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Evolving hypopituitarism as a consequence of traumatic brain injury (TBI) in childhood—call for attention

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Abstract

Hypopituitarism is a common complication of TBI in long-term survivors, more frequent than previously realized. It may be partial or complete, sometimes very subtle without visible lesions in hypothalamo-pituitary region and is diagnosed only by biochemical means. Neuroendocrine abnormalities caused by TBI may have significant implications for the recovery and rehabilitation of these patients. The subjects at risk are those who have suffered moderate to severe trauma, although mild intensity trauma may precede hypopituitarism also. Particular attention should be paid to this problem in children and adolescents. We describe a patient with hypopituitarism thought to be idiopathic due to mild head trauma which caused diabetes insipidus in childhood, gradual failure of pituitary hormones during the period of growth and development, and metabolic (dyslipidemia), physical (obesity), and cognitive impairments in the adult period.

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Authors and Affiliations

  1. Clinic of Endocrinology, Diabetes and Metabolic Disease, University Clinical Center, Hajduk Veljkova 1-3, 21000, Novi Sad, Serbia

    Milica Medic-Stojanoska

  2. Neuroendocrine Unit, Institute of Endocrinology, University Clinical Center, Belgrade, Serbia

    Sandra Pekic & Vera Popovic

  3. Institute for Laboratory Medicine, University Clinical Center, Novi Sad, Serbia

    Nikola Curic

  4. Center of MRI, Institute of Oncology, Sremska Kamenica, Serbia

    Dragana Djilas-Ivanovic

Authors
  1. Milica Medic-Stojanoska
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  2. Sandra Pekic
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  3. Nikola Curic
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  4. Dragana Djilas-Ivanovic
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  5. Vera Popovic
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Correspondence to Milica Medic-Stojanoska.

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Medic-Stojanoska, M., Pekic, S., Curic, N. et al. Evolving hypopituitarism as a consequence of traumatic brain injury (TBI) in childhood—call for attention. Endocr 31, 268–271 (2007). https://doi.org/10.1007/s12020-007-0037-4

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  • DOI: https://doi.org/10.1007/s12020-007-0037-4

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