Skip to main content
SpringerLink
Log in

Plasma Selenium Levels in First Trimester Pregnant Women with Hyperthyroidism and the Relationship with Thyroid Hormone Status

  • Published:
Biological Trace Element Research Aims and scope Submit manuscript

Abstract

The thyroid gland has the highest selenium (Se) concentration per unit weight among all tissues. The aims of the present study were to evaluate the Se levels in the plasma of hyperthyroidic pregnant women and to investigate the association between maternal plasma Se concentrations and thyroid hormone levels. The study population consisted of 107 pregnant women, 70 healthy pregnant women (group 1) and 37 pregnant women with hyperthyroidism (group 2). The plasma free triiodothyronine (fT3) and free thyroxine (fT4) levels were significantly higher, and the plasma thyroid-stimulating hormone (TSH) and Se levels were significantly lower in group 2 than in group 1 (p < 0.05). A correlation analysis showed a positive correlation between Se and fT4 in group 1 and with TSH in group 2 (p < 0.05). Decreased maternal serum antioxidant trace element Se in hyperthyroidic pregnant women compared with normal pregnant women supported the hypothesis that hyperthyroidism was associated with decreased antioxidant response.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Schwarz K, Foltz CM (1957) Selenium as an integral part of factor 3 against dietary necrotic liver degeneration. J Am Chem Soc 79:3292–3293

    Article  CAS  Google Scholar 

  2. Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG (1973) Selenium: biochemical role as a component of glutathione peroxidase. Science 179:588–590

    Article  CAS  PubMed  Google Scholar 

  3. Zhao X, Yao H, Fan R, Zhang Z, Xu S (2014) Selenium deficiency influences nitric oxide and selenoproteins in pancreas of chickens. Biol Trace Elem Res 161:341–349

    Article  CAS  PubMed  Google Scholar 

  4. Yao H, Zhao W, Zhao X, Fan R, Khoso PA, Zhang Z, Liu W, Xu S (2014) Selenium deficiency mainly influences the gene expressions of antioxidative selenoproteins in chicken muscles. Biol Trace Elem Res 161:318–327

    Article  CAS  PubMed  Google Scholar 

  5. Yao HD, Wu Q, Zhang ZW, Zhang JL, Li S, Huang JQ, Ren FZ, Xu SW, Wang XL, Lei XG (2013) Gene expression of endoplasmic reticulum resident selenoproteins correlates with apoptosis in various muscles of Se-deficient chicks. J Nutr 143:613–619

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  6. Berry MJ, Banu L, Larsen PR (1991) Type I iodothyronine deiodinase is a selenocysteine-containing enzyme. Nature 349:438–440

    Article  CAS  PubMed  Google Scholar 

  7. Berry MJ, Kieffer JD, Harney JW, Larsen PR (1991) Selenocysteine confers the biochemical properties characteristic of the type I iodothyronine deiodinase. J Biol Chem 266:14155–14158

    CAS  PubMed  Google Scholar 

  8. Manna D, Roy G, Mugesh G (2013) Antithyroid drugs and their analogues: synthesis, structure, and mechanism of action. Acc Chem Res 46(11):2706–2715

    Article  CAS  PubMed  Google Scholar 

  9. Lin SL, Wang CW, Tan SR, Liang Y, Yao HD, Zhang ZW, Xu SW (2014) Selenium deficiency inhibits the conversion of thyroidal thyroxine (T4) to triiodothyronine (T3) in chicken thyroids. Biol Trace Elem Res 161:263–671

    Article  CAS  PubMed  Google Scholar 

  10. Köhrle J, Jakob F, Contempre B, Dumont JE (2005) Selenium, the thyroid and the endocrine system. Endocr Rev 26:944–984

    Article  PubMed  Google Scholar 

  11. Negro R (2008) Selenium and thyroid autoimmunity. Biologics 2:265–273

    PubMed Central  CAS  PubMed  Google Scholar 

  12. Duntas LH (2010) Selenium and the thyroid: a close-knit connection. J Clin Endocrinol Metab 95:5180–5188

    Article  CAS  PubMed  Google Scholar 

  13. Marcocci C, Leo M, Altea MA (2012) Oxidative stress in Graves’ disease. Eur Thyroid J 1:80–87

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  14. Duntas LH (2006) The role of selenium in thyroid autoimmunity and cancer. Thyroid 16:455–460

