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Urinary Profile of 6β-Hydroxycortisol in Workers Exposed to Aluminum

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Abstract

The aim of the present study was to evaluate whether aluminum exposure may cause alterations of cytochrome P 4503A4 by measuring the urinary excretion of 6β-hydroxycortisol as biomarker. There is a positive correlation between urinary 6β-hydroxycortisol and aluminum excretion (p < 0.05). The correlations between occupational duration, smoking habits, and age were also evaluated. The increased excretion of the biomarker suggests that this element may induce formation of cytochrome P 450 in exposed individuals.

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Acknowledgements

The authors would like to thank Stabiligen Co, France for its generous gift of a 6β-hydroxycortisol ELISA kit.

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Authors and Affiliations

  1. Department of Toxicology, Faculty of Pharmacy, Hacettepe University, 06100, Sihhiye, Ankara, Turkey

    T. Baydar & G. Sahin

  2. Gulhane Military Medical Academy, 06010, Etlik, Ankara, Turkey

    A. Aydin

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  1. T. Baydar
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  2. A. Aydin
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  3. G. Sahin
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Correspondence to G. Sahin.

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Baydar, T., Aydin, A. & Sahin, G. Urinary Profile of 6β-Hydroxycortisol in Workers Exposed to Aluminum. Biol Trace Elem Res 120, 36–41 (2007). https://doi.org/10.1007/s12011-007-0073-1

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  • DOI: https://doi.org/10.1007/s12011-007-0073-1

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