Abstract
Medicinal or herbal spices are grown in tropical moist evergreen forestland, surrounding most of the tropical and subtropical regions of Eastern Himalayas in India (Sikkim, Darjeeling regions), Bhutan, Nepal, Pakistan, Iran, Afghanistan, a few Central Asian countries, Middle East, USA, Europe, South East Asia, Japan, Malaysia, and Indonesia. According to the cultivation region surrounded, economic value, and vogue, these spices can be classified into major, minor, and colored tropical spices. In total, 24 tropical spices and herbs (cardamom, black jeera, fennel, poppy, coriander, fenugreek, bay leaves, clove, chili, cassia bark, black pepper, nutmeg, black mustard, turmeric, saffron, star anise, onion, dill, asafoetida, celery, allspice, kokum, greater galangal, and sweet flag) are described in this review. These spices show many pharmacological activities like anti-inflammatory, antimicrobial, anti-diabetic, anti-obesity, cardiovascular, gastrointestinal, central nervous system, and antioxidant activities. Numerous bioactive compounds are present in these selected spices, such as 1,8-cineole, monoterpene hydrocarbons, γ-terpinene, cuminaldehyde, trans-anethole, fenchone, estragole, benzylisoquinoline alkaloids, eugenol, cinnamaldehyde, piperine, linalool, malabaricone C, safrole, myristicin, elemicin, sinigrin, curcumin, bidemethoxycurcumin, dimethoxycurcumin, crocin, picrocrocin, quercetin, quercetin 4’-O-β-glucoside, apiol, carvone, limonene, α-phellandrene, galactomannan, rosmarinic acid, limonene, capsaicinoids, eugenol, garcinol, and α-asarone. Other than that, various spices are used to synthesize different types of metal-based and polymer-based nanoparticles like zinc oxide, gold, silver, selenium, silica, and chitosan nanoparticles which provide beneficial health effects such as antioxidant, anti-carcinogenic, anti-diabetic, enzyme retardation effect, and antimicrobial activity. The nanoparticles can also be used in environmental pollution management like dye decolorization and in chemical industries to enhance the rate of reaction by the use of catalytic activity of the nanoparticles. The nutritional value, phytochemical properties, health advantages, and both traditional and modern applications of these spices, along with their functions in food fortification, have been thoroughly discussed in this review
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Introduction
Nowadays, people have been more conscious about the co-relation between the food product and healthy life to cure nutrition-related diseases and promote quality of life [178]. This thought brought many advantages to the food industry, including the provision to provide functional food products that fulfill people’s demands along with good standards
In order to meet a purchaser’s expectations in the quality and hygiene of food products, nowadays researchers are trying to apply nanotechnology in current food science [361]. Therefore, different types of nanostructures like nanoliposomes [195], nanoemulsions [514, 881], and nanoparticles [700] are used in the food industry to sustain and develop proposal features [102]. The process of better packaging methods and governance of food standards and protectiveness were a few of the very important studied areas in food nanotechnology [179, 336]. There is a debate about the application of nanotechnology in food, as this might compromise food indemnity,therefore, recent provisions of the application of nanomaterials in food and medicine are incipient [73] only through recommendations given by the US (FDA) Department of Health and Human Services 2014 and the European Food Safety Association (EFSA) [265]. The scientific community has focused on nanotechnology-based techniques in order to detect hygiene-related problems and hazards of recent foods that might develop during and after food processing [168]
Investigation into the effectiveness of nanotechnology in the formulation of food products might associate with the encapsulation of nutritious ingredients like vitamins [93], antioxidants [370, 411], and polyphenols [179]. Thus, various additives applied during food development, especially those derived from agricultural processing wastage or naturally like fruits and spices, have a significant potential for application in nanotechnology [179]. All these products are utilized for their unique properties like color, aroma, flavor, and preservation of food [278]
The technology and science in which nanoparticles have been utilized are as follows: medical [709], electronics, agricultural [772], chemical [942], and pharmaceutical [757]. Most of the research studies till now performed on the application of nanoparticles with spices mainly focus on 1) in vitro studies, 2) fortification, 3) food industry, 4) packaging, 5) aroma and drug industry and 6) textile industry
Since all spices contain an ample amount of bioactive components that are used to synthesize nanoparticles, these nanoparticles can be used in various types of food products to make them more nutritious that have enormous health-beneficial effects. The antibacterial activity of green synthesized silver nanoparticles has been evaluated against Klebsiella pneumoniae and Bacillus subtilis [836]. Soshnikova et al. [880] prepared the gold and silver nanoparticles with the water extract of dried fruits of Amomum villosum called Fructus Amomi (cardamom) to assess catalytic and antioxidant effects and prevention activity for breast cancer cells [880]. Krishnan et al. [487] synthesized silver nanoparticles with seed extracts of cardamom that showed its cytotoxic effect against Hep-2 cell line [487]. Taami et al. [906] evaluated the antioxidant efficacy of biodegradable starch film containing nanoemulsions of Bunium persicum essential oil fortified with cinnamaldehyde [906]. Arif et al. [84] investigated a substitute treatment therapy to cure rheumatoid arthritis with fennel seed selenium nanoparticles in arthritic BALB/c mice [84]
Nowadays, in human nutrition, spices provide eminent historical significance. The bioactive components present in spices make them more popular for centuries. They have been applied for their health advantages and also for coloring or flavoring food products [207]. Day by day, the application of spices in different types of food has been enhanced as they provide various pharmacological and physiological benefits. Medicinal spices have been taken great importance by the recent biomedical research, as spices have been used traditionally in producing either nutraceuticals or functional foods due to their health-beneficial properties. India possesses rank three in the world spices market with an 8.8% share. India possesses the first position in turmeric, coriander, pepper, fenugreek, and some other spices export. The USA, Germany, and Malaysia are the main trading countries. Spices provide aroma due to the presence of volatile oils and oleoresin [147]
Spices play an important role in terms of medicinal benefits. Spices are utilized as anti-inflammatory, carminative, antioxidants, and antiseptic. In the current scenario, spices are gaining interest due to the bioactive compounds and their biological effect and chemical structure. Phytochemicals like alkaloids, phenolic compounds, flavonoids, tannins, and flavones are present in spices and can be used as a powerful drug against dengue and Ebola viruses. Chikungunya virus can be cured by using ginger extract. Spices have antioxidant properties and have proof of oxidative alternation of low-density lipoprotein cholesterol in the formation of atherosclerosis. Spices containing various bioactive components have an anticancer effect as examined in model animals [147]. The active compounds of the spices are essential oils, and the spices, namely black pepper, cinnamon, cloves, coriander, chili, and cumin, are enriched with essential oils having pharmaceutically active components such as piperine, cinnamaldehyde, eugenol, allicin, curcumin, and linalool [658]. Spices are used as therapeutic agents with antimicrobial, anti-inflammatory, anticancer, and antioxidant properties. Carotenoids, eugenol, and curcumin in saffron, clove, and turmeric are the active constituents in spices evidenced by a phytochemical evaluation that exposes the effective nature of these spices. The benefits represented by these spices are immunity boosters, especially during the phase of the pandemic, and their incorporation into our regular diet could enhance disease control mechanisms [773]
In recent years, the societal needs and interest in the application of renewable, natural, and biodegradable resources have enhanced. Food consumers and producers have increased their demands for the quality of processed food products, especially in the area of enhancing shelf life while protecting nutritional and organoleptic properties. Spices have been reported to have a high potential to be applied as important, renewable, and biodegradable sources of chemicals like polyphenols having great antimicrobial/antioxidant properties [460]. Spices have been significantly utilized to increase or improve the flavor of food through their preservative properties [956]. Spices possess a significant role in food safety. The retardation effect of spices and derivatives on the propagation of fungi, bacteria, yeasts, and microbial toxins synthesis has been reported,therefore, they have been applied in food preservation. Spices are recently utilized for increasing the flavor and shelf life of food products because of their bactericidal or bacteriostatic effect [282]
In this review, the ethnobotanical aspects of 24 spices have been covered along with their bioactive and nutritional potential. The role of those spices in food fortification and their potential in nanotechnology have also been explored
Ethnobotanical Knowledge Related to Spices and Herbs
Spices and herbs are the plant parts. Figure 1 describes the botanical perspective of the spices and herbs
Cardamom (Elettaria cardamomum)
Small cardamom belongs to the family Zingiberaceae. Small cardamom capsules (fruits) show beneficial health effects which are related to the traditional and modern pharmaceutical aspects. It is used in traditional medicines to prevent asthma, nausea, teeth and gum infections, diarrhea, cataracts, indigestion, cardiac attack, and kidney failure. Cardamom fruits are utilized as a fragrance, spice, and flavoring ingredient in food products [89]. In Ayurveda, for the treatment of food poisoning, cardamom has been applied and at present, plant-based creams and soaps are made with cardamom oils [973]. The large cardamom is called ‘cash crops’ cultivated between altitudes of 600 and 2000 m in the tropical moist evergreen jungle of Eastern Himalayas in India (Sikkim, and Darjeeling regions), Bhutan, and Nepal. The fruit is reddish-brown to dark pink, trilocular, and many-seeded capsule. The seeds possess 2–3% essential oils that contain medicinal properties. These are utilized as a supplement to formulate different types of medicine [379, 866]. India is the highest producer of cardamom (26.51 thousand tons) [563]. The small cardamom is called ‘Queen of all Spices’ and grows in the tropical rain forest at altitudes of 762–1524 m, where it rains about 381 cm per year. It is cultivated commercially in Guatemala, India, Sri Lanka, and Tanzania. The fruits are narrow-walled, soft-skinned, and oblong. The green fruits contain 15–20 aromatic reddish-brown seeds. The seeds possess volatile oil, which is utilized for the flavoring of bread, cakes, curries, and other culinary purposes. Confectionery and coffee products are also flavored with small cardamom. It is also applied in several neural, gastrointestinal, and cardiovascular diseases [681]
Black jeera (Bunium persicum)
In traditional and folkloric medicine, black jeera has been utilized for the treatment of different types of diseases like nasopharyngeal, gastrointestinal, cardiac, respiratory, ocular, neurological, and urinary tract problems [559]. This plant is popular as a spice [352]. The roots and seeds are used as spices that provide flavor to the food [360]. About 70% of the world’s cumin is produced in India (725.42 thousand tons) [104]. Black jeera belongs to the family Apiaceae, which is a topical plant and is found in Pakistan, Iran, Afghanistan, and a few Central Asian countries. This plant is a branched and perennial herb, its glandular root is irregular and circular in shape, and the height of this herb is around 40–60 cm. The leaves are properly dissected, freely, pinnate, and capillary, and the white color flowers little in shape have symmetrical little pollen tubes, sepals, and petals and are present in compact umbels. The darkish-brown-colored fruits are round in shape and warm to the taste [617]
Fennel (Foeniculum vulgare)
Fennel belongs to the family Apiaceae and is an aromatic and medicinal plant applied for the treatment of galactagogue, carminative, digestive, diuretic, respiratory problems, and gastrointestinal diseases. The seeds are utilized as a flavoring ingredient to prepare dishes like ice cream, baked goods, meat and fish dishes, alcoholic beverages, and herb mixtures [749]. Fennel is applied as medicine with purgatives to diminish their side effects due to their carminative properties. Fennel seeds are consumed fresh as a sweetener and help in curing eyesight. Fennel contains phytoestrogens that improve the growth of breast tissue and induces an increased milk supply in breastfeeding mothers [20]. In the year 2020, 137.29 thousand tons of fennel seeds were produced in India [512]. Fennel is an upright, branching perennial herb that has tender, feathery, hair-like foliage. The height of the tree is around 6.6 ft (2 m), and it is used for its anise-flavored foliage. The seeds are utilized in cooking. It has been cultivated in almost all countries [620]
Poppy (Papaver somniferum)
Poppy is a traditional plant commonly called Khashkhash/Afyon belonging to the family Papaveraceae and is used as medicine. As per Unani literature, it has significant therapeutic values and is applied as a sedative, analgesic, narcotic, stimulant, and nutritive agent. It helps to prevent various types of diseases like insomnia, headache, cough, cardiac asthma, and biliary colic [582]. Poppy is cultivated throughout the world and is native and grown as an ornamental flower in South East Asia, Europe, South America, and North America. Poppyseed oil is a healthy edible oil and is utilized for various purposes. The purified opium (dried latex from plant fruit) is also used as a major therapeutic component. Purified poppy has been used to balance Vata and Kapha, dosha, and pitta dosha [572]. Poppy seeds are popular as a spice and are utilized to make fortified bread and confections [170]. Afghanistan possesses the highest acreage (6800 tons) for opium poppy cultivation [891]. The opium poppy grows for the whole year and is diploid (2n = 14) with a dominating self-pollinating mode of cross-breeding [926]. Plants are vertical, yearly herbs, height is about 1–1.5 m, stalk green, soft, and hairy. The roots are fine and medium and the leaves are tall, broad, and alternately arranged with serrated margins. The color of the flowers may be varied from red to black to white. The fruits have various cells and are of little size, and they get broken on their own, and the capsule is round and longitudinally grooved [492]
Clove (Syzygium aromaticum)
Cloves have many medicinal applications and are popular in treating mouth and throat inflammation and toothache. The main constituent of clove is eugenol possessing wide antibacterial properties against gram-negative, gram-positive, and acid-fast bacteria, and also fungi. Cloves are popular for their carminative, and antiemetic activities. In China, cloves have been consumed for medicinal purposes to prevent different types of diseases since 240 BC. Traditionally, cloves have been consumed for the treatment of stomach irritation, diarrhea, liver disease, bowel problems, flatulence, nausea, vomiting, and to maintain the nerve system. Cloves have been used to prevent different infections such as tuberculosis, malaria, cholera, and scabies. In America, it is traditionally utilized for preventing candida, worms, viruses, and several bacterial and protozoan infections [151]. The flower buds called clove are popular as a spice [119]. India is the leading producer of clove (1.20 thousand tons) [563]. Clove belongs to the family Myrtaceae and is a medium-sized plant (8–12 m), indigenous to the Maluku islands in East Indonesia. Currently, it is cultivated in Malaysia, Indonesia, India, Sri Lanka, Madagascar, Tanzania, and mostly the Zanzibar island [422]
Cassia bark (Cinnamomum cassia)
Cassia bark belongs to the family Lauraceae and is an evergreen, tropical aromatic plant that is utilized as a traditional spice. It is also used in traditional Chinese medicine utilized throughout the world [1012]. The leaves and bark of this plant are utilized as spices in home kitchens and their synthetic analogs or distilled essential oils are utilized as flavoring agents in the beverage and food industry [188, 230]. Cinnamon is obtained from the bark of tender branches and is utilized as a fragrance. It is used for its spicy flavor throughout the world. It is applied as a regular condiment. Cassia bark is distributed throughout Vietnam, China, India, and Indonesia. The bark of Cinnamomum cassia is Cinnamomi cortex that is popular as spices and is used as a seasoning in the western part of the world. It is also used as food supplement in some countries. It is used as a source of coumarin in America [983]. As per the Japanese, Unani, Ayurveda, and traditional Chinese medicine, the herb is utilized to prevent various diseases such as ischemic brain injury, dyspepsia, peptic ulcer, diabetes, and cancer [1005]. The major producer and exporter of cassia bark is Sri Lanka (48,002 MT) [817]. The plant is evergreen, its height is around 10 m, the branches are rigid, the bark is soft, and the color is yellowish. The leaves are leathery and grow up to 11–16 cm with dot tips,the color of the upper leaf is dark green and that of the below leaf is light green. The color of the flower is inconspicuous yellow and has a bad odor; the flowers are cylindrical in shape with 6 lobes. The size of the fruits is small with flabby berrylike structure [385]
Black pepper (Piper nigrum)
Piper nigrum belongs to the family Piperaceae Black pepper fruit is considered as “King of spices.” It is used to increase the flavor, and taste of foods. It shows biological activities due to the presence of different bioactive phytocompounds. Traditionally, the black pepper is used as veterinary drugs and in the treatment of gastrointestinal diseases and ear–nose–throat problems. Black pepper is considered as part of the kingdom of medicinal agents due to its important bioactive compounds with potential pharmacological and nutraceutical utilizations [910]. Black pepper is grown in various tropical regions such as India, Brazil, and Indonesia. Pungent and hot peppercorns are obtained from black pepper and are used as a preservative, medicinal agents, and in perfumery. The application of whole peppercorn or its active components has been used to formulate medicines, to prepare foods, sauces, and meat dishes. It is used in various traditional medicinal systems like Unani and Ayurvedic [821]. India is the greatest producer of black pepper (91.63 thousand tons) [563]. This plant is a flowering timbered perennial climbing vine and easily grows in the shadow of backing trees, maximum height is about 13 feet or 4 m and roots may emerge from leaf nodes if the vine contact with the ground. The plant leaves are heart-shaped, the length is 5–10 cm, and 3–6 cm diagonally, it has 5–7 eminent palmate veins. The flowers are little in shape, monoecious with different male and female flowers but may be polygamous. The fruits are 3–4 mm in diameter, known as a drupe. The dried fruits of black pepper are called peppercorn. The color of fully ripe fruits is dark red, and the diameter is about 5 mm. Each of the fruits consists of one seed, and a stem possesses 20–30 fruits [220]
Coriander (Coriandrum sativum)
Coriander seed is used as a spice, which possesses medicinal and nutritional properties. It helps in the treatment of nausea, bed cold, vomiting, belly diseases, and seasonal fever. It is utilized as a medicine to prevent rheumatism, worms, indigestion, and joint pain [737]Coriandrum sativum belongs to the family Umbelliferae The mature fruits contain delightful and fresh flavor due to the presence of essential oil. It is mostly utilized throughout the world in the ground or volatile isolate form to add flavor to tobacco products, sweets, beverages, and baked goods and as a basic ingredient in curry powder and also to make perfumes and soaps. It is cultivated as a household plant [175]. The largest producer of coriander seed is India (677.21 thousand tons) [701]. It is cultivated in India, especially in Karnataka, Tamil Nadu, Rajasthan, Andhra Pradesh, Madhya Pradesh, and Bihar. This plant is thin, glabrous, and branched. The fresh leaves are round and aerial leaves are extended. The flowers are white and look like an eggplant. The fruits are oval and partitioned into two parts. The flowering season of coriander is winter [611]
Nutmeg (Myristica fragrans)
Drugs are produced with the essential oil, and extracts of nutmeg. It has various pharmacological properties. In traditional medicines, nutmeg is utilized as a narcotic, carminative, stimulant, emmenagogue, abortifacient, reduced appetite, diarrhea, rheumatism, and muscle spasm. In China and India, nutmeg is used in producing medicines, and foods due to its availability and biological properties [412]Myristica fragrans is called “nutmeg.” Two spices are formed from it, namely mace and nutmeg. Nutmeg is the seed kernel beneath the fruit, and mace is the red lacy enveloping the kernelMyristica fragrans belongs to the family Myristicaceae It is indigenous to the Moluccas, native to Sri Lanka, India, and Indonesia. It is cultivated in many tropical countries like South Africa and Sri Lanka [675]. In 2021, the production of nutmeg in India is 15.24 thousand tons [563]. Nutmeg is an evergreen aromatic plant. The height of this tree is about 5–13 m, occasionally 20 m. The bark possesses watery red to pink juice. Leaves are dark green, have shiny surface, and settled upon alternately along the branches. The leaf stem is about 1 cm long. Flowers are bell-shaped, pale yellow, flabby, and fleshy. The fruits are yellow, fleshy, drooping, soft, and 6–9 cm long with a lengthwise ridge. Seeds are extremely ovoid (2–3 cm long), whitish, firm, fleshy, and lateral by red-brown veins and the mace becomes bright red and is more corneous when fresh, and when dried becomes brittle and the color becomes yellowish-brown. Nutmeg is famous as a spice and contains several therapeutic activities. It shows a characteristic pleasant fragrance and a little hot taste. It is utilized to increase the flavor of puddings, baked foods, confections, meats, sausages, saucers, vegetables, beverages, curry powder, teas, soft drinks, or added to milk, and alcohol [664]
Black mustard (Brassica nigra)
Brassica nigra belongs to the family Brassicaceae. It is popular as a spice and a cheap source of antimicrobial agents [732]. It is cultivated in the Mediterranean region and several other countries such as Europe, and India. It is the main source of the mustard seed which is utilized as a spice [22]. In 2019, Nepal is the world’s largest producer of mustard seeds accounting for more than 32% of the global production [529]. For the treatment of malaria, seeds are powdered and pasted with water and then taken with or without “ Injera” [320]. The height of this tree is about 2–7 cm, broadly branching, pubescent or glabrate. The lower leaves are thin petiolate and densely pinnatifid and have one marginal big lobe and 2–4 little adjacent ones,the upper leaves are little-petiolate or sessile, dentate. The flowers are bright yellow colored, 3–5 inches wide [939]. Black mustard seed has been utilized as a remedy for brain and lung edema, neurotic pain, rheumatoid arthritis, paralysis, migraine, and epilepsy in Iranian traditional medicine [470]
Turmeric (Curcuma longa)
Curcuma longa L belongs to the family Zingiberaceae family. It is a perennial herb. The height of this tree is approximately 3.5 ft [83]. It is indigenous to Southern Asia [345]. In 2021, the major producer of turmeric is India (1102.91 thousand tons) [563]. Curcumin plays an important role as a therapeutic agent. For different diseases, it is used in human clinical trials [496]. Indian turmeric is most famous compared to other countries due to the presence of curcuminCurcuma longa rhizome is called Haldi or turmeric. Turmeric is also known as “Indian saffron.” It is commonly used as an antiseptic and shows high medicinal and nutritional value. Rhizome of Curcuma longa is utilized as a spice for its flavoring properties. It is utilized as medicinal food due to its therapeutic properties [187]. In Ayurveda, it has been utilized as an ethnomedicine and coloring agent to dye unmordant cotton, wool, and silk. It is utilized in the Indian medicinal system to prevent stomachache, antacid, carminative, blood purifier, wound healing, and inflammation [545]. It is cultivated broadly in Asia, especially in China, and India. It is distributed throughout subtropic, and tropic areas of the world. It is also cultivated in Japan, Southern China, Taiwan, Burma, and Indonesia as well as in Africa. The color of the flower of this plant is dull yellow [967]
Bay leaves (Laurus nobilis)
Laurus nobilis belongs to the family Lauraceae It is a small evergreen plant, marketed as sweet bay leaves, and Roman or Turkish laurel [932]. It is a fragrant and aromatic plant that contains volatile components and fixed oil (non-volatile oil of plant origin) as well as camphor. It is indigenous to South Europe [123]. The dried leaves and essential oil are applied in cosmetics, in foods as a spice, in drugs, and also for industrial purposes for the seasoning of fish, meat products, and soups. Bay leaves are utilized in the food industry as food preservatives due to their antimicrobial properties. The volatile and fixed oil present in fruits is mainly required for the formation of soap [163]. It is cultivated in the tropical and subtropical regions of East Asia, South, and North America. The natural residence of this herb is found in the Mediterranean area. Traditionally, bay leaves have been utilized in Mediterranean cuisine for seasoning, as well as fruits are used to treat rheumatism, viral infections, cough, digestive problems, diarrhea, and other health conditions in the folk medicine system [256]. India is the largest producer of bay leaves (6.20 thousand tons) [563]. This plant is a shrub. The height of this plant is about 2–20 m, thin, glabrous twigs, and thin oblong-lanceolate, sturdy leaves and dioecious with the female, and male flowers on a different tree. The flower grows in couples alongside a leaf with a pale yellow-green color. The diameter of fruits is about 1 cm. The fruits ripen in the downfall, and the shape of the fruit is oval [56]
Saffron (Crocus sativus)
Saffron is the dried orifice of the Crocus sativus flower that is used as a spice. It is considered among the main terroir products and a source of income for many areas of Morocco. According to Chinese, Ayurvedic, Mongolian, Egyptian, Greek, and Arabic medicines, saffron has been taken into account as a preventive measure for various diseases. It is utilized as a source of traditional medicine from ancient times. Saffron shows many therapeutic properties like antidepressant activity, treating sexual problems, digestion problems, lowering cholesterol levels, controlling blood sugar levels, healing second-degree burns, and treating eye disability [633]. The largest producer and exporter of Saffron is Iran (430 tons) [826]. The Crocus sativus belongs to the family Iridaceae It is an herbaceous perennial plant that grows up to 10 to 25 cm long, developing from its bulbs. The bulb is of sub-ovoid shape and available in different forms and sizes [1022]
Star anise (Illicium verum)
Illicium verum belongs to the family Illicuaceae It is an evergreen aromatic plant sometimes contaminated with very poisonous Japanese star anise and toxic star anise that possess various neurotoxic sesquiterpenes [981]. Star anise is indigenous to the Southwest of China. It is cultivated in tropical, and subtropical areas of Asia [274]. The production of star anise seed in Vietnam is more than 5000 tons per year and the combined production of Vietnam, and China is more than 25,000 tons per year [832]. It is a medium-sized tree. The height of this tree is about 8–15 m and the breadth is 30 cm. The color of the bark is white to bright grey. The leaves are 6–12 cm tall, sturdy, alternate, simple, complete, glabrous, very bright, and usually packed with bundles at the end of the branches. The flower is large, diameter is 1–1.5 cm, bisexual, white–pink to red to greenish-yellow, axillary, and lonely [962]. Dry fruits and seeds of star anise are popular as a spice in Chinese cuisine. Star anise oil is applied naturally for otalgia, and rheumatism, as an antiseptic, cough, toothache, sinusitis, and also as food preservatives traditionally. The star anise oil is utilized to treat dysentery, flatulence, and spasmodic pains and relieves colic [831]
Shallot/ Onion (Allium cepa)
A highly consumable vegetable, onion, is well known for its flavor. It is the third most important horticulture spice having remarkable marketable importance [925]Allium cepa belongs to the family Amaryllidaceae. The edible portion of the onion is the root, which is also called as the bulb. The colors of onion varied from purple to yellow to red to white green and may be categorized by its rancidity [870]. According to the medicinal characteristics, traditionally onion has been utilized in the prevention of several diseases and applied as a blood purifier for athletes in ancient Greece. Onion is used to heal wound, pneumonia, and diuretic. Onion is considered as one of the essential spice or vegetables and has been considered as a medicine in India since the sixth century [416]. India is the highest onion producer (28,853.35 thousand T) in 2020–2021 [257]. Onion is distributed in temperate areas like North America, Europe, Asia, and Africa [156]. This plant is a biennial plant with fortuitous, fibrous roots, and glaucous leaves. The bulb is produced of converging, large flabby leaf bases. When the bulb matures, the outward leaf base dries, becomes slender, many-colored, and produces a defensive coat, while the inside leaf bases thicken and develop the bulb which may be globose, egg-shaped, or extended. According to the cultivar, the size of the onion varies differently [533]
Dill (Anethum graveolens)
Anethum graveolens belongs to the family Apiaceae It has been utilized since ancient times in Ayurveda. It is a famous, aromatic, and annual herb. Dill seeds are used as a spice and also produce essential oil. The dill seeds are used as a preventive agent for diuretic, carminative, and stomachache in Ayurveda [403]. The highest producer country of dill is India (30.40 thousand T) [563]. The height of this plant is about 90 cm. It has thin stems. Leaves are alternate and are finally divided three or four times into winged sections slightly wider than the same type leaf of fennel, and the yellow flower forms into umbels. The seeds are very little in size. The dry fruits are known as schizocarps [747]. It naturally grows in the Mediterranean area, Southern, and Central Asia. It is cultivated broadly throughout the world [997]
Fenugreek (Trigonella foenum-graecum)
