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The past decade has seen significant progress in understanding the genomic landscape of endocrine neoplasia. Although molecular tests are not part of the routine workup of most endocrine neoplasms, advances in the field have substantially improved the standards of endocrine pathology practice by improving tumor classification systems as well as leading to the development of genotype-phenotype correlations, translational biomarkers, risk stratifications, and opportunities for potential novel therapies. Furthermore, discoveries of new germline pathogenic variants have expanded the spectrum of genetic susceptibility in patients with apparently sporadic endocrine neoplasia.
This special issue of Endocrine Pathology focuses on important advances in molecular pathology of endocrine neoplasia that are useful to practicing pathologists, endocrinologists, oncologists, surgeons, researchers, and learners with an interest in endocrine neoplasia. In this special issue, the manuscripts span molecular alterations in pituitary, thyroid, parathyroid, and adrenal cortical neoplasms; paragangliomas; and pheochromocytomas, as well as epithelial neuroendocrine neoplasms (neuroendocrine tumors and neuroendocrine carcinomas) of various anatomic sites [1,2,3,4,5,6,7,8,9,10,11]. Evidence-based data reviewed by world-renowned experts will help readers appreciate the current basis of modern endocrine pathology practice that is essential to optimizing patient care.
I hope that this special issue will serve as a valuable reference for both the scientific and medical audiences. At this time, I would like to thank all authors for their contributions and the reviewers for their efforts to ensure the highest standards for these papers. I also acknowledge the meticulous work provided by the editorial office as well as the outstanding work of the production team that enabled a rapid and smooth publication process during the COVID19 pandemic.
Ozgur Mete, MD, FRCPC
Editor-in-Chief, Endocrine Pathology.
References
Asa SL, Mete O, Ezzat S. Genomics and Epigenomics of Pituitary Tumors: What Do Pathologists Need to Know? Endocr Pathol (2021). https://doi.org/10.1007/s12022-021-09663-4.
Juhlin CC, Erickson LA. Genomics and Epigenomics in Parathyroid Neoplasia: from Bench to Surgical Pathology Practice. Endocr Pathol (2020). https://doi.org/10.1007/s12022-020-09656-9.
Barletta JA., Nosé V, Sadow PM. Genomics and Epigenomics of Medullary Thyroid Carcinoma: From Sporadic Disease to Familial Manifestations. Endocr Pathol (2021). https://doi.org/10.1007/s12022-021-09664-3.
Soares P, Póvoa AA, Melo M, Vinagre J, Máximo V, Eloy C, Cameselle-Teijeiro JM, Simões MS. Molecular Pathology of Non-familial Follicular Epithelial–Derived Thyroid Cancer in Adults: From RAS/BRAF-like Tumor Designations to Molecular Risk Stratification. Endocr Pathol (2021). https://doi.org/10.1007/s12022-021-09666-1.
Volante M, Lam AK, Papotti M, Tallini G. Molecular Pathology of Poorly Differentiated and Anaplastic Thyroid Cancer: What Do Pathologists Need to Know? Endocr Pathol (2021). https://doi.org/10.1007/s12022-021-09665-2.
Cameselle-Teijeiro JM, Mete O, Asa SL, LiVolsi V. Inherited Follicular Epithelial-Derived Thyroid Carcinomas: From Molecular Biology to Histological Correlates. Endocr Pathol (2021). https://doi.org/10.1007/s12022-020-09661-y.
Juhlin CC, Bertherat J, Giordano TJ, Hammer GD, Sasano H, Mete O. What Did We Learn from the Molecular Biology of Adrenal Cortical Neoplasia? From Histopathology to Translational Genomics. Endocr Pathol (2021). https://doi.org/10.1007/s12022-021-09667-0.
Papathomas TG, Suurd DPD, Pacak K, Tischler AS, Vriens MR, Lam AK, de Krijger RR. What Have We Learned from Molecular Biology of Paragangliomas and Pheochromocytomas? Endocr Pathol (2021). https://doi.org/10.1007/s12022-020-09658-7.
Volante M, Mete O, Pelosi G, Roden AC, Speel EJM, Uccella S. Molecular Pathology of Well-Differentiated Pulmonary and Thymic Neuroendocrine Tumors: What Do Pathologists Need to Know? Endocr Pathol (2021). https://doi.org/10.1007/s12022-021-09668-z.
Asa SL, La Rosa S, Basturk O, Adsay V, Minnetti M, Grossman AB. Molecular Pathology of Well-Differentiated Gastro-entero-pancreatic Neuroendocrine Tumors. Endocr Pathol (2021). https://doi.org/10.1007/s12022-021-09662-5.
Uccella S, La Rosa S, Metovic J, Marchiori D, Scoazec JY, Volante M, Mete O, Papotti M. Genomics of High-Grade Neuroendocrine Neoplasms: Well-Differentiated Neuroendocrine Tumor with High-Grade Features (G3 NET) and Neuroendocrine Carcinomas (NEC) of Various Anatomic Sites. Endocr Pathol (2021). https://doi.org/10.1007/s12022-020-09660-z.
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Mete, O. Special Issue on Molecular Pathology of Endocrine Neoplasms: Understanding the Basis of Endocrine Pathology Practice. Endocr Pathol 32, 1–2 (2021). https://doi.org/10.1007/s12022-021-09670-5
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DOI: https://doi.org/10.1007/s12022-021-09670-5