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Stem Cells in Bone Regeneration

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Abstract

Bone has the capacity to regenerate and repair itself. However, this capacity may be impaired or lost depending on the size of the defect or the presence of certain disease states. In this review, we discuss the key principles underlying bone healing, efforts to characterize bone stem and progenitor cell populations, and the current status of translational and clinical studies in cell-based bone tissue engineering. Though barriers to clinical implementation still exist, the application of stem and progenitor cell populations to bone engineering strategies has the potential to profoundly impact regenerative medicine.

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Authors and Affiliations

  1. Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, 257 Campus Drive Room GK106, Stanford, CA, 94305-5461, USA

    Graham G. Walmsley, Ryan C. Ransom, Elizabeth R. Zielins, Tripp Leavitt, John S. Flacco, Michael S. Hu, Michael T. Longaker & Derrick C. Wan

  2. Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Hagey Building, 257 Campus Dr., Stanford, CA, 94305, USA

    Graham G. Walmsley, Ryan C. Ransom, Michael S. Hu, Andrew S. Lee & Michael T. Longaker

  3. Department of Surgery, John A. Burns School of Medicine, University of Hawai’i, Honolulu, Hawai’i, USA

    Michael S. Hu

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  1. Graham G. Walmsley
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  2. Ryan C. Ransom
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  3. Elizabeth R. Zielins
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  5. John S. Flacco
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  9. Derrick C. Wan
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Correspondence to Derrick C. Wan.

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Walmsley, G.G., Ransom, R.C., Zielins, E.R. et al. Stem Cells in Bone Regeneration. Stem Cell Rev and Rep 12, 524–529 (2016). https://doi.org/10.1007/s12015-016-9665-5

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  • DOI: https://doi.org/10.1007/s12015-016-9665-5

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