Skip to main content

Advertisement

SpringerLink
Log in

Serum Arsenic and Lipid Peroxidation Levels in Patients with Multiple Sclerosis

  • Published:
Biological Trace Element Research Aims and scope Submit manuscript

Abstract

Oxidative stress plays a crucial role in the pathogenesis of multiple sclerosis (MS). Previous studies have shown that oxidative stress is one of the main underlying mechanisms of arsenic-induced cellular damage. The aim of this study was to assess the serum levels of arsenic and its relationship with lipid peroxidation in MS patients from Tabriz, as the third polluted city of Iran. The study population included 38 MS female patients and 38 age-matched healthy controls. Serum malondialdehyde (MDA) and arsenic levels were measured using thiobarbituric acid reactive substances (TBARS) assay and electrothermal atomic absorption spectrometry, respectively. The results showed that the arsenic (P < 0.01) and MDA (P = 0.03) levels were significantly higher in patients with MS than those in control. Moreover, serum levels of arsenic and MDA were positively correlated in MS patients. The elevated levels of serum arsenic might explain the increased oxidative stress in MS patients. We suggest that high arsenic levels in serum may lead to MS development, and therefore, exposure to this metal should be limited.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

References

  1. Goldenberg MM (2012) Multiple sclerosis review. P T 37(3):175

    PubMed Central  PubMed  Google Scholar 

  2. Sahraian MA, Khorramnia S, Ebrahim MM, Moinfar Z, Lotfi J, Pakdaman H (2010) Multiple sclerosis in Iran: a demographic study of 8,000 patients and changes over time. Eur Neurol 64(6):331–336

    Article  PubMed  Google Scholar 

  3. Naziroglu M, Kutluhan S, Övey IsS, Aykur M , Yurekli VA (2013) Modulation of oxidative stress, apoptosis, and calcium entry in leukocytes of patients with multiple sclerosis by Hypericum perforatum. Nutr Neurosci

  4. Nazıroğlu M, Yürekli VA (2013) Effects of antiepileptic drugs on antioxidant and oxidant molecular pathways: focus on trace elements. Cell Mol Neurobiol 33(5):589–599

    PubMed  Google Scholar 

  5. Jomova K, Jenisova Z, Feszterova M, Baros S, Liska J, Hudecova D et al (2011) Arsenic: toxicity, oxidative stress and human disease. J Appl Toxicol 31(2):95–107

    CAS  PubMed  Google Scholar 

  6. Lu T-H, Tseng T-J, Su C-C, Tang F-C, Yen C-C, Liu Y-Y et al (2014) Arsenic induces reactive oxygen species-caused neuronal cell apoptosis through JNK/ERK-mediated mitochondria-dependent and GRP 78/CHOP-regulated pathways. Toxicol Lett 224(1):130–140

    Article  CAS  PubMed  Google Scholar 

  7. Yousefi B, Faghfoori Z, Karami H, Ahmadi Y, Nasser Samadi, Badalzadeh R et al. (2014) The effects of Ramadan fasting on endothelial function in patients with cardiovascular diseases. Eur J Clin Nutr. doi:10.1038/ejcn.2014.6

  8. Haider L, Fischer MT, Frischer JM, Bauer J, Höftberger R, Botond G et al (2011) Oxidative damage in multiple sclerosis lesions. Brain 134(7):1914–1924

    Article  PubMed Central  PubMed  Google Scholar 

  9. Ferretti G, Bacchetti T, Principi F, Di Ludovico F, Viti B, Angeleri VA et al (2005) Increased levels of lipid hydroperoxides in plasma of patients with multiple sclerosis: a relationship with paraoxonase activity. Mult Scler 11(6):677–682

    Article  CAS  PubMed  Google Scholar 

  10. Giovannoni G, Heales SJ, Silver NC, O’Riordan J, Miller RF, Land JM et al (1997) Raised serum nitrate and nitrite levels in patients with multiple sclerosis. J Neurol Sci 145(1):77–81

    Article  CAS  PubMed  Google Scholar 

  11. Acar A, Cevik MU, Evliyaoglu O, Uzar E, Tamam Y, Arıkanoglu A et al (2012) Evaluation of serum oxidant/antioxidant balance in multiple sclerosis. Acta Neurol Belg 112(3):275–280

    Article  PubMed  Google Scholar 

  12. Gharibzadeh S, Hoseini SS (2008) Arsenic exposure may be a risk factor for Alzheimer’s disease. Authors’ reply. J Neuropsychiatry Clin Neurosci 20(4):501–501

    Article  PubMed  Google Scholar 

  13. Mathew L, Vale A, Adcock JE (2010) Arsenical peripheral neuropathy. Pract Neurol 10(1):34–38

    Article  PubMed  Google Scholar 

  14. Rios R, Zarazúa S, Santoyo M, Sepúlveda-Saavedra J, Romero-Díaz V, Jiménez V et al (2009) Decreased nitric oxide markers and morphological changes in the brain of arsenic-exposed rats. Toxicology 261(1):68–75

    Article  CAS  PubMed  Google Scholar 

  15. Yen CC, Ho TJ, Wu CC, Chang CF, Su CC, Chen YW et al (2011) Inorganic arsenic causes cell apoptosis in mouse cerebrum through an oxidative stress-regulated signaling pathway. Arch Toxicol 85(6):565–575

    Article  CAS  PubMed  Google Scholar 

  16. Fulgenzi A, Zanella SG, Mariani MM, Vietti D, Ferrero ME (2012) A case of multiple sclerosis improvement following removal of heavy metal intoxication. Biometals 25(3):569–576

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

The authors wish to thank the Students’ Research Committee, Tabriz University of Medical Sciences for financial support. We also thank the staff of research laboratory in chemistry faculty for their technical supports.

Conflict of Interest

The authors have no conflicts of interest in regard to this research or its funding.

Author information

Authors and Affiliations

  1. Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

    Bahman Yousefi, Yasin Ahmadi & Vahid Shafiei irannejad

  2. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Bahman Yousefi

  3. Students’ Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran

    Bahman Yousefi & Zeinab Faghfoori

  4. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Amir Ghorbanihaghjo

  5. Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran

    Zeinab Faghfoori

Authors
  1. Bahman Yousefi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yasin Ahmadi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Amir Ghorbanihaghjo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Zeinab Faghfoori
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Vahid Shafiei irannejad
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Bahman Yousefi.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yousefi, B., Ahmadi, Y., Ghorbanihaghjo, A. et al. Serum Arsenic and Lipid Peroxidation Levels in Patients with Multiple Sclerosis. Biol Trace Elem Res 158, 276–279 (2014). https://doi.org/10.1007/s12011-014-9956-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12011-014-9956-0

Keywords

Search

Navigation