Abstract
This study aimed to identify differentially expressed LncRNAs in testis tissue of male rats induced by high-fat diet and their changes after zinc supplementation, by constructing a high-fat feeding rat model, and then supplemented with zinc, and observed the expression of LncRNA in three groups of normal, high-fat fed, and zinc-intervened rats. Experimental studies show that the semen parameters of male rats with high-fat diet were decreased but recovered after zinc supplementation, and the related LncRNA also changed. Zinc may improve the high-fat diet-induced reduction of semen parameters by changing the expression of related LncRNA.
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Data Availability
The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
References
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This study was sponsored by the S&T Program of Hebei (Grant No. 21377796D and 226Z7722G) and the Hebei Natural Science Foundation (Grant No.H2021314001).
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Jiajie Bi performed the experiments. Bo Sun analyzed the data. Huanhuan Li and Yuejia Li collated the data. Jing Ma and Jiajie Bi wrote the manuscript. Jing Ma and Shusong Wang conceived the idea, designed the study, collected the funds, and revised the manuscript. All authors read and approved the final version of the manuscript.
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Ma, J., Bi, J., Sun, B. et al. Zinc Improves Semen Parameters in High-Fat Diet-Induced Male Rats by Regulating the Expression of LncRNA in Testis Tissue. Biol Trace Elem Res 201, 4793–4805 (2023). https://doi.org/10.1007/s12011-022-03550-7
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DOI: https://doi.org/10.1007/s12011-022-03550-7