Trigonella foenum-graecum belongs to the family Fabaceaeis. It is an ancient medicinal plant. It is widespread throughout the world. It has been utilized as medicine and traditional food. Current investigation has determined fenugreek as an important herbal tree having a powerful effect on curing diseases and as a source of bioactive compounds for the pharmaceutical industry such as steroidal hormones [871]. The leaf and the seed of fenugreek are consumed as a spice. It is also utilized as an ingredient in traditional medicine due to its strong flavor and aroma [4]. Fenugreek is recommended as a valuable medicine to prevent various diseases like mucosal problems, digestive problems, fever, sore throat, wounds, swollen glands, skin irritation, diabetes, bronchitis, and ulcer in the ancient Indian traditional medicinal system like Ayurveda [687]. The largest producer of fenugreek is India (115,929 metric tons). But a substantial amount of the production is eaten internally in the country [347]. The height of the fenugreek plant is about 1–2 feet. It has green trifoliate leaves. The flower color changes from white to yellow. The plant retains narrow pods. The length of the pods is about 15 cm, and they possess an average of 10–20 seeds [589]
Asafoetida (Ferula assafoetida)
Ferula assafoetida belongs to the family Apiaceae It is one of the more valuable plants among the 30 species of Ferula. It is distributed in Iran. It is an herbaceous, and perennial plant. It has been found in Iranian folk medicine as a carminative, antispasmodic, aromatic, digestive, expectorant, laxative, sedative, nerving, analgesic, anthelmintic, antiseptic, and aphrodisiac agent. It is a valuable plant used in veterinary, traditional medicine, and also for non-medicinal purposes. Kerman in Iran is the leading producer of this plant [157, 331]. The rhizome or tap root is used as a spice. It is popular in curing digestive disorders. It is utilized in recent herbalism in preventing bronchitis, hysteria, nervous situations, asthma, whooping cough, infantile pneumonia, reduced blood pressure, and flatulent colic. Since ancient times, in Ayurveda, and the Unani system, it is broadly utilized. Asafoetida is naturally found in a topical zone, particularly in Central Asia, Eastern Iran to Afghanistan. Afghanistan is the highest producer of asafoetida (23,021 thousand tons). At present time, it grows in Afghanistan and Iran from where it is exported to other places. It has been utilized as a cookery agent. It has large carrot-shaped roots, and when they become 4–5 years old the diameter is about 12.5–15 cm [554]
Celery (Apium graveolens)
Apiumgraveolens belongs to the family Apiaceae. The dried and ripe celery seeds are popular as a spice. It has been applied for the treatment of diuretics, spasms, stomach problems, and heart tonic to reduce blood pressure in African traditional medicine [515]. India is the highest producer of celery (30.40 thousand tons) [563]. It is also used to cure joint pain. The center portion of the root of celery is fugitive. The stem is branched, notched, juicy, and hardy. The leaves are winged and ovate. The flower size is small and the color is white to greenish-white. Petals are circular and fruits are schizocarp with two mericarps, suborbicular to ellipsoid in shape and a little bitter in taste [55]. It is mainly famous in countries like Iran, Algeria, the Caucasus, India, and America [479]
Chilli (Capsicum frutescens)
Capsicum frutescens belongs to the family Solanaceae It is a temperate plant. Cayenne pepper/chili is used traditionally in medicine and in the diet as an ingredient in warm sauces [32]. Chilli is utilized in ethnomedicinal treatments of postnatal care to cure erectile problems, nutrition therapy, pain management, as a circulatory medicine, as a tonic for arthritis, and rheumatic pains, lower the blood glucose level, for cholesterol extraction [413]. India is the largest producer of chili (3992 thousand tons) [563]. It is a perennial shrub/household annual plant. It has little vertical, wheat-shaped fruit that is spicy in flavor, and the fruit color changes from green to pale yellow that converts into red color when it ripens. The most commonly wild pepper species is found in the tropical region of China, namely Hainan and Yunnan territory [238]. This plant is a yearly growing plant or short-lived perennial herb. Its stem is striate, glabrous, 1–4 feet long according to growing conditions and weather. The leaves are oval, slightly leathery, the color is dark green, soft, height is 2.5 inches, and 1 inch broad. The flowers are naturally conifer or funnel, having five petals, combined, and white. The fruits are vertical, ellipsoid-conical to lanceoloid, with a length of about 10–20 mm and a diameter of 3–7 mm [50]
Allspice (Pimenta dioica)
Pimenta dioica belongs to the family Myrtaceae It contains an aromatic flavor and tastes similar to a mixture of nutmeg, cinnamon, and cloves; hence, it is called allspice. It is topical to the Caribbean area mainly Cuba and Jamaica. It grows naturally at an average temperature between 180 and 240. The plant is broadly cultivated in temperate areas throughout the world as a decorative plant, because of its catching appearance, and fragrance [745]. It is an evergreen plant. The height of this plant is up to 15 m with pale brown bark. The leaves are normal, opposite, oblong-elliptical, 6–20 cm long, with pellucid glands that provide an all-spice odor when squeezed. The flowers are tiny in size, whitish with a peculiar aroma, each of the flowers contains four petals, and the color of the flower is white and deciduous. The flowers are grown during March–June. The fruits mature in 3–4 months and are picked for spice collection when it is fully matured but still green. The fruits contain two kidney-shaped seeds [859, 860]. Since time immemorial, allspice is popular as a valuable spice due to its medicinal, and culinary properties. Its leaves are utilized to flavor the rice and provide a good aroma. Water extract of the berries is applied to cure diarrhea and flatulence. The powdered fruits are utilized for rheumatism, neuralgia, and aromatic provoking in digestive problems traditionally in India. It is effective in tonics, purgatives, and anodyne against neuralgia. In Turkey, it is utilized as an aphrodisiac when taken along with honey. The oil of the fruits and leaves are used in the food industry, specially in tanning, and meat as well as in cosmetic products, and perfumery compositions [745]
Kokam (Garcinia indica)
Garcinia Indica belongs to the family Clusiaceae It is a little to moderate-sized plant that is used as traditional house medicine for infections, flatulence, and heart attack. Numerous therapeutic activities of the fruit are documented in Ayurveda, like curing infusion, skin disease (rashes caused by allergies), scalds, chaffed skin, relief from sunstroke, treatment for dysentery, treatment of burns and mucous diarrhea, as an appetizer, to recover appetite, to reduce thirst, cardiotonic, piles, bleeding, and tumors. Kokam is prepared by sun-drying. The outer part of the fruit is used as a spice to add flavor and color to dishes. Kokam is a tropical evergreen tree. It is a thin plant having drooping dals height of about 15–20 m. It is native to the Western ghats area of India and distributed along North, and South Karnataka, Konkan, Goa, North Malabar, Coorg, West Bengal, Wayanad, and Assam [367, 395]
Greater galangal (Alpinia galangal)
Alpinia galangal belongs to the family Zingiberaceae It is distributed in tropical regions. It is mainly utilized in ethnomedicine and in food preparation. It is native to Indochina and Southeast China, especially Hainan, Guangdong, and Guangxi. It is cultivated throughout Eastern Himalayas, West Bengal, and Assam. It is utilized conventionally in Chinese medicine and Ayurveda. In China, rhizome from this plant has been utilized to treat bracing the circulatory system, stomach aches, colds, and to lower swelling [133]. It is commonly utilized for the treatment of bronchitis, eczema, coryza, gastritis, otitis interna, ulcers, morbilli, pityriasis Versicolor, cholera, to wash the mouth, and emaciation [279]. Indonesia is the leading producing country of galangal (303.53 million kg) [222]. It contains aromatic and tuberous rootstocks. The flowers are 30 cm long, greenish-white, and bracts ovate are lanceolate. Leaves are glabrous, oblong, lanceolate, and green, paler beneath, to some extent callus white margins. The color of the fruits varied from red cherry to orange [904, 965]
Sweet flag (Acorus calamus)
Since ancient times, the sweet flag exhibits various traditional, and ethnomedicinal applications in Siddha, Ayurveda, Unani, and Chinese medicine to treat different types of health problems such as bronchitis, nervous problem, appetite loss, chest pain, colic, cramps, diarrhea, digestive problem, flatulence, gastric problem, indigestion, rheumatism, sedative, cough, fever, inflammation, depression, tumors, hemorrhoids, skin ailment, numbness, and vascular diseases. The rhizome is used as a spice to provide flavor to food and alcoholic beverages [741]. Since ancient times, the sweet flag has been harvested. It is commonly cultivated in Asian countries. It is a very important tree in medical sciences [865]Acorus calamus belongs to the family Acoraceae It is an annual plant having weird and extensively branched, aromatic rhizome, tubular, up to 205 cm thick, the color changes from purplish-brown to lightly brown on the outside and white in the middle portion. The leaves contain one eminent midvein. This plant rarely grows flowers or produces fruits. The flowers are 3–8 cm long, tubular in shape, greenish-brown and are surrounded by a multitude of circular spikes. The fruits are little in size like berries, having some seeds [121]
Nutritional Potential of Spices
Spices help to keep the body healthy and fit [86] (Fig. 2). The spices contain carbohydrates, minerals, proteins, and vitamins. Table 1 and Table 2 portray the nutritional composition of the spices and herbs. Though spices are used in very small quantities in food, the amount of protein, fat, carbohydrate, and energy, which can be acquired from the spices is very negligible; however, the spices are rich source of various essential oils and fatty acids; thus, it is a source of essential nutrients for body development and to maintain immune system
Carbohydrate
Carbohydrates are present in fennel, especially glucose, fructose, and sucrose, and are found in all the parts of fennel. The carbohydrates are composed of sugars that are naturally formed. Sucrose is the most valuable sugar in plants. Few percentages of sucrose could have been hydrolyzed to their monosaccharides to enhance the fructose, and glucose level in fennel that plays a valuable role for the contribution of carbon skeletons for the production of other compounds, and in the energetic metabolism. Mainly carbohydrates play an important role as major structural compounds and as short-term energy storage compounds [130]. Fennel and nutmeg contain an abundant amount of carbohydrates [21, 958]. Onion contains nonstructural carbohydrates (NSC) like sucrose, glucose, fructose, and fructo-oligosaccharides (FOS) such as fructo-furanosylnystose, ketose, and nystose [140]. Bay leaves are rich source of carbohydrates especially sucrose, fructose, and glucose [374]. Carbohydrates like L-arabinose, glucose, galactose, rhamnose, and polysaccharides present in asafetida [969]. Kokam contains carbohydrates, especially xylose, and glucose [1004]. The carbohydrate content of different types of spices is described in Table 1. The highest carbohydrate-rich spice is cassia bark (80.59%), and the minimum amount is observed in chili (3%)
Protein
Protein helps in building up the body tissue, distributes as fuel source. Protein helps in the survival period of humans, and animal. Protein plays an important role in diet for maintaining proper functions of the body [35]. It is observed that cassia bark contains protein and provides good nutritional quality due to the presence of many essential amino acids like glutamic acid, lysine, aspartic acid, leucine, and valine. Naturally, the protein quality is determined by the amino acid profile [47]. The major amino acids present in onion are glutamine acid, and arginine [897]. Fenugreek is rich source of free amino acids such as histidine, and isoleucine that can provoke the secretion of insulin. Fenugreek provides an adequate amount of lysine. The quality of fenugreek lysine is the same as soybean lysine. For this reason, fenugreek is taken as dietary supplement. It is noted that fenugreek seeds contain significant concentrations of leucine, glutamine, asparagine, threonine, and arginine [1023]. Asafoetida contains mainly arabinogalactan protein [444]. Chili and poppy have several amino acids like isoleucine, tryptophan, threonine, leucine, lysine, methionine, cysteine, phenylalanine, tyrosine, valine, arginine, histidine, alanine, aspartic acid, glutamine acid, glycine, proline, and serine [182, 922]. Black mustard is the rich source of protein among the spices covered in this review article (26.08 g/100 g)
Fatty Acids
Nowadays, the importance of essential fatty acids like alpha-linolenic acid, and linoleic acid, and their metabolites in animal, and human health is a vital topic in science [828]. Fatty acids help in the metabolic mechanism of living organisms. It is a source of several bioactive particles, energy, and structural elements [357]. Dietary fatty acids especially monounsaturated, and polyunsaturated fatty acids constituent the plasma lipoprotein profile and decrease the chances of heart problems [898]. Fatty acids can be divided into (1) saturated (2) monounsaturated (3) polyunsaturated. Cardamom contains fatty acids like saturated (myristic acid, palmitic acid, stearic acid, arachidic acid), mono-unsaturated (palmitoleic acid, oleic acid), polyunsaturated (linoleic acid, alpha-linolenic acid, eicosenoic acid) [89]. It is evidenced that palmitic acid is the major fatty acid present in the oil of cassia bark [47]. Fennel fixed oil contains some major fatty acids like palmitic acids, oleic acid, and linoleic acid [762]. The major fatty acid in poppy is linoleic acid covering 70.7–75.2% of the total fatty acid content [542]. During the ripening of coriander fruit, the amount of monounsaturated fatty acid has been increased, while the amount of polyunsaturated and saturated fatty acids is decreased. Coriander contains various fatty acids, namely myristic acid, stearic acid, palmitic acid, behenic acid, arachidic acid, petroselinic acid, oleic acid, linoleic acid, and linolenic acid [653]. Palmitic acid, lauric acid, myristic acid, myristoleic acid, stearic acid, oleic acid, palmitoleic acid, and linoleic acid are obtained from nutmeg [1016]. The fatty acids like stearic, palmitic, heptadecanoic, linoleic, oleic, linolenic, eicosenoic, arachidic, behanic, heneicosanoic, erucic, lignoceric, docosadienoic, and nervonic are present in Brassica nigra [435, 436]. Saturated fatty acids exist in an abundant amount in saffron [209]. Chinese star anise contains more palmitic, oleic, and linoleic acid [426]. The predominant fatty acid in Allium cepa is linoleic acid followed by oleic and palmitic acid [332]. Dill seed oil contains about 8.51% of saturated fatty acids (stearic acid, and palmitic acid) and about 91.35% of an unsaturated fatty acids [873]. Egyptian fenugreek oil contains 13.8% linolenic acid, 33.7% linoleic, and 35.1% oleic acid [898]
Minerals
Minerals are known as micronutrients that play an important role in the body's immunity system and metabolism. Spices are considered as good sources of minerals. The insufficiency of mineral content in human body is attributed due to 1) improper absorbance and 2) inadequate intake. Enzymes required several minerals as the co-factor for proper activity and function. These enzymes got deactivated due to the absence of minerals [979]. Minerals are important for the antioxidant activity. Inadequate consumption of mineral-enriched food products is observed among a vast number of economically backward people. Mustafa [631] studied that calcium (Ca), phosphorus (P), potassium (k), sodium (Na), and magnesium (Mg) are present in spices. The spices, Elattaria cardamomum, and Curcuma longa contain ample amounts of important trace elements like manganese (Mn), iron (Fe), and zinc (Zn). Derivative of minerals in spices helps in various activities of the body’s growth like Fe assists in cellular growth, oxygen transport, and oxidative metabolism. Similarly, calcium and copper are critical to maintain various physiological activities. Zn plays a valuable role in replication and cellular immune response. Consumption of spices can add minerals into the diet and contributes a nutritious effect. But excess level of minerals consumption can cause toxicity. It is observed that Ca, Na, K, and Mg were comprehensively higher in all the spices. Ca content is higher in laurus leaves and black seed. Copper is relatively very less in all spices [631]. K, Ca, Mg, P, sulfur (S), and iron (Fe) are present in Foeniculum vulgare and cardamom. Particularly, cardamom leaves and capsules possess significant levels of Mn and Zn [89, 749]. Poppy contains minerals like K, P, Ca, Mg, Na, and Fe [630]. Clove is one of the spices that is one of the highest rich sources of manganese and is important for enhancement of bone strength and metabolism and contributes in the development of enzymes. The occurrence of the strong appearance of the clove is due to the presence of K, Mg, and Ca [151]Cinnamomum cassia possesses an ample amount of Ca [47]. The electrolytes like K, and Na and minerals such as Fe, Ca, Cu, Mg, Mn, P, Zn are present in Myristica fragrans [21]. Mg, P, Ca, and K are present in adequate amount in turmeric [710]. The seeds of star anise are source of minerals like Cu, Ca, Fe, K, Mn, Mg, and Zn [831]. Calcium is present in a higher amount in the brown skin of the onion and the whole onion contains an ample amount of Zn, Mg, Fe, and Mn [140]. Dill contains micronutrients like Fe, Zn, Cu, and Mn and four macronutrients Mg, K, Ca, and P but Fe, Ca, and P [782]. Fenugreek seed and asafoetida are good sources of Fe and Ca [679, 710]. P, Zn, Mg, Mn, Ca, Se, Cu, Na, Pt, Fe, and K are some important minerals present in celery [822]. Chili contains minerals like K, Ca, Fe, P, Na, Mg, Cu, and Zn that play a valuable role in human health development [669]. kokum contains minerals like Ca, Mn, Mg, and K that protect against heart disease, control blood pressure, and heart rate [109]
Vitamins
Vitamins like vitamin A, C, riboflavin, thiamine, niacin, and pyridoxine (B6) are present at higher amounts in cardamom [281]. The coriander green leaves possess important vitamins like vitamin C, riboflavin, niacin, and vitamin A [634]. The valuable vitamins like niacin (B3), thiamin (B1), riboflavin (B2), pantothenic acid (B5), pyridoxine (B6), folic acid (B9), and vitamins E and C are present in poppy [673]. Cassia bark has important vitamins like vitamin C, and A [329]. Fennel is rich source of vitamins like B2, C, B1, B3, B6, folate, and vitamins A, E, and K [130]. Vitamins E, A, and C are the main vitamins of nutmeg [21]. Clove is one of the rich sources of vitamin K, and C [151]. Vitamins like B2, vitamin C, K, and B6 are present in abundant amounts in black pepper [853]. Turmeric is an exuberant source of vitamin C, and pyridoxine [710]. One of the main constituents of saffron is vitamins especially B1, and B2 [321]. Many essential B-complex vitamins like riboflavin, pyridoxine, niacin, thiamin, and vitamins C and A are present in adequate amounts in anise seeds [830]. Onion provides high amounts of folic acid, and vitamin B6 [897]. Dill contains mainly vitamin E, and A [782]. Fenugreek seeds contain adequate amount of vitamin C, A, B1, and nicotinic acid [1023]. Vitamin C is mainly present in celery [443]. Chili is one of the great source of vitamin C that is a potent antioxidant that develops natural immunity against diseases. Chili also contains vitamin A which is a fat-soluble vitamin that assists to reduce the health hazards caused by free radicals and assists in the formation of red blood cells and other B-complex vitamins B6, K, B3, B2, and B1 [182]. It is noted that kokam leaves are rich source of ascorbic acid and B-complex vitamins that assist to maintain blood pressure and heart rate [395]. Vitamins C and A are found in adequate amount in greater galangal [122]
Fiber
Fiber is a very important nutrient in maintaining the human health and has been found to decrease the level of cholesterol, decrease the chances of different types of cancers and bowel disorders, maintain carbohydrates and lipid metabolism, cure gut function, and assist in constipation problem and well-being of individual [35]. Fibers are composed of a group of compounds such as non-starch polysaccharides (pectin, cellulose, hemicelluloses, and mucilage), polyphenol propane, and lignin. The fibers are present in most of the plants and cannot be hydrolyzed within the human body [310]. Cassia bark contains a high amount of crude fiber [47]. Fennel, nutmeg, and clove are rich sources of dietary fiber [21, 130, 151]. It has been observed that total dietary fiber is high in brown skin of onion [140]. Black pepper, turmeric, onion, and kokam are good sources of dietary fiber [710, 756, 853, 897]. The maximum fiber content is seen in cassia bark (53.1%), and the lowest amount is reported in chili (1.4%)
Bioactive Potential of Selected Spices and Herbs
Nowadays, it has become important to search for natural bioactive components to replace synthetic compounds. The bioactive compounds from natural sources have several advantages over the synthetic drug molecules and have several side effects [809, 810]. Spices are a very necessary resource due to the presence of an ample amount of bioactive components (Table 3), for the searching of a new substitute, and bioactive molecules in drug formation studies for different types of diseases [803]. Spices possess various phytochemicals that contain antioxidative activity and lead to a decrease in inflammation, modulation of detoxification of enzymes, manifestation of the immune system, antibacterial, and antiviral activities [513]. Spices contain various active components like phenolic acids, phthalides, polyacetylenes, flavonoids, coumarins, and terpenes and are recommended to be potent antioxidants [86]
Elettaria cardamomum (Cardamom)
The main constituent present in cardamom is 1,8-cineole, which is responsible for its characteristic aroma. The potential antimicrobial effect is observed in cardamom essential oil (CEO) against gram-negative and gram-positive microorganisms [656]. The volatile oil is the most important component of cardamom, has its characteristic aroma. The oil contains small mono- or sesquiterpene hydrocarbons. It is mainly formed by oxygenated compounds,all of these are potential aroma compounds. The aroma variations in different sources of cardamom are due to the alteration of proportion of the 1,8-cineole and esters. The minor compounds like alcohols, methyl eugenol, and terpene hydrocarbon are present in cardamom. The characteristic aroma of cardamom is formed by the combined effects of major components like 1,8-cineole and alpha-terpinyl acetate. These compounds are found to be carminative, antiseptic, anti-inflammatory, and stimulating [481]. The cancer can be treated by various methods like chemotherapy, radiation therapy, palliative care, surgery, targeted cancer therapy, etc. However, these methods exhibited toxic side effects on the patient’s normal cell, and overall health condition. For this reason, spices have been used as an alternative way to treat the breast cancer, with bioactive components like anthocyanin, alkaloids, flavonoids, terpenes, and phenylpropanoids which can retard biological activities occurred with breast cancer cell growth. In traditional Ayurveda, cardamom is used in human diet to prevent the growth of cancerous cell. Cardamom is a profoundly used spice and shows anti-carcinogenic potential due to the presence of DCM (diindolylmethane) and IC3 (indole-3-carbinol) that can destroy breast cancer cells and retard prioliferation. These compounds also give additional anticancer benefits by developing host immune response. For this reason, it is suggested that cardamom should be intake regular basis. Phytochemicals like limenonene and cineole present in cardamom act as chemoprotective [977]
Bunium persicum (Black jeera)
The various extracts of seeds, and essential oil of Bunium persicum has been analized for antioxidant activity by three methods, namely ammonium thiocyanate, DPPH assay, and beta-carotene bleaching. It is observed that the highest antioxidant activity is found in methanolic extract of oil. The major components of Bunium persicum oil are gamma-terpinene and cuminaldehyde as evaluated by the GC/MS method. With the help of column chromatography, the methanol extract of the plant has been fractioned. In this fraction, p-coumaric acid, kaempferol, and caffeic acid have been observed in the antioxidant activity. It is confirmed that cardamom oil and methanolic extract showed radical scavenging and antioxidant activityBunium persicum is hydrodistillized to form the pale yellow-colored essential oil which contains about 24 compounds that comprise 97.20% of the oil. The oil is made of oxygenated monoterpenes, and hydrocarbons like alpha-thujene, sabinene, alpha-pinene, myrcene, beta-pinene, alpha-terpinene, p-cymene, alpha-terpinolene, p-Menthe-3-ene-7-al, cuminyl alcohol, beta-caryophyllene, gamma-eleman, beta-bisabolene, beta-selinene, myristicin, germacrene B, and dillapiol. Other main components of the oil are limonene, cuminaldehyde, and p-cymene [839]. It has been observed that various phytochemicals like terpenes (sesquiterpene, monoterpene, oxygenated monoterpenes, oxygenated sesquiterpenes), aliphatic compounds, steroids, terpenoids, campesterol, esters, stigmasterol, fatty acids, alkaloids, resins, tannins, thymoquinone, phenolics, saponins, and flavonoids are obtained in Bunium persicum. Some components such as gamma-terpinene-7-al, and beta-sinensal are found in black jeera. The pleasant aroma of the oil is mainly contributed by cumaldehyde. The oil is used to produce perfumes, and other cosmetics. The reduction in the quality of the spice is due to the presence of beta-pinene, gamma-terpinene, and p-cymeneBunium persicum showed potential antifungal effects due to the existence of p-cymene and cuminaldehyde [126]
Foeniculum vulgare (Fennel)
In the methanolic extract of fennel seed, 56 bioactive phytochemical compounds were determined. The phytochemicals detected depend on the molecular formula, peak location, retention time, molecular weight, MS-fragments, and pharmacological actions. Alcohols, alkanes, ethers, carboxylic acids, esters, nitro compounds, alkenes, hydrogen-bonded alcohols, aliphatic fluoro compounds, and phenols are identified in fennel seeds through Fourier Transform Infrared Spectroscopy (FTIR). Fennel contains ample amounts of phytochemical compounds like cyclohexene, 4-isopropenyl-1-methoxymethoxymethyl, O-alpha-D-glucopyranosyl-(1- > 3)-beta-D-fructo, L-fenchone, estragole, 2-propyl-tetrahydropyran-3-ol, benzaldehyde, 4-methoxy, anethole, 2-methoxy-4-vinylphenol, ascaridole epoxide, d-mannose, pterin-6-carboxylic acid, 4-methoxybenzoic acid, allyl ester, arisaldehyde dimethyl acetal, 1-propyl-3, 6-diazahomoadamantan-9-ol, 4-(2,5-dihydro-3-methoxyphenyl) butylamine, corymbolone, apiol, fenretinide, dihydroxanthin, 1-(4-methoxyphenyl)-1, 5-pentanediol, 1-heptatriacotanol, gibberellic acid, 2, 3-dimethoxy-5-methyl-6-decaisoprenyl-chinon, 2-[4-methyl-6-(2,6,6-trimethylcyclohex-1-enyl) hexa-1,3,5-trienyl] cyclo, cis-vaccenic acid, 6,9,12,15-docosatetraenoic acid, methyl ester, dl-3beta-hydroxyl-d-homo-18-nor-5 alpha, 8 alpha, 14 beta-androst-13 (1), 5 Ah-3a, 12-methano-1H-cyclopropa [ 5’, 6’] cyclodeca [1’, 2’: 1, 5] cyclo, (22S)-21-acetoxy-6alpha, 11beta-dihydroxy-16alpha, 17alpha-propylmethylenedioxyp, oxiraneoctanoic acid, 3-octyl-, methyl ester, ingol 12-acetate, alpha-D-glucopyranoside, and 2,24a,6a,8a,9,12b,14a-octamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,1 as identified by chromatogram GC–MS method [381]. Essential oil is present in ample amount in fennel seeds that provides the characteristic flavor. Seeds contain several lipophilic and hydrophilic compounds like carotenoids, phenols, chlorophylls, unsaturated fatty acids, and phytosterols. These compounds act as potential antioxidant agent and prevent various types of diseases [760]. The major phytoconstituents of fennel seeds are volatile aroma compounds, phenols, and phenolic glycosides like trans-anethole (81.63% and 87.85%), fenchone, and estragole. It is reported that the major acaricidal agents are fenchone and p-anisaldehyde that have proven effectiveness against dermatoghagoides pteronyssinus, and dermatophagoides farinae. In another investigation, anethole and its polymer like photo anethole, and dianethole are proved to be active oestrogenic agents. It is proved that anethole acts as protective antithrombotic agent due to its vasorelaxant action, antiplatelet activity, and clot destabilizing effect. However, estragole may cause anxiety as the structure of estragole is similar to methyleugenol. Estragole has carcinogenic property. The maximum limit of estragole in non-alcoholic beverage is 10 mg/ kg. Phenolic acids like 5-O-caffeoylquinic acid, 3-O-caffeoylquinic acid, 4-O-caffeoylquinic acid, 1,3-O-di-caffeoylquinic acid, and 1,4-O-di-caffeoylquinic acid, and the flavonoids such as rosmarinic acid, eriodictyol-7-rutinoside, and quercetin-3-rutinoside are found in fennel. Phenolic compounds are considered to be a preventive measure against various diseases like inflammation, cardiovascular disease, and cancer [749]
Papaver somniferum (Poppy)
The main active secondary compound of poppy seed is benzylisoquinoline alkaloids (BIAs). Several bioactive compounds like phenolic compounds, alkaloids, flavonoids, and polyunsaturated fatty acids are present in poppy seed. It has been utilized as food ingredients. Poppy seed oil is a rich source of polyunsaturated fatty acids. Poppy possesses lactic acid, meconic acid, and alkaloids like morphine, codeine, noscapine, thebaine, papaverine, aporphines, protoberberine, rhoeadines, benzophenanthridine, and tetrahydroisoquinolines. Poppy seed oil contains tocopherol, and unsaturated fatty acids. At present, poppy seed oil is utilized in infant formulas due to the absence of narcotic properties. Due to the presence of important phytochemicals like tocopherol, the seed oil is used as a nutraceutical supplements in different types of food products. Linoleic acid (68%) is the major fatty acid found in poppy seed oil. Poppy seed oil contains unsaturated fatty acids like linolenic acid, oleic acid, linoleic acid, and palmitoleic acid, and the principal saturated fatty acids such as arachidic acid, stearic acid, and palmitic acid. The poppy seed oil is used for food processing due to the presence of a high amounts of linoleic acid. Poppy possesses neutral elements like melanoidin, opionin, and meconin. Poppy contains organic acids such as meconic, lactic, caffeic, and ferulic acids. Tocotrienols and tocopherols have made the poppy seeds valuable for preventing various diseases like cancer, autoimmune, cardiovascular, metabolic, bone, and neurological disorders. Due to the presence of excessive amounts of tocotrienols and α-tocotrienols in the plasma membrane, the poppy seed oil possessed antioxidant activity and it has the potential to retard the lipid oxidation [621]. Various secondary metabolites such as saponins, tannins, cardiac glycosides, phytosterols, and terpenoids are present in poppy seed. Volatile compounds like 9-octadecanoic acid, methylester, (E, E),9-tetradecen-1-ol, acetate, (E),9,12-octadecadienoic acid, cis-9,10-epoxyoctadecan-1-ol, and undec-10-ynoic acid as determined by GC–MS. Different types of functional compounds like carboxylic acid, alcohols, phenols, aldehydes, anhydrides, amides, esters, ketones, unsaturated aliphatics, unsaturated heterocycles, aromatics, amines, nitro compound, alkanes, and alkenes are determined by FT-IR in poppy seed. It is utilized potentially in various ways in the field of pharmacy and food technology to prevent various human diseases [632]
Syzygium aromaticum (Clove)
