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Intranasal Steroids in the Treatment of Allergy-Induced Rhinorrhea

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Abstract

While nasal congestion has been identified as one of the most bothersome and prevalent symptoms of allergic rhinitis, it is underappreciated that many patients find rhinorrhea also to be bothersome. Rhinorrhea as a symptom of allergic rhinitis virtually never occurs alone; about 97% of patients with allergic rhinitis suffer from at least two symptoms, a finding that underscores the advantage of treating a broad range of symptoms with a single medication. Along with sneezing and nasal obstruction, rhinorrhea is a classic acute symptom of allergic rhinitis; it appears as a late-phase symptom as well. In this review, the characterization and epidemiology of rhinorrhea, the pathophysiology of rhinorrhea in allergic rhinitis, the roles played by mediators in early- and late-phase rhinorrhea, the prevalence and impact of this symptom, and the efficacy and safety of available treatment options are all discussed in context of relevant literature. A review of the clinical studies assessing the efficacy of intranasal corticosteroids (INS) for rhinorrhea is presented. Many clinical studies and several meta-analyses conclusively demonstrate that, in addition to being safe and well-tolerated, INS are more effective than other agents (including oral and intranasal antihistamines) across the spectrum of AR symptoms, including rhinorrhea and nasal congestion.

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References

  1. Dykewicz MS, Fineman S, Skoner DP et al (1998) Diagnosis and management of rhinitis: complete guidelines of the joint task force on practice parameters in allergy, asthma and immunology. Ann Allergy Asthma Immunol 81(pt 2):478–518

    Article  PubMed  CAS  Google Scholar 

  2. Bousquet J, Van Cauwenberge P, Khaltaev N, ARIA Workshop Group; World Health Organization et al (2001) Allergic rhinitis and its impact on asthma (ARIA). J Allergy Clin Immunol 108(5 Suppl):S147–S334

    Article  PubMed  CAS  Google Scholar 

  3. Bousquet J (2008) Allergic rhinitis and its impact on asthma (ARIA) 2008 update. Allergy 63(Suppl 86):8–160

    Article  PubMed  Google Scholar 

  4. Miri S, Farid R, Akbari H, Amin R (2006) Prevalence of allergic rhinitis and nasal smear eosinophilia in 11- to 15-yr-old children in Shiraz. Pediatr Allergy Immunol 17:519–523

    Article  PubMed  Google Scholar 

  5. Canonica GW, Bousquet J, Mullol J, Scadding GK, Virchouw JC (2007) A survey of the burden of allergic rhinitis in Europe. Allergy 62(Suppl 85):17–25

    Article  PubMed  Google Scholar 

  6. Shedden A (2005) Impact of nasal congestion on quality of life and work productivity in allergic rhinitis. Findings from a large online survey. Treat Respir Med 4:439–446

    Article  PubMed  Google Scholar 

  7. Attitudes about allergies (2008) key findings. Schering Corporation/Merck & Co

  8. Van Hoecke H, Vastesaeger N, DeWulf L, Sys L, van Cauwenberge P (2006) Classification and management of allergic rhinitis patients in general practice during pollen season. Allergy 61:705–711

    Article  PubMed  Google Scholar 

  9. van Cauwenberge P, Bachert C, Passalacqua G, European Academy of Allergology and Clinical Immunology et al (2000) Consensus statement on the treatment of allergic rhinitis. Allergy 55:116–134

    Article  PubMed  Google Scholar 

  10. Skoner DP (2001) Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis. J Allergy Clin Immunol 108:S2–S8

    Article  PubMed  CAS  Google Scholar 

  11. Canakcioglu S, Tahamiler R, Saritzali G et al (2009) Evaluation of nasal cytology in subjects with chronic rhinitis: a 7-year study. Am J Otolaryngol 30:312–317

    Article  PubMed  Google Scholar 

  12. Abuabara A (2007) Cerebrospinal fluid rhinorrhea: diagnosis and management. Med Oral Patol Oral Cir Bucal 12:E397–E400

    PubMed  Google Scholar 

  13. Scadding GK, Durham SR, Mirakian R, British Society for Allergy and Clinical Immunology et al (2008) BSACI guidelines for the management of allergic and non-allergic rhinitis. Clin Exp Allergy 38:19–42

