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Accuracy of sex estimation by morphometric evaluation of foramen magnum using computed tomography – a systematic review and meta-analysis

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Abstract

The objective of this study is to determine whether the morphometric evaluation of the foramen magnum using computed tomography can be used as an accurate tool in estimating the sex of an individual. An extensive search of the databases, PubMed, ProQuest, Google Scholar, and Scopus, was carried out to procure articles that fulfilled the inclusion criteria. The AQUA tool was used to assess the quality of the included studies. A random effects model was used for the meta-analysis of the eligible studies using the STATA software, version 16, 2019 at 95% CI and p ≤ 0.05. Eleven eligible articles that measured the transverse and sagittal diameters of the foramen magnum using computed tomography were included in this study. The sagittal diameter of the foramen magnum was greater than the transverse diameter, and both the diameters were greater in males than in females. Meta-analysis revealed that both transverse and sagittal diameters were more reliable for male sex estimation. Since there is a dimensional variation between the male and female foramen magnum, it can be used for initial sex identification and also as an auxiliary to other advanced methods of sex estimation.

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The data that supports the findings of this study will be provided by the corresponding author upon reasonable request.

References

  1. Lynnerup N. Forensic anthropology and human identification. Scandinavian J Forensic Sci. 2013. https://doi.org/10.2478/sjfs-2013-0005.

    Article  Google Scholar 

  2. Thompson T, Errickson D, editors. Human remains: another dimension: the application of imaging to the study of human remains. Academic Press. 2017. https://doi.org/10.1016/B978-0-12-804602-9.00006-0.

  3. Rai H, Keluskar V, Patil S, Bagewadi A. Accuracy of measurements of foramen magnum and occipital condyle as an indicator for sex determination using computed tomography. Indian J Health Sci Biomed Res (KLEU). 2017. https://doi.org/10.4103/2349-5006.198595.

    Article  Google Scholar 

  4. Dawson C, Ross D, Mallett X. Sex determination. Forensic Anthropol. 2011;61–94. https://doi.org/10.1201/b10727-4.

  5. Gapert R, Black S, Last J. Sex determination from the foramen magnum: discriminant function analysis in an eighteenth and nineteenth century British sample. Int J Legal Med. 2008. https://doi.org/10.1007/s00414-008-0256-0.

    Article  PubMed  Google Scholar 

  6. Spradley MK, Jantz RL. Sex estimation in forensic anthropology: skull versus postcranial elements. J Forensic Sci. 2011. https://doi.org/10.1111/j.1556-4029.2010.01635.x.

    Article  PubMed  Google Scholar 

  7. Kelley MA. Sex determination with fragmented skeletal remains. J Forensic Sci. 1979. https://doi.org/10.1520/jfs10802j.

    Article  PubMed  Google Scholar 

  8. Scheuer L, Black S. Preface. Develop Juvenile Osteol. 2000;ix–x. https://doi.org/10.1016/b978-012624000-9/50001-0.

  9. Romanes GJ. Cunningham’s textbook of anatomy. 12 ed. Oxford: Oxford university press. 1981;114.

  10. Annuar SH. Sex and height determination by foramen magnum morphometry using multiplanar reconstruction (MPR) CT skull images (Doctoral dissertation, Universiti Sains Malaysia).

  11. Le Blanc-Louvry I, Thureau S, Duval C, Papin-Lefebvre F, Thiebot J, Dacher JN, et al. Post-mortem computed tomography compared to forensic autopsy findings: a French experience. Eur Radiol. 2013. https://doi.org/10.1007/s00330-013-2779-0.

    Article  PubMed  Google Scholar 

  12. Garofalo EM. Radiography/nondestructive analysis. Int Encycloped Biol Anthropol. 2018;1–3. https://doi.org/10.1002/9781118584538.ieba0420.

  13. Jackowski C, Wyss M, Persson A, Classens M, Thali MJ, Lussi A. Ultra-high-resolution dual-source CT for forensic dental visualization—discrimination of ceramic and composite fillings. Int J Legal Med. 2008. https://doi.org/10.1007/s00414-008-0224-8.

    Article  PubMed  Google Scholar 

  14. Zdilla M, Russell M, Bliss K, Mangus K, Koons A. The size and shape of the foramen magnum in man. J Craniovertebr Junction Spine. 2017. https://doi.org/10.4103/jcvjs.jcvjs_62_17.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Zhan M, Cui J, Zhang K, Chen Y, Deng Z. Estimation of stature and sex from skull measurements by multidetector computed tomography in Chinese. Leg Med. 2019. https://doi.org/10.1016/j.legalmed.2019.101625.

    Article  Google Scholar 

  16. Darwish R, Salama N, Elsirafy M, Kholeif W. Identification of sex from foramen magnum of Egyptian skulls using three dimensional computed tomography. Ain Shams J Forensic Med Clin Toxicol. 2014.https://doi.org/10.21608/ajfm.2014.19158.

  17. Henry BM, Tomaszewski KA, Ramakrishnan PK, Roy J, Vikse J, Loukas M, et al. Development of the Anatomical Quality Assessment (AQUA) Tool for the quality assessment of anatomical studies included in meta-analyses and systematic reviews. Clin Anat. 2016. https://doi.org/10.1002/ca.22799.

    Article  PubMed  Google Scholar 

  18. Henry BM, Tomaszewski KA, Walocha JA. Methods of Evidence-Based Anatomy: a guide to conducting systematic reviews and meta-analysis of anatomical studies. Ann Anat. 2016. https://doi.org/10.1016/j.aanat.2015.12.002.

