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Meta-analysis of association studies between five candidate genes and type 2 diabetes in Chinese Han population

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Abstract

The multiple small-scale association studies of candidate genes for type 2 diabetes mellitus in the Chinese Han population have shown inconsistent results. Here, we performed a meta-analysis to evaluate the contribution of five candidate genes to the pathogenesis of type 2 diabetes in the Chinese Han population. We searched for relevant published papers and used STATA v.11.0 to perform a meta-analysis on six single-nucleotide polymorphisms in five genes—ADIPOQ-rs2241766 (SNP45) and -rs1501299 (SNP276), ADRB3-rs4994 (Trp64Arg), CAPN10-rs3792267 (SNP43), ENPP1-rs1044498 (K121Q), and PPARGC1A-rs8192678 (Gly482Ser)—in the Chinese Han population under an additive genetic model. The pooled odds ratios (95% confidence intervals and P-values) were 0.71 (0.60–0.83; P < 0.001) for ADIPOQ-rs2241766, 0.79 (0.64–0.97; P = 0.027) for ADIPOQ-rs1501299, 1.27 (1.07–1.51; P = 0.006) for ADRB3-rs4994, 0.79 (0.57–1.10; P = 0.163) for CAPN10-rs3792267, 1.41 (1.13–1.76; P = 0.003) for ENPP1-rs1044498, and 1.54 (1.34–1.81; P < 0.001) for PPARGC1A-rs8192678. There was high heterogeneity for ADIPOQ-rs2241766, ADIPOQ-rs1501299, and CAPN10-rs3792267 (I 2 = 74.9, 69.4, and 75.8%, respectively), but not for ADRB3-rs4994, ENPP1-rs1044498, and PPARGC1A-rs8192678 (I 2 = 0.0, 43.4, and 23.3%, respectively). Under an additive genetic model, the C allele of ADRB3-rs4994, the C allele of ENPP1-rs1044498, and the A allele of PPARGC1A-rs8192678 increase the risk of type 2 diabetes in the Chinese Han population.

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Abbreviations

T2DM:

Type 2 diabetic mellitus

NGT:

Normal glucose tolerance

GWAS:

Genome wide association study

SNP:

Single-nucleotide polymorphism

ADIPOQ:

Adiponectin C1Q and collagen domain containing

ADRB3:

Adrenergic-beta-3-receptor

ENPP1:

Ectoenzyme nucleotide pyrophosphate phosphodiesterase 1

PPARGC1A:

Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha

CAPN10:

Calpain 10

FTO:

Fat mass and obesity

OR:

Odds ratios

CNKI:

China National Knowledge infrastructure

HWE:

Hardy–Weinberg equilibrium

ADA:

American Diabetes Association

WHO:

World Health organization

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Acknowledgments

We would like to express our appreciation to National Basic Research Program of China (973 program, 2006CB503900, 2011 CB504001), National Natural Science Foundation of China (3077103) and National High Technology Research and Development Program (863program, 2006AA02A409).

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The authors declare that they have no conflict of interests.

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Correspondence to Ji Linong.

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Chen Jing and Han Xueyao contributed equally to this work.

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Jing, C., Xueyao, H. & Linong, J. Meta-analysis of association studies between five candidate genes and type 2 diabetes in Chinese Han population. Endocrine 42, 307–320 (2012). https://doi.org/10.1007/s12020-012-9643-x

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