    Article  PubMed  CAS  Google Scholar 

  14. Akerlund A, Andersson M, Leflein J, Lildholdt T, Mygind N (2005) Clinical trial design, nasal allergen challenge models, and considerations of relevance to pediatrics, nasal polyposis, and different classes of medication. J Allergy Clin Immunol 115:S460–S482

    Article  PubMed  Google Scholar 

  15. Horak F, Stübner UP, Zieglmayer R, Ing D, Harris AG (2002) Effect of desloratadine versus placebo on nasal airflow and subjective measures of nasal obstruction in subjects with grass pollen-induced allergic rhinitis in an allergen-exposure unit. J Allergy Clin Immunol 109:956–961

    Article  PubMed  CAS  Google Scholar 

  16. Bousquet J, Annesi-Maesano I, Carat F et al (2005) Characteristics of intermittent and persistent allergic rhinitis: DREAMS study group. Clin Exp Allergy 35:728–732

    Article  PubMed  CAS  Google Scholar 

  17. Gawchik S, Goldstein S, Prenner B, John A (2003) Relief of cough and nasal symptoms associated with allergic rhinitis by mometasone furoate nasal spray. Ann Allergy Asthma Immunol 90:416–421

    Article  PubMed  CAS  Google Scholar 

  18. Pratter MR (2006) Chronic upper airway cough syndrome secondary to rhinosinus diseases (previously referred to as postnasal drip syndrome): ACCP evidence-based clinical practice guidelines. Chest 129:63S–71S

    Article  PubMed  Google Scholar 

  19. Sanu A, Eccles R (2008) Postnasal drip syndrome. Two hundred years of controversy between UK and USA. Rhinology 46:86–91

    PubMed  CAS  Google Scholar 

  20. Schulman, Ronca, and Bucuvalas, Inc. (SRBI). Allergies in America: A Landmark Survey of Nasal Allergy Sufferers. Executive Summary. Available at http://www.myallergiesinamerica.com/. Accessed 8 December, 2009)

  21. Long AA (2007) Findings from a 1000-patient internet-based survey assessing the impact of morning symptoms on individuals with allergic rhinitis. Clin Ther 29:342–351

    Article  PubMed  Google Scholar 

  22. Min Y-G, Choi B-Y, Kwon S-K et al (2001) Multicenter study on the prevalence of perennial allergic rhinitis and allergy-associated disorders. J Korean Med Sci 16:697–701

    PubMed  CAS  Google Scholar 

  23. Kaiser HB, Findlay SR, Georgitis JW et al (1998) The anticholinergic agent, ipratropium bromide, is useful in the treatment of rhinorrhea associated with perennial allergic rhinitis. Allergy and Asthma Proc 19:23–29

    Article  CAS  Google Scholar 

  24. Baraniuk JN (1997) Pathogenesis of allergic rhinitis. J Allergy Clin Immunol 99:S763–S772

    Article  PubMed  CAS  Google Scholar 

  25. Jeffery PK, Haahtela T (2006) Allergic rhinitis and asthma: inflammation in a one-airway condition. BMC Pulm Med 6(Suppl I):S5–S17

    Article  PubMed  Google Scholar 

  26. Izquierdo I, Merlos M, García-Rafanell J (2003) Rupatadine: a new selective histamine H1 receptor and platelet-activating factor (PAF) antagonist. Drugs Today 39:451–468

    Article  PubMed  CAS  Google Scholar 

  27. Berger WE (2003) Overview of allergic rhinitis. Ann Allergy Asthma Immunol 90(Suppl 3):7–12

    Article  PubMed  Google Scholar 

  28. Horak F (2002) Impact and modulation of nasal obstruction. Allergy 57(Suppl 75):25–28

    Article  PubMed  Google Scholar 

  29. Mygind N, Nielsen LP, Hoffman HJ et al (2001) Mode of action of intranasal corticosteroids. J Allergy Clin Immunol 108:S16–S25

    Article  PubMed  CAS  Google Scholar 

  30. Bachert C (2002) The role of histamine in allergic disease: re-appraisal of its inflammatory potential. Allergy 57:287–296

