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Glucocorticoid-Induced Osteoporosis: A Review

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Clinical Reviews in Bone and Mineral Metabolism Aims and scope Submit manuscript

Abstract

Glucocorticoid (GC)-induced osteoporosis is the main cause of secondary osteoporosis. Fractures, which are often asymptomatic, can occur in as many as 50% of patients receiving chronic GC therapy. GCs have direct and indirect effects on bone cells (osteoblasts, osteocytes, and osteoclasts) with a suppression of bone formation and an increased bone resorption. The management of patients exposed to GCs should include the use of the minimal effective dose of GC, general health measures, and adequate intakes of calcium and vitamin D. Bisphosphonates are nowadays largely used in GC-induced osteoporosis and teriparatide has proved its efficiency as well.

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Acknowledgment

This study was made possible by grants from the Bioregos “Pays de la Loire” program and INSERM and was also supported by a grant from the French Society for Rheumatology (SFR).

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Authors and Affiliations

  1. Faculté de Médecine, INSERM, U 922–LHEA, 49045, Angers, Cedex, France

    Béatrice Bouvard, Erick Legrand, Maurice Audran & Daniel Chappard

  2. Service de Rhumatologie, CHU d’Angers, 49933, Angers, Cedex, France

    Béatrice Bouvard, Erick Legrand & Maurice Audran

Authors
  1. Béatrice Bouvard
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  2. Erick Legrand
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  3. Maurice Audran
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  4. Daniel Chappard
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Correspondence to Daniel Chappard.

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Bouvard, B., Legrand, E., Audran, M. et al. Glucocorticoid-Induced Osteoporosis: A Review. Clinic Rev Bone Miner Metab 8, 15–26 (2010). https://doi.org/10.1007/s12018-009-9051-9

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