Phenolic compounds like hydroxycinnamic acids, flavonoids, hydroxybenzoic acids, and hydroxyphenyl propens are present in abundant amounts in clove flowers. Eugenol is the main bioactive compound of clove ranging from 9381.70 to 14,650 mg/100 g of fresh plant material. Clove contains gallic acid, phenolic acid, and other gallic acid derivatives as hydrolysable tannins at a higher level. Clove possesses phenolic acids like elagic, ferulic, caffeic, and salicylic acid and the flavonoids such as quercetin, kaempferol, and its glycosylated moiety. Eugenol is contributed 89% of the clove essential oil. Eugenol acetate and β-cariofileno contributed 5%-15% of the clove essential oil. The other valuable compound is obtained in the essential oil of clove is α-humulene at a level up to 2.1%. Clove has some volatile compounds in its essential oil like farnesol, limonene, benzaldehyde, 2-heptanone, β-pinene, and ethyl hexanoate in lower concentrations. This plant is utilized for centuries as a medicinal plant and food preservative especially as an antioxidant agent and also showed antimicrobial effects [607]. The phytochemicals like hydrocarbon, monoterpenes, and sesquiterpenes are found in ample amounts in clove. Various studies demonstrated that eugenol showed anticancer, antioxidant, antiseptic, antidepressant, antispasmodic, anti-inflammatory, antiviral, antifungal, analgesic, and antibacterial effects against various pathogenic bacteria like S. aureus and methicillin-resistant Staphylococcus epidermidis It has protective activity against CCl4-induced hepatotoxicity and it provides powerful lethal effectiveness against the propagation of several parasites such as Haemonchus contortus, Giardia lamblia, Fasciola gigantica, and Schistosoma mansoni. Eugenol is broadly applied in dentistry due to its penetrating power into dental pulp tissue. Sesquiterpenes have been found to possess anti-carcinogenic activity. It is reported that eugenol is able to donate the hydrogen atom and subsequently neutralized the phenoxyl radical that results in the occurrence of steady molecules which do not develop or enhance the rate of oxidation. Eugenol possessed carbon chain link combined with the aromatic ring that can be engaged in phenoxil radical stabilization with the help of resonance. Calamenene, calacorene, and humulenol are identified in clove by gas chromatography–mass spectroscopy (GC–MS). Biflorin, 5,7-dihydroxy-2-methylchromone-8-C-β-D-glucopyranoside, orsellinic acid glucoside, myricetin, rhamnocitrin, and oleanolic acid are found in clove and showed their efficacy in retarding oral pathogens [134]. The gas chromatography evaluation of hexane extract of clove determined the presence of compounds like chavibetol, 2,6,6,9-tetramethyl-1,4,8-cycloundecatriene, and copaene [113]
Cinnamomum cassia (Cassia bark)
The main active component of cassia bark is essential oil like cinnamaldehyde (0.003 mg/ mL). Essential oil consists of cinnamic acid, coumarin, cinnamyl alcohol, and 2-methoxycinnamaldehyde. Essential oil showed anti-platelet aggregation, antioxidant, anti-diabetic, and antifungal activities [1017]. Terpenes are found in cassia bark oil in abundant quantity. Four chemical classes are obtained in the crude extract of cassia bark like oxygenated sesquiterpenes, oxygenated monoterpenes, sesquiterpene hydrocarbon, and other oxygenated compounds. Trans-cinnamaldehyde is predominantly present in the extracted cinnamon oil. The other compounds are guaiacol, benzenepropanal, cis-cinnamaldehyde, bornyl acetate, acetophenone, geranyl acetate, tetradecanal. Oxygenated monoterpenes are eucalyptol, linalool, borneol, L-α-terpineol, benzaldehyde, anethole, and eugenol. The sesquiterpene hydrocarbons are α-cubebene, copaene, β-caryophyllene, α-muurolene, trans-α-bergamotene, α-humulene, α-amorphene, 1 s-cis-calamenene, calarene, cedrene, and β-cadinene. Oxygenated sesquiterpenes consist of caryophyllene oxide, and tau.-muurolol [410]. Glycosides, terpenoids, and phenylpropanoids are other main compounds in cassia bark. Cinnzeylanol, anhydrocinnzeylanol, 2,3-dehydroanhydrocinnzeylanine, 1-acetylcinncassiol A, 16-O-β-D-glucopyranosyl-19-deoxycinncassiol G, perseanol, and D1 glucoside are the diterpenoids isolated from cassia bark. Cinnacasside B, cinnacassoside D, cinnacasolide E, and samwiside are glycosides isolated from cassia bark. Other chemical compounds are present in cassia bark like benzyl benzoate, 2-hydroxybenzaldehyde, 3-phenylpropanol, 2,2,4,6,6-pentamethylheptane, 2,5,9-trimethyldecane, 2-ethyl-5propylphenol, 3,4-dimethoxyphenethyl alcohol, 2,5-dimethylundecane, benzaldehyde, phenylethyl alcohol, benzenepropanal, acetophenone, 1,3-dimethylbenzene, styrene, 2,2,4-trimethyl-1,3-pentanediol, decanal, 2,6,10-trimethyldodecane, rosavin, coumarin, dihydromelilotoside, evofolin B, and cinncassin C [1012]
Piper nigrum (Black pepper)
The most abundant chemical alkaloid present in black pepper is piperine. Other alkaloids are piperanine, piperylin A, piperettine, pipericine, and piperolein B. Black pepper possesses an abundant amount of polyphenols as compared to white pepper. It is recorded that alkaloids, some aromatic compounds, flavonoids, amides, and lignans are found in black pepper. Some volatile oils like γ-cadinol, γ-guanine, and (E)-β-ocimene were determined by high-resolution gas chromatography, column chromatography, and gas chromatography-mass spectrometry (GC–MS) in black pepper [5]. Piperine enhances the bioavailability of many medicines, and nutrients by retarding several metabolizing enzymes. Piperine shows various pharmacological activities like antioxidant, antihypertensive, antiplatelet, antitumor, anti-asthmatic, analgesic, anti-inflammatory, anti-diarrheal, antidepressants, antispasmodic, immunomodulatory, anti-thyroids, anticonvulsant, antibacterial, antifungal, hepato-protective, larvicidal, and insecticidal activities. Piperine is found to increase fertility, cognitive action, provoke the intestinal activity, and improve the pancreatic enzymatic activity that help to fight indigestion. Most of the researchers identified various compounds in black pepper-like phenolics, steroids, neolignans, terpenes, and chalcones. Some of the compounds are brachyamide B, dihydro-pipericide, N-trans-feruloyltyramine, N-formylpiperidine, guineensine, pentadienoyl as piperidine, isobutyl-eicosatrienamide, piperamide, sarmentine, sarmentosine, and retrofractamide. Four isomers have been isolated from piperine like chavicine, piperine, isopiperine, and isochavicine [220]. Phytochemical compounds of black pepper fruit are 3-carene, propanedioic acid, dimethyl ester, cyclohexene, 1,6-octadien-3-ol,3,7-dimethyl, 2-methyl-1-ethylpyrrolidine, 2-isopropenyl-5-methylhex-4-enal, L-α-terpineol, pyrrolizin-1,7-dione-6-carboxylic acid, methyl ester, 7-epi-cis-sesquisabinene hydrate, phenol, eugenol, α.copaene, naphthalene, epiglobulol, caryophyllene,1,4,7-cycloundecatriene, 1,5,9,9-tetramethyl-,Z,Z,Z,α-ylangene, cedran-diol, 8S,13,isocalamendiol, cinnami acid, desacetylanquidine, trans-1,2-diaminocyclohexane-N,N,N,N-tetraacetic acid, phytol, eicosanoic acid, 2,5,5,8a-tetramethyl-6,7,8,8a-tetrahydro-5H-chromen-8-ol, Z-5-methyl-6-heneicosen-11-one, 2H-1,2-benzoxazine-3-carbonitrile, fenretinide, 11-dehydrocorticosterone, ursodeoxycholic acid, 5α-cholan-24-oic acid, and stigmasterol as determined by GC/ MS [607]
Coriandrum sativum (Coriander)
Coriander seed contains geranyl acetate, linalool, and camphor as phytochemical compounds. Coriander seed possesses phenols and flavonoids. Essential oils from coriander seeds contain camphene, β-pinene, β-myrcene, and 4-carene. Monoterpene hydrocarbons like limonene, γ-terpinene, and p-cymene are the second principal chemical group found in the essential oil, the other chemical classes include the sesquiterpenes compounds [2]. Linalool is present at high concentrations in the essential oil of coriander seed. The other essential oils are triglyceride oil and petroselinic acid. The compositional evaluation of coriander seed revealed the presence of alcohols (linalool, geraniol, α-terpineol, terpinene-4-ol), hydrocarbons, ketones (camphor), and esters (linalyl acetate). Linalool provides a pleasant, and floral-like odor [570]. In an investigation, the HPLC analysis revealed the existence of hesperidin, apigenin, luteolin, hyperoside, diosmin, vicenin, orientine, dihydroquercetin, chrysoeriol, catechin, salicylic acid, ferulic acid, dicoumarin, gallic acid, esculetin, 4-hydroxycoumarin, esculin, maleic acid, tartaric acid, and arbutin in coriander [634]
Myristica fragrans (Nutmeg)
Nutmeg seeds contain malabaricone C, dehydrodiisoeugenol, and malabaricone B. Malabaricone C is the active component present in high amount in nutmeg seed which showed higher antioxidant activity than the other two compounds. Polyphenols are isolated at higher amount in the methanol extract of nutmeg [525]. Secondary metabolites like steroids, saponins, alkaloids, flavonoids, phenols, tannins, phlobatannins, anthraquinones, coumarins, cardiac glycosides, anthocyanin, emodins, chalcones, and triterpenoids are identified by qualitative evaluation of the nutmeg seed extracts. Nutmeg seed contains resin, quinines, thiols, terpenoids, gum, and mucilages [933]. Nutmeg seed contains major components like terpene hydrocarbons (camphene, sabinene, pinene, phellandrene, p-cymene, terpinene, myrcene, and limonene,all together they constitute approximately 60%-80% of the oil. Oxygenated terpenes (terpineol, linalool, and geraniol contribute at least 5%-15% of the oil. Aromatic ethers like safrole, myristicin, elemicin, eugenol derivatives, and eugenol contribute about 15–20% of the total composition. Lignans have been found in nutmeg seed and showed antimicrobial effects against Shigella dysenteriae, Bacillas subtilis, and Staphylococcus aureus [585]
Brassica nigra (Black mustard)
Black mustard contains some bioactive compounds like indoles, isothiocyanates, thiocyanates, and oxazolidine-2-thiones [663]. Various phytochemical compounds are found in Brassica plants like phenolic acid, phenolics, polyphenols, carotenoids (β-carotene, zeaxanthin, and lutein), tannins, saponins, anthocyanins, phytosteroids, aromatic, and aliphatic amines, flavonoids, phytosterols chlorophyll, alkaloids, glucosinolates, glycosides, and terpenoids. Black mustard seed contains phenolics (catechin, epicatechin, myricetin, quercetin, gallic acid, and rutin), phlobatannins, tocopherols, glutathione reducing sugar, and volatile oil and possessed antiradical and antioxidant potential [643]. The major glucosinolate present in black mustard seed is sinigrin (24.5–61.2 g/kg fresh weight) present in black mustard seed. Sinigrin can be hydrolyzed to allyl-isothiocyanate which provides the characteristics of the pungent odor. The other glucosinolate is sinalbin [529]
Curcuma longa (Turmeric)
The main active component of turmeric is curcumin (10.16 mg/g-16.48 mg/g). Turmeric is an orange-yellow-colored lipophilic polyphenol substance which is derived from the rhizomes of the plant. Curcumin has anticancer, antioxidant, anti-inflammatory, anticoagulant, antifertility, antifungal, antiprotozoal, antiviral, antifibrotic, antivenom, antiulcer, hypotensive, and anticholesteremic activities. It plays a valuable role in the treatment, and prevention of different types of diseases like neurological, cancer, autoimmune, cardiovascular disease, and diabetes [328]. Curcumin possessed antimicrobial activity against Mycobacterium tuberculosis, Staphylococcus aureus, Salmonella paratyphi, and Trichophyton gypseum Curcumin is a compound naturally considered as safe, and effective. Turmeric root possesses curcuminoid, which is comprised of bidemethoxy-curcumin, curcumin, and demethoxycurcumin. Curcumin is a valuable compound of the traditional treatment method known as Jiawei Xiaoyao in China. The compound also prevents metabolic disease, lung disease, and liver disease. Curcumin is applied to decrease postoperative inflammation and is safe to consume at a high dose without any toxicity [476]. Some bioactive compounds found in the rhizome of turmeric are α-turmerone, ar-turmerone, and β-turmerone as determined by high-performance liquid chromatography (HPLC) [189]. Turmeric contains volatile compounds like camphor, eucalyptol, and β-pinene which are considered as strong antifungal compounds. Other volatile compounds are present in ample amounts in the essential oil of turmeric like phenyl propionoids, monoterpenes, and sesquiterpenes. Some other volatile compounds are α-pinene, camphene, α-phellandrene, 3-carene, β-cymene, β-elemene, α-santalene, caryophyllene, α-farnesene, zingiberene, β-cedrene, α-bisabolol, and β-sesquiphellandrene as identified by SH-GC–MS in turmeric essential oil [375, 377]
Laurus nobilis (Bay leaves)
Bay leaf contains volatile oils and alkaloids. Current investigation on bay leaves proposed that leaves contain the major sesquiterpene lactone, costunolide, and its α-methylene-γ-butyrolactone moiety [584]. They play an important role in preventing flatulence colic and enhancing the gastric fluid secretion. Bay leaves possess isoquercitrin compound which is responsible for its alkyl radical scavenging activity. Dehydrocostus lactone, zaluzanin D, and (1 R,4S)-1-hydro-peroxy-p-menth-2-en-8-ol acetate are identified from methanol extract of bay leaves that is responsible for the trypanocidal activity. Isoquercetin (flavonoid) is an active principle of bay leaves. In another investigation, bay leaves contain guaianolides eremanthin and germacronolide costunolide [129]. 1,8-cineole is the major component of bay leaves. The other predominant components are α-terpinyl acetate, sabinene, apinene, limonene, linalool, terpinene-4-ol, β-pinene, bornyl acetate, aterpineol, myrcene, α-phellandrene, p-cymene, methyleugenol, germacrene D, α-thujene, β-elemol, camphene, and eugenol [239]. The other sesquiterpene lactones are (1 3b-chlorodehydrocostuslactone, and (2 5a,9-dimethyl-3-methylene-3,3a,4,5,5a,6,7,8-octahydro-1-oxacyclopenta [c] azulene-2-one as identified by chromatographic separation. Various secondary metabolites are isolated from bay leaves like monoterpene, germacrene alcohols, catechin, procyanidin derivatives, laurenobiolide, glycosylated flavonoids, and megastigmane glucosides [217]
Crocus sativus (Saffron)
Safranal, crocins, and picrocrocin constituents present in saffron provide flavor and color to food products and have health-promoting properties. Other phytochemical compounds are phenolic (flavonols and anthocyanins), flavonoids, degraded carotenoid compounds like crocins, and crocetin. Crocin 1 or α-crocin is the major compound of saffron flower. It exhibits antioxidant potential through neutralizing free radicals and by defending cells, and tissues from oxidation [432]. Saffron contains little amount of carotenoids like zeaxanthin, carotenes, lycopene, xanthone-carotenoid glycosidic conjugate, mangicrocin, and picrocrocin. Picrocrocin is colorless glycoside and product of zeaxanthin degeneration. It is the second most abundant constituent which is responsible for the bitter taste of saffron [528]. The odor of saffron occurs due to the presence of safranal which is a product of natural deglycosylation of picrocrocin [548]. Some investigations revealed that saffron flower extract contains an abundant amount of polyphenol components that help to decrease the free radicals activity and contributes in building the defense mechanism to the various organs like lung, kidneys, liver, and heart. It is proved that saffron and its carotenoid pigment, crocin, showed antioxidant and hypolipidemic properties. Some studies showed that crocin has neuroprotective activity [725]. Saffron flower contains other compounds like delphinidin, and kaempferol (flavonoid) that exerted antioxidant activity and these can be used in cosmetics, food products, and phytopharmaceuticals. The red color and yellowish red hues of saffron occurs due to the presence of crocetin esters. Pollen has isorhamnetin glycosides and kaempferide compounds. Malvidin glycoside, delphinidin, kaempferol aglycone, and petunidin are the phenolic compounds found in the perianth. Flavonol, quercetin, and 3-O-β-sophoroside are found in the petals of saffron flower [615]. The aroma rich active compounds of saffron like 4-ketoisophorone, isophorone, phenylethyl alcohol, 2-pentanol, α,β-ionone, isophorone oxide which are evaluated by GC–MS [211]
Illicium verum (Star anise)
Shikimic acid is the precursor molecule present in abundant amount in star anise fruit. It is applied in the preparation of oseltamivir, which acts as an antiviral drug for influenza A and influenza B. The essential oil of anise consists of sesquiterpenes, prenylated C6-C3 compounds, lignans, and flavonoids that provide various medical properties. The characteristics taste of anise is due to the presence of anethole compound. Star anise essential oil contains myrcene, α-pinene, γ-terpineol, α-phellandrene limonene, linalool, estragole, α-cubebene caryophyllene oxide, trans-anethole, and α-humulene that have various biological properties. Tannins, alkaloids, limone, safrol, and farnesol and some small amount of nitrogenous compounds, 14 hydrocarbon compounds, and 22 oxygenated hydrocarbon derivatives such as p-allylanisole, anisyl acetone, anisaldehyde, p-cumin aldehyde, p-allylpen, palmitic acid, linoleic acid, and foeniculin are isolated from the fruit of anise [201]. Other investigations suggested that anise fruit contains β-sitosterol, car-3-ene, cineol, 4 (10)-thujene, and hydroquinone ethyl ether. Sesquicitronellene, copaene, anisketone, methyl-3-methoxy-benzoate, methyl isoeugenol, p-hydroxy benzoic acid, nerolidol, and m-methoxy-a-benzyl benzene acetic acid are identified in anise [748]. Sabinene, 1,8-cineole, anisaldehyde, borneol, 4-methoxypropiophenone, bisabolene, O-nitrobenzoic acid, germacrene D, trans-nerolidol, geranyl isobutyrate, chavicol, and p-cumic aldehyde are some volatile oils which have been identified in star anise. Star anise fruit also contains toluene, octane, and undecane [693]. Trans-anethole is the main active compound present in star anise fruit which provides a characteristics aroma. Researchers observed that anethole shows a peripheral antinociceptive activity, and provides treatment for painful, and inflammatory problems [231]. Antifungal properties are found in anise fruit due to the presence of trans-anethole in the oil. Trans-ocimene, β-clemene, bergamotene, and α-cadinol are the other most valuable compounds found in star anise [831]
Allium cepa (Onion)
Onion contains several secondary metabolites like saponins, flavonoids, and phytosterols. The most active compounds of onion are quercetin, and quercetin 4’-O-β-glucoside which are responsible for the formation of brown, and yellow compounds [579]. Various phytochemicals that present in onion are polysaccharides, organosulfur compounds, and phenolic. Sulfur-containing compounds such as onionin A and cysteine sulfoxides are the major bioactive compounds of onion. Anthocyanins are also found in onion. The compound cysteine sulfoxides consists of methiin, cyclophilin, isoalliin, and propiin [1015]. Quercetin aglycon is also found in onion. Onion contains three types of alkyl cysteine sulfoxides (ACSOs,(1 trans-(+ -S-1-propenyl-L-cysteine sulfoxide (PECSO which is naturally obtained in the higher amount and is responsible for the lachrymatory activity, (2 (+ -S-methyl-L-cysteine sulfoxide (MCSO, and (3 (+ -S-propyl-L-cysteine sulfoxide (PCSO [140]
Anethum graveolens (Dill)
Some phytochemicals like polyphenols, essential oil, and furanocoumarin are present in dill. Dill seeds essential oil contains 1-methoxy-4-(2-propenyl)benzene, D-( +)-carvone, humulene, 6-methyl-2,4-di-t-butyl-phenol, 1-allyl-2,5-dimethoxy-3,4-methylenedioxybenzene(diplaniol), eicosane, heptadecane, docosane, n-heneicosane, n-pentacosane, tricosane, octacosane, dioctyl ester of 1,2-phenyldicarboxylic acid, and n-nonacosane [999]. Dill seeds possess the most valuable bioactive compounds like flavonoids, glycosides, alkaloids, tannins, saponins, steroids, terpenoids, phenols, resins, and iridoid glycosides [45]. The main active components of dill seeds are dill apiol, carvone, limonene, and α-phellandrene. Ethanol extract of dill exhibited phenolic acids like protocatechuic, vanillic, caffeic, ferulic, p-coumaric, syringic, chlorogenic, o-coumaric, rosmarinic, and trans-cinnamic acid. Dill seed essential oil consists of sabinene, α-thujene, α-pinene, p-cymene, myrcene, dill ether, γ-terpinene, trans-carveol, iso-dihydro carveol, and anethole in small amounts. Other compounds of dill seed essential oil are myristicin, trans-dihydrocarvone, E, E-2,6 dimethyl-3,5 octatetraene, linalyl acetate, piperitone, thujyl alcohol, grandisol, 2-carene, o-isopropenyltolune, 1,2-diethoxyethane, diphenol, and bis-1,2 benzene dicarboxylic acid. 3-hydroxy-α-ionol, 8-hydroxygeraniol-D-glucopyranoside, p-menth-2-ene-1,6-diol-D-glucopyranoside, 3-hydroxy-β-ionol 3-O-β-D-glucopyranoside, and quercetin 3-O-β-D-glucuronide [180]
Trigonella foenum-graecum (Fenugreek)
Fenugreek seeds contain tannins and polyphenol. Alkaloids, steroids, and saponins are present in fenugreek seed showed anti-diabetic effects. Some other bioactive compounds like trigonelline, orientin, isoorientin, isovitexin, and vitexin are isolated and quantified by HPLC system. The method UHPLC-ESI–MS/MS identify some compounds like sarsasapogenin, and pinitol [857, 861]. Fenugreek seed also contains flavonoids that provide anti-inflammatory and antinociceptive properties. Polysaccharides and volatile compounds are obtained in an abundant amount in fenugreek seed. Some volatile compounds are dextroamphetamine, 2-methyl pyrrolidine, benzene methanol,a-(chloromethyl), astaxanthin, buffa-20,22-dienolide, 4a-phorbol 12,13-decanoate, psi.,.psi.-carotene, 9,19-cyclolanost-24-en-3-ol,acetate, hydrocortisone acetate, 2-propane-1-amine,N-ethyl, methyl ester, ethyl iso-allocholate, lycoxanthin, betulin, 1,1,2,2-tetrahydro-1,1’-dimethoxy, and rhodopin [838]. The main active compound of fenugreek seed is galactomannan which is a long-chain polysaccharide. Galactomannan occupies a huge portion in the total bioactive composition of the seed extract. 4-hydroxy isoleucine and diosgenin are isolated in fenugreek seed. Fenugreek seed provides its characteristics odor due to the presence of trigonelline [888]. It is applied in the production of imitation maple syrup, rum, artificial flavoring for licorice, vanilla, and butterscotch. The other phytochemicals found in fenugreek seeds are sapogenins, diosgenin, gitogenin, yamogenin, yuccagenin, neogitogenin, sarsasapogenin, tigogenin, smilagenin, and choline. The secondary metabolites are lignins and flavonoids (flavones, flavonones, flavanols, flavonols, proanthocyanidins, isoflavones, and anthocyanins). The most common flavonoids obtained from fenugreek are kaempferol, quercetin, and luteolin. Fenugreek contains phenolic compounds such as chlorogenic, scopoletin, coumarin, caffeic, and p-coumaric acids [519]
Ferula assafoetida (Asafoetida)
Assafoetida is rich source of polysulfides, sesquiterpene, coumarins, phenolic acid, and flavonoids. The main active compound of assafoetida is rosmarinic acid (RA) (phenolic acid) which is isolated by the HPLC. RA shows anti-inflammatory properties by decreasing the manifestation of COX-2 enzymes and their activity. The strong defensive and therapeutic activities of this compound for communicable diseases are recommended because of its antioxidant, and anti-inflammatory effects. The other phenolic acids are apigenin, luteolin, rutin (asafetida), vanillic acid, and ferulic acid which are formed by SBUp1 isolate [685]. Assafoetida root contains various coumarins, and terpenoids that provide anti-HSV activity. The sesquiterpene coumarins are badrakemin acetate, Pellerin, assafoetidnol A, assafoetidnol B, gummosis, polyanthus, neveskone, galbanic acid, 5-hydroxyumbelliprenin, and 8-acetoxyumbelliprenin are identified in the gum resin of assafoetida [3]. Assafoetida possesses polyphenols like flavonoid glycosides, and tannins which have anti-HSV effect [322]. Monoterpenes, and sulfur-containing compounds are volatile compounds found in assafoetida. Three main sulfur compounds are 2-butyl 3-(methylthio)-2-propenyl disulfide, 2-butyl 1-propenyl disulfide, and 1-(methylthio) propyl 1-propenyl disulfide. The other chemical compounds present in asafetida are umbelliprenin, tadshiferin, galbanic acid, conferol, franesiferol A, assafoetidin, ferocaulicin, kamolonol, saradaferin, 10-R-acetoxy-11-hydroxyumbelliprenin, 10-R-karatavicinol, lehmferin, feselol, ligupersin A, epi-conferdione, microlobin, asadisulfide, foetisulfide C, 7-oxocallitristic acid, picealactone C, 15-hydroxy-6-en-dehydroabietic acid, vanillin, taraxacin, and fetidone A [946]
Apium graveolens (Celery)
Celery seed oil contains flavonoids, terpenoids, and lactones. Essential oil is extracted from celery seed by steam distillation. The main active constituent of celery seed is limonene (essential oil). The other oils are a-p-dimethyl styrene, caryophyllene, N-pertyl benzene, a-selinene, sedanenolide, N-butyl phthalide, b-element, sabinene, linalool, trans-1 2-epoxylimonene, isovaleric acid, cis-dihydrocarvone, terpinene-4-ol, trans-dihydrocarvone, trans-p-menth-2,8-diene-1-ol, 1-cis-p-menth-2,8-diene-1-ol, α-terpineol, trans-8-diene 1-ol, carvone, salience, several sesquiterpene, thymol, and perialdehyde. The characteristics flavor of celery is mainly due to the presence of two lactones which are 3-butyl 4,5 dihydrophthalide (sedanolide), and 3-n-butylphthalide [293]. Various phenolics like furanocoumarins, and flavones found in celery. Glycosides, and steroids are present in celery. Celery seeds contain phytochemicals like apiin, caffeic acid, chlorogenic acid, apigenin, ocimene, rutaretin, isopimpinellin, bergapten, seslin, osthenol, umbelliferone, isoimperatorin, and gravebioside A and B. Sedanolide, and sedanonic anhydride found in celery seed oil that is responsible for its aroma. The other chemical constituents of celery are 8-hydroxyl-5-methoxypsoralen, myristic acid, and octadecanoic acid [42]
Capsicum frutescens (Chili)
Chili contains valuable bioactive compounds like steroids, phenolic compound, flavonoids, saponins, coumarins, anthroquinones, proanthocyanidins, carotenoids, polyphenols, terpenoids, and alkaloids. The main active component of chili is capsaicinoids [665]. The capsaicinoid alkaloid is responsible for pungent taste of chili. The major capsaicinoids are dihydrocapsaicin (DHCap), and capsaicin (Cap). The minor capsaicinoids are homodihydrocapsaicin (HDHCap), nordihydrocapsaicin (NDHCap), and homocapsaicin (HCap) [311]
Pimenta dioica (Allspice)
Allspice leaves contain bioactive compounds like gallic acid, ferulic acid, rutin, and chlorogenic acid. Allspice is utilized in traditional medicine and provides characteristic aroma due to the presence of volatile oil. Allspice contains phenolic compounds like quercetin, ericifolin, and eugenol [924]. Some other phytochemical compounds are catechin, methyl gallate, syringic acid, caffeic acid, pyro catechol, ellagic acid, coumaric acid, vanillin, naringenin, cinnamic acid, taxifolin, and kaempferol. Polyphenols are also found in allspice [270]. The main active constituent of allspice leaves is eugenol present in essential oil. The others are β-caryophyllene, linalool, cineole, and α-humulene. Eugenol showed therapeutic activities like anti-inflammatory, analgesic, local anesthetic, and antibacterial effects. Some of the essential oils are α-pinene, β-myrcene, limonene, α-terpineol, chavicol, and germacrene [248]. Volatile compounds of allspice leaves are methyl eugenol, β-guaiene, and naphthalene. The compounds α-phellandrene and β-phellandrene are identified in allspice [923]
Garcinia indica (Kokum)
Kokam is a rich source of anthocyanin pigments like cyaniding-3-sambubioside, and cyaniding-3-glucoside. Hydroxyl citric acid that has been isolated from kokum possess anti-obesity effect. A polyisoprenylated benzophenone derivative garcinol is the main active component present in kokam fruit. It provides chelating, and antioxidant activity. The chemical constituents of kokam fruits are tannin, pectin, and organic acid [644]. Isogarcinol is also found in kokam fruit. Xanthohumol and isoxanthochymol are isolated at higher amounts in kokum. Flavonoids, benzophenones, xanthones, and lactones are identified in kokam fruit. Kokam fruit contains an abundant amount of Cambogia, besides Garcia-2, and garcim-1, which are the main oxidative products of garcinol along with mangosteen, macurin, clusianone, guttiferone (I, J, K, M, N), gambogic acid, and oblongifolin (A, B, C) [485]. Garcinol is a fat-soluble and yellow-colored pigment. It is isolated by hexane and ethanol extraction. Garcinol exhibits antimicrobial effects against Staphylococcus aureus It acts as an antitumor agent by apoptosis through the initiation of caspases and also acts as an anticancer agent. Flavonols, leucoanthocyanidins, and catechins are the bioflavonoids that alter the permeability of capillaries, accelerate the ethanol metabolism and decrease inflammation and edematic reactions [395]
Alpinia galangal (Greater galangal)
Greater galangal contains various phytochemical compounds like 1’S-1’-acetoxy eugenol, α-fenchyl acetate, β-farnesene, α-bergamotene, β-bisabolene, β-sitosterol diglucoside (AG-7), β-pinene, 1’-acetoxychavicol acetate (galangal acetate), β-sitsterylarabinoside (AG-8), 1’S-1’-acetoxychavicol acetate (ACE), and p-hydroxycinnamaldehyde. The essential oils like mono sesquiterpene, as well as (E)-methyl cinnamate, are present in greater galangal root and are responsible for the characteristic odor. These essential oils are used in food products, and medicine. Volatile oils and flavonoids are isolated from galangal. 1’S-1’-acetoxychavicol acetate (ACE) provides a pungent flavor of galangal root. Galangal also possesses p-hydroxybenzaldehyde, and phenylpropanoids. 1,8-cineol is the main active compound of galangal root. Galangal rhizome possesses P-coumaryldiacetate, 4-hydroxybenzaldehyde, trans-coniferyldiacetate, phenylpropanoids, (E)-4-acetoxy cinnamyl ethylether, (E)-4-acetoxy cinnamyl alcohol, (E)-4-hydroxycinnamaldehyde, (S)-1’-ethoxy chavicol acetate, and 4-acetoxy cinnamyl acetate. Some other compounds are diterpene ((E)-8β,17-epoxylabd-12-ene-15,16-dial), curcuminoid (1,7-bis (4-hydroxyphenyl)-1,4,6-heptatrien-3-one), and bisdemethoxycurcumin [203]. Rhizome essential oil consists of camphor and guaiol. Galangal rhizome exerted eleven flavonols (galangin, major flavonols), one flavan 3-ol, dihydroflavonols, and flavanone [203]. The non-methylated flavonols are myricetin, kaempferol, and quercetin,methoxylated flavonols are galangin 3-methyl ether, kaempferide, kumatakenin, isorhamnetin, and quercetin 3-methyl ether; polyglycosylated flavonol called as galangoflavonoside is isolated from galangal rhizome. The dihydroflavonol ((2R,3R-alpinone (sd, pinobanksin 3-acetate, flavan 3-ol (catechin, and flavanone (pinocembrin are also isolated from this spice [944]
Acorus calamus (Sweet flag)
The main active compound of sweet flag rhizome is α-asarone (essential oil) [741]. The essential oil of sweet flag rhizome consists of (E)-methyl isoeugenol, methyl eugenol, α-cedrene, β-asarone, and camphor. Other chemical constituents of essential oil extracted from sweet flag rhizome are α-pinene, camphene, (D)-limonene, 1,8-cineol, linalool, terpinene-4-ol, α-terpineol, bornyl acetate, estragole, α-funebrene, copaene, α-gurjunene, α-bulnesene, β-caryophyllene, germacrene D, cuparene, α-cadinene, β-calacorene, α-cadinol, acorenone, α-bisabolol, acorone, preisocalamenediol, shyobunone, cryptoacorone, (Z)-sesquilavandulol, dehydroxyisocalamendiol, α-selinene, cedrol, berganotene, α-palchoulene, α-guaiadiene, 4-(5-hydroxy-2,6,6-trimethyl-1-cyclohexen-1-yl)-3-buten-2-one, dehydrofukinone, elemicin, monoterpenoids, and sesquiterpenoids [538]. Sweet flag also contains some bioactive compounds like 2-allyl-5-ethoxy-4-methoxyphenol, lysidine, epieudesmin, spathulenol, furylethyl ketone, borneol, nonanoic acid, galgravin, retusin, (9E,12E,15E)-9,12,15-octadecatrien-1-ol, geranyl acetate, butyl butanoate, sakuranin, acetic acid, acetophenone, α-ursolic acid, dehydroabietic acid, methyl ether, and apigenin 4,7-dimethyl ether. Phenylpropanoids, xanthone glycosides, flavones, lignans, and steroids are found in sweet flag, which possesses several pharmacological activities such as antibacterial, insecticidal, larvicidal, mutagenic, cytotoxic, hepatoprotective, anticonvulsant, smooth muscle relaxant, neuroleptic, and smooth muscle stimulant activity. The essential oil also contains trans-β ocimene, aristolene, α-humulene, viridiflorene, kessane, asaronaldehyde, aspidinol, and phytol [684]
Health Benefit Potential