    Article  PubMed  CAS  Google Scholar 

  31. Okuda M, Watase T, Mezawa A, Liu C-M (1988) The role of leukotriene D4 in allergic rhinitis. Ann Allergy 60:537–540

    PubMed  CAS  Google Scholar 

  32. Nathan RA (2008) The pathophysiology, clinical impact, and management of nasal congestion in allergic rhinitis. Clin Ther 30:573–586

    Article  PubMed  CAS  Google Scholar 

  33. Fujikura T, Shimosawa T, Yakuo I (2001) Regulatory effect of histamine H1 receptor antagonist on the expression of messenger RNA encoding CC chemokines in the human nasal mucosa. J Allergy Clin Immunol 107:123–128

    Article  PubMed  CAS  Google Scholar 

  34. Frieri M, Therattil J, Chavarria V et al (1998) Effect of mometasone furoate on early and late phase inflammation in patients with seasonal allergic rhinitis. Ann Allergy Asthma Immunol 81:431–437

    Article  PubMed  CAS  Google Scholar 

  35. Ciprandi G, Tosca MA, Passalacqua G, Canonica GW (2001) Intranasal mometasone furoate reduces late-phase inflammation after allergen challenge. Ann Allergy Asthma Immunol 86:433–438

    Article  PubMed  CAS  Google Scholar 

  36. Ortolani C, Foresi A, Di Lorenzo G et al (1999) A double-blind, placebo-controlled comparison of treatment with fluticasone propionate and levocabastine in patients with seasonal allergic rhinitis. FLNCO2 Italian study group. Allergy 54:1173–1180

    Article  PubMed  CAS  Google Scholar 

  37. Konno A, Yamakoshi T, Terada N, Fujita Y (1994) Mode of action of a topical steroid on immediate phase reaction after antigen challenge and nonspecific nasal hyperreactivity in nasal allergy. Int Arch Allergy Immunol 103:79–87

    Article  PubMed  CAS  Google Scholar 

  38. Umland SP, Nahrebne K, Razac S et al (1997) The inhibitory effects of topically active glucocorticoids on IL-4, IL-5, and interferon-γ production by cultured primary CD4+ T cells. J Allergy Clin Immunol 100:511–519

    Article  PubMed  CAS  Google Scholar 

  39. Naclerio RM, Adkinson NF, Creticos PS, Baroody FM, Hamilton RG, Norman PS (1993) Intranasal steroids inhibit seasonal increases in ragweed-specific immunoglobulin E antibodies. J Allergy Clin Immunol 92:717–721

    Article  PubMed  CAS  Google Scholar 

  40. Holm AF, Godthelp T, Fokkens WJ et al (1999) Long-term effects of corticosteroid nasal spray on nasal inflammatory cells in patients with perennial allergic rhinitis. Clin Exp Allergy 29:1356–1366

    Article  PubMed  CAS  Google Scholar 

  41. Bascom R, Wachs M, Naclerio RM, Pipkorn U, Galli SJ, Lichtenstein LM (1988) Basophil influx occurs after nasal antigen challenge: effects of topical corticosteroid pretreatment. J Allergy Clin Immunol 81:580–589

    Article  PubMed  CAS  Google Scholar 

  42. Rak S, Jacobson MR, Sudderick RM et al (1994) Influence of prolonged treatment with topical corticosteroid (fluticasone propionate) on early and late phase nasal responses and cellular infiltration in the nasal mucosa after allergen challenge. Clin Exp Allergy 24:930–939

    Article  PubMed  CAS  Google Scholar 

  43. Weiner JM, Abramson MJ, Puy RM (1998) Intranasal corticosteroids versus oral H1 receptor antagonists in allergic rhinitis: systematic review of randomised controlled trials. BMJ 317:1624–1629

    PubMed  CAS  Google Scholar 

  44. Yáñez A, Rodrigo GJ (2002) Intranasal corticosteroids versus topical H1 receptor antagonists for the treatment of allergic rhinitis: a systematic review with meta-analysis. Ann Allergy Asthma Immunol 89:479–484

    Article  PubMed  Google Scholar 

  45. Naclerio R (2008) Intranasal corticosteroids reduce ocular symptoms associated with allergic rhinitis. Otolaryngol Head Neck Surg 138:129–139

