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Primary Pancreatic GIST — A-Single Centre Case Series and Systematic Review of Literature

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Abstract

Purpose

GISTs arising from organs outside GI tract are defined as extragastrointestinal GISTs (EGIST). The majority of EGISTs arise from small intestinal mesentry, mesocolon, omentum, retroperitoneum, abdominal wall, liver and pancreas with pancreas comprising less than 5% of it. Due to limited data, it is unknown if the results of GIST can be generalised for EGISTs. We thereby present the largest single-centre case series of primary pancreatic GIST so far with review of existing literature.

Methods

A total of 9 patients of primary pancreatic GIST were treated at our institute from September 2016 to February 2023. After literature search for all studies published before February 2023, 51 articles including 57 patients were identified. Their clinicopathological data and survival analysis were assessed.

Results

The median age of patients treated at our centre was 53 years with a female predominance. The most common epicentre was pancreatic head with abdominal pain as the most common presenting symptom. All 57 patients documented in literature belonged to a similar age group with similar gender predilection. The factors impacting DFS were histologic type, mitotic index, NIH risk category and adjuvant therapy. The median DFS was 74 months with a 5-year DFS being 71.9%, while the 5-year OS was 90.4%.

Conclusion

Pancreatic GIST is a rare entity. Due to limited evidence and evolving literature, results cannot be generalised to a larger population. Larger case series with longer follow-up data are required to further understand the disease biology and long-term outcomes of pancreatic GIST.

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Data Availability

The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

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  1. Gastrointestinal and Hepato-pancreato-biliary services, Department of Surgical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, 400012, India

    Vipul Gupta, Amit Chopde, Vikram Chaudhari, Shailesh V. Shrikhande & Manish S. Bhandare

  2. Department of Pathology, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, 400012, India

    Munita Bal

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All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by V.G., A.C.. The first draft of the manuscript was written by V.G. and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Manish S. Bhandare.

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Gupta, V., Chopde, A., Chaudhari, V. et al. Primary Pancreatic GIST — A-Single Centre Case Series and Systematic Review of Literature. J Gastrointest Canc (2024). https://doi.org/10.1007/s12029-024-01024-8

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