Spices and herbs provide phytochemicals that protect from various diseases, inhibit oxidation, and remove free radicals (the byproducts of biochemical methods). They also provide preventive measures against various neurological diseases, cardiac disorders, other physiological diseases and protect valuable biomolecules from oxidative damage [643] (Fig. 3). Table 3 summarizes the health benefit potential of the important spices and herbs
Elettaria cardamomum (Cardamom)
Anti-inflammatory Effects
Cardamom seed oil has been applied at a dose of 175–280 µl/kg on carrageenan-induced hind paw edema in male albino rats to analyze its anti-inflammatory effects [52]. 30 mg/kg of indomethacin has been taken as standard. 86.4% inhibition has been found with 280 µl/kg of cardamom oil,thus, the cardamom oil has a high potency with respect to the inflammatory activity of indomethacin. 69.2% inhibition has been observed with 175 µl/kg of cardamom oil [494]
Cardiovascular Health
Various bioactive compounds such as flavonoids, alkaloids, saponins, terpenes, and glycosides steroids have been extracted from cadamom, which have cardioprotective effects. It has been observed that at a high dose of 500 mg/kg of cardamom extract is able to reduce the SGPT (serum glutamic pyruvic transaminase) levels, LDH (lactate dehydrogenase) levels, SGOT (serum glutamic-oxaloacetic transaminase) levels, total protein levels, serum albumin levels, cholesterol levels, LDL cholesterol level, VLDL cholesterol level, total chlorides level, alkaline phosphatase levels, and triglycerides, and recover HDL cholesterol level. It has been observed that at a low dose of 100 mg/kg.bw the cardamom extract is able to reduce the triglyceride level in doxorubicin-induced cardiac problem in rats [829]
Gastrointestinal Activity
Cardamom extract (unfiltered methanolic extract (TM), petroleum ether solution (PS), insoluble (PI) methanolic extract, and essential oil (EO)) at a dose of 100–500, 12.5–50, 12.5–150, and 450 mg/kg has been administered to rats to analyze its gastrointestinal protective activity. The extracts of cardamom considered are able to retard the gastric damages induced by aspirin and ethanol significantly though the damage induced by pylorus ligation has not been inhibited successfully. For the EtOH-induced gastric ulcer, TM reduced lesions by 70% at the dose of 500 mg/kg of cardamom oil. At the dose of 50–100 mg/kg of cardamom oil, the PS fraction lowered the problems by 50%; the same effect has been observed for the fraction of PI at a dose of 450 mg/kg. The best gastroprotective activity has been observed in the PS fraction at the dose of 12.5 mg/kg of oil, which retarded lesions by 100% [400]
Anti-diabetic Effect
The role of cardamom has been proved and accepted by accurate scientific analysis to control diabetes. At a dose of 1 mg/mL, aqueous and methanol extracts of cardamom have been analyzed for their in vitro α-amylase and α-glucosidase inhibition activity and antioxidant properties. 10.41% and 13.73% retardation of α-glucosidase have been observed for aqueous and methanol extract of cardamom, respectively. 82.99% and 39.93% retardation for α-amylase have been observed for methanol and aqueous extract of cardamom, respectively [28]
Obesity Management
In an experiment, cardamom has been given at the dose of 3 g/day for 3 months to the non-alcoholic fatty liver patients, suffering from excess level of SIRT1 (sirtuins) [221]. Researchers have suggested that several parameters related to diabetes, and obesity like fat mass and obesity-associated (FTO), leptin receptor (LEPR), carnitine palmitoyltransferase 1A (CPT1A), lamin A/ C, and peroxisome proliferator-activated receptor gamma (PPAR-gamma) can be managed by the administration of green cardamom at a 3 g/day doses for 16 weeks in women suffering from polycystic ovary syndrome [197]. Researchers have observed that obesity can be managed with a dose of 1% of cardamom powder for 8 weeks for high-fat diet-induced obese rats [992]
Antimicrobial Effect
The growth of Salmonella typhi, Staphylococcus aureus, E. coli, Streptococcus mutans, Candida albicans, Bacillus pulmilus, and Listeria monocytogenes have been inhibited by the application of 10 mg/ml of cardamom essential oil (CEO). CEO showed a potential antifungal, and antibacterial effects [89]
Antioxidant Activity
The thiocyanate method has been used by researchers to estimate the antioxidant potential of methanolic extract of green cardamom extract. The percentage retardation of peroxidation is 84.2–90%. With varying solvent concentrations, the antioxidant activity of green cardamom extract various [148]
Central Nervous System Activity
Scholars have investigated the effectiveness of cardamom extract and its main phytoconstituents over Alzheimer's disease (AD). It has been reported that multiple drug targets have been bound with α-terpinyl acetate. Cardamom extract retarded the butyrylcholinesterase (BuChE), acetylcholinesterase (AChE), decreased Aβ-induced neurotoxicity, hydrogen peroxide-induced oxidative stress, and anti-amyloidogenic activity. The cardamom extract has improved the effects of AD and multi-targeted directed ligand (MTDL) capacity [204]
Bunium persicum (Black jeera)
Anti-inflammatory Effects
Hydroalcoholic extract and essential oil derived from Bunium persicum extracts have been tested for anti-inflammatory activity. The extracts of black jeera exhibited significant anti-inflammatory effects. Researchers have studied the anti-inflammatort activity of black jeera extract on Carrageenan-, Formalin-, and Croton oil-induced ear edema for rats [824, 825]
Anti-diabetic Effect and Anti-obesity Effect
The extract of Bunium persicum has been investigated for its anti-diabetic and anti-obesity activities. It has been evidenced that black jeera is able to retard the glycoside hydrolase activity. Hydroalcoholic extract of Bunium persicum is able to reduce the albumin glycation and aggregation because of the presence of higher concentrations of polyphenolic compounds [126]
Antimicrobial Effect
Different types of extracts of Bunium persicum essential oil (BPEO) have been studied for their antimicrobial properties against various strains of bacteria. The test revealed that essential oil possessed higher inhibition effect on gram-positive bacteria than gram-negative bacteria. Phenolic compounds like cuminaldehyde, γ-terpinene, and p-cymene are responsible for antimicrobial activity. The essential oil present in black jeera is responsible for the bacterial decay. Various food-borne pathogens like Escherichia coli, Bacillus cereus, Bacillus subtilis, Klebsiella pneumonia, Listeria monocytogenes, Proteus vulgaris, Pseudomonas aeruginosa, Salmonella enteritidis, and Staphylococcus aureus have been inhibited by BPEO. P-cymene and cuminaldehyde are responsible for the antifungal activities against various phytopathogenic fungi like Candida albicans, Aspergillus spp., Saccharomyces cerevisiae, Penicillium chrysogenum, Alternaria mali, Botrytis cinerea, Colletotrichum lindemuthianum, Fusarium oxysporum, and Verticillium dahlia [126]
Cardiovascular Health
In animal (rats) model, the cardiovascular effect of Bunium persicum extract have been analyzed. Hypercholesterolemic rats have been selected in the experiment, and Bunium persicum extract has been administered to them to measure the effectiveness of black jeera extract in terms of protecting cardiovascular health. Researchers observed that the extract is able to maintain the lipid profile; thus, the cardiorespiratory ability has also been enhanced [824, 825]
Gastrointestinal Activity
A placebo-controlled, randomized, and double-blind study have been indicated the potential of Bunium persicum as an herbal remedy for gastrointestinal problem. Anti-inflammatory, spasmolytic, antioxidant, carminative, and immunomodulatory properties have been reported for caraway [439]. No significant activity of caraway has been found on the symptoms or inflammatory markers like irritable bowel syndrome. Researchers found the neutral effect of caraway on gastrointestinal symptoms [1]
Antioxidant Activity
The essential oil derived from black jeera and methanol and aqueous extract of the same have been analyzed for its antioxidant potential. It has been reported that the methanol extract possess higher antioxidant potential in comparison with the other extracts as evidenced by DPPH assay and inhibitory effect against the lipid peroxidation and betacarotene oxidation [839]
Foeniculum vulgare (Fennel)
Anti-inflammatory Activity
Compared to the indomethacin, fennel essential oil showed significantly lesser anti-inflammatory activity. The fennel oil exhibited the similar activity at the doses of 0.050 and 0.200 mL kg−1 in comparison with etodolac. It has been reported that fennel essential oil possessed anti-inflammatory activity as observed in animal model (rats) [672]
Anti-diabetic Effect
Essential oil is derived from fennel has been administered to diabetic rats. It has been reported that the essential oil is able to reduce the hyperglycemia. The serum glutathione peroxidase can be managed successfully with the fennel essential oil. The detrimental effects on pancreas, and kidney can also be recovered. Therefore, fennel seed can be utilized as a anti-diabetic drug [269]
Anti-obesity Effect
It has been reported that ethanolic extract of fennel seed is able to decrease the body weight of rats by 12%, while the same has been reduced by 6.4% for rats fed with Orlistat enriched diet. The triglyceride level has not been influenced by Orlistat and plant extract. The ethanolic extract of fennel seed has been used as a promising anti-obesity drug as it is able to maintain the lipid profile; simultaneously, it is able to decrease the body weight. Molecular docking study revealed that stigmast-5-en-3-ol ( a bioactive compound found in fennel seed) is able to control the obesity problem [323]
Antimicrobial Effect
Essential oil of fennel seed is more effective in terms of antimicrobial activity in comparison with the alcoholic and hexane extracts of the seed. Essential oil, alcoholic, and diethyl ether extracts exhibited potential inhibition effect against Bacillus cereus, E. coli, Salmonella typhi, and Staphylococcus aureus Lower minimum inhibitory concentration (MIC) value has been found in essential oil extract for the microorganisms, namely Bacillus subtilis, Bacillis cereus, Bacillus megaterium, E. coli, Klebsiella sp., Pseudomonas aeruginosa, Salmonella typhi, Sarcina lutea, Shigella boydii, Shigella dysenteriae, Shigella shiga, Shigella sonnie, and Staphylococcus aureus. The alcoholic, diethyl ether, and hexane extracts showed lower MIC value against Candida albicans, Aspergillus flavus, Bacillus cereus, E. coli, Salmonella typhi, and Staphylococcus aureus Both the methanolic, and ethanolic extracts have showed similar antimicrobial effect. In the same experiment, acetone extract showed lower MIC value compared to aqueous extract. The higher antifungal effect has been reported in acetone and diethyl ether extracts compared to essential oil [44]
Cardiovascular Health
Methanolic, and water extracts of fennel had potential cardiovascular activity. The extract has been reported for its ability to decrease down the level of plasma lipid. The decreased triglyceride level has the ability to cure the fatty liver problem and it also helps to maintain a healthy blood flow in the coronary arteries. The fennel extract has been given intravenously to the rats, which is able to decrease the blood pressure significantly without influencing the heart rate and respiration. This may be due to its anti-atherogenic and hypolipidemic properties. The water extract possessed lower hypotensive activity [110]
Gastrointestinal Effect
Researchers have studied the effectivity of Foeniculum vulgare aqueous extract (FVE) for its effectiveness in prevention of gastrointestinal ulcer. Fennel aqueous extract has been administered at the doses of 75, 150, and 300 mg/kg to rats. It has been reported that the ethanol-induced gastric problem can be cured with the FVE. The research has been provided to evaluate the potential of heated fennel therapy in increasing the recovery of gastrointestinal function [193]. Three hundred and eighty-one patients suffering from gastric tumor, hepatobiliary, and pancreatic have been selected. The patients are partitioned into two groups: 1) group has given heated fennel therapy, while 2) the other group has taken heated rice husk therapy. Researchers have reported that time to first flatus, first defecation, and fasting time are significantly reduced for the group has been treated with heated fennel therapy [593]
Antioxidant Activity
Researchers have investigated the effectiveness of water, and methanolic extracts of ajwain, and fennel seeds for their antioxidant activity, and phenolic potential. Ascorbic acid has been considered as control. At a concentration of 240 µg/ml of methanolic extract of fennel seed possessed 71.67% greater OH-scavenging activity by in comparison with control. It has been reported by the researchers that the FRAP activity of methanol, and aqueous extracts is in the range of 7–48 µm Fe (II)/g. Polyphenolic compounds derived from fennel seed may be responsible for antioxidant capacity [887]
Central Nervous System Activity
Researchers have investigated the neuroprotective activity of fennel seed on lead (Pb)-induced brain neurotoxicity of rat model. The male BALB/c mice of same age group have fed with 75%, 100% ethanol extracts of fennel seed, simultaneously, 0.1% Pb has also been administered at various doses (20 mg/kg/day, and 200 mg/kg/day). The 75% of ethanol extract has been found with most promising effect. Researchers have concluded that neuronal toxicity can be reduced with fennel seed by controlling the oxidative stress [149]
Papaver somniferum (Poppy)
Cardiovascular Health
Poppy seed helps in increasing the oxygen flow in the blood. The seed protects the activity of the heart may be due to the presence of essential micronutrients [599]
Anti-diabetic Effect
Poppy seed is considered as an effective ant-diabetic agent. The seed helps in the treatment of diabetes may be due to the presence of manganese [599]
Antimicrobial Effect
Poppy seed has been tested for its antimicrobial potential against E.coli, and Salmonella It has been reported that the methanol extract of poppy seed successfully inhibits the growth of E.coli and Salmonella species. The aqueous extract inhibits the growth of coliform bacteria [599]
Antioxidant Activity
Researchers have considered poppy seed oil as a potential antioxidant agent. They have fed 35 Wistar rats with poppy seed oil, and sun flower oil have been administered orally at a doses of 250, and 500 mg/kg/day to 35 Wistar rats. The diesel has been dissolved in equal levels of sunflower oil for 21 days, while untreated rats have been introduced as control. The serum nitrite concentrations have been progressively increased for all of the rats included in the experiment. The blood MDA (malondialdehyde) concentrations have also increased. Though it has been reported that the rats were fed with poppy seed oil at a dose of 500 mg/kg/day, the blood MDA level has enhanced slightly for the rats those have fed with poppy seed at a dose of 500 mg/kg/day. The erythrocyte catalase activity and blood glutathione concentrations have been reduced for poppy seed oil-treated rats [41]
Central Nervous System Activity
The opium alkaloids like codeine, morphine, thebaine, and papaverine are present in small amounts in dry poppy seed. The components have a little effect on the human nervous system. In contrary, the chemicals may possess few health benefits. The poppy seed may act as a painkiller for nervous irritability [751]
Syzygium aromaticum (Clove)
Anti-inflammatory Activity
At the doses of 50 mg/kg, 100 mg/kg, and 200 mg/kg, the ethanol extract of clove showed a significant anti-inflammatory activity for formalin-induced edema in rats. The anti-inflammatory activity is exerted may be due to the presence of tannins, and flavonoids, as these compounds are able to retard the phosphodiesterases activity. The activity of the compounds rely on the biosynthesis of protein cytokines. Prostaglandin is one of the key anti-inflammatory substance. Prostaglandins can be retarded by tannins and flavonoids. The anti-inflammatory activity has been demonstrated for different types of non-steroidal anti-inflammatory agents (NSAIDS) [917]
Anti-diabetic Effect
The anti-diabetic effect of essential oil of clove has been evaluated by researchers with the help of an α-amylase enzyme assay. α-amylase is an enzyme in humans that breaks down the starch into simple sugars. Researchers have observed a decrease in carbohydrate digestion and glucose absorption value may be due to the lower enzyme activity. The postprandial rise is reduced in blood glucose. The clove essential oil showed poor anti-diabetic activity than the standard anti-diabetic compound like ascorbase. The presence of insulin-mimetic agents in clove is responsible for anti-diabetic activity [907]
Anti-obesity Effect
Researchers have evaluated the anti-obesity effect of S. aromaticum ethanol extract (SAE) both in vitro and in vivo condition. In vitro study, the effect of SAE treatment on adipocyte differentiation in 3T3-L1 cells has been evaluated for analyzing the anti-obesity activity of SAEIn vivo study, to investigate the anti-obesity activity of SAE, mice are divided into 3 groups: a control group, a group that consumed a high-fat diet (HFD group), and a group that consumed an HFD supplemented with 0.5%(w/w) SAE (HFD + SAE group). All the parameters like serum triglyceride (TG), the body weight, white adipose tissue (WAT), total cholesterol (TC), high-density lipoprotein (HDL) cholesterol, glucose, insulin, leptin, hepatic lipid accumulation, and levels of lipid metabolism-related parameters have been assessed after 9 weeks of feedingIn vitro evaluation of the effect of SAE treatment on 3T3-L1 cells showed that it had potentially retarded the transformation of cells into adipocytes in a dose-dependent manner. SAE supplementation had significantly reduced HFD-induced enhancement in the body weight, liver weight, WAT mass, serum TG, TC, lipid, glucose, insulin, and leptin levels. In HFD-fed mice, fat deposition are retarded by SAE via the suppression of transcription factors integral to lipogenesis, and adipogenesis [414]
Antimicrobial Effect
The alcoholic extract of clove has decreased the bacterial propagation as perceived by the researchers through zone inhibition test. The extract contains quinine, which may responsible for the reduction in bacterial growth [242, 607]
Cardiovascular Health
Clove extract have a membrane-stabilizing effect on the cardiac cell membrane. Clove extract is able to reduce the enzyme salvation. The clove extract possessed free radical scavenging activity, lipid peroxidation, and antioxidant activity may be due to the presence of flavonoids, and other phenolic compounds. Researchers have investigated and showed that clove extract is able to prevent myocardium damage as evidenced by isoproterenol-induced damages in myocardium [721]
Gastrointestinal Effect
Gastric mucus is a protective factor for the gastric mucosa and contains viscous, elastic, adherent, and transparent gel, which has been made by water, and glycoproteins, which enveloped the whole gastrointestinal mucosa [797]. Eugenol, and clove oil have been examined in the rat model with gastric problem. Compared to the control, it has been found that the doses of 100 and 250 mg/kg of clove oil and eugenol have increased the mucus formation. The free radical scavenging activity of the clove extract may be the reason for a decreased mucosal injury. It is concluded that the gastroprotective mechanism of the eugenol and clove essential oil is connected to factors that enhanced the resistance of the mucus barrier and mucus production [798]
Antioxidant Activity
Researchers have investigated the antioxidant potential of clove essential oil with DPPH radical scavenging activity and ferric reducing power. They have found the DPPH radical scavenging activity and the ferric reducing power. With the help of the DPPH method, the samples have been estimated for their radical scavenging capacity, which relied on the scavenging of the stable DPPH [816]
Central Nervous System Activity
Researchers have carried out in vivo investigation to estimate the neuropharmacological effects of the ethanolic extract of clove with the help of behavioral models of mice. The anxiolytic activities of clove extract have been evaluated through plus maze (EPM), open field test (OFT), hole cross test (HCT), and hole-board test (HBT), respectively. The tail suspension test (TST), and forced swimming test (FST) have been conducted to identify the antidepressant effects. The thiopental sodium (TS)-induced sleeping time test have been conducted to analyze the sedative-hypnotic capacity of the extract. Researchers have observed that in the extract-treated group, the behavior of the mice are altered as perceived through HCT, and OFT in comparison with the control group. Thus, it is obvious that the locomotor actions of the mice have been reduced. The potential sedative response of the extract has been ensured by a TS-induced sleeping time test. The sleeping time for control group is 45.4 min, while the same for 500 mg/kg BW extract-treated group is 87 min. It can be concluded that the inlaying effect of any phytoconstituents with γ-aminobutyric acid (GABAA) or benzodiazepine (BZD) receptors is responsible for the neurological response [373]
Cinnamomum cassia (Caasia bark)
Anti-inflammatory Activity
Researchers have investigated the anti-inflammatory activity of cinnamic acid, cinnamic aldehyde, cinnamic alcohol, and coumarin, the compounds derived from cassia bark. The carrageenan (Carr)-induced mouse paw edema and lipopolysaccharide (LPS)-stimulated mouse macrophage models have been considered to analyze the anti-inflammatory activity. The nitric oxide (NO) generation and tumor necrosis factor have been retarded in cinnamic aldehyde-treated mouse. The Carr-induced paw edema of mouse has been reduced by cinnamic aldehyde. The glutathione peroxidase, catalase, and superoxide dismutase activities are enhanced in the paw tissue with cinnamic aldehyde. It is reported that cinnamic aldehyde has emaciated myeloperoxidase (MPO) and MDA activities in the paw edema after Carr administration [527]
Anti-diabetic Effect
500 mg of capsules of cassia bark is supplied twice daily to the patients. For the treatment of type 2 diabetes, 1 g of cassia bark powder is given for 12 weeks to reduce glycosylated Hb, fasting blood glucose level, and serum level of malondialdehyde, to enhance serum glutathione and superoxide dismutase level [778]. In another investigation, at various doses of cassia bark extract are given for 6 weeks. It is observed that blood glucose level is significantly reduced in a dose-dependent manner in comparison with the control. The intestinal glycosidase activity is reduced, while the serum insulin level and HDL-cholesterol level are increased after 6 weeks of administration of cassia bark extract. It can be concluded that blood glucose level has been maintained with cassia bark extract. The cassia bark extract is able to reduce the blood glucose level by decreasing the carbohydrate absorption in the small intestine [49]
Anti-obesity Effect
Researchers have demonstrated that at various doses of 50, 100, and 200 µg/mL of cassia bark extract are able to increase the lipid deposition in white adipocytes and to enhance the oxidation ability of fatty acid and are able to prevent obesity-induced type 2 diabetes. The doses of 100 and 300 mg/kg of WEBC (water extracts of barks of C. cassia) are able to reduce the total cholesterol level, serum glucose level, insulin, and lipid storage significantly in obese mice. The doses of 0.1 and 0.2 mg/mL of WEBC are capable to enhance the ATP levels [1012]
Cardiovascular Health
Scholars have reported that various doses of 10, 30, and 50 µg/mL of WEBC are able to retard the proliferation of vascular smooth muscle cells (VSMCs), which may prevent cardiovascular disorder. It is demonstrated that a dose of 750 mg/kg of WEBC is able to reduce the serum levels of LDL, TG, and BNP (brain natriuretic peptide) significantly and is able to increase the Ca2+Mg2+-ATP enzyme activity, and to incresae the contents of PCR (polymerase chain reaction), ATP, and ADP in streptozotocin (STZ)-induced myocardial damage diabetic rats [1012]
Antimicrobial Effect
Researchers have investigated about the antimicrobial activity of cassia bark extract. The extract exhibited a wide spectrum of antibacterial effects against fish pathogenic bacteria. Particularly, it showed the potential inhibitory effect against Listonella anguillarum, Streptococcus iniae, and Edwardsiella tarda In liquid medium, the Minimum Inhibitory Concentration (MIC) value of the extract is 75.8 ~ 189.6 µg/mL against gram-positive bacteria and is 75.8 ~ 113.8 µg/mL against gram-negative bacteria. It showed potential bactericidal action against gram-negative bacteria in comparison with gram-positive bacteria. The viable cell counts of L. anguillarum and S. iniae are decreased with the increase in the concentrations of the cassia bark extract [610]
Gastrointestinal Effect
Researchers have investigated about the strong co-relation between bioactive components present in cinnamon bark and its gastrointestinal (GI) actions. Trans-cinnamic acid (TrCin), an organic acid, and its derivatives have been analyzed for regulating the activity of gastrointestinal track. The gastric emptying (GE) test has been conducted to analyze the gastrointestinal activity. 6 cinnamic derivatives like 3,4,5-trimethoxycinnamic acid, cinnamic acid, p-methoxy cinnamic acid, 2-(trifluoromethyl) cinnamic acid, 3-(trifluoromethyl cinnamic acid, and trans 4-(trifluoromethyl) cinnamic acid showed better delaying effect. TrCin, rosmarinic acid, p-coumaric acid, and its derivatives have been analyzed for their α-glucosidase inhibitory action, which may be co-related with gastric emptying and leads to weight loss, and satiety. Therefore, tannins, which are present in cassia bark extract, are able to reduce the demand for food intake by delaying the digestion action and by delaying the digestive track emptying. Researchers have reported that cassia bark extract is helpful in different GI-related disorders like constipation, and diarrhea [815]
Antioxidant Activity
Researchers have investigated the antioxidant activity of cassia bark extract. 70% of ethanol and warm aqueous extracts of cassia bark have been used to evaluate its antioxidant activity by the DPPH radical scavenging activity, and ABTS radical scavenging activity. It is reported that the warm aqueous extract possess the DPPH radical scavenging activity and ABTS radical scavenging activity of 84.93% and 82.20%, respectively, while the ethanolic extract possesses the DPPH radical scavenging activity and ABTS radical scavenging activity of 90.25% and 92.21%, respectively. Researchers have analyzed the NO retardation activity for the cassia bark extract. It has been reported that the NO generation is reduced by 10.15 µM in the ethanol extract and 14.57 µM in the warm aqueous extract [523]
Central Nervous System Activity
Scholars have proposed that the ischemic injury in the animal brain is improved by the administration of 80 mg/kg of cinnamophilin (component of cassia bark). The oxygen–glucose deprivation-induced neuronal injury can be treated with cinnamophilin. The aqueous-soluble extract of cassia bark possessed a substance known as procyanidin Type-A trimer (trimer1), which is able to decrease the cell lumps through improving the movement of intracellular calcium. It is also able to reduce the oxygen–glucose deprivation-induced decreasing activities on glutamate uptake [746]
Piper nigrum (Black pepper)
Anti-inflammatory Activity
At the doses of 10 and 15 mg/kg of plethysmometer, piperine showed anti-inflammatory activity in rats. At a dose of 10 mg/kg, both ethanol and hexane extracts exhibited the anti-inflammatory effect [919]
Anti-diabetic Effect
Piperine (main component of black pepper) showed hypoglycemic effect in normal mice. In hyperglycemic rats, anti-lipid peroxidative, anti-hyperglycemic, and antioxidant activities are found through the administration black pepper orally. In acute and subacute study models, blood glucose levels are influenced with piperine in alloxan-induced diabetic rats. Piperine is given orally at doses of 10, 20, and 40 mg/kg body weight to alloxan-induced diabetic rats. It is reported that piperine is able to increase the blood glucose level at the high dose in the acute study. In the subacute study, piperine is given at a doses of 5, 10, and 20 mg/kg body weight. It is reported that piperine is able to reduce the glucose level. 5% of black pepper has been administered for 8 weeks in the diet of rats. It is reported that it is able to enhance the serum cholesterol, serum liver cholesterol concentration, and hepatic cholesterol-7a-hydroxylase level [445]
Anti-obesity Effect
Researchers investigated the effect of black pepper to control the obesity as a herbal drug [781]. Scholars have investigated the anti-obesity activity of black pepper, Terminalia arjuna, and Lagenaria siceraria. Obesity has been induced in Wistar albino rats with high-fat diet for 28 days. Group I is considered as control (1% of carboxy methyl cellulose (CMC)); group II is considered as obese control (1% of CMC) with high-fat diet; groups III, IV, V, and VI have been treated with several polyherbal tablet formulations of Lagenaria siceraria alone or in combination with other plant extracts of black pepper and Terminalia arjuna (400 mg/kg bw); group VII is taken formulation (400 mg/kg bw), and group VIII is considered as standard (Orlistat 45 mg/kg bw). In comparison with standard, the organ weight, food consumption tendency, body weight TC, TG, LDL, and locomotor activity are decreased, and HDL levels are enhanced in high-fat diet-fed rats treated with the black pepper, Terminalia arjuna, and Lagenaria siceraria [730]
Antimicrobial Effect
A dose of 40 µg/disc of black pepper extract has been selected for examining its inhibitory effect against gram-positive bacteria like S. albus, and B. megaterium and gram-negative bacteria such as E. coli, S. typhi, and P. aeruginosa, and a fungus A. niger. Carbon tetrachloride, benzene, chloroform, ethyl acetate, acetone, ethanol, and aqueous extracts of black pepper showed the inhibitory activity against S. albus. Carbon tetrachloride, benzene, chloroform, ethyl acetate, acetone, and ethanol extracts showed the inhibitory activity against P. aeruginosa and S. typhi. carbon tetrachloride, benzene, ethanol, and distilled water exhibited inhibitory activity against E. coli and B. megaterium [453]
Cardiovascular Health
The alkaloid piperine is derived from black pepper ranging from ~ 5–13%. Piperine is a compound with proven beneficial effect on cardiovascular disease (CVDs). In CVDs, the oxidation status, lipid metabolism, and inflammation have been mediated by the use of black pepper. Piperine showed favorable effects for atherosclerosis. Piperine is capable to inhibit lipid droplet development, lipid peroxidation, oxidized low-density lipoprotein uptake in macrophages, adherence of inflammatory cells to endothelial monolayer, to develop cholesterol efflux from macrophages, to recover lipid profile, to promote myocardial ischemia, cardiac damage, cardiac fibrosis, show antihypertensive, antithrombosis effect, and to protect arterial stenosis through retarding vascular smooth muscle cell proliferation [980]
Gastrointestinal Effect
Researchers have proved that the black pepper and its main constituent piperine is an effective gastrointestinal stimulant and relaxant [707]. A neurotransmitter of the parasympathetic nervous system is Ach, cause gastrointestinal stimulation by the activation of muscarinic receptors. The piperine, and pepper extract showed similar effect to that of Ach [569]. Pepper has been utilized for medicinal purpose like constipation [591]
Antioxidant Activity