    Article  PubMed  Google Scholar 

  46. Penagos M, Compalati E, Tarantini F, Baena-Cagnani CE, Passalacqua G, Canonica GW (2008) Efficacy of mometasone furoate nasal spray in the treatment of allergic rhinitis. Meta-analysis of randomized, double-blind, placebo-controlled, clinical trials. Allergy 63:1280–1291

    Article  PubMed  CAS  Google Scholar 

  47. Anolik R, Mometasone Furoate Nasal Spray With Loratadine Study Group (2008) Clinical benefits of combination treatment with mometasone furoate nasal spray and loratadine vs monotherapy with mometasone furoate in the treatment of seasonal allergic rhinitis. Ann Allergy Asthma Immunol 100:264–271

    Article  PubMed  CAS  Google Scholar 

  48. Berkowitz RB, Bernstein DI, LaForce C et al (1999) Onset of action of mometasone furoate nasal spray (Nasonex®) in seasonal allergic rhinitis. Allergy 54:64–69

    Article  PubMed  CAS  Google Scholar 

  49. Chervinsky P, Kunjibettu S, Miller DL et al (2007) Long-term safety and efficacy of intranasal ciclesonide in adult and adolescent patients with perennial allergic rhinitis. Ann Allergy Asthma Immunol 99:69–76

    Article  PubMed  CAS  Google Scholar 

  50. Di Lorenzo G, Pacor ML, Pellitteri ME et al (2004) Randomized placebo-controlled trial comparing fluticasone aqueous nasal spray in mono-therapy, fluticasone plus cetirizine, fluticasone plus montelukast and cetirizine plus montelukast for seasonal allergic rhinitis. Clin Exp Allergy 34:259–267

    Article  PubMed  Google Scholar 

  51. Fokkens WJ, Jogi R, Reinartz S et al (2007) Once daily fluticasone furoate nasal spray is effective in seasonal allergy rhinitis caused by grass pollen. Allergy 62:1078–1084

    Article  PubMed  CAS  Google Scholar 

  52. Hebert JR, Nolop K, Lutsky BN (1996) Once-daily mometasone furoate aqueous nasal spray (Nasonex™) in seasonal allergic rhinitis: an active- and placebo-controlled study. Allergy 51:569–576

    PubMed  CAS  Google Scholar 

  53. Kaiser HB, Naclerio RM, Given J, Toler TN, Ellsworth A, Philpot EE (2007) Fluticasone furoate nasal spray: a single treatment option for the symptoms of seasonal allergic rhinitis. J Allergy Clin Immunol 119:1430–1437

    Article  PubMed  CAS  Google Scholar 

  54. LaForce CF, Dockhorn RJ, Findlay SR et al (1994) Fluticasone propionate: an effective alternative treatment for seasonal allergic rhinitis in adults and adolescents. J Fam Pract 38:145–152

    PubMed  CAS  Google Scholar 

  55. Mandl M, Nolop K, Lutsky BN, 194-079 Study Group (1997) Comparison of once daily mometasone furoate (Nasonex) and fluticasone propionate aqueous nasal sprays for the treatment of perennial rhinitis. Ann Allergy Asthma Immunol 79:370–378

    Article  PubMed  CAS  Google Scholar 

  56. Meltzer EO, Kunjibettu S, Hall N et al (2007) Efficacy and safety of ciclesonide, 200 microg once daily, for the treatment of perennial allergic rhinitis. Ann Allergy Asthma Immunol 98:175–181

    Article  PubMed  CAS  Google Scholar 

  57. Nathan RA, Berger W, Yang W et al (2008) Effect of once-daily fluticasone furoate nasal spray on nasal symptoms in adults and adolescents with perennial allergic rhinitis. Ann Allergy Asthma Immunol 100:497–505

    Article  PubMed  Google Scholar 

  58. Prenner B, Lanier BQ, Bernstein D, Shekar T, Teper A. Mometasone furoate nasal spray reduces the ocular symptoms of seasonal allergic rhinitis. J Allergy Clin Immunol 2010 (in press)

  59. Ratner PH, Wingertzahn MA, van Bavel JH et al (2006) Efficacy and safety of ciclesonide nasal spray for the treatment of seasonal allergic rhinitis. J Allergy Clin Immunol 118:1142–1148

