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Association of Serum Concentration of Different Trace Elements with Biomarkers of Systemic Oxidant Status in Dairy Cattle

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Abstract

There has been some recent criticism about the reliability of the assays commonly used to measure oxidant status in cattle, because some recent publications suggested that the concentration of different trace elements influences the results of these assays. The aim of this study was to test the correlation in 502 bovine serum samples between the concentration of several trace elements (Br, Co, Cr, Cu, Fe, I, Mn, Mo, Ni, Se, Sr, V and Zn) and markers of oxidant status (reactive oxygen species (ROS) and total serum antioxidant capacity (SAC)). The Oxidative Stress index (OSi) was also calculated as ROS/SAC. Some significant correlations were found, although weak (|ρ| < 0.50). Therefore, the relationships observed might be attributed to the different pro- and antioxidant effect of the different elements rather than to the assays detecting these elements instead of the oxidised molecules or total antioxidant potential, respectively. The OSi was poorly correlated (|ρ| ≤ 0.36) with the concentration of the studied trace elements, and therefore, its use is recommended to assess shifts in the systemic redox balance.

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Acknowledgments

The authors wish to thank Lucia Casanova and the staff of RIAIDT for technical support, the owners of the farms where this study was conducted for their assistance and the Xunta de Galicia for funding their research in oxidant status of dairy cattle through the grants 10MRU261004PR and CN2012/327. Other than funding, the sponsor took no part in any aspect of the study or in writing or submitting the manuscript for publication. A. Abuelo held a FPU fellowship (Ref. AP2010-0013) from the Spanish Ministry of Education, Culture and Sports while the field work was conducted.

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Authors and Affiliations

  1. Graham Centre for Agricultural Innovation, School of Animal and Veterinary Sciences, Charles Sturt University and NSW Department of Primary Industries, Wagga Wagga, NSW, 2678, Australia

    Angel Abuelo & Víctor Alves-Nores

  2. Departamento de Patología Animal, Facultad de Veterinaria, Universidade de Santiago de Compostela, 27002, Lugo, Spain

    Angel Abuelo, Joaquín Hernandez, Víctor Alves-Nores, José L. Benedito & Cristina Castillo

Authors
  1. Angel Abuelo
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  2. Joaquín Hernandez
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  3. Víctor Alves-Nores
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  4. José L. Benedito
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  5. Cristina Castillo
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Corresponding author

Correspondence to Angel Abuelo.

Ethics declarations

All the experimental work was conducted in accordance with the European and Spanish legislation on the use of animals for research. All animal use was previously approved by the Bioethical Committee of the University of Santiago de Compostela and animals were enrolled with owner consent.

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The authors declare that they have no competing interests.

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Abuelo, A., Hernandez, J., Alves-Nores, V. et al. Association of Serum Concentration of Different Trace Elements with Biomarkers of Systemic Oxidant Status in Dairy Cattle. Biol Trace Elem Res 174, 319–324 (2016). https://doi.org/10.1007/s12011-016-0713-4

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  • DOI: https://doi.org/10.1007/s12011-016-0713-4

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