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Effects of Aluminum Exposure on Bone Mineral Density, Mineral, and Trace Elements in Rats

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Abstract

The purpose of the study was to investigate the effects of aluminum (Al) exposure on bone mineral elements, trace elements, and bone mineral density (BMD) in rats. One hundred Wistar rats were divided randomly into two groups. Experimental rats were given drinking water containing aluminum chloride (AlCl3, 430 mg Al3+/L), whereas control rats were given distilled water for up to 150 days. Ten rats were sacrificed in each group every 30 days. The levels of Al, calcium (Ca), phosphorus (P), magnesium (Mg), zinc (Zn), iron (Fe), copper (Cu), manganese (Mn), selenium (Se), boron (B), and strontium (Sr) in bone and the BMD of femur were measured. Al-treated rats showed lower deposition of Ca, P, and Mg compared with control rats. Levels of trace elements (Zn, Fe, Cu, Mn, Se, B, and Sr) were significantly lower in the Al-treated group than in the control group from day 60, and the BMD of the femur metaphysis in the Al-treated group was significantly lower than in the control group on days 120 and 150. These findings indicate that long-term Al exposure reduces the levels of mineral and trace elements in bone. As a result, bone loss was induced (particularly in cancellous bone).

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Acknowledgments

This study was supported by a grant from the Natural Science Fund of Heilongjiang Province of China (C 200935).

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Authors and Affiliations

  1. College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, People’s Republic of China

    Xinwei Li, Chongwei Hu, Yanzhu Zhu, Hao Sun, Yanfei Li & Zhigang Zhang

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  1. Xinwei Li
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  2. Chongwei Hu
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  3. Yanzhu Zhu
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  4. Hao Sun
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  5. Yanfei Li
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Correspondence to Yanfei Li or Zhigang Zhang.

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Li, X., Hu, C., Zhu, Y. et al. Effects of Aluminum Exposure on Bone Mineral Density, Mineral, and Trace Elements in Rats. Biol Trace Elem Res 143, 378–385 (2011). https://doi.org/10.1007/s12011-010-8861-4

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  • DOI: https://doi.org/10.1007/s12011-010-8861-4

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