer’s Association NIRG-11-205535 and ISF (to D.F.). There are no conflicts of interest.

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Authors and Affiliations

  1. Department of Neurobiology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel

    Dorit Farfara, Dorit Trudler, Ella Doron-Mandel & Dan Frenkel

  2. Department of Zoology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 69978, Israel

    Hana Tuby, Lidya Maltz & Uri Oron

  3. Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel

    Dorit Trudler & Dan Frenkel

  4. Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA

    Robert J. Vassar

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  1. Dorit Farfara
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Correspondence to Uri Oron.

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Farfara, D., Tuby, H., Trudler, D. et al. Low-Level Laser Therapy Ameliorates Disease Progression in a Mouse Model of Alzheimer’s Disease. J Mol Neurosci 55, 430–436 (2015). https://doi.org/10.1007/s12031-014-0354-z

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