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The Expression of FBP1 after Traumatic Brain Injury and Its Role in Astrocyte Proliferation

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Abstract

Far upstream element binding protein 1 (FBP1) has been identified as an upstream gene of p27kip1 (p27), which is a key regulator of mammalian cell cycle regulation and neurogenesis. To elucidate the expression and function of FBP1 in central nervous system lesion and repair, we performed a traumatic brain injury (TBI) model in adult rats. We observed that FBP1 protein level significantly reduced at day 3 after injury, and the downregulation of FBP1 was predominant in astrocytes, which were largely proliferated after injury. Furthermore, in vitro, overexpression of FBP1 was concomitant with the up-regulation of p27 and reduction of PCNA in LPS-induced astrocyte proliferation. These results suggest that a decreased level of FBP1 in brain is involved in the proliferation of glial cells after TBI.

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Acknowledgment

This work was supported by the National Natural Science Foundation of China (grants numbers 81171139 and 812713681).

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Authors and Affiliations

  1. Department of Neurosurgery, The Second Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, People’s Republic of China

    Wei Zhao, Yong Wang, Wei Shi, Yang Chen, Gang Cai, Jialei Chen, Ming Qian & Wei Xu

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  1. Wei Zhao
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  2. Yong Wang
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  3. Wei Shi
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  4. Yang Chen
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  5. Gang Cai
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  6. Jialei Chen
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  7. Ming Qian
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  8. Wei Xu
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Correspondence to Wei Xu.

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Wei Zhao and Yong Wang contributed equally to this work.

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Zhao, W., Wang, Y., Shi, W. et al. The Expression of FBP1 after Traumatic Brain Injury and Its Role in Astrocyte Proliferation. J Mol Neurosci 51, 687–694 (2013). https://doi.org/10.1007/s12031-013-0049-x

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  • DOI: https://doi.org/10.1007/s12031-013-0049-x

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