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Mitochondrial Dysfunction in Arsenic-Induced Hepatotoxicity: Pathogenic and Therapeutic Implications

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Abstract

Mitochondria are vital cellular organelles associated with energy production as well as cell signaling pathways. These organelles, responsible for metabolism, are highly abundant in hepatocytes that make them key players in hepatotoxicity. The literature suggests that mitochondria are targeted by various environmental pollutants. Arsenic, a toxic metalloid known as an environmental pollutant, readily contaminates drinking water and exerts toxic effects. It is toxic to various cellular organs; among them, the liver seems to be most affected. A growing body of evidence suggests that within cells, arsenic is highly toxic to mitochondria and reported to cause oxidative stress and alter an array of signaling pathways and functions. Hence, it is imperative to highlight the mechanisms associated with altered mitochondrial functions and integrity in arsenic-induced liver toxicity. This review provides the details of mechanistic aspects of mitochondrial dysfunction in arsenic-induced hepatotoxicity as well as various ameliorative measures undertaken concerning mitochondrial functions.

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Acknowledgements

The authors are thankful to the Indian Council of Medical Research (ICMR), New Delhi, India (grant No. 58/51/2011-BMS) in the form of ad-hoc scheme project sanctioned to VK.

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  1. Neurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110067, India

    Chandra Prakash

  2. Applied Sciences, UIET, Maharshi Dayanand University, Rohtak, Haryana, 124001, India

    Sunil Chhikara

  3. Department of Biochemistry, Maharshi Dayanand University, Rohtak, Haryana, 124001, India

    Vijay Kumar

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CP, SK, and VK conceptualized the idea. CP prepared the initial draft. SK and VK prepared the final manuscript.

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Prakash, C., Chhikara, S. & Kumar, V. Mitochondrial Dysfunction in Arsenic-Induced Hepatotoxicity: Pathogenic and Therapeutic Implications. Biol Trace Elem Res 200, 261–270 (2022). https://doi.org/10.1007/s12011-021-02624-2

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