Few in vitro investigations proved that reactive oxygen species are retarded by piperine and showed defensive activity against oxidative lesions [244]. In an in vivo study, it has been observed that piperine or black pepper are able to reduce lipid peroxidation and exhibited antioxidant potential. The oxidative stress is inhibited by black pepper by holding superoxide and hydroxyl free radicals, retarding lipid peroxidation and human lipoxygenase, and reducing lung carcinogenesis in rats [220]
Central Nervous System Activity
At various doses of 50, and 100 mg/kg of methanolic extract of black pepper are administered orally for 21 days for memory increasing activity in Alzheimer’s disease model in rats. In an in vivo study, the memory-increasing activities through the administration of the extract of black pepper have been estimated by radical arm-maze. In the radical arm-maze task, the reference memory is reduced and work memory is increased. The memory activity is enhanced by the use of the methanolic extract of black pepper. Researchers have proposed that amyloid β (1–42)-induced local memory diminished has been ameliorated by methanolic extract of black pepper through depletion of the oxidative stress in the hippocampus of rats [220]
Coriandrum sativum (Coriander)
Antimicrobial Activity
Researchers have reported that coriander essential oil is able to retard a wide spectrum of micro-organisms. The essential oil showed antibacterial activity against Staphylococcus aureus, gram-negative bacteria strain like E. coli, Klebsiella pneumonia, Salmonella typhimurium, and Pseudomonas aeruginosa The cell death may be due to the action of coriander essential oil. The fungicidal activity has been found in coriander essential oil against the Candida strains, which has been examined by minimal lethal concentrations (MLC). It is similar to that of MIC value extent from 0.05 to 0.4% (v/v). Coriander essential oil constitutes cyclodecane, 2-Hexen-1-ol, and 3-hexane-1-ol, which may responsible for the antimicrobial activity [87, 412]
Anti-diabetic Effect
In an obese-hyperglycemic, and hyperlipidemic rat model, a dose of 20 mg/kg of coriander extract is given orally that is able to control insulin resistance, and glycemia. It also able to reduce the increased level of insulin, total cholesterol (TC), LDL-cholesterol, triglyceride (TG), and various components of the metabolic syndrome. It can able to enhance the cardioprotective indices. It is concluded that the extract of coriander is capable to enhance insulin secretion, glucose uptake, metabolism, and to reduce hyperglycemia [87, 412]
Anti-inflammatory Activity
The injection of carrageenan is given to hind paw of rats, resulting in the development of edema, arising at its highest within the first 60 min. During the first hour, the retardation is peaked by 29% for the group of rats, which has been examined by polyphenol fraction of Coriandrum sativum seed (PCS) at the dose of 25 mg/kg body weight (BW). The retardation is peaked by 48% for the group, which has been treated with 50 mg/kg BW of coriander seed. The retardation is peaked by 34% for the group, which has been experimented with diclofenac. The retardation is peaked continuously at the 3rd hour by 39, 55, and 57% for group, which has been tested with PCS at a dose of 25 and 50 mg/kg BW and diclofenac, respectively. At the later stage of the experiment, the amounts have been fixed on an ultimate retardation, which is around 87, 92, and 95%. Carrageenan is applied as a chemical, which is able to provoke the salvation of inflammatory mediators. During the first hour after injection, the first phase is characterized by the salvation of histamine, serotonin, and kinins. The second phase is characterized by salvation of prostaglandin [586]
Cardiovascular Health
Arterial blood pressure of anesthetized rabbits is partly blocked through atropine, which is due to the use of coriander crude extract. In rabbit aorta, the development of vasodilatation for phenylephrine and K+-induced constriction are due to the utilization of coriander crude extract and caused cardio-depressant effect. In the organic, and water fractions, bioassay-directed fractionation showed the isolation of spasmolytic, and spasmogenic components. Therefore, diuresis is developed by coriander crude extract at a dose of 1–10 mg/kg. Coriander seed extract is able to retard the electrically evoked constrictions of spiral strips and tubular segments of separated central middle ear artery of rabbits [587]. The analysis of the protective effect of coriander seed on the cardiac injury has been done on isoproterenol-induced cardiotoxicity model in male rats. Rats are pre-examined with methanolic extract of coriander seed at various doses of 100, 20, or 300 mg/kg orally for 30 days. They are subsequently given with isoproterenol (85 mg/kg BW) for the last 2 days. It has been reported that in the cardiac tissue of isoproterenol-tested rabbits the levels of endogenous antioxidants, ATPases, plasma lipids, and the other markers of cardiac injury have been reduced. It is concluded that myocardial infarction are inhibited with methanolic extract of coriander seed through retarding myofibrillar injury and also postulated the oxidative damage, which is inhibited due to the presence of the ample amount of polyphenolic content in coriander seed extract. It has been reported that the coriander seed extract is able to scavenged the isoproterenol generated reactive oxygen species (ROS) efficiently [51]
Gastrointestinal Effect
In rats, the activity of coriander has been examined for gastric mucosal damage caused through ethanol, NaCl, NaOH, indomethacin, and pylorus ligation. In the treatment, the doses of 250 and 500 mg/kg of coriander have been administered orally. It is observed that it is able to prevent the gastric mucosal damage through pylorus ligation, ethanol-related reduction in nonprotein sulfhydryl groups (NP-SH), ulcerogenic activities of various necrotizing agents, and ethanol-induced histopathological wounds. The gastroprotective effect of coriander is able to prevent gastric mucus, and indomethacin-induced ulcers. The protective activity of coriander against ethanol-induced injury of gastric tissue has been connected to the free-radical scavenging property of various antioxidant constituents like coumarins, linalool, flavonoids, catechins, terpenes, and polyphenolic compounds that exist in coriander. The compounds create a protective layer through hydrophobic interactions to retard the ulcer [51]
Antioxidant Activity
Researchers have evaluated the free radical scavenging activity and antioxidant activity of coriander seed. Coriander seed is able to minimize the oxidative stress of streptozotocin-induced diabetic rats. The insulin level is enhanced and blood glucose level is reduced by the administration of seed powder in the diet of diabetic rats. The method of peroxidative destruction is retarded, antioxidant levels, and antioxidant enzymes are reactivated by the administration of coriander seed powder to diabetic rats. The scavenging effect has been observed in the seed against hydroxyl radicals, and superoxides in a concentration-related manner [234]
Central Nervous System Activity
Scholars have identified the chemical composition of coriander essential oil to analyze its cytotoxic activity in SH-SY5Y human neuroblastoma cells, to evaluate its neuronal electrophysiological effects. Apart from this the changes in the extracellular signal-regulated kinase (ERK) and adenylate cyclase1 (ADCY1) expression are also been evaluated. It has been evidenced from the Western blotting, and 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide MTT assay that the coriander essential oil can influence the ERK and ADCY1 expression. The cytotoxic effects of the coriander essential oil and linalool has been reported by researchers [173]
Myristica fragrans (Nutmeg)
Anti-inflammatory Activity
Researchers have proved that nutmeg seed extract possessed anti-inflammatory activity through the retardation of TNF-α, IL-6, IL-1β, and NO formation. It is observed that the main macrophage-derived inflammatory mediators are PGE2, and NO. IL-1β, IL-6, and TNF-α are valuable inflammatory cytokines. However, it has been recommended that inhibition of IL-1β, IL-6, TNF-α, and NO is the best technique to decrease inflammation [243]
Antimicrobial Effect
Some investigations exhibited that 60% of nutmeg seed essential oil is able to inhibit the S. typhi, S. aureus, S. dysenteriae, and S. epidermidis The growth of S. aureus, and E. coli are inhibited by the use of nutmeg essential oil. 0.5% of essential oil is able to inhibit the growth of E.faecalis, which has been found in teeth canals. Nutmeg essential oil is considered as a safe protective component for oral care products [585]
Anti-diabetic Effect
Scholars have evaluated the effectiveness of nutmeg seed fot the anti-diabetic effect on alloxan-induced diabetic rats. Normal fasted, glucose fed, and alloxan-induced diabetic rats are given the petroleum ether extract of Myristica fragrans (PEMF) orally. It is observed that a dose of 200 mg/kg of PEMF is able to reduce the blood glucose level after regular treatment of PEMF for 2 weeks. The body weight, organ-like pancreas, liver weight, Hb content, and lipid profile are improved in alloxan treated rats in comparison with diabetic control rats [878]
Anti-obesity Effect
Nutmeg is utilized as tonic, stomachic, carminative, aphrodisiac, and nervous stimulant. It has been demonstrated that in the tetrahydrofuran type lignans (THF)-treated mice, the body weights, and weight gain have been reduced compared to the high-fat diet (HFD)-induced obese mice. A group treated with THF can inhibit the enhancement in the body weight, adipose tissue mass, glucose, and LDL levels than HFD treated group. The acetyl-CoA carboxylase (ACCs) and AMP-activated protein kinase (AMPK) activators are the important factors which regulate the energy storage and management within the animal body. The ACCs, and AMPK are abundant in nutmeg extract, which may responsible for the anti-obesity effect of nutmeg [652]
Cardiovascular Health
Hyalinization of muscle fibers with focal cellular infiltration or infarction of muscle fiber has been revealed by the administration of isoproterenol (ISO) in the heart tissue of rats. Deposition of inflammatory substance is found in the focal cells, which revealed that ISO may destroy the heart tissue. There are no changes in cardiac structure by the administration of nutmeg extract (NM) in heart tissue of treated rats. The effect is same as that of the control group. It is revealed that cardiac tissue is not injured by NM. It is concluded that NM showed protective activity on the myocardium against ISO [429]
Gastrointestinal Effect
Ethanol-induced ulcer models are mostly recommended for the investigation of the gastro-protective effect of nutmeg. In the ethanol-induced ulcer model, the histopathological evaluation of gastric mucosa revealed the damage in lamina propria, damage of superficial epithelium, infiltration of mononuclear cells in the mucosa, degenerative changes in gastric glands, completion of blood vessels, and gastric damage. But pretreatment with sucralfate, and nutmeg ethanolic extract significantly decreased the changes in gastric mucosa and have been reported to provide protection against alcohol-induced gastric damages. Therefore, researchers have concluded that ethanol-induced gastric ulcer is suppressed with nutmeg seed ethanolic extract [812]
Antioxidant Activity
Researchers have compared that the antioxidant activity of nutmeg seed with the synthetic antioxidants like propyl gallate butylated hydroxytoluene (BHT), and butylated hydroxyanisole (BHA). Nutmeg exhibited potential activity in the deoxyribose assay. It is able to maintain the durability of fats like margarine, and butter and oils such as olive, sunflower, and corn against oxidation at 1100 C. In comparison with the BHT, the greater antioxidant activity of nutmeg has been evidenced through Trolox equivalent antioxidant capacity. The antioxidant activity of nutmeg may be due to the presence of compounds like phenylpropanoid, lignans, monoterpenoid including 4-allyl-2, 6-dimethoxyphenol, terpinene-4-ol, and α-terpineol [399]
Central Nervous System Activity
Psychoactive properties such as anxiogenic, and hallucination can be prevented with nutmeg. The physiology of central nervous system has been modulated by the use of nutmeg. The forced swim test (FST) and the tail suspension test (TST) have been used to assess the antidepressant activity of the n-hexane extracts of nutmeg seed in mice. They are subjected to three various doses, e.g., 5, 10, and 20 mg/kg BW, orally. It has been reported that the nutmeg seed extract exhibited antidepressant activity in nutmeg extract treated mice [346]
Brassica nigra (Black mustard)
Anti-inflammatory Activity
Researchers have analyzed the anti-inflammatory effect of ethanolic and water extracts of black mustard seed. At the doses of 200 mg/kg, and 500 mg/kg the extract of black mustard seed are made. Wistar albino rats have been considered for Carrageenan-induced paw edema in vivo analysis to ascertain the anti-inflammatory activity of the black mustard seed. Aspirin-treated group has been considered as the control group. Both the ethanolic, and aqueous extracts of black mustard seed showed the significant retardation of paw edema in comparison with the control group as reported by the researchers [146]
Antimicrobial Effect
Silver nanoparticles along with antibiotics Vancomycin has been applied as a standard anti-bacterial agent against K. pneumonia, P. acnes, and P. aeruginosa The organisms cannot be inhibited by 1 mM AgNO3 But the fabricated silver nanoparticles alone, and a combination of antibiotics exerted significant inhibitory activity against the bacteria considered. The highest synergistic and antibacterial effects have been observed for P. acnes. Researchers have reported that the efficacy of silver nanoparticles are increased in conjunction with standard antibiotics. The organisms, namely P. acne, Candida albicans, Microsporum canis, and Trichophyton mentagrophytes, can be inhibited with mustard seed-silver nanoparticles. The free radicals generated from silver nanoparticles, the interaction between microbial cell membrane and the AgNPs, and the interaction between silver ion and the respiratory cycle of microbes may be the reason for which the inhibitory activities can be observed [680]
Anti-diabetic Effect
The acetone, aqueous, ethanol, and chloroform extracts of black mustard seed are selected to treat streptozotocin-induced diabetic rats. The dose of 200 mg/kg BW of aqueous extract are given to diabetic rats daily for 30 days. The mustard seed extracts are able to reduce the fasting serum glucose (FSG) levels compared to control groups. The serum lipid is lowered, and glycosylated hemoglobin (HbA1c) is enhanced in tested rats in comparison with the control group [76]
Cardiovascular Health
The black mustard seed is a rich source of antioxidant α-tocopherol. The aqueous extract of mustard seed is able to retard the lipid peroxidation induced through ferrous sulfate ascorbate in the human erythrocyte membranes. The mucilaginous fraction of mustard seed is administered into rats. It showed no differences in triglyceride levels and serum cholesterol [284]. The activities between mustard seed oil and fish oil have been evaluated in 360 patients suffering from acute myocardial infarction (MI) in a 1-year randomized placebo-controlled experiment. The treatment has been given to all patients for 18 h after symptoms of an acute MI. 1.08 g/day of fish oil are administered orally to group A patient, 2.9 g/day of mustard seed oil are given to group B orally, and 118 patients are taken as the control group. It has been reported that decrease in total angina pectoris, cardiac arrhythmias, and left ventricular is observed in mustard seed oil- and fish oil-treated patients [642]
Antioxidant Activity
Superoxide dismutase (SOD) is antioxidant enzyme. The enzyme catalyzed the transformation of superoxide to hydrogen peroxide. It defends the cell against oxidative stress. Researchers have carried out an investigation, where 150 mg/kg of Brassica nigra seed has been used to enhance the SOD level of pentylenetetrazole (PTZ)-treated mice. It has been reported that the mustard seed extract is able to remove free radicals and is a potent antioxidant [470]
Central Nervous System Activity
Researchers have evaluated the effect of B. nigra fixed oil (BNO) on the alterations in memory caused by β-amyloid. 42 Wistar rats are divided into 7 groups: 1) control, 2–3) the group is taken BNO at the doses of 462.5 and 925 mg/kg, 4) sham group, 5) Alzheimer group is taken 50 mg/µl/side β-amyloid. The regular gavage of BNO has been carried out for 2–21 days post-amyloid injection. In Morris water maze task, the spatial memory has been analyzed from 21 to 26 days. It is reported that the BNO treated rats the journey distance has been reduced in comparison with the group, which has been treated with β-amyloid alone. The brain memory improving activity of BNO may be due to the presence of 11-eicosenoic acid and erucic acid [647]
Curcuma longa (Turmeric)
Anti-inflammatory Activity
Researchers have reported about the effect of curcumin derived from turmeric on anti-inflammatory activity in rats, and human trials [583, 989]. The laboratory investigation has determined the number of various molecules like cyclooxygenase 2, phospholipase, lipoxygenase, leukotrienes, thromboxane, prostaglandins, nitric oxide, collagenase, elastase, hyaluronidase, monocyte chemoattractant protein-1 (MCP-1), interferon-inducible protein, tumor necrosis factor (TNF), and interleukin-12 (IL-12) that evolved in inflammation. These molecules can be inhibited with curcumin [181]
Antimicrobial Effect
The antimicrobial effect of various fractions of Curcuma longa rhizome has been evaluated against Staphylococcus aureas. The Staphylococcus aureas has been treated with C. longa extract. The microbial cell death may be due to the deformation of cytoplasmic membrane as reported from the scanning electron microscopic observation. It is reported that C. longa rhizome extract showed a wide spectrum of antimicrobial activity. Thus, it can be stated that the turmeric is able to control the microbial infections [345, 851]
Anti-diabetic Effect
Diabetes is treated with turmeric rhizome powder mixed with amla juice, and honey. Researchers have reported that postprandial serum insulin levels are enhanced by the administration of 6 g of turmeric. But it is not able to influence the plasma glucose concentrations or GI within healthy persons. Turmeric showed the activity on the secretion of insulin. Curcuminoids are the active component derived from turmeric rhizome. The curcuminoid is able to reduce the lipid peroxidation by controlling the effects of antioxidant enzymes such as glutathione peroxidase, superoxide dismutase, and catalase at maximum levels [290]. Curcumin and its derivatives like diacetyl curcumin, dimethoxy curcumin, and bisdemethoxycurcumin are responsible for antioxidant activities. Freeze-dried turmeric rhizome powder along with milk can be used as an efficient and safe anti-diabetic supplement as explored by the researchers [729]. Isopropanol and acetone extracts of turmeric are capable to retard the enzyme Human Pancreatic Amylase (HPA) resulting in the lowering of the starch hydrolysis, which ultimately reduce the glucose levels [961]
Gastrointestinal Effect
The curcumin functions by nuclear factor (NF)-kB inhibition. The formation of adherence molecules and inflammatory cytokines are decreased with curcumin. It is able to ameliorate the gastric damage, to recover from gastric mucosal injury, to reduce the leucocyte adherences, intracellular adherence molecule 1, and tumor necrosis factor (TNF)-α formation in nonsteroidal anti-inflammatory drugs (NSAIDs)-induced gastropathy in rats [934]. Abdominal pain or irritation, and Irritable Bowel Syndrome (IBS) are reduced by the administration of Curcuma longa extract. It is also able to enhance the IBS quality. Curcumin is able to treat the acetaminophen (APAP)-induced hepatitis through the recovery of liver histopathology through reduced restitution of GSH, oxidative stress, and inflammation of the liver [877]
Cardiovascular Health
Turmeric contains antioxidants that inhibit damage to cholesterol; therefore, has provided a protective activity against atherosclerosis. Turmeric is able to reduce free radicals as it contains vitamins C and E. It is reported that triglycerides, cholesterol, and other lipids move in the bloodstream. They are the risk factors for cardiovascular disorders which may be reduced with curcumin. A standard American diet rich in refined saturated fat, carbohydrates, and fiber has been administered to mice. The diet has been mixed with turmeric has been given to mice. It has been reported that the mice those have been fed with the turmeric added diet possessed 20% less blockage of the arteries after 4 months in comparison with that mice fed with the American diet. In another investigation, rabbits fed with turmeric enriched diet to treat the atherosclerosis disease. It has been reported that the cholesterol, and triglycerides levels have been reduced in the turmeric treated rabbits [961]
Anti-obesity Effect
Researchers have investigated about the potential anti-obesity activity of the turmeric, and curcumin extracts. A high level of turmeric extract is able to prevent the formation of cholesterol and triglycerides [743]. The anti-adipogenesis potential of turmeric extract may be due to its ability to retard the formation of lipid droplets, triglycerides, and cholesterol in HepG2 cells. The turmeric extract showed better anti-obesity activity in comparison with curcumin [165]
Antioxidant Activity
Researchers have evaluated the antioxidant activity of different fractions of methanolic extract of turmeric rhizome [761]. The ethylacetate fraction possessed DPPH free radical scavenging activity with IC50 = 9.86 µg/mL. At a similar concentration, the ethylacetate fraction showed higher DPPH radical scavenging activity, and ABTS radical scavenging activity in comparison with n-hexane, and water fractions [199]
Central Nervous System Activity
Researchers have investigated the chemical composition of the essential oil of turmeric rhizome to analyze its neuropharmacological effect. At a dose of 50–200 mg/kg of EO of turmeric has been given to albino mice to assess its sedative, behavioural, anxiolytic, and anticonvulsant activities. It is reported that the head dips are reduced, locomotor activities are retarded, and total sleeping time are extended with the application of EO. EO is able to defend the mice from pentylenetetrazol-induced convulsions. It is reported that EO of turmeric possessed anticonvulsant, anxiolytic, and sedative effects [671]
Laurus nobilis (Bay leaves)
Anti-inflammatory Activity
Researchers have considered mice for analyzing the anti-inflammatory activity of bay leaf essential oil. In the carrageenan-induced hind paw edema in mice, the water, and ethanol extracts of bay leaf have been reported for its potential of anti-inflammatory effect without causing any gastric injury [931]
Antimicrobial Effect
A wide range of microorganisms are inhibited with Laurus leave essential oil [124]. The greater antibacterial activity has been found in Laurus essential oil in comparison with tetracycline antibiotics [212]. It is reported that bay leave essential oil can alter membrane-embedded proteins, damage cellular membranes, enhance the permeability of the membrane, damage the transit system of the membrane [868]. The EO showed antibacterial properties may be due to the presence of terpenes. Researchers have revealed the gram-positive bacterial strains and the gram-negative bacteria can be inhibited with essential oil. The outside membrane of gram-negative bacteria provides protection against the EO, that is why the essential oils are more effective against the gram-positive bacteria than the gram-negative bacteria [909]. 1,8-cineole is the main active compound responsible for the antimicrobial effect of bay leave EO [172]. The antagonistic, and synergistic effects of 1,8-cineole along with the oxygenated terpenes may be the reason behind the inhibitory potential of Laurus essential oil on microbial growth. Microorganisms like Kocuria rhizophila, Staphylococcus aureus, E. coli, Pseudomonas aeruginosa, and Salmonella abony can be inhibited with bay leaf essential oil [298]
Anti-diabetic Effect
Researchers have investigated the effect of bay leave extract on biochemical, and histopathological changes in β-cells for Streptozotocin (STZ)-induced diabetic male albino rats. 30 healthy adult male albino rats have been considered. The rats have been divided equally into 5 groups: diabetic Laurus nobilis extract group (DLN), control group (C), diabetic group (D), Laurus nobilis extract group (LN), and diabetic acarbose (DA) group. It is reported that the D group rats have exerted several degenerative, and necrotic changes in their kidney, liver, and pancreas, while the normal histology is found in DLN rats. D groups showed a reduction in insulin immunostaining in the pancreatic β-cells in comparison with the C groups. The diabetic rats have been treated with Laurus nobilis, and have also been treated with acarbose, which have exhibited the reduction in glucose concentration, aspartate aminotransferase (AST), γ-glutamyltransferase (GGT), and alanine aminotransferase (ALT) enzyme in comparison with D groups. It is reported that bay leave showed important activity on blood glucose levels. The bay leave is able to increase the regeneration of pancreatic islets. It is also able to restore the altered liver enzymes, total protein levels, urea, creatinin kinase, calcium, and ferritin to near-normal levels [609]
Gastrointestinal Effect
Scholars have considered rats to evaluate the gastroprotective effect of various extracts of bay leave (chloroform and methanol). The methanolic and chloroform crude extracts can decrease the gastric damage significantly. The extracts are able to provide more efficient protection. The extracts of bay leave is able to ensure the relationship between the antiradical activity, and pharmacological efficacy [885]
Antioxidant Activity
Various flavonols and glycosides are present in bay leave. Bay leave contains water-soluble antioxidant compounds that can be connected to the several health-beneficial effects [216]
Crocus sativus (Saffron)
Anti-inflammatory Activity
Anti-inflammatory effect has been found in water extract of saffron petals. The presence of crocin in saffron is responsible for the anti-inflammatory activity [633]
Antimicrobial Effect
Researchers have evaluated the antimicrobial activity of the non-polar extract of saffron flower stamens. It has been reported that saffron flower extract can inhibit both the growth of gram-positive, and gram-negative bacteria [903]. The diethyl ether extract of saffron stamens (DES) is able to inhibit the foodborne pathogen species like Listeria monocytogenes, Salmonella enterica subsp In. bongori, Staphylococcus aureus, and E. coli [1009]
Anti-diabetic Effect
Scholars have evaluated the anti-diabetic activity of water extract of saffron. α-Amylase and α-glucosidase enzymes are retarded with saffron water extract. Thus, researchers have concluded that saffron water extract is able to prevent diabetes [509]. It is reported that phenolic compounds derived from saffron showed hypoglycemic activity through the maintenance of insulin sensitivity, postprandial blood glucose levels, and acute insulin secretion. The extract is also able to retard the glucose absorption rate from the intestines into bloodstream [1001]
Gastrointestinal Effect
Many studies have demonstrated that the effectiveness of saffron on gastrointestinal system. It is reported that saffron is able to treat the stomach related problems, amenorrhea, menstruation problem, the problem related to anus displacement, hemorrhoids, decrease in appetite, intestinal fermentation related problems. Safranal derived from saffron is able to decrease the surface spreading of gastric ulcers, to normalize gastric volume, and to maintain the histological changes in gastrointestinal track [633]
Cardiovascular Health
Researchers have demonstrated the capability of saffron on cardiovascular activity. The saffron is able to provoke chronotropic, inotropy, and to decrease KCI induced constriction in vascular, non-vascular smooth muscle. In hypertensive and normotensive anesthetized rats, the blood pressure is decreased with water extract of saffron. This investigation recommended that smooth muscle contractility may not be affected with crocin [706]. The hydroalcoholic extract of saffron showed the hypotensive effect because of the retardation of the rennin-angiotensin system in angiotensin II hypertensive rats. The saffron extract showed hypotensive activity by decreasing the calcium salvation into the sarcoplasmic reticulum, antagonism toward adrenergic receptors, and retardation of calcium channel [1011]
Anti-obesity Effect
The body weight of rats is decreased with saffron stigma ethanolic extract. The ethanolic extract of saffron is able to reduce the appetite. It is reported that the saffron extract has possessed mood-improving activity. The saffron extract is able to reduce snacking, and appetite. It is observed that saffron extract intake in women can reduce their body weight, and snacking within 60 days. Researchers have recommended that body weight can be reduced with the consumption of saffron supplemented diet [581]
Antioxidant Activity
Researchers have identified the antioxidant potential of saffron in various extracts [725]. Saffron is able to protect the free radical-induced injured organs like lungs, kidney, liver, and heart as observed in hamsters [955]. It is reported that at a dose of 0.45 mg/ml of soaked, and decocted saffron is the most efficient one to cure the injured organs. The superoxide dismutase activity can be enhanced with saffron extract, while the lipid peroxidation can be reduced [561]
Central Nervous System Activity
Scholars have evaluated the neuropharmacological activities of crocetin, saffron, crocin, and safranal in the peripheral, and CNS [984]. Saffron and its active constituents showed protective activities like anxiolytic, antidepressant, antinociceptive, hypnotic, and cytoprotective [506]. Saffron, and its constituents are able to decrease the opioid withdrawal syndrome, and to cure neurodegenerative diseases such as Parkinson’s disease, epilepsy disease, brain ischemia, and memory impairment. It is reported that age-related macular degeneration and Alzheimer’s disorders are prevented with saffron [640]
Illicium verum (Star anise)
Antimicrobial Effect
The crude ethanol extract of star anise exhibited antimicrobial properties against S. aureus and A. baumannii. The star anise ethanol extract is also able to inhibit P. aeruginosa. The diethyl ether (EE) fraction of star anise has provided greater inhibitory activity in comparison with crude extract. The supercritical CO2 extract of star anise exhibited an antibacterial effect against A. baumannii. Though the supercritical CO2 extract did not show any antibacterial property against the other two bacteria. The EE fractions and alcohol extract showed a wide antibacterial spectrum against these three bacteria. The EE fraction of star anise has possessed MIC value of 0.25 mg/mL. It showed higher antimicrobial activity against S. aureus in comparison with the crude extract. Similar results have been reported by the researchers for gram-negative bacteria, namely A. baumannii and P. aeruginosa [994]
Anti-inflammatory Activity
Researchers have revealed the anti-inflammatory activity of star anise. The anti-inflammatory activity has been reported in water extract of star anise as per the investigation carried out on the intestinal smooth muscles of mice. The water extract of star anise is able to reduce the serum level of TNF-α, and IL-1β [94]
Anti-diabetic Effect
Scholars have investigated the anti-glycation effect of ethanolic extract of star anise. The protein glycation retardation has been evaluated by human serum albumin (HAS)-fructose glycation model. Similarly, sodium dodecyl sulfate (SDS) polyacrylamide gel electrophoresis has been conducted to analyze the cross-linked advanced glycation endproducts (AGEs). The star anise extract has been given to streptozotocin-induced diabetic rats for 7 weeks. After that, the anti-glycation activity has been analyzed. Star anise extract exhibited a good inhibitory activity in comparison with the standard inhibitor (rutin). The extract of star anise is able to decrease the lipid, blood glucose level, urea, liver functions parameters, and renal AGEs levels in streptozotocin-induced diabetic rats. It is reported that star anise can prevent diabetes-associated problems [447, 448, 455]
