Abstract
Purpose
Music has recognized beneficial effects on cancer patients; however, very little is known about the molecular processes which produce these benefits. The aim of this work was to evaluate the effect of music on proliferation and gene expression in gastric cancer cells.
Methods
AGS gastric cancer cells were exposed to metal and classical music, and subsequently cell proliferation and expression of genes associated with apoptosis and cell-cycle control were evaluated.
Results
Proliferation of AGS cells increased when exposed to metal music, but not when exposed to classical music. Gene expression of caspase-3 and 8 and cyclin B1 increased in response to both musical genres; classical music repressed the expression of p53, and metal music repressed the expression of PUMA.
Conclusions
This is the first study to demonstrate music as a modulator of gene expression in a cancer cell line. Additional experiments are required to better understand the mechanisms of how different musical genres can induce changes in gene expression.
References
Lestard N dos R, Valente RC, Lopes A, Capella MAM. Direct effects of music in non-auditory cells in culture. Noise Health. 2013;15(66):307.
Bro ML, Jespersen KV, Hansen JB, Vuust P, Abildgaard N, Gram J, et al. Kind of blue: a systematic review and meta-analysis of music interventions in cancer treatment. Psychooncology. 2018;27(2):386–400.
Bradt J, Dileo C, Magill L, Teague A. Music interventions for improving psychological and physical outcomes in cancer patients. Cochrane Database Syst Rev. 2016;15(8):CD006911.
Bieligmeyer S, Helmert E, Hautzinger M, Vagedes J. Feeling the sound - short-term effect of a vibroacoustic music intervention on well-being and subjectively assessed warmth distribution in cancer patients-A randomized controlled trial. Complement Ther Med. 2018;40:171–8.
Fukui H, Toyoshima K. Music increase altruism through regulating the secretion of steroid hormones and peptides. Med Hypotheses. 2014;83(6):706–8.
Fancourt D, Williamon A, Carvalho L, Steptoe A, Dow R, Lewis I. Singing modulates mood, stress, cortisol, cytokine and neuropeptide activity in cancer patients and carers. Ecancermedicalscience. 2016;10:631.
Lestard N dos R, Capella MAM. Exposure to music alters cell viability and cell motility of human nonauditory cells in culture. Evid Based Complement Alternat Med. 2016;2016:1–7.
Jones H, Feth L, Rumpf D, Hefti A, Mariotti A. Acoustic energy affects human gingival fibroblast proliferation but leaves protein production unchanged. J Clin Periodontol. 2000;27(11):832–8.
Kirste I, Nicola Z, Kronenberg G, Walker TL, Liu RC, Kempermann G. Is silence golden? Effects of auditory stimuli and their absence on adult hippocampal neurogenesis. Brain Struct Funct. 2015;220(2):1221–8.
Lee H, Saini N, Parris AB, Zhao M, Yang X. Ganetespib induces G2/M cell cycle arrest and apoptosis in gastric cancer cells through targeting of receptor tyrosine kinase signaling. Int J Oncol. 2017;51(3):967–74.
Xu YX, Wang B, Zhao XH. In vitro effects and the related molecular mechanism of galangin and quercetin on human gastric cancer cell line (SGC-7901). Pak J Pharm Sci. 2017;30(4):1279–87.
Kong G-M, Tao W-H, Diao Y-L, Fang P-H, Wang J-J, Bo P, et al. Melittin induces human gastric cancer cell apoptosis via activation of mitochondrial pathway. World J Gastroenterol. 2016;22(11):3186–95.
Sui C-G, Meng F-D, Li Y, Jiang Y. Antiproliferative activity of rosamultic acid is associated with induction of apoptosis, cell cycle arrest, inhibition of cell migration and caspase activation in human gastric cancer (SGC-7901) cells. Phytomedicine. 2015;22(9):796–806.
Shalini S, Dorstyn L, Dawar S, Kumar S. Old, new and emerging functions of caspases. Cell Death Differ. 2015;22(4):526–39.
Huang K-H, Fang W-L, Li AF-Y, Liang P-H, Wu C-W, Shyr Y-M, et al. Caspase-3, a key apoptotic protein, as a prognostic marker in gastric cancer after curative surgery. Int J Surg. 2018;52:258–63.
Yasuda M, Takesue F, Inutsuka S, Honda M, Nozoe T, Korenaga D. Overexpression of cyclin B1 in gastric cancer and its clinicopathological significance: an immunohistological study. J Cancer Res Clin Oncol. 2002;128(8):412–6.
Hikisz P, Kiliańska Z. Puma, a critical mediator of cell death — one decade on from its discovery. Cell Mol Biol Lett. 2012;17(4):646–69.
Yu J, Zhang L. PUMA, a potent killer with or without p53. Oncogene. 2008;27(Suppl 1):71–83.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of Interest
The authors declare that they have no conflict of interest.
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Ramírez-Rivera, S., Bernal, G. Music Is Capable of Inducing Changes in Gene Expression in Gastric Cancer Cells. J Gastrointest Canc 50, 175–180 (2019). https://doi.org/10.1007/s12029-019-00203-2
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12029-019-00203-2