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Moderate-Severe White Matter Lesion Predicts Delayed Intraventricular Hemorrhage in Intracerebral Hemorrhage

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Abstract

Background

Most existing studies have focused on the correlation between white matter lesion (WML) and baseline intraventricular hemorrhage (IVH) in patients with intracerebral hemorrhage (ICH), whereas few studies have investigated the relationship between WML severity and delayed IVH after admission. This study aimed to investigate the correlation between WML severity and delayed IVH and to verify the association between WML and baseline IVH.

Methods

A total of 480 patients with spontaneous ICH from February 2018 to October 2020 were selected. WML was scored using the Van Swieten Scale, with scores of 0–2 representing nonslight WML and scores of 3–4 representing moderate-severe WML. We determined the presence of IVH on baseline (< 6 h) and follow-up computed tomography (< 72 h) images. Univariate analysis and multiple logistic regression were used to analyze the influencing factors of baseline and delayed IVH.

Results

Among 480 patients with ICH, 172 (35.8%) had baseline IVH, and there was a higher proportion of moderate-severe WML in patients with baseline IVH (20.3%) than in those without baseline IVH (12.7%) (P = 0.025). Among 308 patients without baseline IVH, delayed IVH was found in 40 patients (12.9%), whose proportion of moderate-severe WML (25.0%) was higher than that in patients without delayed IVH (10.8%) (P = 0.012). Multiple logistic regression results showed that moderate-severe WML was independently correlated with baseline IVH (P = 0.006, odds ratio = 2.266, 95% confidence interval = 1.270–4.042) and delayed IVH (P = 0.002, odds ratio = 7.009, 95% confidence interval = 12.086–23.552).

Conclusions

Moderate-severe WML was an independent risk factor for delayed IVH as well as baseline IVH.

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Acknowledgments

Thanks to all the coworkers who made a contribution to this research and to all the patients who made this research possible.

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Authors and Affiliations

  1. Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

    Mengying Yu, Dongqin Zhu, Zhixian Luo, Yunjun Yang & Haoli Xu

  2. The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

    Zhifang Pan

  3. Medical College of Soochow University, Suzhou, Jiangsu, China

    Haoli Xu

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  1. Mengying Yu
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Contributions

MY wrote the manuscript. MY and ZL interpreted the data and prepared the tables and figures. DZ, YY, and HX revised the manuscript for intellectual content. MY and HX acquired the data. DZ, HX, and YY contributed to the conception and design of the study. ZP contributed to the database supplement and manuscript revision. All authors read and approved its publication.

Corresponding author

Correspondence to Haoli Xu.

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Source of support

This study was supported by the Scientific Research Incubation Project (FHY2019072); the Science and Technology Planning Projects of Wenzhou (grant Y2020169); the Wenzhou Major Program of Science and Technology Innovation (Grant ZY2020012); the Health Foundation for Creative Talents in Zhejiang Province, China (grant 2016); and the Project Foundation for the College Young and Middle-aged Academic Leader of Zhejiang Province, China (grant 2017).

Conflicts of Interest

All authors declare that they have no conflicts of interest.

Ethical approval/informed consent

The authors adhered to ethical guidelines, and this study was approved by the institutional review board. Written informed consent was waived because of the retrospective design.

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Yu, M., Zhu, D., Luo, Z. et al. Moderate-Severe White Matter Lesion Predicts Delayed Intraventricular Hemorrhage in Intracerebral Hemorrhage. Neurocrit Care 37, 714–723 (2022). https://doi.org/10.1007/s12028-022-01543-x

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  • DOI: https://doi.org/10.1007/s12028-022-01543-x

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