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Chromium Supplementation on the Growth Performance, Carcass Traits, Blood Constituents, and Immune Competence of Broiler Chickens Under Heat Stress: a Systematic Review and Dose–Response Meta-analysis

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Abstract

Several studies have been conducted to assess the effects of supplemental dietary chromium (Cr) on broiler chickens under heat stress (HS) conditions, but the shape and strength of the associations between Cr supplementation and broiler chickens’ responses to HS remain unclear. Therefore, the current systematic review and meta-analysis investigated the effectiveness and dose–response relationship of Cr. The results indicated non-linear dose–response associations between Cr supplementation and body mass gain (BMG), feed intake (FI), feed conversion ratio (FCR), carcass, breast, leg, and abdominal fat relative weight (Pnon-linearity < 0.05). The maximum BMG, FI, and the relative weight of carcass, breast, and leg would be achieved with 1200, 1100, 900, 800, and 800 ppb of Cr, respectively, while the lowest FCR and abdominal fat relative weight might be obtained with the supplementation of 1100 and 1000 ppb of Cr, compared with no Cr supplementation. Referring to BMG, supplementation with 1200–1700 ppb inorganic Cr or 2700 ppb or less organic Cr had a significant beneficial effect on the BMG, while NanoCr supplementation did not influence this outcome variable. A non-linear association was observed for blood total cholesterol concentration (TC, Pnon-linearity < 0.05), with the maximum reduction of TC concentration observed at approximately 900 ppb of Cr. The cholesterol-lowering effect of Cr (≤ 2400 ppb) was only found in severe HS conditions. Moreover, supplemental Cr caused a significant linear reduction in the blood triglycerides and glucose concentrations (P < 0.05). The blood concentrations of triiodothyronine, thyroxine, and insulin increased linearly, and the corticosterone concentration reduced, with increasing supplemental Cr (P < 0.05). There was a non-linear inverse association between Cr supplementation and cortisol level (Pnon-linearity < 0.05), and the lowest concentration of cortisol was observed with the supplementation of 1000 ppb of Cr. Meanwhile, significant positive linear associations between Cr supplementation and bursa percentage, thymus percentage, infectious bronchitis vaccine titer, avian influenza vaccine titer, Newcastle disease vaccine titer, cutaneous basophil hypersensitivity response, and serum immunoglobulin G level were found (P < 0.05). However, Cr supplementation caused a linear reduction in the heterophil/lymphocyte ratio (P < 0.05). Based on the obtained results, the recommended optimum amount of supplemental Cr is 1100 ppb.

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Data Availability

The datasets analyzed during the current study are available from the corresponding author on reasonable request.

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  1. Department of Animal Science, College of Agriculture and Natural Resources, Razi University, PO Box 6,715,685,418, Kermanshah, Iran

    Alihossein Piray & Saheb Foroutanifar

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A. H. P. and S. F. designed the study, performed the literature searches, and conducted data extraction; A. H. P. analyzed the data and prepared the manuscript. The authors read and approved the final manuscript.

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Piray, A., Foroutanifar, S. Chromium Supplementation on the Growth Performance, Carcass Traits, Blood Constituents, and Immune Competence of Broiler Chickens Under Heat Stress: a Systematic Review and Dose–Response Meta-analysis. Biol Trace Elem Res 200, 2876–2888 (2022). https://doi.org/10.1007/s12011-021-02885-x

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