    Article  PubMed  Google Scholar 

  19. Tellioglu AM, Durum Y, Gok M, Karakas S, Polat AG, Karaman CZ. Suitability of foramen magnum measurements in sex determination and their clinical significance. Folia Morphol (Warsz). 2018. https://doi.org/10.5603/fm.a2017.0070.

    Article  PubMed  Google Scholar 

  20. More C, Saha N, Vijayvargiya R. Morphological analysis of foramen magnum for gender determination by using computed tomography. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;1(2):51–56.

  21. Meral O, Belkıs Toklu B, Meydan R, Kaya A, Karadayı B, Acar T. Sex estimation from foramen magnum parameters in adult Turkish population: a computed tomography study. Leg Med. 2020. https://doi.org/10.1016/j.legalmed.2020.101775.

    Article  Google Scholar 

  22. Abo El-Atta HMH, Abdel-Rahman RH, El-Hawary G, Abo El-Al-Atta HM. Sexual dimorphism of foramen magnum: an Egyptian study. Egypt J Forensic Sci. 2020. https://doi.org/10.1186/s41935-019-0167-x.

    Article  Google Scholar 

  23. Singh PK, Tamrakar D, Karki S, Menezes RG. Determination of sex from the foramen magnum using 3DCT: a Nepalese study. Kathmandu Univ Med J (KUMJ). 2017;15(57):61–5.

    CAS  Google Scholar 

  24. Aghakhani K, Kazemzadeh N, Ghafurian F, Soltani B, Soltani S. Gender determination using diagnostic values of foramen magnum. Int J Med Toxicol Forensic Med. 2016;6(1):29–35.

    Google Scholar 

  25. Teodoru-Raghina D, Marinescu M, Diaconeasa A, Olteanu B, Perlea P, Dragu M. Crania sexual dimorphism of an European subpopulation: CT scan discriminant function analysis in a Romanian subadult casuistry. Rom J Leg Med. 2017;25:373–8.

    Google Scholar 

  26. Toneva D, Nikolova S, Harizanov S, Georgiev I, Zlatareva D, Hadjidekov V, et al. Sex estimation by size and shape of foramen magnum based on CT imaging. Leg Med. 2018. https://doi.org/10.1016/j.legalmed.2018.09.009.

    Article  Google Scholar 

  27. Mehta M, Saini V, Patel MN, Menon SK. Applicability and reliability of foramen magnum for sex determination in contemporary Western Indian population: a computed tomographic study. J Forensic Radiol Imag. 2019. https://doi.org/10.1016/j.jofri.2019.05.005.

    Article  Google Scholar 

  28. Zappalá M, Lightbourne S, Heneghan NR. The relationship between thoracic kyphosis and age, and normative values across age groups: a systematic review of healthy adults. J Orthop Surg Res. 2021. https://doi.org/10.1186/s13018-021-02592-2.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Slima SR, Abdou ER. Orbital and foramen magnum variables for sex determination in Egyptians using computed tomographic images. Egyptian J Forensic Sci Appl Toxicol. 2020;20(4):73–83.

    Article  Google Scholar 

  30. Aljarrah K, Packirisamy V, Al Anazi N, Nayak SB. Morphometric analysis of foramen magnum and occipital condyle using CT images for sex determination in a Saudi Arabian population. Morphologie. 2022. https://doi.org/10.1016/j.morpho.2021.07.006.

    Article  PubMed  Google Scholar 

  31. Atreya A, Shrestha R, Bhandari K, Malla SK, Acharya S, Menezes RG. Morphometric analysis of the foramen magnum in sex estimation: an additional 3DCT study from Nepal on a larger sample. Health Sci Rep. 2022. https://doi.org/10.1002/hsr2.999.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Humphrey LT. Growth patterns in the modern human skeleton. Am J Phys Anthropol. 1998. https://doi.org/10.1002/(sici)1096-8644(199801)105:1<57::aid-ajpa6>3.0.co;2-a.

    Article  PubMed  Google Scholar 

  33. Richards GD, Jabbour RS. Foramen magnum ontogeny in Homo sapiens: a functional matrix perspective. Anat Rec Adv Integr Anat Evol Biol. 2010. https://doi.org/10.1002/ar.21319.

    Article  Google Scholar 

  34. Saleh S, Allam W, Mahmoud H. Sex determination by measuring length and breadth of foramen magnum at computed tomographic images of skull. Egyptian J Forensic Sci Appl Toxicol. 2019. https://doi.org/10.21608/ejfsat.2019.12227.1071.

  35. Frayer DW, Wolpoff MH. Sexual Dimorphism. Annu Rev Anthropol. 1985. https://doi.org/10.1146/annurev.an.14.100185.002241.

    Article  Google Scholar 

  36. Page MJ, McKenzie J, Bossuyt P, Boutron I, Hoffmann T, mulrow cindy d, et al. Updating guidance for reporting systematic reviews: development of the PRISMA 2020 statement. 2020. https://doi.org/10.31222/osf.io/jb4dx.

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Contributions

Dr. Anabelle L.V.C. Fernandes (AF) Conceptualization; data curation; methodology; formal analysis; writing—original draft Dr. Arvind Shetti (AS) Data curation; formal analysis; writing—review and editing. Dr. Vasanti Lagali-Jirge (VJ) Conceptualization; methodology; formal analysis; writing—review and editing. Dr. Vaishali Keluskar Supervision; validation; visualization.

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Correspondence to Anabelle Louise Veiga Coutinho Fernandes.

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Fernandes, A.L.V.C., Shetti, A., Lagali-Jirge, V. et al. Accuracy of sex estimation by morphometric evaluation of foramen magnum using computed tomography – a systematic review and meta-analysis. Forensic Sci Med Pathol 20, 268–279 (2024). https://doi.org/10.1007/s12024-023-00613-6

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