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X-linked hypogammaglobulinemia and isolated growth hormone deficiency: an update

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Abstract

X-linked hypogammaglobulinemia and isolated growth hormone deficiency (XLH–GHD, OMIM # 307200) is a primary immunodeficiency disorder characterized by pan-hypogammaglobulinemia and isolated growth hormone deficiency. The disease, which is only known to occur in a single family, shares many features with X-linked agammaglobulinemia (XLA, OMIM # 300300). The current review summarizes the clinical, laboratory and genetic features of the disease as they have unfolded over the past quarter century since its description.

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Authors and Affiliations

  1. Immunophysiology Section, Metabolism Branch, NCI, NIH, National Institutes of Health, Bldg. 10, Rm. 4N115, MSC 1374, Bethesda, MD, 20892, USA

    Donn M. Stewart, Lan Tian, Luigi D. Notarangelo & David L. Nelson

  2. Division of Immunology, Children’s Hospital, Harvard Medical School, Karp Research Building, Boston, MA, USA

    Luigi D. Notarangelo

  3. Istituto di Medicina Molecolare “Angelo Nocivelli”, Clinica Pediatrica, Universita’ di Brescia Spedali Civili, Piazzale Spedali Civili 1, 25123, Brescia, Italy

    Luigi D. Notarangelo

Authors
  1. Donn M. Stewart
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  2. Lan Tian
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  3. Luigi D. Notarangelo
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  4. David L. Nelson
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Correspondence to David L. Nelson.

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Stewart, D.M., Tian, L., Notarangelo, L.D. et al. X-linked hypogammaglobulinemia and isolated growth hormone deficiency: an update. Immunol Res 38, 391–399 (2007). https://doi.org/10.1007/s12026-007-0052-9

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  • DOI: https://doi.org/10.1007/s12026-007-0052-9

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