Gastrointestinal Effect
Researchers have investigated the star anise extract as an anti-gastroulcerogenic agent in the rat model. Various extracts like aqueous–alcoholic, petroleum ether, and essential oil have been considered. The rats are fed with a dose of 1250 mg/kg bw petroleum ether extract and 2500 mg/kg bw for aqueous ethanol extract. Rats have been divided into three main groups: treated animals, negative control groups (fed with distilled water), and positive control groups (administered with various extracts). It is reported that aqueous–alcoholic extract possesses the greatest antioxidant activity. The petroleum ether extract showed the lowest effect. The higher anti-ulcerogenic activity has been found in aqueous–alcoholic extract in comparison with famotine (a reference drug). The aqueous–alcoholic extract is able to increase the superoxide dismutase activity and catalase activity and is able to induce the glutathione reductase activity [382]
Central Nervous System Activity
Scholars have investigated the action of star anise extract on the central nervous system (CNS). In this experiment, the male albino mice and rats have been examined. The parameters like locomotor activity, general behavior, sleeping pattern, anxiety, and myocoordination activity have been used to analyze the CNS activity. The rats and mice are separated into 5 groups with 6 animals in each group and have examined for 1 week. At a dose of 200 mg/kg of all extracts have been administered through intraperitoneal injection. It is reported that the extracts of star anise are able to decrease the locomotor activity, prolong the phenobarbitone induced sleeping time, form alteration in a general behavior pattern, and possess anxiolytic effects. Though, the extracts are not able to alter the muscle coordination activity. The methanol extracts are more effective in comparison with the ethyl acetate, and hexane extracts. It is reported that the most potential CNS depressant activity and anxiolytic effects are found in these three extracts without altering the motor coordination [202]
Antioxidant Activity
Researchers have evaluated the antioxidant activity of star anise constituents. The methanolic extract of star anise showed antioxidant potential (as appeared in DPPH assay) with IC50 of 61 mg/ml. Among the different types of fractions, antioxidant activity has been found in the ethyl acetate (IV-EA) with IC50 of 18 mg/ml. In the sub-fractions, the most potent antioxidant activity has been observed in the ethyl acetate soluble sub-fraction of ethyl acetate fraction (IV-EA-EA-S) with IC50 value of 42 mg/ml. The protocatechuic acid, Illicium verum extract (IV-E), and IV-EA showed antioxidant potential with IC50 of 2000, 1400, and 600 mg/ml, respectively [92]
Allium cepa (Onion)
Anti-inflammatory Activity
Researchers have evaluated the anti-inflammatory activity of ethanolic extract of onion. Sprague Dawley rats (250–300 g) have been considered to analyze the anti-inflammatory activity of onion extract. The standard drugs like tramadol and diclofenac sodium have been considered to compare the anti-inflammatory activity of onion. The carrageenan-induced paw edema of rats can be retarded with the administration of ethanolic extract of onion [415]
Antimicrobial Activity
Scholars have evaluated the antimicrobial activity of onion EO at various concentrations (50, 100, 200, 300, and 500 ml/l) against Salmonella enteritidis and Staphylococcus aureus. The EO extracts of onion are able to inhibit fungies like Aspergillus niger, Penicillium cyclopium, and Fusarium oxysporum [141]
Anti-diabetic Activity
Researchers have analyzed the anti-diabetic activity of onion in alloxan-induced diabetic rats. Thirty-six male albino rats are given with alloxan through intraperitoneal route to evaluate the anti-diabetic activity of onion. The rats have been divided into six groups (6 rats/group). The group A consists of rats those are not induced with alloxan and untreated, group B rats (induced but untreated), group C rats (administered with glibenclaimide), rats of group D, E, and F are induced, treated with 1, 2, and 3 mL/100 g BW of onion juice, respectively. It is reported that onion is able to reduce the blood glucose levels, and the lipid profile significantly in untreated rats [33]
Anti-obesity Activity
Scholars have investigated the effects of the onion extract on the expression of inflammatory mediators from the adipose tissue in a high-fat diet-induced obese rat model. Dawley rats have been separated into three groups: control, high-fat diet (HF), and high-fat diet with onion extract. The all the groups have been treated for 8 weeks. It is reported that the epididymal, and perirenal fat weights are not influenced significantly, whereas the mesenteric fat weight is reduced significantly in the groups treated by high-fat diet with onion peel extract in comparison with the HF groups. A greater adiponectin mRNA level has been identified for the group fed with high-fat diet with onion supplementation in comparison with the other groups. IL-6 mRNA level has been reduced slightly in rats fed onion extract supplementation in comparison with the HF groups [579]
Cardiovascular Activity
Flavonoids derived from onion, which are able to prevent cardiovascular disease, and heartburn. Quercetin is able to decrease the blood pressure in hypertensive persons, to activate platelets, and to treat cardiovascular disease [398]. Stroke, coronary heart disease, and hypertension have been associated with inflammation or atherosclerosis. Researchers have revealed that oxidative stress can be reduced with quercetin through mopping free radicals. Therefore, quercetin is able to decrease the chances of stroke, and heart disease. In another study, 24 healthy persons with ages between 35 and 55 years have been considered. They have been separated into two groups of 12 each having 7 females and 5 males suffering from moderate hypercholesterolemia. One of the groups has been administered with 100 mL of onion, while the other group has been considered as control. It is reported that LDL-C, waist circumference, and total cholesterol are decreased after 8 weeks substantially for the group fed with onion. It is reported that onion juice is able to enhance the LDL oxidation lag time, and antioxidant activity, which is helpful in the prevention of CVD [183]
Antioxidant Activity
Researchers have evaluated the antioxidant capacity of flavonoids, organosulfur compounds, and polyphenols are present in ample amounts in onion. Three onion cultivars, namely Borettana di Rovato, Dorata di Parma, and Rossa di Toscana, have been considered to evaluate their antioxidant potential in terms of total phenolic content, DPPH, FRAP (ferric reducing antioxidant power), and TEAC (Trolox equivalent antioxidant capacity) potential. The highest antioxidant potential has been observed in Rossa di Toscana [536]. The subcritical water, hot water, and ethanol extracts of onion have been considered to evaluate the antioxidant potential in terms of ferric thiocyanate (FTC), DPPH, and lipid peroxidation inhibitory ability [518]. Other researchers have investigated a relevance between the antioxidant activity, and organosulfur compounds of the onion by the methods like ABTS (2,2’-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid), ORAC (oxygen radical absorbance capacity), and DPPH [473]. The antioxidant activity has been reported in organosulfur compounds. Researchers have selected 400 broiler chickens to evaluate the effects of phenol-rich onion for their antioxidant capacity, production, digestion, and immune response. At various concentrations, the phenol-rich onion extract (PROE) has been given to each group (100/group) for 35 days. It is confirmed that antioxidant enzyme activities (glutathione peroxidase, catalase, and superoxide dismutase) are enhanced with PROE because of flavonoids, and phenol [667]
Central Nervous System Activity
Researchers have evaluated the neuroprotective effect of Onion in aluminium chloride-induced neurotoxicity. 50 mg/kg/day of aluminium chloride, and 50–200 mg/kg/day of onion have been administered to Swiss albino male mice. It is reported that onion is able to enhance catalase, and glutathione (GSH) activities and to lower the nitrate/ nitrite, acetylcholinesterase (AChE), and lipid peroxidation. Quercetin, kaempferol, cycloartenol, and phytosterols like lophenol, 24-ethyl cycloartenol, and 24-methyl lophenol present in onion possessed neuroprotective effect [183]
Anethum graveolens (Dill)
Anti-inflammatory Activity
Researchers have evaluated the effects of dill seed, and the extract of aerial part to determine its anti-inflammation potential. The dill extract has been evaluated for its anti-inflammatory activity against formalin-induced inflammation in rats and the diclofenac gel as a reference. The inflammation has been induced by injecting formalin in the paw of rats. After that the weight of the rats has been measured by plethysmometer and the paw volume has been assessed. The experiment has been conducted for 8 days. Researchers have divided the rats into 3 groups of 6 male rats: the diclofenac gel groups, formalin groups, and dill-oil groups. Two grams of dill oil with 100 mg dill extract has been administered to dill-oil groups. Two grams of gel with 20 mg diclofenac Na has been given to the diclofenac groups. In these groups, the mean paw amounts have been changed after Formalin-induced inflammation on the 1st day. In diclofenac gel and dill-oil-administered groups, the paw volume has been changed after injecting the formalin on daily basis for 8 days in comparison with the control groups, which may show a significant reduction. Paw volume has been more reduced in dill groups in comparison with the diclofenac groups. Plethysmometer has been conducted to evaluate the results of paw volume. It is reported that the dill-oil is capable to reduce the paw volume significantly [639]
Antimicrobial Activity
Dill extracts have been reported for its Helicobacter pylori inhibiting activity. The potential antibacterial activity has been found in organic, and water extracts, and the essential oils of dill against fungi (two molds like Aspergillus flavus, Penicillium islandicum, yeast such as Candida albicans)Candida albicans, Aspergillus niger, and Saccharomyces cerevisiae are inhibited by D-carvone and D-limonene. The antimicrobial effect may be characterized by furanocoumarin present in dill [607]
Gastrointestinal Activity
The dill extract has been reported to possess antisecretory, and mucosal protective activities against ethanol, and HCl-induced gastric mucosa damage in mice. Dill extract is capable enough to reduce the total acid content as perceived by the researchers. Rabbit intestine constrictions are decreased with dill essential oil. Ethanol extract of dill has been retarded histamine and acetylcholine-induced constrictions of guinea-pig ileum. Some digestive problems like flatulence, stomachache, and indigestion are improved with dill [354]. Dill water is reported to show a cooling effect in stomach. Dill is able to prevent gripe, to improve colic, and hiccups. It is reported that essential oil is able to decrease foaming, and also to act as a light carminative [378]
Antioxidant Activity
The antioxidant potential of the acetone, and essential oil extracts of dill has been investigated by researchers through the methods like DPPH, reducing power, and chelating effect. The ethanol, hexane, and ethyl acetate extracts of dill have been evaluated for their antioxidant potential through the methods like reducing power, DPPH radical scavenging, Trolox equivalent antioxidant capacity, chelating power, and β-carotene bleaching [854]. The carbon tetrachloride-induced hepatotoxicity in albino rats have been considered to analyze the antioxidant activity of ethanolic extract of dill [914]. It is reported that ethanolic extract of dill (100 mg/Kg wt) is able to restore the antioxidant enzymes and serum enzymes activity that are increased in treated rats. The antioxidant capacity of ethyl acetate, dichloromethane, n-hexane, and ethanol extracts of dill have been examined by nitric oxide radical scavenging, DPPH, N,N-dimethyl-p phenylendiamine, ferric ion-chelating capacity, ferric reducing antioxidant power, and phosphor molybdenum-reducing antioxidant power. It has been reported that the ethanolic extract of dill possessed the highest antioxidant power. Though, in terms of ferric ion chelation effect the dichloromethane extract possess the maximum value. The chlorogenic acid (6.04 µg/g extract) is the dominant phenolic acid as reported by the researchers. The EO fraction contains lower amounts of phenolic compounds (35.1 mg GAE g−1 extract) [180]
Anti-diabetic Activity
Various extractions of dill, and its essential oil have been given to diabetic rats. The extracts, and EO of dill are able to decrease low-density lipoprotein cholesterol, triglycerides, total cholesterol, very-low-density lipoprotein cholesterol, and glucose levels remarkably, and to enhance the HDL-C levels. The antioxidant and hypoglycemic activities have been found in dill. Flavonoids, and phenolic proanthocyanidins compounds derived from dill showed antioxidant potential. The anti-diabetic activity of dill may be due to the enhancement of fecal excrement, bile acids formation, retardation of the absorption of intestinal cholesterol, and the ability to bind the bile acids in the intestine [402]. The hypolipidemic activity of dill may be due to the presence α-phellandrene, carvone, and limonene. Histopathological tests exhibited various extracts of dill, which are used to treat diabetic rats are able to normalize the deposition of lipid in the heart, liver, and pancreas. The hypoglycemic effect of dill may be due to the presence of alkaloids, flavonoids, terpenoids, tannins, and phytosterols in dill extract. It is proposed that the dose of 300 mg/kg of hydroalcoholic extract of dill is able to reduce the fasting blood glucose level. Various extracts of dill at the concentrations of 0.032, 0.065, 0.125, 0.25, 0.5, and 1 mg/ml have been fed to the type 2 diabetic rats to decrease the fructosamine level [333]
Anti-obesity Activity
Researchers have investigated the anti-obesity activity of Anethum graveolens aqueous extract (AGAE). AGAE is able to act as a strong anti-obesity agent through the 5-hydroxytryptamine (5-HT) metabolism mediation, to enhance 5-HT turnover in the brain of rats, the concentrations of tryptophan in the brain and blood. AGAE has been administered to rats orally for 7 days. It is able to decrease the tendency in food consumption of obese rats, resulting in reduced body weight. Researchers have described important facts about the 5-HT concentration in the brain which is a neurotransmitter. It plays an important role in feeding behavior. Obesity and hyperphagia have been produced with reduced concentration of 5-HT in the brain [125]
Cardiovascular Activity
Scholars have evaluated the effectiveness of the hydroalcoholic extract of dill on the cardiovascular activity of overweighted male rats. Thirty-two overweight male rats weighing 350–400 g having aged 12 weeks have been separated into four equal groups like endurance training + dill extract (ETr + DEx), endurance training (ETr) for 10 weeks in 5 sessions/week, dill extract (DEx) at a dose of 300 mg/kg BW, and control (Ct). Eight rats weighing 240–280 g in the non-obese control (NCt) groups have been considered to analyze the cardiovascular activity. After the final intervention session, the fasting plasma lipid concentration has been assessed for 48 h. It is reported that in the Ct groups, LDL-C, TC, TG, VLDL-C, TC/HDL-C, and HDL-C levels are enhanced in comparison with the NCt groups. The plasma concentration of LDL-C, VLDL-C, TG, TC/HDL-C, and LDLC/HDL-C is reduced in the ETr + DEx groups and in the ETr groups in comparison with Ct groups. It is reported that the plasma lipid profile is maintained with endurance training. It has been confirmed by the researchers that the dill extract is more efficient to prevent cardiovascular disease [59]
Trigonella foenum-graecum (Fenugreek)
Anti-inflammatory Activity
Researchers have evaluated the anti-inflammatory effect of petroleum ether extract of fenugreek. Fenugreek petroleum ether extract (FSPEE) has been evaluated and examined on rats against formaldehyde, and carrageenan-induced paw edema. At a dose of 0.5 mL/kg of FSPEE has been given to rats to analyze the anti-inflammatory activity. It is reported that FSPEE is able to decrease 37%, and 85% inflammation of the paw in the formaldehyde and carrageenan-induced paw edema, respectively. It is reported that anti-inflammatory activity has been found in fenugreek petroleum ether extract because of the presence of linoleic, and linolenic acids [716]
Antimicrobial Activity
Scholars have evaluated the antimicrobial activity of acetone, aqueous, and methanol extracts of fenugreek against Staphylococcus and E. coli. The methanol extract has been reported as the most efficient one in terms of antimicrobial activity followed by acetone extract, and aqueous extract [840]
Anti-diabetic Activity
Researchers have evaluated the anti-diabetic effect of extract of Trigonella foenum-graecum (IND01) on the neonatal streptozotocin-induced rat (n-STZ) model with diabetes mellitus (DM). At a dose of 50 mg/kg of streptozotocin (STZ) has been injected in the rat pups. It is reported that DM has been evaluated after 8 weeks through measuring fasting serum glucose (SG) level. At a dose of 10 mg/kg of standard drug (glyburide) has been given to n-STZ rats orally. At a dose of 100 mg/kg of IND01 has been given to n-STZ rats for 28 days. In the acute study, the SG levels have been taken at periodical intervals. In the subacute study, the serum insulin, and glycosylated hemoglobin (HbA1c) levels have been recorded on day 28. The HbA1c, SG levels, and body weights are increased significantly for n-STZ induced rats. Pancreatic islet β-cells and serum insulin levels are reduced in control groups. The treatment with glyburide and IND01 exhibited significant reversal of n-STZ-induced changes. The histology sections of the pancreas showed the ability of IND01 to enhance the size and number of pancreatic islet β-cells. It is reported that IND01 is able to treat DM and also to maintain the glycemic activities in n-STZ induced diabetic rats [491]
Anti-obesity Activity
Scientists have evaluated the anti-obesity activity of Fenugreek (INDUS810). The mice aged 4 weeks have been consumed with a high-fat diet, and a normal diet together with or without of 200 mg/kg of INDUS810 by intraperitoneal injection twice/week to analyze the anti-obesity activity of fenugreek. It is reported that in high-fat diet-induced mice, the weight are decreased with INDUS810 in liver, epididymal white adipose tissue, interscapular brown adipose tissue. INDUS810 is able to reduce the serum cholesterol level, and low-density lipoprotein cholesterol, to maintain the insulin sensitivity in mice. INDUS810 is also able to retard the lipid deposition and to enhance the lipolysis activity in mature adipocytes. INDUS810 can enhance protein levels of sirtuin 1, peroxisome proliferator-activated receptor α, peroxisome-proliferator-activated receptor-gamma co-activator 1β, and sirtuin 3. It is capable to activate the adenosine monophosphate-activated protein kinase that may decrease the lipid levels within adipocytes. It is reported that INDUS810 is considered as a potential anti-obesity agent [196]
Gastrointestinal Activity
Researchers have observed that the fenugreek seed exhibited anti-ulcer activity. Omeprazole, a well known proton pump blocker has been comparable to the effect of fenugreek. The drug is utilized to treat gastrointestinal disorders like gastritis, gastroesophageal reflux disorder, and duodenum and gastric ulcer. A gel fraction, and aqueous extract of fenugreek exhibited effective ulcer defensive activities, which may be characterized by its antisecretory activity and effectiveness over mucosal glycoproteins as reported by researchers in a ethanol-induced gastric ulcer in rats. It is reported that water extract of fenugreek has possessed antioxidant activity, which may retard the ethanol-induced gastric damage in the rats. In comparison with omeprazole, a better gastroprotective activity has been reported in insoluble gel fraction of fenugreek. This may be due to the presence of flavonoids and beneficial polysaccharides in fenugreek [338]. The defensive mechanism of flavonoids in the mucosa may be the reason for the gastrointestinal protective effect of fenugreek [991]
Antioxidant Activity
Scholars have reported that the lipid peroxidation is enhanced, and the antioxidant molecules like α-tocopherol, glutathione, and β-carotene are altered with fenugreek in alloxan-diabetic rats. 2 g/kg BW of fenugreek powder supplementation has been given to alloxan-diabetic rats for 1 month to evaluate the antioxidant and lipid peroxidation capacity. The fenugreek powder is able to normalize the oxidative stress, and lipid peroxidation. It is reported that antioxidant activity has been found in insoluble part of fenugreek [888]
Cardiovascular Activity
Researchers have investigated the cardioprotective activity of fenugreek, and garlic on hypercholesterolemic rats. For 8 weeks, the rats are given a high-cholesterol diet along with garlic (2%), and fenugreek (10%), and their combination. Myocardial infarction (MI) has been induced with isoproterenol. MI has been associated with enhancement of serum iron, circulatory troponin, disarrangement of activities of cardiac ATPase, reduced ceruloplasmin. It is reported that isoproterenol-induced compromised antioxidant status is improved with garlic and fenugreek and the combination of both garlic and fenugreek [627]
Central Nervous System Activity
Researchers have investigated the neuropharmacological effect of fenugreek. The neuropharmacological activity has been observed with petroleum ether extract (PE), total alcoholic extract (TA), total aqueous extract (TQ), total alkaloidal extract (TK), total glycoside extract (TG), fenugreek oil (FO) in diosgenin (DI), and trigonelline (TR)-induced albino Wistar rats. At the dose of 100 mg/kg BW of PE, TA, TQ, and FO have been given to rats. At the dose of 50 mg/kg BW of DI, TK, TG, and TR have been given to rats intraperitoneally. At a dose of 150 ug/kg of chlorpromazine hydrochloride (CP) and at a dose of 48 mg/kg of caffeine (CF) have been utilized as standard. It is reported that except TQ, all the other extracts are able to stimulate of the activity of central nervous system (CNS). While, TQ possessed CNS depressant activity. It is reported that fenugreek extracts contain bioactive components (isovitexin, and rhaponticin) that showed CNS depressant, and stimulant potential [641]
Ferula assafoetida (Asafoetida)
Anti-inflammatory Activity
Researchers have evaluated the anti-inflammatory activity of asafoetida. Phenolic compound present in asafoetida is responsible for anti-inflammatory activity. 2.5 mg/kg of asafoetida has been administered to mouse to treat the carrageenan-induced paw edema. The bioactive compounds like sesquiterpene coumarins are present in asafoetida, which may retard the 5-lipoxygenase activity. Ferulic acid and flavonoid components derived from asafoetida possessed strong antioxidant potential and act as an anti-inflammatory agent [114]
Antimicrobial Activity
Scholars have investigated the antimicrobial effect of ethanol, ethyl acetate, methanol, chloroform, and aqueous extracts of asafoetida. The antifungal effect against Candida albicans and Aspergillus niger and the antibacterial effect of asafoetida extracts against Klebsiella pneumonia, Bacillus subtilis, Staphylococcus aureus, and E. coli have been analyzed through well diffusion process and assessment has been done with the minimum inhibitory concentration (MIC). The inhibition zone has been compared with standards such as fluconazole (0.1 mg/ml) and ciprofloxacin (0.1 mg/ml). It is reported that antimicrobial activity has been found in methanol, ethyl acetate, and ethanol extracts. The highest inhibitory activity has been observed in methanol extract. The ethyl acetate, methanol, and ethanol extracts showed the MIC values of 1 mg/ml and 2 mg/ml, respectively, for the examined organisms [690]
Anti-diabetic Activity
Scientists have analyzed the hypoglycemic effect of the asafoetida extract in streptozotocin-induced diabetic rats. Male Wistar rats have been divided into several groups like control groups, rats fed with 50, 100, and 300 mg/kg doses of asafoetida. Asafoetida extract has been administered regularly through drinking water to diabetic rats for 4 weeks. The serum glucose level is reduced in diabetic rats treated with 50 mg/kg of asafoetida extract in comparison with diabetic rats. It is reported that hypoglycemic activity has been found in streptozotocin-induced diabetic rats with asafoetida extract (50 mg/kg) after 2 weeks. Tannins and phenolic acids (ferulic acid) present in asafoetida are responsible for the anti-diabetic activity [38]
Anti-obesity Activity
Researchers have identified the effectiveness of asafoetida over liver steatosis, weight enhancement, lipid deposition, and leptin level. Aqueous solution of fructose (10%) has been administered in a regular basis to both the control and treated rats. At the doses of 25 or 50 mg/kg (PO) of asafoetida oleo-gum resin has been administered to two treated groups. Tap water, and standard chow food have been given to the control group. It is reported that asafoetida is able to reduce the size of epididymal adipocytes, body weights, abdominal fat, and serum leptin levels. Researchers have observed that fat lowering and anti-obesity activity have been found in asafoetida that may also prevent liver steatosis in type 2 diabetic rats [106]
Gastrointestinal Activity
Scholars have evaluated the effects of asafoetida oleo-gum resin on gastrointestinal diseases like digestion, parasite, bloating, and cancer [387]. Scholars have assessed the effectiveness of asafoetida in the prevention of dyspepsia. Asafoetida possessed anti-diarrhea, anti-parasite, anticancer, and liver defensive effects. Asafoetida is able to prevent gastrointestinal diseases [553]
Cardiovascular Activity
Scientists have analyzed the effect of asafoetida essential oil (AEO) on ischemia–reperfusion-induced damage in isolated rat hearts. Forty-eight male Wistar rats have been separated into 6 groups: 1–3) AEO groups, 4) control groups, 5) vehicle groups, and 6) carvedilol groups. The hearts have been subjected to ischemia treatment (for 30 min) followed by reperfusion (120 min) for the control group. In other groups, hearts have been perfused with carvedilol (10 µM), vehicle (tween 0.1%), and AEO (0.125, 0.25, or 0.50 µL/g heart) for 5 min. The myocardial dysfunction has been significantly more acute only in group 3 in comparison with the control group. In group 3, the creatine kinase and lactate dehydrogenase activities are reported as the markers of myocardial damage. It is reported that the isolated rat hearts have been perfused with AEO (0.5 µl/g heart), which may spoil the myocardial ischemic-reperfusion damage [285]
Antioxidant Activity
Researchers have reported that NO scavenging activity has been found in methanolic gum extract of asafoetida [235]. Researchers have revealed that the superoxide dismutase (SOD) enzyme activity are reduced in mouse brain tissue in the pentylenetetrazole (PTZ)-induced mouse [304]. The superoxide radical has been formed on the surface of the brain of mouse. The superoxide radical has not been scavenged with asafoetida by enhancing the superoxide dismutase enzyme. In the asafoetida treated groups, MDA (malondialdehyde) level is decreased in comparison with PTZ groups. Asafoetida gum extract is able to reduce the lipid peroxidation and oxidative destruction because of antioxidant activity [469]
Central Nervous System Activity
Some studies proposed that asafoetida acts as a neuroprotective, and nerve stimulative agent [371]. Asafoetida oleo gum resin is able to increase the re-myelination and regeneration, and to reduce the rate of lymphocyte infiltration in the neuropathic tissue in mice. It is proved that monoamine oxidase B (MAO-B) are retarded with asafoetida resin. Asafoetida resin is able to treat the neurodegenerative diseases like Alzheimer’s and Parkinson’s diseases. Furthermore, it is noted that asafoetida showed acetylcholinesterase (AChE) retarding activity in the snail nervous system. It also possessed memory-enhancing activity [459]
Apium graveolens (Celery)
Anti-inflammatory Activity
Researchers have proposed that isolated, and total fractions of celery seed may possess anti-inflammatory activity [524]. The aqueous extract of celery possessed flavonoids like apiin, apigenin, and phenolic acids are responsible for anti-inflammatory activity. It is evidenced that antioxidants like apigenin can reduce the generation of hydrogen peroxide and anti-immunoglobin E-induced histamine salvation. The flavonoids can retard the cyclooxygenase-2 (COX-2) activity. It is reported that coumarins, and phthalides are present in hexane extract of celery are responsible for the anti-inflammatory activity [742]
Antimicrobial Activity
Researchers have evaluated the antimicrobial effect of methylated spirit, methanol, ethanol, and hexane extracts of celery against different bacterial strains like Psteropseda aeruginosa, Staphylococcus aureus, E. coli, Salmonella typhi, and Bacillus subtilis and fungal strains like Candida glaberata, Trchophyton longifusus, Candida albicans, Fusarium solani, and Aspergillus flavus. It is reported that Salmonella typhi, E. coli, Staphylococcus aureus, Bacillus subtilis, and Psteropseda aeruginosa are inhibited effectively by the different celery extracts. While the B. subtilis, and S. typhi are inhibited with the methanolic fraction. The methanolic fraction showed lower inhibitory activity against E. coli. P. aeruginosa is less inhibited with methylated spiritA. flavus is strongly inhibited with the ethanolic fraction of celery [480]
Antioxidant Activity
Methanolic fractions of celery showed the highest antioxidant potential followed by methylated spirit, and ethanolic extract. It is reported that the highest ABTS radical scavenging activity has been possessed by ethanolic fraction followed by the methylated spirit and ethanolic extract [254, 480]
Anti-diabetic Activity
Researchers have analyzed the anti-diabetic activity of celery extract with a few biochemical and hematological parameters in alloxan-induced diabetic rats. 50 adults albino rats have been divided into five equal groups: group 1—control groups (administered with normal saline of 0.5 ml/kg dose), group II—administered with 1 ml of the extract (425 mg/kg BW) for 1 month, group III—2 doses of alloxan (150 mg/kg), group IV—1 ml extract (425 mg/kg BW) injected to treat the diabetic rats for 30 successive days, and group V—14.2 mg/kg of metformin-treated diabetic rats (for 30 successive days). It is reported that the blood glucose level is decreased and insulin secretion, RBC, WBC count, PVC, and the neutrophil percentage are enhanced in diabetic rats with ethanol extract of celery after 1 month of treatment. Therefore, researchers have reported that the celery extract is able to reduce the WBC count, the average value of LDL-C, serum cholesterol, triglyceride, ESR, urea, uric acid, and creatinine in diabetic groups. The anti-diabetic activity of celery extract is similar to that of metformin (a standard drug for treatment of diabetes) [576]
Anti-obesity Activity
Researchers have investigated the anti-obesity activities of celery. Celery seed ethyl acetate fraction (CSEA) (contains p-coumaric acid, and isoferulic acid) showed higher anti-adipogenesis in the 3T3-L1 cells in comparison with the ethanolic extract of celery seed. This may be due to the reduction in adipogenic hormones like adiponectin and leptin. The adipocyte-related transcription factors and gene expression levels including αp2, C/EBPα, and PPAR-gamma are reduced with CSEA [521]
