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Prognostic Factors of Rectal Cancer in Southern Iran

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Abstract

Background

Rectal cancer accounts for one-third of all colorectal cancer (CRC) cases. Due to physiological and anatomical differences, some researchers consider rectal cancer as a separate organ malignancy during the recent decades. However, limited studies have been conducted in this regard in Iran. Therefore, the aim of this study is to determine survival of rectal cancer and its, affecting factors in Fars province, southern Iran.

Methods

In this cohort study, we used the data of 387 patients with rectal cancer gathered by the Colorectal Research Center of Shiraz University of Medical Sciences between 2007 and 2015. The impact of 35 explanatory factors including demographic information, medical history, pathologic data, and imaging findings was evaluated using Cox regression analysis.

Results

Out of all patients, 111 ones (29%) died. The median follow-up period was 36 months. The patients’ mean age at diagnosis was 56.72 ± 13.89 years. Their 5-year survival was 65% (95% CI: 58–69%). The results of multiple Cox regression analysis showed that sex (male/female; HR = 1.73, 95% CI: 1.15–2.67), vascular invasion (yes/no; HR = 2.40, 95% CI: 1.45–3.99), and lymph node ratio (> 0.2 vs ≤ 0.2; HR = 2.19, 95% CI: 1.41–3.40) were significantly correlated to survival.

Conclusion

Various geographical parts of Iran show different rates regarding rectal cancer survival. A better 5-year survival rate was detected by this study for the patients with rectal cancer in Fars province, southern Iran, compared to many parts of the country. Moreover, gender, vascular invasion, and nodal status played an important role in survival of rectal cancer.

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References

  1. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65(2):87–108. https://doi.org/10.3322/caac.21262.

    Article  PubMed  Google Scholar 

  2. Marley AR, Nan H. Epidemiology of colorectal cancer. Int J Mol Epidemiol Genet. 2016;7(3):105–14.

    PubMed  PubMed Central  Google Scholar 

  3. Arnold M, Sierra MS, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global patterns and trends in colorectal cancer incidence and mortality. Gut. 2017;66(4):683–91. https://doi.org/10.1136/gutjnl-2015-310912.

    Article  PubMed  Google Scholar 

  4. Favoriti P, Carbone G, Greco M, Pirozzi F, Pirozzi RE, Corcione F. Worldwide burden of colorectal cancer: a review. Updat Surg. 2016;68(1):7–11. https://doi.org/10.1007/s13304-016-0359-y.

    Article  Google Scholar 

  5. Rezaianzadeh A, Safarpour AR, Marzban M, Mohaghegh A. A systematic review over the incidence of colorectal cancer in Iran. Ann Colorectal Res. 2015;3(1):e25724. https://doi.org/10.17795/acr-25724.

    Article  Google Scholar 

  6. Dolatkhah R, Somi MH, Bonyadi MJ, Asvadi Kermani I, Farassati F, Dastgiri S. Colorectal cancer in Iran: molecular epidemiology and screening strategies. J Cancer Epidemiol. 2015;2015:643020–10. https://doi.org/10.1155/2015/643020.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Bufill JA. Colorectal cancer: evidence for distinct genetic categories based on proximal or distal tumor location. Ann Intern Med. 1990;113(10):779–88.

    Article  CAS  Google Scholar 

  8. Minoo P, Zlobec I, Peterson M, Terracciano L, Lugli A. Characterization of rectal, proximal and distal colon cancers based on clinicopathological, molecular and protein profiles. Int J Oncol. 2010;37(3):707–18.

    Article  CAS  Google Scholar 

  9. Tamas K, Walenkamp AM, de Vries EG, van Vugt MA, Beets-Tan RG, van Etten B, et al. Rectal and colon cancer: not just a different anatomic site. Cancer Treat Rev. 2015;41(8):671–9. https://doi.org/10.1016/j.ctrv.2015.06.007.

    Article  CAS  PubMed  Google Scholar 

  10. Glynne-Jones R, Hughes R. Critical appraisal of the ‘wait and see’ approach in rectal cancer for clinical complete responders after chemoradiation. Br J Surg. 2012;99(7):897–909. https://doi.org/10.1002/bjs.8732.

    Article  CAS  PubMed  Google Scholar 

  11. Talaiezadeh A, Tabesh H, Sattari A, Ebrahimi S. Cancer incidence in southwest of Iran: first report from Khuzestan population-based cancer registry, 2002-2009. Asian Pac J Cancer Prev. 2013;14(12):7517–22.

    Article  Google Scholar 

  12. Ali Hussein Alhurry AM, Rezaianzadeh A, Rahimikazerooni S, Abdzaid Akool M, Bahrami F, Shahidinia SS, et al. A review of the incidence of colorectal cancer in the Middle East. Ann Color Res. 2017;5(3–4):e46292. https://doi.org/10.5812/acr.46292.

