Abstract
Our aim is to evaluate the serum zinc levels in Hepatitis B liver cirrhosis patients and clarify the relationship between the serum zinc levels and the development of hepatocellular carcinoma (HCC). From January 2009 to December 2019, 295 included patients diagnosed with Hepatitis B liver cirrhosis received nucleos(t)ide analogues (NUCs) therapy at China-Japan Union Hospital of Jilin University. Their comprehensive medical records were retrospectively analyzed, and to analyze the relationship between hypozincemia and hepatitis B-related HCC. Twenty-eight of 295 patients (9.49%) developed HCC during an observation period of the median follow-up time was 42 months. Compared with the non-zinc deficiency group, the zinc deficiency group is older, has a higher proportion of hepatic encephalopathy, higher levels of aspartate aminotransferase(AST), international normalized ratio(INR) and TB, and lower levels of cholinesterase (CHE), creatinine, and platelet counts (P< 0.05). Multivariate analysis showed that zine (HR=0.854, 95%CI 0.725–1.007; P=0.061), zinc is not significant for reducing the incidence of HCC, as liver disease progresses, the proportion of zinc deficiency is getting higher and higher, Child-Pugh C. The proportion of grade zinc deficiency accounted for 64.86%. Child-Pugh grade C was more than Child-Pugh grade B and A, p<0.001. Zinc deficiency is associated with hepatic encephalopathy, and other complications related to hepatitis B and liver cirrhosis. But the relationship with hepatocellular carcinoma still needs further study.
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All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Shuai Wang, Xuemei Fan, Yang Gao, Mingqi Hong, and Lijuan Zuo. The first draft of the manuscript was written by Shuai Wang, Yan Xu and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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The present study was implemented following the Declaration of Helsinki and was approved by the Ethics Committee of China-Japan Union Hospital of Jilin University.
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Wang, S., Fan, X., Gao, Y. et al. The Relationship Between Zinc Deficiency and Hepatocellular Carcinoma Associated with Hepatitis B Liver Cirrhosis: A 10-year Follow-up Study. Biol Trace Elem Res 201, 114–120 (2023). https://doi.org/10.1007/s12011-022-03156-z
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DOI: https://doi.org/10.1007/s12011-022-03156-z