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The Influence of Condition on Permeation of Ca(II) Ions from Solutions of Selected Calcium’s Salts Through Model Membrane

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Abstract

The permeation of calcium’s ions from calcium solutions of fumarate, gluconate, and citrate through model membrane from the donor chamber to the acceptor chamber has been examined. Process was traced depending on the concentration of the appropriate calcium’s salts (1, 2.5, and 5 mmol/l) and pH value of acceptor environment (1.3, 6.2, and 7.4) which imitated natural conditions appearing in the digestive tract. The amount of permeating Ca(II) ions (percent) and their Ca(II) availability AUC (0–6 h) has been determined. In dependence on the conditions, penetration was as follows: 30.3–95.2% of calcium ions from fumarate solution; 73.0–90.1% of Ca(II) from citrate solution; and 19.0–95.0% of Ca from gluconate solution. The investigation indicates that the amount of permeated Ca(II) ions and their availability are connected with the concentration of the calcium salt and pH of acceptor environment. Fumarate and citrate are available at pH value of acceptor environment 1.3 and 6.2 and gluconate at the pH value of 6.2 and 7.4. These substances are practically unavailable from the acceptor environment at pH value 1.3 for gluconate and 7.4 for fumarate. Results suggest that calcium citrate can be available for organism independently from pH value of acceptor environment.

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Acknowledgments

The research is financed from sources for the realization of the project and co-financed by the European Regional Development Fund as part of the Operating Program of Innovative Economy no. UDA-POIG.01.03.1-00-133/08-00 “Innovative technologies of the production of bio-preparations on the basis of new generation of eggs” in years 2009–2011.

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Authors and Affiliations

  1. “Biochefa” Pharmaceutical Research and Production Plant, Kasztanowa 3, 41-200, Sosnowiec, Poland

    Barbara Dolińska, Agnieszka Mikulska & Florian Ryszka

  2. Department of Applied Pharmacy, Medical University of Silesia, Kasztanowa 3, 41-200, Sosnowiec, Poland

    Aneta Ostróżka-Cieślik

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  1. Barbara Dolińska
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  2. Agnieszka Mikulska
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  3. Aneta Ostróżka-Cieślik
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  4. Florian Ryszka
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Correspondence to Barbara Dolińska.

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Dolińska, B., Mikulska, A., Ostróżka-Cieślik, A. et al. The Influence of Condition on Permeation of Ca(II) Ions from Solutions of Selected Calcium’s Salts Through Model Membrane. Biol Trace Elem Res 140, 95–102 (2011). https://doi.org/10.1007/s12011-010-8675-4

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  • DOI: https://doi.org/10.1007/s12011-010-8675-4

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