    Article  PubMed  CAS  Google Scholar 

  60. Scadding GK, Lund VJ, Jacques LA, Richards DH (1995) A placebo-controlled study of fluticasone propionate aqueous nasal spray and beclomethasone dipropionate in perennial rhinitis: efficacy in allergic and non-allergic perennial rhinitis. Clin Exp Allergy 25:737–743

    Article  PubMed  CAS  Google Scholar 

  61. van As A, Bronsky EA, Dockhorn RJ et al (1993) Once daily fluticasone propionate is as effective for perennial allergic rhinitis as twice daily beclomethasone dipropionate. J Allergy Clin Immunol 91:1146–1154

    Article  PubMed  Google Scholar 

  62. Vasar M, Houle P-A, Douglass J-A et al (2008) Fluticasone furoate nasal spray: effective monotherapy for symptoms of perennial allergic rhinitis in adults/adolescents. Allergy Asthma Proc 29:313–321

    Article  PubMed  CAS  Google Scholar 

  63. Kaiser HB, Findlay SR, Georgitis JW et al (1995) Long-term treatment of perennial allergic rhinitis with ipratropium bromide nasal spray 0.06%. J Allergy Clin Immunol 95:1128–1132

    Article  PubMed  CAS  Google Scholar 

  64. Wallace DV, Dykewicz MS, Bernstein DI, Joint Task Force on Practice; American Academy of Allergy, Asthma and Immunology; American College of Allergy, Asthma and Immunology; Joint Council of Allergy, Asthma and Immunology et al (2008) The diagnosis and management of rhinitis: an updated practice parameter. J Allergy Clin Immunol 122:S1–84

    Article  PubMed  Google Scholar 

  65. Atrovent Nasal spray 0.03% (ipratropium bromide) package insert. Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc.; 2007

  66. Milgrom H, Biondi R, Georgitis JW et al (1999) Comparison of ipratropium bromide 0.03% with beclomethasone dipropionate in the treatment of perennial rhinitis in children. Ann Allergy Asthma Immunol 83:105–111

    Article  PubMed  CAS  Google Scholar 

  67. Meltzer EO, Orgel HA, Bronsky EA et al (1992) Ipratropium bromide aqueous nasal spray for patients with perennial allergic rhinitis: a study of its effect on their symptoms, quality of life, and nasal cytology. J Allergy Clin Immunol 90:242–249

    Article  PubMed  CAS  Google Scholar 

  68. Georgitis JW (1992) The anticholinergic treatment of allergic perennial rhinitis. J Allergy Clin Immunol 90:1071–1076

    Article  PubMed  CAS  Google Scholar 

  69. Dockhorn R, Aaronson D, Bronsky E et al (1999) Ipratropium bromide nasal spray 0.03% and beclomethasone nasal spray alone and in combination for the treatment of rhinorrhea in perennial rhinitis. Ann Allergy Asthma Immunol 82:349–359

    Article  PubMed  CAS  Google Scholar 

  70. Rodrigo GJ, Yañez A (2006) The role of antileukotriene therapy in seasonal allergic rhinitis: a systematic review of randomized trials. Ann Allergy Asthma Immunol 96:779–786

    Article  PubMed  CAS  Google Scholar 

  71. Nielsen LP, Dahl R (2003) Comparison of intranasal corticosteroids and antihistamines in allergic rhinitis: a review of randomized, controlled trials. Am J Respir Med 2:55–65

    PubMed  CAS  Google Scholar 

  72. Stempel DA, Thomas M (1998) Treatment of allergic rhinitis: an evidence-based evaluation of nasal corticosteroids versus nonsedating antihistamines. Am J Man Care 4:89–96

    CAS  Google Scholar 

  73. Ratner PH, Howland WC III, Arastu R et al (2003) Fluticasone propionate aqueous nasal spray provided significantly greater improvement in daytime and nighttime nasal symptoms of seasonal allergic rhinitis compared with montelukast. Ann Allergy Asthma Immunol 90:536–542

    Article  PubMed  CAS  Google Scholar 

  74. Martin BG, Andrews CP, van Bavel JH et al (2006) Comparison of fluticasone propionate aqueous nasal spray and oral montelukast for the treatment of seasonal allergic rhinitis symptoms. Ann Allergy Asthma Immunol 96:851–857