Cardiovascular Activity
Scholars have evaluated the effect of alcoholic, and water extracts of celery on the blood pressure of anesthetized rabbits [12]. It is proposed that the hypotensive effect has been higher in ethanol extract in comparison with aqueous extract. At a dose of 0.3 mg/kg of Atropine can block the hypotensive effect of ethanol extract [344]
Gastrointestinal Activity
Scientists have proposed that the ethanol extract of celery is able to prevent the cytodestructive, and indomethacin agents (25% NaCl, 80% ethanol, and 0.2 M NaOH) induced gastric ulcer. Basal gastric secretion are reduced and gastric mucosa are protected with ethanol extract, which may be due to its antioxidant activity. Tannins, and flavonoids derived from celery are able to treat ulcer [42]
Central Nervous System Activity
Researchers have analyzed the neuroprotective activity of celery. The insilico study has been considered to evaluate the neuroprotective activity of celery. It is reported that Choline present in celery is able to bind the acetylcholinesterase (Ache), Slc5a7, and choline acetyltransferase (Chat). The insilico research showed the activity in the neurotransmitter secretion process, neurotransmitter biosynthesis process, and neurotransmitter metabolic process. It is reported that neuroprotective activity has been found in celery by the interaction of Ache, Slc5a7, and Chat [555]
Capsicum frutescens (Chili)
Antimicrobial Activity
Researchers have evaluated the effect of bell pepper on few foodborne bacteriaSalmonella typgimurium is inhibited with bell pepper extract [174]. It is observed that Listeria monocytogenes, Salmonella typhimurium, Staphylococcus aureus, and Bacillus cereus are inhibited with bell pepper extract. The isopropanol, and water extracts of chili showed anti-bacterial effects, which may be due to the presence of capsaicin in bell pepper. It is recommended that Pseudomonas aeruginosa, and Salmonella found in beef meat are inhibited by isopropanol and aqueous extract of pepperClostridium, Bacillus, and Salmonella sp are inhibited by an aqueous extract of pepper. The antibacterial activity has been found in isopropanol extract against Salmonella typhimurium, Listeria monocytogenes, Staphylococcus aureus, and Bacillus cereus [477]
Anti-inflammatory Activity
At a range of 0–100 µg/mL concentration, the yellow, red, and green chili extracts exhibited anti-inflammatory activity. The anti-inflammatory activity of chili may be due to its free radicals scavenging property [719]
Antioxidant Activity
Researchers have assessed the antioxidant potential of chili through different in vitro methods, namely ABTS, DPPH, and FRAP. The yellow and red chili have possessed the antioxidant potential of 5.18 µmol TE/g fw and 3.89 µmol TE/g fw, respectively, as assessed by ABTS method. The antioxidant activity of green chili (43.29 µmol TE/g fw) has been found greater than red chili (2.82 µmol TE/g fw) as assessed by DPPH method. Similar results have also been reported for green bell (46.36 µmol TE/g fw) and red chili (16.15 µmol TE/g fw) as assessed by FRAP method [719]
Anti-diabetic Activity
Scholars have evaluated the anti-glycation properties of crude methanolic extract of chili. The anti-glycation capability of the water, ethyl acetate, n-hexane, and crude methanolic fractions of chili is higher than that of chloroform fraction. Scholars have proposed that the chili extracts are able to treat complications associated with diabetes [449]
Anti-obesity Activity
Capsaicin derived from chili has been reported for its high-fat diet-induced chronic low-grade inflammation (CLGI) decreasing activity, which may be connected with anti-obesity activity. Capsaicin is able to reduce the amount of glycerol-3-phosphate dehydrogenase (GDPH) activity and intracellular triglyceride in 3T3-L1 adipocytes, to retard the leptin, PPAR-gamma, and C/EBPα expression. 0.075% capsaicin is able to reduce the lipid deposition in epididymal adipose tissue and mesenteric tissue in high-fat diet-induced obese mice. The serum level of glucose, triglycerides, and cholesterol levels are reduced with capsaicin [107]
Cardiovascular Activity
Researchers have evaluated the cardioprotective activity of capsaicin in anesthetized dogs, and rabbits at a dose of 10–300 µg/kg. The induced hypertension is not affected with phentolamine, hexamethonium, and tolazoline in dogs and rabbits. In dogs, the hypotension has been reduced with atropine. The heart rate has not been affected or slightly enhanced in atropine-treated dogs with capsaicin. The contractile force or rate of atria of rabbit, and dog is not affected with capsaicin. In the dog, the constrictive activity of capsaicin is decreased slightly in upper mesenteric arteries. The capsaicin is able to contract the cerebral arterial strips [50]
Gastrointestinal Activity
Researchers have investigated about the digestion provoking activity of chili may be due the presence of capsaicin. The activities of digestive enzymes in the small intestine and pancreas, stimulation of saliva, and secretion of bile have been connected to the digestive stimulatory activity of chili that also augmented the salivary amylase activity. Chili is able to increase the fat absorption, and digestion in high-fat-consumed rats, as reported by researchers. Capsaicin, chili extracts, and other phytochemicals are able to enhance the permeability of intestinal epithelial cells and the rate of gastric emptying. Chili can stimulate the acid secretion, and irritation character. The concentration-dependent cytopathic activity has been observed with chili extracts on oral mucosal fibroblasts. The defensive nature against gastric mucosa damages has been found with capsaicin, and chili extract. Chili is able to defend the gastric mucosa due to the activation of gastrointestinal transient receptor potential vanilloid subtype 1 (TRPV1), antioxidant enzymes, and retardation of inflammatory factors. Capsaicin is capable to treat ulcers by retarding acid secretion. The epigastric pain, fullness, dyspeptic symptoms, nausea, and heartburn are reduced by the administration of capsaicin, and red pepper in heartburn, and dyspeptic patients [784]
Central Nervous System Activity
Scholars have investigated about the neuroprotective activity of phenolic extract of chili, and as an inhibitor of monoamine oxidase and cholinesterase activities. Scholars have evaluated the OH radicals scavenging capabilities, DPPH, and membrane-stabilizing activity of the phenolic extract of chili. The activities may take place may be due to the retardation of Fe2+-induced lipid peroxidation in rat brain tissue. It is reported that the mitochondrial MAO, BChE, and AChE inhibitory activity are found in the phenolic extract of chili. Chili is able to control the neurodegenerative disease like Parkinson’s disease [661]
Pimenta dioica (Allspice)
Anti-inflammatory Activity
Researchers have evaluated the effect of allspice on anti-inflammatory activity. It is reported that the extract of Pimenta dioica (PD) is able to enhance the proinflammatory cytokines IL-6 and TNF-α by 150% and 166%, respectively. Eugenol derived from essential oil of PD is able to modulate the inflammatory response [540]
Antimicrobial Activity
Scholars have examined the essential oil of PD against pathogenic fungi, and bacteria. It is reported that the five bacterial strains, namely P. aeruginosa, E. coli, A. baumannii, and S. aureus, and the yeast such as C. albicans are inhibited with EO extract of PD. The antibacterial effect has been found in EO of allspice against P. aeruginosa and MRSA [260]
Anti-diabetic Activity
It has been reported by researchers that the protein glycation can be retarded with allspice. Therefore, allspice is utilized as a potential anti-diabetic agent [745]
Antioxidant Activity
The antioxidant capacity for the aqueous soluble fraction, dichloromethane extract, and ethyl acetate soluble fraction of allspice has been evaluated through the oil stability index process, and ferric thiocyanate method. The free radical scavenging potential of allspice has been evaluated through DPPH assay [471]. Allspice is able to retard the xanthine oxidase activity by 74.83% [745]
Central Nervous System Activity
The vaso relaxing, and hypotensive activity have been reported for water extract of allspice. The rodents have been considered to evaluate the hypotensive activity of water extract of allspice. It is reported that the aqueous extract of allspice is able to depress the CNS spontaneously in hypertensive rodents. The hypotensive action is not mediated by cholinergic or β-adrenergic ways [902]
Cardiovascular Activity
Researchers have considered the anesthetized normotensive rats to evaluate the hypotensive effect of water, ethanolic extracts of allspice, and various fractions of the aqueous extract. At various doses (30, 70, and 100 mg/kg) of aqueous extracts of allspice have been given to the anesthetized normotensive rats intravenously. It is reported that allspices extracts are able to reduce the mean arterial blood pressure. A dose of 100 mg/kg of the aqueous extract showed the highest hypotensive effect in comparison with the ethanolic extract. The highest hypotensive effect has been reported in the aqueous fraction of allspice [893]
Garcinia indica (Kokum)
Anti-inflammatory Activity
Researchers have evaluated the effect of water extract of Garcinia indica fruit rind (GIE) for anti-inflammatory activity in cotton pellet-induced granuloma, and carrageenan-induced paw edema in rats. The dose of 400 mg/kg, and 800 mg/kg of GIE have been administered to the Wistar rats orally. A dose of 10 mg/kg of diclofenac sodium has been considered as standard drug. Four sterile cotton pellets have been implanted in the ventral portion in the granuloma model in each rat. Pellet implanted rats are administered with diclofenac, and GIE orally for 8 days. The functions of the aspartate transaminase (AST), alkaline phosphatase (ALP), and alanine transaminase (ALT) have been examined from the serum. Rats, which are treated with GIE, decrease the cotton pellet granuloma, and paw edema in comparison with carrageenan treated and cotton pellet implanted rats, respectively. The ALP, AST, and ALT activities attenuated with the treatment of GIE. It has been reported that anti-inflammatory activity has been observed in GIE because of antioxidant potential, and lysosomal membrane stabilization through virtue of its phenolic compounds [677]
Antioxidant Activity
Some investigations showed the effect of ethanolic, and water extracts of kokam for its antioxidant activity in Wistar albino rats. The biochemical parameters such as lipid peroxidation (LPO), sulfoxide dismutase (SOD), glutathione (GSH), and catalase (CAT) have been considered to analyze the antioxidant activity. It has been reported that the methanolic extract of kokam possessed free radical retardation activity. The β-carotene linoleate and DPPH methods have been considered to evaluate the free radical scavenging activity of chloroform extract of kokam. A strong antioxidant property has been found in methanolic extract of kokam in comparison with the standard ascorbic acid. The superoxide anion scavenging function has been reported for garcinol derived from kokum by phenazine methosulphate/ NADH nitroblue tetrazolium method [395]
Gastrointestinal Activity
Researchers have suggested that the ethanolic, and water extracts of kokam possessed ulcer protective activity. It has been reported that the ethanolic and aqueous extracts of kokam possessed ulcer protective properties against HCl/ethanol-induced gastric damage and indomethacin-inducedulcerogenesis. At a dose of 500 mg/kg of ethanolic, aqueous extracts of kokam has been administered to rats orally. It has been reported the ethanolic, and aqueous extracts of kokum are able to decrease ulcer in the HCl/ethanol and indomethacin induced gastric damage in rats [678]
Anti-obesity Activity
The hyperlipidemic effect has been found in methanolic extract of kokam as observed by the researchers in cholesterol-induced hyperlipidemic rat model. It has been reported that the methanolic extract of kokum is able to reduce the LDL-C, total cholesterol, triglycerides, VLDL-C, and to enhance HDL-C. It has been reported that hydroxy citric derived from kokam is able to decrease the body weight, appetite, and retard lipogenesis [557]
Anti-diabetic Activity
Fasting blood glucose level is reduced with kokam extract in streptozotocin-induced hyperglycemic rats. At a dose of 400 mg/kg of water extract of kokum has been administered to rats. It has been reported that the water extract possessed anti-hyperglycemic effect and can enhance the oral glucose tolerance. Garcinol derived from Kokam possessed strong glycation retarding effect as it can reduce the protein glycation in a bovine serum albumin/fructose process [395]
Central Nervous System Activity
The neuroprotective activity has been found in methanolic extract of kokam against 6-hydroxydopamine (6-OHDA), which is an indicator for its anti-Parkinson’s activity in rats. Lipopolysaccharide (LPS) induced anti-inflammatory mediators expression is decreased with garcinol. The anticholinesterase activity has been observed in kokam. The expression of neurofilament proteins and neurite outgrowth are inhibited with cyanidin-3-glucoside [81]
Antimicrobial Activity
Researchers have evaluated the antibacterial effect of the crude methanolic extract of kokam. The doses of 500, and 1000 µg/mL of methanolic extract of kokum have been considered to analyze the antimicrobial activity. At a dose of 500 mg/mL of kokam extract exhibited the highest inhibition against S. aureus, and P. aeruginosa At a dose of 1000 mg/mL of kokam extract exhibited the highest inhibition against S. aureus, and P. aeruginosa. It is reported that the methanol extract of kokam cannot exert any inhibition against E. coli [930]
Cardiovascular Activity
Scholars have studied about the effectiveness of kokum extract on cardiovascular diseases. The values of atherogenic coefficient (AC), atherogenic index of plasma (AIP), and cardiac risk ratio (CRR) have been significantly greater in the group of rats fed with Western diet in comparison with normal groups. The AC, AIP, and CRR levels are normalized with garcinol-enriched fraction (GEF) [532]
Alpinia galangal (Greater galangal)
Anti-inflammatory Activity
Many researchers have evaluated the anti-inflammatory activity of galangal. The p-coumaryl alcohol-γ-O-methyl ether substantially, and selectively reduce the formation of interferon-gamma (IFN-γ) in CD4 + Th (T helper) cells. Hydroxychavicol acetate and acetoxychavicol derived from galangal are able to prevent the inflammatory immune diseases caused through indulgent activation. Galangal is able to reduce the granuloma weight in croton oil-induced granuloma pouch rat model and carrageenan-induced paw inflammation [205]
Anti-diabetic Activity
Researchers have reported that aqueous, and methanolic extracts of galangal have been administered to normal rabbits to evaluate the anti-diabetic activity of galangal. It has been reported that galangal is able to reduce the blood glucose level [39]
Antimicrobial Activity
Scholars have reported that the human immunodeficiency virus type-1 (HIV-1), and human cytomegalovirus (HCMV) are retarded potentially with methanolic extract of galangal. The antimicrobial activity has been observed in the essential oil of galangal. It is evidenced by scholars that ethyl acetate and ether extracts of galangal possessed antibacterial activityStaphylococcus aureus is inhibited by 1,8-cineole derived from galangal. It has been reported that the ethanol extract of galangal exhibited potential inhibitory activity as observed by the broth dilution method against Staphylococcus aureus. Pseudomonas aeruginosa, Klebsiella pneumonia, E. coli, S. aureus, and Streptococcus pyogenes are inhibited with water extract of galangalErysipelothrix rhusiopathiac, Staphylococcus aureus, Streptococcus suis, Pseudomonas aeruginosa, E. coli, Pasteurella multocida, and Arcanobacterium pyogenes are inhibited by essential oil extracted from galangal. The combined effect of α-bisabolene, 1,8-cineole, and 4-allyphenyl acetate derived from galangal are responsible for the antimicrobial activity [744]
Gastrointestinal Activity
The antiulcer activity has been found in galangal, which may be due to the action of cytoprotective, and antisecretory. At a dose of 500 mg/kg of ethanolic extract of galangal is able to decrease the gastric secretion in hypothermic restraint stressing, and pyrrolic ligation rats [53]
Antioxidant Activity
Many studies have proposed that the antioxidant potential has been found in galangal and its isolates. A potential antioxidant property with an IC50 value of 550 µg/ml has been observed in the essential oil of galangal. It has been reported that the aqueous, methanolic extracts and volatile oils exhibited free radical scavenging activity significantly as appeared through the DPPH method. At neutral pH, galangal showed higher antioxidant capacity in comparison with the acidic pH. The reducing power, superoxide anion scavenging activity, and Fe2+ chelating activity have been found in ethanolic extract of galangal in a concentration-related manner. Furthermore, lipoxygenase inhibitor activity has been found in galangal. It is reported that the methanol and dichloromethane (DCM) of galangal possessed antioxidant activity [551]
Anti-obesity Activity
Researchers have investigated the anti-obesity activity of ethanol extract of galangal in a cafeteria diet-fed obese rats. In albino rats, obesity has been induced with a cafeteria diet consumption regularly for 6 weeks. At a dose of 500 mg/kg of ethanol extract of galangal has been administered for 6 weeks regularly. It has been reported that the ethanol extract of galangal is able to reduce the parametrial adipose tissue weight, body weight, energy intake, deposition of hepatic triglycerides, liver weight, leptin, and serum lipid levels. The galangal extract is also able to retard the pancreatic lipase activity [850]
Cardiovascular Activity
Scholars have found the bioactive constituents such as 5-hydroxy-7-(4″-hydroxy-3″-methoxyphenyl)-1-phenyl-3-heptanone, and galangin present in galangal which are capable to exert antioxidant, and anti-inflammatory effect through retarding the COX-2 activity, salvation of histamine, serotonin, and kinin. The LDL level is reduced in the blood with the extracts of galangal [13]. It is reported that galangin can control the cell membrane integrity, can decrease oxidative stress, and is able to improve cardiac systolic/diastolic dysfunction in the cardiac myocytes stressed with doxorubicin induced rats [752]. The galangal juice has been administered to broiler chicken. It has been reported that the galangal juice is able to decrease the level of triglyceride in the broiler bloodstream. For improving cardiovascular problems, the galangal extract has been mixed with Phyllanthus embilica, which is able to reduce the level of circulating LDL-C [224, 227]
Central Nervous System Activity
Scientists have reported that the effectiveness of galangal to stimulate the cognitive activity and to enhance the antioxidant activity, and Na+/K+ATPase, simultaneously it can reduce acetylcholinesterase activity. Therefore, galangal is able to cure the neurodegenerative diseases such as Alzheimer’s, and Parkinson’s disorders [224, 227]
Acorus calamus (Sweet flag)
Central Nervous System Activity
Researchers have evaluated the effect of ethanol extract of Acorus calamus (AC) on monoamine levels of the brain and unconditioned electrical function. It is reported that sweet flag is able to enhance α activity, serotonin level, and the norepinephrine level within the cerebral cortex in rats. Furthermore, sweet flag is able to enhance the dopamine level in the midbrain, and caudate nucleus. Sweet flag showed anti-depressive activity through changing the brain monoamine levels in various brain areas and through altering electrical action. Researchers have conducted a clinical investigation in 50 cases of depression. It is reported that the degree of acute depression is decreased with AC [626]
Anti-inflammatory Activity
Scholars have investigated the anti-inflammatory effect of AC on severe, and chronic treated rat models. Croton oil granuloma pouch inflammatory response, carrageenan-induced paw edema, and cotton pellet granuloma production have been retarded with AC extract orally. The anti-inflammatory activity has been found with AC extract in severe, chronic, and immunologic rat models [976]
Antioxidant Activity
The ethyl acetate extract of AC has been reported to possess antioxidant activity as reported through DPPH method [14]. It is reported that 0.2 g/mL of AC extract exhibited the highest antioxidant effect (86.43%). α-asarone is an active compound of AC has been administered peritoneally before the rats are going to be expressed to noise-stress for 1 month. It has been reported that α-asarone possessed antioxidant activity against sounding-stress-induced alterations in the rat brain [573]
Cardiovascular Activity
Researchers have investigated the effectiveness of AC essential oil to reduce blood pressure. β-asarone and α-asarone derived from sweet flag possessed hypotensive effect as evaluated on the anesthetized dogs. The alcoholic extract of AC showed hypotensive activity on dog. 45 patients with ischemic heart disorders have been considered by researchers. They have been treated with AC extract. It has been reported that AC is able to decrease the body weight, serum cholesterol, SLDL (serum low-density lipoprotein), cure chest pain, improve ECG, and to enhance SHDL (serum high-density lipoproteins) [567]
Gastrointestinal Activity
Scholars have reported that ethanol extract of AC has defended gastroduodenal mucosa and retarded gastric secretion in rats against the damages caused by reserpine, pyloric ligation, indomethacin, and cysteamine administration. A dose of 500 mg/kg of AC extract showed anti-ulcerogenic and anti-secretory effects in rats subjected to reserpine, indomethacin, pyloric ligation, and cysteamine administration. The AC extract possessed protective activity against cytodestructive agents. It is reported that AC is able to treat gastropathy [131]
Antimicrobial Activity
Scientists have reported that Bacillus subtilis, Staphylococcus aureus, E. coli, Bacillus megaterium, Salmonella paratyphi A and B, Salmonella marcescens, Proteus vulgaris, Staphylococcus citreus, and Shigella dysomei have been inhibited with alcohol extract of ACStaphylococcus aureus has been inhibited with the acetate buffer, alcohol, ether, and dilute sulfuric acid extract of ACStreptococcus viridans, Streptococcus pyogenes, Diplococcus pneumoniae, Corynebacterium diphtheriae, E. coli, Salmonella typhi, Salmonella paratyphi A and B, Staphylococcus aureus, and Shigella flexneri have been inhibited with the extract of AC. Antifungal activity has been found in essential oil against A. jumigatis, A. nidulans, Penicillium aculeatum, Phomopsis destuctum, citrus decay pathogens Penicillium digitatum, P. italicum, Diplodia natalensis, Altemaria tenuis, Candida albicans, Epidermophyton cresens, Aspergillus oryzae, and Microsporum gypseumPenicillium selenium, Aspergillus niger, and Saccharomyces (yeast) have been inhibited with alcoholic extract. It is reported that antiviral activity has been observed in alcoholic extract of AC against Herpes simplex virus HSV-1, and HSV-2 [957]
Anti-diabetic Activity
The methanolic extract of sweet flag showed α-glucosidase inhibitory activity. The α-glucosidase inhibitory activity has been measured with IC50 value at 54.90 µg/ml. Standard acarbose has been showed the IC50 value of 39.12 µg/ml for α-glucosidase inhibitory activity. The flavonoids and polyphenols present in the sweet flag are responsible for the anti-diabetic effect [185]
Anti-obesity Activity
Researchers have evaluated the effectiveness of β-asarone in high-fat diet (HFD)-induced obese mice. The β-asarone is able to retard the metabolic transformations and glucose intolerance, to reduce the body weight, cholesterol level in adipose tissue in mice. The lipid-lowering effect has been observed with water extract of sweet flag [844, 845]
Food Industry Application of Selected Spices
Spices and herbs have been used in different food products either in the form of powder, extract, encapsulated material, or in raw form (Table 4). Figure 4 describes the application of spices and herbs in different food systems along with the methods of application
Meat-based Food Product
Green and dried cardamom has been ground, dipped in water, and the hydrodistillation method with the help of clevenger type apparatus has been used to extract the EO. Thereafter, the EO has been applied to the chicken drumsticks to increase its shelf life by 2–3 days [464]. Cardamom seeds have been dried in shade and ground. 500 cc of 80% of ethanol has been added to 100 g of the dried powder and stored at room temperature (220 C) for 1 day. After filtration, the alcohol extract has been dried at 400 C temperature. The extract has been used on lamb meat to increase the quality in terms of flavor, taste, and enhance the shelf life of lamb meat [837]
EOs have been extracted from Zataria Multiflora and Bunium persicum The extracted EOs have been used to produce chitosan-loaded nanoemulsions. The nanoemulsion has been applied to turkey meat to enhance its shelf life up to 15–18 days and to improve its microbial quality [441]. To improve the cholesterol profile and nutrient digestibility of broiler chicks, the dried and milled seeds of Zataria Multiflora and Bunium persicum are used [852]. Nanocellulose, Mentha piperita essential oil, and Bunium persicum essential oil have been mixed at various percentages to prepare a biodegradable active poly-lactic acid composite films to enhance the shelf life of ground beef up to 4–7 days [911]. To improve the nutritional quality of boiler chicken meat, the chicks have been fed with different diet composition where corn-soybean meal-based diet has been taken as control. The other diet compositions are 10 ppm avilamycin + basal diet, 0.25% of cumin powder + basal diet, 0.75% of cumin powder + basal diet, 0.25% of black cumin powder + basal diet, and 0.75% black cumin powder + basal. It has been observed that the basal diet give satisfactory results [823]. The Trachyspermum ammi EO (NTEO), and Bunium persicum EO (NBPEO) have been used to prepare chitosan based nanoemulsions and chitosan based nanoemulsions have been applied to hamburgers to improve its microbial quality [875]. 1–2% of Bunium persicum EO along with tween 80 (emulsifier), and glycerol (plasticizer) have been used to make chitosan films and the films have been applied on chicken fillet to retard its chemical spoilage and to improve its microbial quality [425]
Lambs have been fed with 1.5% FSP (fennel seed powder) and diet without FSP (control) to improve the nutritional composition and to reduce the fat oxidation [351]. EO has been extracted from the fennel seed and applied to chicken thighs to extend its shelf life [417]. Different formulas have been considered with fennel and lettuce powders to reduce the bacterial growth, to improve the aroma and to replace the nitrite in sausage [726]
Dried and powdered poppy seeds have been used to decrease fat content and to improve the sensory scores, pungent flavor, textural attributes, and color feature of buffalo meat cookies [334]. Dried Poppy seeds have been used to prepare poppy paste, the paste has been applied to chevon nuggets to reduce the microbial activity, fat content, and to increase the protein percentage, sensory score, and shelf life [421]. Poppy seeds at different percentages (1, 3, and 5%) have been administered to chevon patties to reduce cholesterol and fat content and to increase the moisture, color, and mineral (Fe, K, Mn, Zn, Ca) profile [645]
Clove extract has been applied to cooked ground beef to decrease its lipid oxidation and to enhance the storage stability and flavor profile of the sample [1003]. The broiler chickens have been fed with diet enriched with clove to improve the physical sensory and microbial characteristics of carcass [899]. The tenderness, moisture content, water holding capacity, and sensory quality of chicken meat has been improved with the application of dried clove powder along with turmeric rhizome [801, 802]. EO derived from clove has been applied to frozen beef patties to improve its sensory quality and to improve oxidative stability [68]. Clove flower EOs and marjoram EOs have been applied to frozen beef patties to enhance oxidative stability, and quality [6]. At 1:5 proportion, clove extract has been applied to fresh beef patties to decrease the lipid, protein oxidation, and hue angle and to improve the quality attributes like elevated chroma value and redness value [90]. 400 mL of 95% of edible ethanol has been added into dried cloves. The mixture has been applied to Chinese-style sausages to retard protein and lipid oxidation, enhance the color, texture, flavor, acceptance, and quality [1013]
Cinnamon and sappan powders and thermoplastic starch have been mixed and extruded to produce active meat packaging film to extend its shelf life [467]. The shelf life of fresh beef has been extended up to15 days through the application of edible film comprised of 0.5, 1, 1.5, and 2% of cinnamon bark EO along with glycerol, and tapioca starch [953]. Nisin and cinnamon EO nanocapsules have been incorporated with sodium alginate coating. The mixture has been applied to beef slices to inhibit microbial growth, decrease lipid oxidation, prolong shelf life up to 15 days, enhance texture, color, odor, juicy characteristic, quality, antioxidant, and sensory properties [1014]. At 4:1 proportion, potassium chloride, carrageenan, and citric acid have been mixed with 0.05% cinnamon EO. The solution has been applied to chicken fillets to reduce the sensory score, and prolong shelf life [456]
0.5% of black pepper has been applied to buffalo meat steaks to increase quality and extend shelf life [575]
1.5% of EO of coriander seeds have been applied to chicken fillet to retard pathogen growth, enhance chemical quality and antioxidant capacity, and extend shelf life [430]
Cellulose acetate film with 500 mg of powdered mustard seeds has been applied to meat product to form moisture-activated antimicrobial film, decrease moisture absorption, and extend shelf life of meat up to 3.68 days [118]
Turmeric and alginate have been applied to chicken, pork, and beef to enhance its storage stability, quality, and to decrease the lipid oxidation. The mixture has improved the shelf life for chicken, and pork up to 12 days, while the shelf life of beef has been extended to 16 days [155]. Dried turmeric rhizomes powder has been applied to broiler chicks to enhance its quality, and marketability [612]. Turmeric and black pepper extracts have been applied to chicken breast fillet to reduce lipid oxidation and proteolysis, to control bacterial count, and to extend shelf life up to 16 days [218]. Acetone solution has been applied to extract curcumin. 200 mL of acetone has been added to10 g of turmeric powder. The solution has been applied to chicken and fish meat to alter color from yellow to reddish brown, to decrease water solubility, and to improve the water absorptivity [283]
Powder of sage and laurel leaves have been applied to cooked meatballs to reduce peroxide value, to enhance sensory characteristic and acceptance, and to extend shelf life [37]. Hydrodistillation by Clevenger-type apparatus has been used to extract EOs from rosemary and bay leaves. The EOs have been applied to minced maronesa beef to enhance pH, decrease microbial load, improve color, and extend the shelf life [970]
Onion peel extract has been applied to ground beef meat to delay protein and lipid oxidation and to inhibit the growth of pathogenic bacteria [618]
The fenugreek seed powder has been applied to rabbit sausage to lower lipid oxidation and to improve antioxidant capacity [1006]
Dairy Based Food Product
Raw bay leaves and cardamom powder have been applied to labneh to increase the physiochemical, sensory, and microbiological properties and shelf life up to 30 days [921]