    Article  Google Scholar 

  13. Heidarnia MA, Monfared ED, Akbari ME, Yavari P, Amanpour F, Mohseni M. Social determinants of health and 5-year survival of colorectal cancer. Asian Pac J Cancer Prev. 2013;14(9):5111–6.

    Article  Google Scholar 

  14. Aryaie M, Roshandel G, Semnani S, Asadi-Lari M, Aarabi M, Vakili MA, et al. Predictors of colorectal cancer survival in Golestan, Iran: a population-based study. Epidemiol Health. 2013;35:e2013004. https://doi.org/10.4178/epih/e2013004.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Fatemi SR, Pourhoseingholi MA, Asadi F, Vahedi M, Pasha S, Alizadeh L, et al. Recurrence and five -year survival in colorectal cancer patients after surgery. Iran J Cancer Prev. 2015;8(4):e3439. https://doi.org/10.17795/ijcp.3439.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Akhavan A, Binesh F, Soltani A. Survival of rectal cancer in Yazd, Iran. Asian Pac J Cancer Prev. 2014;15(12):4857–60.

    Article  Google Scholar 

  17. Moradi A, Khayamzadeh M, Guya M, Mirzaei HR, Salmanian R, Rakhsha A, et al. Survival of colorectal cancer in Iran. Asian Pac J Cancer Prev. 2009;10(4):583–6.

    PubMed  Google Scholar 

  18. Rasouli MA, Moradi G, Roshani D, Nikkhoo B, Ghaderi E, Ghaytasi B. Prognostic factors and survival of colorectal cancer in Kurdistan province, Iran: a population-based study (2009-2014). Medicine. 2017;96(6):e5941. https://doi.org/10.1097/md.0000000000005941.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Aarts MJ, Lemmens VE, Louwman MW, Kunst AE, Coebergh JW. Socioeconomic status and changing inequalities in colorectal cancer? A review of the associations with risk, treatment and outcome. Eur J Cancer (Oxford, England : 1990). 2010;46(15):2681–95. https://doi.org/10.1016/j.ejca.2010.04.026.

    Article  Google Scholar 

  20. Wu L, Pang S, Yao Q, Jian C, Lin P, Feng F, et al. Population-based study of effectiveness of neoadjuvant radiotherapy on survival in US rectal cancer patients according to age. Sci Rep. 2017;7(1):3471. https://doi.org/10.1038/s41598-017-02992-7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Russu PC, Molnar C, Gurzu S, Jung I, Voidazan TS, Copotoiu C. The role of clinical and pathological assessment in choosing the best therapeutic management to improve survival in rectal cancer. Rom J Morphol Embryol. 2016;57(4):1253–9.

    PubMed  Google Scholar 

  22. Yokoyama S, Matsuda K, Watanabe T, Mitani Y, Ieda J, Iwamoto H, et al. Perineural invasion is associated with poor survival after preoperative chemoradiation therapy for advanced lower rectal cancer. Dig Surg. 2017;34(5):387–93. https://doi.org/10.1159/000453591.

    Article  PubMed  Google Scholar 

  23. Dianatinasab M, Ghaem H, Rezaianzadeh A, Hosseini SV, Khazraei H. Colorectal cancer mortality in Shiraz, Iran. Asian Pac J Cancer Prev. 2016;17(8):4101–5.

    PubMed  Google Scholar 

  24. Ghabeljoo M, Jafarabadi MA, Mohammadi SM, Hajizadeh E, Kazemnejad A, Fatemi SR. Patterns of survival for anatomical sites of colorectal cancer with shift to advanced lesions in Iran. Asian Pac J Cancer Prev. 2011;12(5):1225–31.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Colorecrtal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

    Seyed Vahid Hosseini, Salar Rahimikazerooni, Alimohammad Bananzadeh, Afrouz Farghadin, Mohammad Zare Band Amiry, Ahmad Izadpanah & Mohammad Mohammadianpanah

  2. Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

    Abbas Rezaianzadeh

  3. Department of Epidemiology, School of public health and safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Sohrab Iranpour

Authors
  1. Seyed Vahid Hosseini
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  2. Abbas Rezaianzadeh
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  3. Salar Rahimikazerooni
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  4. Alimohammad Bananzadeh
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  6. Mohammad Zare Band Amiry
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  9. Sohrab Iranpour
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Correspondence to Salar Rahimikazerooni.

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Hosseini, S.V., Rezaianzadeh, A., Rahimikazerooni, S. et al. Prognostic Factors of Rectal Cancer in Southern Iran. J Gastrointest Canc 53, 113–121 (2022). https://doi.org/10.1007/s12029-020-00553-2

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  • DOI: https://doi.org/10.1007/s12029-020-00553-2

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