    Article  CAS  PubMed  Google Scholar 

  15. Dumont JE, Corvilain B, Contempre B (1994) The biochemistry of endemic cretinism: roles of iodine and selenium deficiency and goitrogens. Mol Cell Endocrinol 100:163–1661

    Article  CAS  PubMed  Google Scholar 

  16. Golstein J, Corvilain B, Lamy F, Paquer D, Dumont JE (1998) Effects of a selenium deficient diet on thyroid function of normal and perchlorate treated rats. Acta Endocrinol (Copenh) 118:495–502

    Google Scholar 

  17. Beckett GJ, Beddows SE, Morrice PC, Nicol F, Arthur JR (2003) Inhibition of hepatic deiodination of thyroxine is caused by selenium deficiency in rats. Biochem J 248:443–447

    Article  Google Scholar 

  18. Flohé L, Andreesen JR, Brigelius-Flohé R, Maiorino M, Ursini F (2000) Selenium, the element of the moon, in life on earth. IUBMBLife 49:411–420

    Google Scholar 

  19. Kryukov GV, Gladyshev VN (2006) Mammalian selenoprotein gene signature: identification and functional analysis of selenoprotein genes using biotransformatic methods. Methods Enzymol 347:84–100

    Article  Google Scholar 

  20. Khong JJ, Goldstein RF, Sanders KM, Schneider H, Pope J, Burdon KP, Craig JE, Ebeling PR (2014) Serum selenium status in Graves’ disease with and without orbitopathy: a case-control study. Clin Endocrinol (Oxf) 80(6):905–910

    Article  CAS  Google Scholar 

  21. Bacić Vrca V, Skreb F, Cepelak I, Mayer L (2004) Supplementation with antioxidants in the treatment of Graves’ disease: the effect on the extracellular antioxidative parameters. Acta Pharm 54(2):79–89

    PubMed  Google Scholar 

  22. Wertenbruch T, Willenberg HS, Sagert C et al (2007) Serum selenium levels in patients with remission and relapse of Graves’ disease. Med Chem 3:281–284

    Article  CAS  PubMed  Google Scholar 

  23. Baloch Z, Carayon P, Conte-Devolx B, Demers LM, Feldt-Rasmussen U, Henry JF, LiVosli VA, Niccoli-Sire P, John R, Ruf J, Smyth PP, Spencer CA, Stockigt JR (2003) Laboratory medicine practice guidelines. Laboratory support for the diagnosis and monitoring of thyroid disease. Thyroid 13:3–126

    Article  PubMed  Google Scholar 

  24. Correia PRM, Oliveira E, Oliveira PV (2002) Simultaneous determination of manganese and selenium in serum by electrothermal atomic absorption spectrometry. Talanta 57:527–535

    Article  CAS  PubMed  Google Scholar 

  25. Kohrle J, Jakob F, Contempre B, Dumont JE (2005) Selenium, the thyroid, and the endocrine system. Endocr Rev 26:944–984

    Article  CAS  PubMed  Google Scholar 

  26. Farber JL, Kyle ME, Coleman JB (1990) Mechanisms of cell injury by activated oxygen species. Lab Invest 62:670–679

    CAS  PubMed  Google Scholar 

  27. Goyens P, Golstein J, Nsombola B, Vis H, Dumont JE (1987) Selenium deficiency as a possible factor in the pathogenesis of myxoedematous endemic cretinism. Acta Endocrinol 114:497–502

    Article  CAS  PubMed  Google Scholar 

  28. Gartner R, Gasnier BC, Dietrich JW, Krebs B, Angstwurm MW (2002) Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations. J Clin Endocrinol Metab 87:1687–1691

    Article  CAS  PubMed  Google Scholar 

  29. Duntas LH, Mantzou E, Koutras DA (2003) Effects of a six month treatment with selenomethionine in patients with autoimmune thyroiditis. Eur J Endocrinol 148:389–393

    Article  CAS  PubMed  Google Scholar 

  30. Vrca VB, Skreb F, Cepelak I, Romic Z, Mayer L (2004) Supplementation with antioxidants in the treatment of Graves’ disease; the effect on glutathione peroxidase activity and concentration of selenium. Clin Chim Acta 341:55–63