    Article  PubMed  CAS  Google Scholar 

  75. Parameswaran K, Fanat A, O’Byrne PM (2006) Effects of intranasal fluticasone and salmeterol on allergen-induced nasal responses. Allergy 61:731–736

    Article  PubMed  CAS  Google Scholar 

  76. Bernstein DI, Creticos PS, Busse WW et al (1996) Comparison of triamcinolone acetonide nasal inhaler with astemizole in the treatment of ragweed-induced allergic rhinitis. J Allergy Clin Immunol 97:749–755

    Article  PubMed  CAS  Google Scholar 

  77. Bousquet J, Neukirch F, Bousquet PJ et al (2006) Severity and impairment of allergic rhinitis in patients consulting in primary care. J Allergy Clin Immunol 117:158–162

    Article  PubMed  Google Scholar 

  78. Price D, Bond C, Bouchard J et al (2006) International Primary Care Respiratory Group (ICPRG) Guidelines: management of allergic rhinitis. Prim Care Respir J 15:58–70

    Article  PubMed  Google Scholar 

  79. Kaliner MA (2001) Physician prescribing practices: the role of patient preference in the selection of nasal steroids. Allergy Asthma Proc 22:S17–S22

    Article  PubMed  CAS  Google Scholar 

  80. Bousquet J, Lund VJ, van Cauwenberge P et al (2003) Implementation of guidelines for seasonal allergic rhinitis: a randomized controlled trial. Allergy 58:733–741

    Article  PubMed  CAS  Google Scholar 

  81. Fokkens WJ (2003) Nasal corticosteroids, first choice in moderate to several allergic rhinitis. What prevents general practitioners from using them? Allergy 58:724–726

    Article  PubMed  CAS  Google Scholar 

  82. Zitt M, Kosoglou T, Hubbell J (2007) Mometasone furoate nasal spray: a review of safety and systemic effects. Drug Saf 30:317–326

    Article  PubMed  CAS  Google Scholar 

  83. Rosenblut A, Bardin PG, Muller B et al (2007) Long-term safety of fluticasone furoate nasal spray in adults and adolescents with perennial allergic rhinitis. Allergy 62:1071–1077

    Article  PubMed  CAS  Google Scholar 

  84. Demoly P (2008) Safety of intranasal corticosteroids in acute rhinosinusitis. Am J Otolaryngol 29:403–413

    Article  PubMed  CAS  Google Scholar 

  85. Omnaris (ciclesonide) package insert (2007) Florham Park, NJ: Altana Pharma, US Inc.

  86. Salib RJ, Howarth PH (2003) Safety and tolerability profiles of intranasal antihistamines and intranasal corticosteroids in the treatment of allergic rhinitis. Drug Saf 26:863–893

    Article  PubMed  CAS  Google Scholar 

  87. Mann RD, Pearce GL, Dunn N, Shakir S (2000) Sedation with “non-sedating” antihistamines: four prescription-event monitoring studies in general practice. BMJ 320:1184–1187

    Article  PubMed  CAS  Google Scholar 

  88. Layton D, Wilton L, Boshier A, Cornelius V, Harris S, Shakir SA (2006) Comparison of the risk of drowsiness and sedation between levocetirizine and desloratadine: a prescription-event monitoring study in England. Drug Saf 29:897–909

    Article  PubMed  CAS  Google Scholar 

  89. Galant SP, Wilkinson R (2001) Clinical prescribing of allergic rhinitis medication in the preschool and young school-age child. What are the options? BioDrugs 15:453–463

    Article  PubMed  CAS  Google Scholar 

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Acknowledgement

Editorial assistance was provided by Karl Torbey, MD, of AdelphiEden Health Communications. This assistance was supported by Schering Corporation, a subsidiary of Merck & Co., Inc., Whitehouse Station, NJ, USA.

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    Robert A. Nathan

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Nathan, R.A. Intranasal Steroids in the Treatment of Allergy-Induced Rhinorrhea. Clinic Rev Allerg Immunol 41, 89–101 (2011). https://doi.org/10.1007/s12016-010-8206-2

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