    Article  CAS  PubMed  Google Scholar 

  31. Pedersen IB, Knudsen N, Carlé A, Schomburg L, Köhrle J, Jørgensen T, Rasmussen LB, Ovesen L, Laurberg P (2013) Serum selenium is low in newly diagnosed Graves’ disease: a population-based study. Clin Endocrinol (Oxf) 79(4):584–590

    Article  Google Scholar 

  32. Bulow Pedersen I, Knudsen N, Carlé A, Schomburg L, Köhrle J, Jørgensen T, Rasmussen LB, Ovesen L, Laurberg P (2013) Serum selenium is low in newly diagnosed Graves’ disease: a population-based study. Clin Endocrinol 79:584–590

    Article  Google Scholar 

  33. Wertenbruch T, Willenberg HS, Sagert C, Nguyen TB, Bahlo M, Feldkamp J, Groeger C, Hermsen D, Scherbaum WA, Schott M (2007) Serum selenium levels in patients with remission and relapse of graves’ disease. Med Chem 3(3):281–284

    Article  CAS  PubMed  Google Scholar 

  34. Diwadkar-Navsariwala V, Diamond AM (2004) The link between selenium and chemoprevention: a case for selenoproteins. J Nutr 134:2899–2902

    CAS  PubMed  Google Scholar 

  35. Kvicala J, Zamrazil V, Soutorova M, Tomiska F (1995) Correlations between parameters of body selenium status and peripheral thyroid parameters in the low selenium region. Analyst 120:959–965

    Article  CAS  PubMed  Google Scholar 

  36. Rayman MP, Thompson AJ, Bekaert B, Catterick J, Galassini R, Hall E, Warren-Perry M, Beckett GJ (2008) Randomized controlled trial of the effect of selenium supplementation on thyroid function in the elderly in the United Kingdom. Am J Clin Nutr 87:370–378

    CAS  PubMed  Google Scholar 

  37. Adali M, Inal-Erden M, Akalin A, Efe B (1999) Effects of propylthiouracil, propranolol, and vitamin E on lipid peroxidation and antioxidant status in hyperthyroid patients. Clin Biochem 32:363–367

    Article  CAS  PubMed  Google Scholar 

  38. Abalovich M, Llesuy S, Gutierrez S, Repetto M (2003) Peripheral parameters of oxidative stres in Graves disease: the effect of methimazole and 131 I iodine treatment. Clin Endocrinol (Oxf) 59:321–327

    Article  CAS  Google Scholar 

  39. Komosinska-Vassev K, Olczyk K, Kucharz EJ, Marcisz C, Winsz-Szczotka K, Kotulska A (2000) Free radical activity and antioxidant defense mechanisms in patients with hyperthyroidism due to Graves’ disease during therapy. Clin Chim Acta 300:107–117

    Article  CAS  PubMed  Google Scholar 

  40. Aslan M, Cosar N, Celik H, Aksoy N, Dulger AC, Begenik H, Soyoral YU, Kucukoglu ME, Selek S (2011) Evaluation of oxidative status in patients with hyperthyroidism. Endocrine 40:285–289

    Article  CAS  PubMed  Google Scholar 

  41. Bednarek J, Wysocki H, Sowiński J (2005) Oxidative stress peripheral parameters in Graves’ disease: the effect of methimazole treatment in patients with and without infiltrative ophthalmopathy. Clin Biochem 38:13–18

    Article  CAS  PubMed  Google Scholar 

Download references

Conflict of Interest

The author reports no conflicts of interest. The author alone is responsible for the content and writing of the paper.

Author information

Authors and Affiliations

  1. Department of Elementary Science Teaching, Education Faculty, Kahramanmaras Sutcu Imam University, Avşar Kampüsü, 46100, Kahramanmaras, Turkey

    Tugba Atilan Arikan

Authors
  1. Tugba Atilan Arikan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Tugba Atilan Arikan.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Arikan, T.A. Plasma Selenium Levels in First Trimester Pregnant Women with Hyperthyroidism and the Relationship with Thyroid Hormone Status. Biol Trace Elem Res 167, 194–199 (2015). https://doi.org/10.1007/s12011-015-0310-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12011-015-0310-y

Keywords

Search

Navigation