100 g of dried Bunium persicum seed EOs has been applied to gouda cheese to reduce lipid oxidation, to retard the growth of gram-positive and gram-negative microorganisms, and to enhance shelf life [806]
Phenolic-enriched extracts of dried fennel seeds have been applied to cottage cheese to enhance antioxidant activity and shelf life up to 14 days [169]. 250 g of aqueous extract of ajwain and fennel seeds has been applied to processed cheese to enhance microbial stability, shelf life, flavor, and acceptance [577]. The water extract of dried fennel seeds has been applied to probiotic yogurt to improve texture, flavor, enhance protection, and bioactive components [99]. EOs have been extracted from Petroselinum crispum and fennel; the EOs have been applied to steamed yogurts to improve its nutritional qualities, physicochemical characteristics, texture, acidity, and taste and to extend the shelf life up to 29 days [356]
The eugenol-lean fraction of clove buds has been applied to mayonnaise to reduce thermal and non-thermal creaming, homogenous, enhance color intensity, reduce power, and enhance antioxidant potential and phenolic content [190]
The EOs of cinnamon bark and black pepper have been applied to traditional African yoghurt to inhibit bacterial propagation [662]
Cardamom and black pepper powder have been applied to paneer to enrich its phenolic profile and to extend shelf life [112]
0.9 wt.% of cellulose nanofibers (CNFs) and 30wt.% of turmeric have been mixed together. The solution has been applied to yoghurt to enhance the color quality and sensory characteristics and to reduce the syneresis [341]. Aqueous extract of curcumin has been applied to milk food product to enhance chemical stability, bioaccessibility, and bioactivity and improve human health [309]. Water extract of turmeric has been applied to yoghurt to enhance nutrient composition, pH, alter color from white to yellowish-orange, reduce carbohydrate, protein content, increase vitamins, minerals, inhibit microbial activity, and acceptance of the product [580]. Water extract of raw turmeric slices have been applied to buffalo milk paneer to increase nutritional, health properties, and quality of the product [884]. In distilled water, 0.50% of lecithin, 4% of curcumin, and an emulsifier have been dissolved to formulate thick emulsion. The emulsion has been applied to kulfi to enhance sensory characteristics (flavor, color, appearance, taste), acceptance, and lower microbial load [841, 843]. Water extract of 5% raw turmeric has been applied to paneer to improve the hardness, cohesiveness, elasticity, gumminess, and chewiness [461]. Nanoemulsified curcumin has been applied to Pelibuey sheep milk to enhance antioxidant potential, TPC, appearance, color, odor, beneficial health effect [807]. The EOs extracted from turmeric has been applied to Cokelek Cheese to inhibit microbial growth, and to reduce the weight loss [437]
Water–ethanol extract of 100 g of star anise has been applied to milk to inhibit bacterial growth, delay spoilage, and to improve the keeping quality of the final product [727]
At the 1:10 proportion, water extract of dill has been applied to yogurt to enhance antioxidant capacity, TPC, acidity, acceptability, nutritional value, and taste, and to lower the water content of the product [938]
The Moringa oleifera and fenugreek seed flours have been applied to buffalo yogurt to enhance the viability of yogurt culture, TPC, antibacterial effect, minerals, functional properties, and nutritional value [250]
At the proportion of 1:5, the olive oil has been added into chili pepper powder; the prepared extract has been applied to Gouda cheese to enhance its quality, to reduce stiffness, and to extend its shelf life [474]
Cereal-based Food Product
The hydro-distillation process with the help of Clevenger-type apparatus has been operated for 3 h at 1000 C to extract EOs of thyme flower shoots, and black cumin seeds. The extracted oils have been applied to corn starch to retard the propagation of food pathogens, and to extend its shelf life [75]
Cinnamon powder has been applied to bread to enhance loaf volume by 2%, acceptability, phenolic content, antioxidant potential, to inhibit mold growth, and to extend shelf life up to 6 days [251]
Black pepper flour has been applied to snack food product to increase the nutritional profile, flavor profile, mineral profile, and the marketability product [17]
Coriander EOs have been applied to wheat, and wheat product to inhibit fungal growth [160]
Turmeric rhizome powder has been applied to biscuits to enhance the nutritional quality, protein content, and antioxidant activity [16]. Turmeric rhizome powder has been applied to Moin-Moin to lower the microbial count [34]. Korean turmeric rhizomes powder has been applied to cake, and wheat flour dough to enhance the antioxidant capacity, and curcumin content [683]. 0.35 g of turmeric extract has been applied to breakfast cereal to enhance antioxidant capacity, curcuminoid content, and TPC [516]
Water extract of 1 g of saffron has been applied to cookies to improve antioxidant activity, enhance sensory properties, increase acceptance, and shelf life [144]
onion powder has been applied to wheat pasta to enhance nutritional value, flavonoids, total dietary fiber, TPC, and antioxidant activity [596]
Germinated fenugreek seed powder has been applied to bread, and biscuits to improve flour quality, nutritional quality, mineral content, acceptability, to reduce gluten content [915]. Water extract of fenugreek seed has been applied to Injera to enhance crude fiber, crude protein, minerals, crude fat content, and to lower the microbial growth [327]. Fenugreek EO has been applied to pearl millet to enhance tendril break, tensile power, melting enthalpy, thermal transition temperatures, morphological properties, surface softness, to retard microbial growth, to increase mechanical, obstacle properties, quality, and prolonged shelf life [253]. Water extract of germinated fenugreek seed has been applied to wheat flour, and biscuits to enhance sensory, chemical properties, and to prevent degenerative disorders [268]
Fruit and Vegetable-based Food Product
Clove EO, and mustard EO have been applied to strawberries to retard fungal growth [24]
Hexane extract of sage, and bay leaves has been applied to fried potato to improve antioxidant activity, and to extend shelf life [670]
Ethanol extract of 40 g of saffron petals has been applied to fresh-cut cucumber to enhance physical properties, quality, to reduce spoilage, and to extend the shelf life [359]
The methanol fraction of dill has been applied to dried fruit extracts to enhance antioxidant capacity, TPC [918]
Miscellaneous Food Product
80% of ethanol extracts of Marrubium vulgare, Physalis alkekengi, Alcea rosea, and Bunium persicum seeds have been applied to mushroom tyrosinase to retard mushroom tyrosinase [638]
Fennel seed powder has been applied to herbal candy to improve the nutritional value, acceptance, and other physicochemical properties [418]
Nanotechnology Application of Spices
Different types of spices like cardamom, black jeera, fennel, poppy, clove, turmeric, bay leaves, fenugreek, etc. are along with some specific solvent such as zinc acetate solution, silver nitrate solution, chitosan solution, etc. are the key elements to synthesize metal, and polymer nanoparticles, zinc oxide nanoparticles, silver nanoparticles, gold nanoparticles, selenium nanoparticles, and polymer nanoparticles which have several health benefits like antioxidant, anti-carcinogenic, anti-diabetic, cytotoxicity activity, enzyme retardation effect, antimicrobial activity, dye decolorization effect, and catalytic activity. A complete discussion on nanoparticles synthesis with the help of different types of spices using various methods and its beneficial applications are portrayed in Fig. 5 and Table 5
Zinc Oxide Nanoparticles
The pure green cardamoms have been cleaned many times and air dried. To produce ZnONPs, 0.2 M zinc acetate solution has been added to 2.2 g of cardamom powder dissolved in 50 ml deionized water and stirred on a magnetic stirrer till dissolve. At 800 C, 5 g of green cardamoms have been boiled in deionized water for 20 min to obtain the purified extract. The produced nanoparticle has been analyzed for its antimicrobial, and anticancer activity [676]
10 mg of fennel seed powder has been soaked in 50 mL of deionized water for 24 h. To the extract 250 mL of deionized water, 41.3 mg of ZnO has been added, the mixture has been placed in an incubator at 990 C. Dark yellow-colored ZnONPs has been formed. The purified ZnONPs has been analyzed for its cytotoxic activity and antimicrobial activity [61]P. anisum and fennel seeds powdered have been dissolved in 800 mL of distilled water and stored in a refrigerator for 1 day. The extract has been used to assess the liver functionality test [127]
5 g of coriander seeds or leaves have been mixed with zinc acetate solution to synthesize ZnO-NPs. The ZnO-NPs have been evaluated for its TFC and TPC content [867]. 90 mL, 1 mM zinc oxide solution has been added into 10 mL of Coriander oleoresin extract to produce ZnO-NPs. The ZnO-NPs have been analyzed for its antibacterial effect, and cytotoxic activity [695]. Water extract of turmeric rhizome has been mixed with Zn acetate solution to prepare ZnONPs. The ZnONPs have been assessed for its antioxidant potential, anti-carcinogenic effect, trypan blue dye exclusion, colony developing, nitrite, and caspase effects [393]
To synthesize ZnONPs, NH4OH, and zinc acetate dehydrates have been added to fenugreek seeds. The prepared ZnONPs have been measured for its capability of seedling growth [192]
The Pure sweet flag rhizome has been mixed with 0.1% of mercuric chloride, and 1 mM of zinc acetate solution to form ZnONPs. The ZnONPs have been estimated for its antimicrobial effect, and cytotoxicity activity [954]
Gold Nanoparticles
To prepare AuNPs, 30 mL of 2.5 × 10–4 M boiling HAuCl4 solution was mixed with 1 mL cardamom seed extract. The synthesized AuNPs have been evaluated for their anticarcinogenic effect, antioxidant, and antibacterial activities [733]
To synthesize Au-NPs, methanol, and alcoholic extracts of black cumin have been mixed with various proportions of 1 mM HAuCl4 The prepared Au-NPs have been analyzed for its urease retardation activity, enzyme retardation, antifungal, antibacterial activities, xanthine oxidase effect, and carbonic anhydrase function [117]
Water extract of 25 mg of cinnamon has been added to 100 µL of 0.1 M NaAuCl4 solution to synthesize AuNPs. The AuNPs have been assessed for their cytotoxicity activity and prostate cancer diminishing activity [186]
30 mg of turmeric rhizome has been added with 2 mL of 10 mM NaOH solution and 1 mL of 1 mM HAuCl4 solution to produce AuNPs. The AuNPs have been measured for their cytotoxic activity [886]
The water extract of fenugreek seeds has been mixed with 2.5 mg of HAuCl4 solution to form AuNPs. The AuNPs have been evaluated for their antioxidant activity [324]
The water extract of sweet flag rhizomes has been mixed with gold chloride solution to synthesize the greenish-yellow to pale pink Acorus calamus gold nanoparticles. The Acorus calamus gold nanoparticles have been evaluated for its antimicrobial activity [820]
Silver Nanoparticles
40 mL of aqueous silver nitrate solution (0.14, 0.16, 0.18, 0.20, and 0.22 g) have been mixed with 10 ml of cardamom seed extract to synthesize the AgNPs. The AgNPs have been evaluated for their antibacterial effects [835]
90 ml of silver nitrate has been mixed with 10 ml of fennel seed extract to produce AgNPs, which have been analyzed for its antibacterial effect [409]
Clove extract- AgNPs have been synthesized with clove bud powder and aqueous 1 mM AgNO3 solution. The Clove extract- AgNPs have been assessed for its antiviral effect, micro hemagglutination, and cytotoxicity activity [592]
10 ml of the fennel seed extract has been mixed with 90 ml of 1 mM silver nitrate solution to prepare AgNPs. The AgNPs have been measured for its anti-viral activity against influenza virus subtype H7N3 and cytotoxicity [292]
To synthesize of AgNPs, AgNO3 has been mixed with 100 mL cassia bark aqueous extract. The AgNPs have been estimated for its capacity to reduce blood glucose level, improve the histopathology of the liver, and kidney tissue conditions [483]
10 ml of black pepper has been mixed with 90 ml of 1 mM silver nitrate solution to form AgNPs. The AgNPs have been evaluated for its anti-carcinogenic effect [486]
To synthesize silver nanoparticles, 100 ml of 0.1 N AgNO3 solution has been mixed with 50 ml of coriander seed extract to evaluate the antimicrobial effects of AgNPs [648]. 10 mL of 0.5 M of aqueous AgNO3 solution has been added into coriander extract to synthesize AgNPs to observe its antibacterial activity [543]. 100 ml of 1 mM AgNO3 solution has been mixed with 20 ml of coriander seed extract to synthesize AgNPs for its antibacterial activity [813]. 99.5 ml of water and 0.5 ml of Coriander oleoresin have been mixed with 1 M of silver nitrate solution to synthesize AgNPs, which have been evaluated for its antioxidant potential [319]. 10 g of coriander seed powder has been mixed with 45 mL of 1 × 10–3 M of AgNO3 solution to synthesize AgNPs to observe its antimicrobial effect, anti-biofilm activity and plasmid curing effect [349]
Nutmeg seed and bark were cleaned continuously with deionized water, dried, and powdered. For biosynthesis of silver nanoparticles, 1 mM of silver nitrate solution has been mixed with 10 g of nutmeg seed powder, which has been done to evaluate the antibacterial activity of AgNPs [408]
Water extract obtained from 5 g of black mustard seed has been mixed with 1 mM of silver nitrate solution. The AgNPs have been evaluated for its antimicrobial effect [680]
AgNO3 solution has been added to turmeric powder to prepare AgNPs and then the AgNPs have been evaluated for its antibacterial effect [943]. 10 ml of curcumin extract has been added to 100 ml of 1 mM silver nitrate to synthesize yellow to yellowish-brown color silver nanoparticles. The nanoparticles have been evaluated for its cytotoxic activity [313]. 6.8 g of curcumin powder or organic turmeric powder has been added to 100 mL of Milli-Q water to make water extract of turmeric powder. To synthesize AgNPs, 2 mL of aqueous extract of turmeric powder has been added to 8 mL of 1 mM AgNO3 solution. The AgNPs have been evaluated for its antibacterial effect [62]. To prepare AgNPs, 1 mM of silver nitrate has been mixed with turmeric rhizome extract. The nanoparticles have been evaluated for its antimicrobial effects [608]. 250 µL of 20 mM curcumin has been dissolved in DMSO, and 2.5 mL AgNO3 to synthesize cAgNPs. The cAgNPs have been evaluated for its antiviral activities [996]. To decrease the curcumin particle size, the filtrate was sonicated in ultrasonicator at 20 kHz frequency for around 20 min. To prepare silver nanoparticles, 20 g of the turmeric powder has been mixed with silver salts. The synthesized AgNPs has been estimated for its anti-carcinogenic effect of AgNPs [365]. Curcumin solution has been added to 75 ml of 1 mM of silver nitrate solution to synthesize AgNPs to observe its antibacterial effect [249]. 1 mL of turmeric extract has been added to 100 mL of 1 mM AgNO3 water solution to produce AgNPs, which have been evaluated for their antioxidant potential, antibacterial activity, cell viability, and hemocompatibility [128]
10 mL of the water extract of bay leaves has been mixed with 50 mL solution of AgNO3 to prepare AgNPs. The AgNPs have been analyzed for its radical scavenging activity [433]
1 mM AgNO3 has been added to 10 ml of the water extract of fenugreek seed to prepare silver nanoparticles, and its antimicrobial activity has been measured [708]
Selenium Nanoparticles
173 mg of sodium selenite salt has been homogenized in 90 mL of deionized water. The mixture has been mixed with 10 mL of fennel seed extract to synthesize 100 mL of selenium nanoparticles to observe its toxicity, and the capability to prevent arthritis [84]
Water extract of fenugreek seed has been added with 1 mM selenium dioxide solution to synthesize SeNPs. The SeNPs have been evaluated for their tumoricidal activity [267]
Carbon Dots Nanoparticles
0.5 g of fine clove powder has been dissolved in 30 mL of water (hydrothermal synthesis) to synthesize carbon dot nanoparticles. The nanoparticles have been evaluated for its antioxidant effect, catalytic, and cytotoxicity effect [495, 498]
Quantum Dot Nanoparticles
600 mg of curcumin has been added to 10 g of zirconia beads in 15 ml of ethanol to synthesis curcumin quantum dots and then tested it for its antimicrobial activity [764]
Fennel seed has been passed through single-step thermal decomposition method to prepare mono-disperse carbon quantum dots. The quantum dots have been analyzed for its photoluminescence [214]
To synthesize graphene quantum dots, fenugreek β-amylase, glutaraldehyde, and aminopropyltriethoxysilane have been used. The graphene quantum dots have been assessed for its biochemical, thermodynamic, and kinetic properties [23]
Polymeric Nanoparticles
To synthesize gelatin nanoparticles, 200–500 mg of gelatin has been mixed with 150 g of cardamom powder. The gelatin nanoparticles have been evaluated to observe its capacity to prevent Glioblastoma disease [649]
The equal amounts of aqueous tripolyphosphate solution and chitosan solution have been added together to ethanol extract of 50 g of fennel seed to synthesize chitosan nanoparticles and then the nanoparticles are tested for its peroxide value, total volatile nitrogen, microbial activity, and sensory attributes [549]
To synthesize chitosan nanoparticles, the water extract of 30 g of clove has been mixed with 1 gm of chitosan solution. After that, 0.5 g of sodium tripolyphosphate has been poured into the solution. The chitosan nanoparticles have been analyzed for its biochemical, and insecticidal effect [271]
2% of shellac powder has been mixed with ethanol extract of 10 g of cassia bark to synthesize colloidal nanoparticles and then the nanoparticles have been tested for its encapsulation efficiency, loading potential, TPC, antioxidant activity [623]. Ethanol extract of 100 g of oregano and cassia bark have been mixed with chitosan solution to synthesize core/shell nanoparticles and then the nanoparticles have been examined for its cytotoxic effect, and mitochondrial transmembrane capacity [423]
NaBH4 solution has been mixed with turmeric powder to synthesize magnetic nanoparticles and then the nanoparticles have been tested for its capacity to obtain curcuminoids, and free phenolic acids [550]. To synthesize curcumin silk fibroin nanoparticles, 0.5 g of silk fibroin (SF) has been mixed with an SF-ionic liquid solution. The curcumin silk fibroin nanoparticles have been evaluated for its free radical scavenging activity and cytotoxic activity [613]. To synthesize nanocurcumin, ethanol extract of curcumin powder has been dissolved into water. The nanocurcumin has been assessed for its antimicrobial effect [833]. To prepare curcumin-loaded chitosan phosphate nanoparticles, the curcumin has been mixed with chitosan solution. The antimicrobial effect, and cytotoxic activity of curcumin-loaded chitosan phosphate nanoparticles have been analyzed [236]. To synthesize curcumin-encapsulated nanoparticles, chitosan solution, curcumin, and TPP have been mixed together. The curcumin-encapsulated nanoparticles have been measured for their stability and hemocompatibility [960]. 5 g of cassava starch has been mixed with 50 mL of 3.16 M sulphuric acid solution to produce starch nanoparticles. The cytotoxic activity, antioxidant activity, and cellular absorption of the synthesized nanoparticles have been observed [96]. To synthesize PBCANPs, 0.1% of chitosan has been dissolved in HCl,0.01% of curcumin powder and 100 µL of BCA monomer have been added to the solution. The PBCANPs have been evaluated for their anti-tumor activity [262]
Conclusion
Spices are gaining interest in terms of functional food formulation, as a source of new drug molecule, in biotechnological industries as a source of novel bioactive components and effective source of functional nanoparticles. Phenolic acids, flavonoids, organic acids, alkaloids, tannins, and health-beneficial pigments are found in spices abundantly. Synthetic antioxidants may possess detrimental health effect, which can be replaced with natural antioxidants that are present in different spices. The application of synthetic and costly antioxidants is reduced which provides health problems and toxicity. Spices are produced mostly in the economically backward countries or in the developing countries; therefore, it is obvious that spices are not only significant in terms of human health development, or in the field of biotechnology, it is also an aid to improve the economy of the countries. The 24 spices expressed in this article are achieving worth financially and improving the lifestyle of the stakeholders associated with the harvesting and post-harvest administration of the spices. In this article, 24 spices have been covered; it has been found that most of the spices have been explored for their bioactive, health-beneficial effects, and functional food development potential, whereas some of them are yet to be searched for their food fortification potential, e.g., sweet flag and galangal have not been explored for their food fortification potential. Most of the spices considered in this article are seasonal in nature. Therefore, adequate preservation methods need to be searched to overcome the issue of seasonal availability of spices described. Spices may be used for a source of natural food pigment. The inedible portions of the spices may be utilized as a source of natural colorant and novel bioactive compounds. Therefore, the wastage parts or inedible portions of the spices can be utilized as a source of natural pigment, and bioactive extraction. Carbon dot-, quantum dot-, metal-, and polymer-based nanoparticles are prepared with several spices like asafoetida, cardamom, black jeera, fennel, fenugreek, poppy, clove, turmeric, bay leaves, sweet flag, etc., using different methods such as green or biogenic synthesis. These nanoparticles possess different health-beneficial potentials like antioxidant, anti-carcinogenic, anti-diabetic, enzyme retardation effect, and antimicrobial activity. The nanoparticles have also been analyzed for their cytotoxic effect. The synthesized nanoparticles possess a significant role in environmental pollution management as some of the nanoparticles hold dye decolorization activity
Data Availability
All relevant data are within the paper
Code Availability
Not applicable
References
Abbasi, B., Daniali, M., Ramezani, H., Derakhshande, M., & Ghiasvand, R. (2018). The effect of Bunium persicum on gastrointestinal symptoms and inflammatory mediators in irritable bowel syndrome patientsIslamic Azad University Science and Research Branch, 1(1), 43–46
Abbassi, A., Mahmoudi, H., Zaouali, W., M’Rabet, Y., Casabianca, H., & Hosni, K. (2018). Enzyme-aided release of bioactive compounds from coriander (Coriandrum sativum L.) seeds and their residue by-products and evaluation of their antioxidant activityJournal of Food Science and Technology, 55(8), 3065–3076https://doi.org/10.1007/s13197-018-3229-4
Abd El-Razek, M. H., Ohta, S., Ahmed, A. A., & Hirata, T. (2001). Sesquiterpene coumarins from the roots of Ferula assa-foetidaPhytochemistry, 58(8), 1289–1295https://doi.org/10.1016/S0031-9422(01)00324-7
Abd Elhamid, E. M., Sadak, M. S., & Tawfik, M. M. (2016). Physiological response of Fenugreek plant to the application of proline under different water regimesResearch Journal of Pharmaceutical, Biological and Chemical Sciences, 7(3), 580–594
Abdallah, E. M. (2018). Black pepper fruit (Piper nigrum L.) as antibacterial agent: A mini-reviewJournal of Bacteriology & Mycology: Open Access, 6(2)https://doi.org/10.15406/jbmoa.2018.06.00192
Abdel-Aziz, M. E., & Morsy, N. F. S. (2015). Keeping quality of frozen beef patties by marjoram and clove essential oilsJournal of Food Processing and Preservation, 39(6), 956–965https://doi.org/10.1111/jfpp.12309
Abdellah, A. M., Sliem, M. A., Bakr, M., & Amin, R. M. (2018). Green synthesis and biological activity of silver-curcumin nanoconjugatesFuture Medicinal Chemistry, 10(22), 2577–2588https://doi.org/10.4155/fmc-2018-0152
Abdellatif, A. A. H., Mahmood, A., Alsharidah, M., Mohammed, H. A., Alenize, S. K., Bouazzaoui, A., Al Rugaie, O., Alnuqaydan, A. M., Ahmad, R., Vaali-Mohammad, M. A., Alfayez, M., Traiki, T. B., Al-Regaiey, K. A., Ali, A. T., Hassan, Y. A. H., & Abdulla, M. H. (2022). Bioactivities of the green synthesized silver nanoparticles reduced using Allium cepa L aqueous extracts induced apoptosis in colorectal cancer cell linesJournal of Nanomaterials, 2022https://doi.org/10.1155/2022/1746817
Abdelsalam, N. R., Fouda, M. M. G., Abdel-Megeed, A., Ajarem, J., Allam, A. A., & El-Naggar, M. E. (2019). Assessment of silver nanoparticles decorated starch and commercial zinc nanoparticles with respect to their genotoxicity on onionInternational Journal of Biological Macromolecules, 133, 1008–1018https://doi.org/10.1016/j.ijbiomac.2019.04.134
Abirami, B., Silva, D., Abinaya, D., Praveenkumar, D., Vinothkumar, A., Saravanan, G., & Achiraman, S. (2017). Biosynthesis of silver nanoparticles derived Acorus calamus rhizome extract and their biomedical applicationJournal of Advanced Applied Scientific Research
Abootalebi, S. N., Mousavi, S. M., Hashemi, S. A., Shorafa, E., Omidifar, N., & Gholami, A. (2021). Antibacterial effects of green-synthesized silver nanoparticles using Ferula asafoetida against acinetobacter baumannii isolated from the hospital environment and assessment of their cytotoxicity on the human cell linesJournal of Nanomaterials, 2021https://doi.org/10.1155/2021/6676555
Aboud, N. S., Hussein, N. J., & Al-Musawi, H. K. (2014). Studying the therapeutic effect of watery &alcoholic extracts extract of Apium graveolens leaves on urinary tract infections caused by Staphylococcus aureus in rabbitsJournal of Babylon University, 22(22), 779–788https://www.researchgate.net/publication/334657403
Achuthan, C. R., & Padikkala, J. (1997). Hypolipidemic effect of Alpinia Galanga (Rasna) and Kaempferia Galanga (Kachoori)Indian Journal of Clinical Biochemistry, 12(1), 55–58https://doi.org/10.1007/BF02867956
Acuña, U. M., Atha, D. E., Ma, J., Nee, M. H., & Kennelly, E. J. (2002). Antioxidant capacities of ten edible North American plantsPhytotherapy Research, 16(1), 63–65https://doi.org/10.1002/ptr.1031
Adahoun, M. A., Al-Akhras, M. A. H., Jaafar, M. S., & Bououdina, M. (2017). Enhanced anti-cancer and antimicrobial activities of curcumin nanoparticlesArtificial Cells, Nanomedicine and Biotechnology, 45(1), 98–107https://doi.org/10.3109/21691401.2015.1129628
Adegoke, G. O., Makinde, O., Falade, K. O., & Uzo-Peters, P. I. (2017). Extraction and characterization of antioxidants from framomum melegueta and Xylopia aethiopicaEuropean Food Research and Technology, 216(6), 526–528https://doi.org/10.1007/s00217-003-0683-6
Adelekan, E. O., Adegunwa, M. O., Adebowale, A. A., Bakare, H. A., & Alamu, E. O. (2019). Quality evaluation of snack produced from black pepper (Piper nigrum L.), plantain (Musa paradisiaca L.), and tigernut (Cyperus esculentus L.) flour blendsCogent Food and Agriculture, 5(1)https://doi.org/10.1080/23311932.2019.1614285
Adibzadeh, P., & Motakef-kazemi, N. (2018). Preparation and characterization of curcumin-silver nanoparticle and evaluation of the effect of poly ethylene glycol and temperatureJournal of Nanoanalysis, 5(3), 156–162
Afshari, M., Pazoki, A., & Sadeghipour, O. (2022). Biochemical changes of coriander ( Coriandrum sativum L. ) plants under drought stress and foliar application of salicylic acid and silicon nanoparticlesJournal of Medicinal Plants and By-Products
Agarwal, R., Gupta, S. K., Agrawal, S. S., Srivastava, S., & Saxena, R. (2008). Oculohypotensive effects of Foeniculum vulgare in experimental models of glaucomaIndian Journal of Physiology and Pharmacology, 52(1), 77–83
Agbogidi, O. M., & Azagbaekwe, O. P. (2013). Health and Nutritional Benefits of Nut Meg (Mystica Fragrans Houtt.)Scientia Agriculturae, 1(2), 40–44http://pscipub.com/Journals/Data/JList/ScientiaAgriculturae/2013/Volume1/Issue2/2.pdf
Agrawal, S., Yallatikar, T., & Gurjar, P. (2019). Brassica nigra: Ethnopharmacological review of a routinely used condimentCurrent Drug Discovery Technologies, 16, 40–47
Agrawal, D. C., Yadav, A., Kesarwani, R., Srivastava, O. N., & Kayastha, A. M. (2020). Immobilization of fenugreek β-amylase onto functionalized graphene quantum dots (GQDs) using Box-Behnken design: Its biochemical, thermodynamic and kinetic studiesInternational Journal of Biological Macromolecules, 144, 170–182https://doi.org/10.1016/j.ijbiomac.2019.12.033
Aguilar-González, A. E., Palou, E., & López-Malo, A. (2015). Antifungal activity of essential oils of clove (Syzygium aromaticum) and/or mustard (Brassica nigra) in vapor phase against gray mold (Botrytis cinerea) in strawberriesInnovative Food Science and Emerging Technologies, 32(September), 181–185https://doi.org/10.1016/j.ifset.2015.09.003
Ahmad, A., Husain, A., Mujeeb, M., Khan, S. A., Alhadrami, H. A. A., & Bhandari, A. (2015). Quantification of total phenol, flavonoid content and pharmacognostical evaluation including HPTLC fingerprinting for the standardization of Piper nigrum Linn fruitsAsian Pacific Journal of Tropical Biomedicine, 5(2), 101–107https://doi.org/10.1016/S2221-1691(15)30152-0
Ahmadi, F., Ghasemi-Kasman, M., Ghasemi, S., Tabari, M. G., Pourbagher, R., Kazemi, S., & Alinejad-Mir, A. (2017). Induction of apoptosis in HeLa cancer cells by an ultrasonic-mediated synthesis of curcumin-loaded chitosan-alginate-STPP nanoparticlesInternational Journal of Nanomedicine, 12, 8545–8556https://doi.org/10.2147/IJN.S146516
Ahmed, ASh., Uddin, A. Q., Kumar, S. A., & Parveen, J. (2017). Evaluation of in vitro antidiabetic and antioxidant characterizations of Elettaria cardamomum (L.) Maton (Zingiberaceae), Piper cubeba L. f. (Piperaceae), and Plumeria rubra L. (Apocynaceae)Pakistan Journal of Pharmaceutical Sciences, 30(1), 113–126
Ahmed, B., Dwivedi, S., Abdin, M. Z., Azam, A., Al-Shaeri, M., Khan, M. S., Saquib, Q., Al-Khedhairy, A. A., & Musarrat, J. (2017). Mitochondrial and chromosomal damage induced by oxidative stress in Zn2+ ions, ZnO-bulk and ZnO-NPs treated Allium cepa rootsScientific Reports, 7(January), 1–14https://doi.org/10.1038/srep40685
Ahmed, B., Shahid, M., Khan, M. S., & Musarrat, J. (2018). Chromosomal aberrations, cell suppression and oxidative stress generation induced by metal oxide nanoparticles in onion (Allium cepa) bulbMetallomics, 10(9), 1315–1327https://doi.org/10.1039/c8mt00093j
Ahmed, L. I., Ibrahim, N., Abdel-Salam, A. B., & Fahim, K. M. (2021). Potential application of ginger, clove and thyme essential oils to improve soft cheese microbial safety and sensory characteristicsFood Bioscience, 42, 101177https://doi.org/10.1016/j.fbio.2021.101177
Ahmed, R. M., Alshafei, N., & Mohamed, H. A. (2022). Green method of synthesis silver nanoparticles as using fenugreek seeds extract ( Trigonella foenum-graecum ) and its application as antibacterial agentUniversity of Bahri Journal of Veterinary Sciences, 1(1), 8–14
Ahuja, K, D, K., Robertson, I, K., & Geraghty, D, P., Ball, M, J. (2006)Effects of chili consumption on postprandial glucose, insulin, and energy metabolismhttps://doi.org/10.1093/ajcn/84.1.63
Airaodion, A. I., Akaninyene, I. U., Ngwogu, K. O., Ekenjoku, J. A., & Ngwogu, A. C. (2020). Hypolipidaemic and antidiabetic potency of Allium cepa (onions) bulb in alloxan-induced diabetic ratsActa Scientifci Nutritional Health, 4(3), 01–08https://doi.org/10.31080/asnh.2020.04.0648
Ajayi, O. A., & Segun-Taiwo, B. A. (2021). Effect of turmeric (Curcuma longa) spice on nutrititional, microbial content of moin-moin and efficacy of spice against selected foodborne pathogensAfrican Journal of Agriculture and Food Science, 4(3), 28–40https://doi.org/10.52589/ajafs-8vinvy88
Ajenu, C., & Imhontu, E. (2021). Comparative evaluation of the proximate and micro-nutritional benefits of pawpaw, carrots, turmeric and coconutJournal of Food Technology & Nutrition Sciences, 1–5https://doi.org/10.47363/jftns/2021(3)124
Ajitha, B., Reddy, Y. A. K., Lee, Y., Kim, M. J., & Ahn, C. W. (2019). Biomimetic synthesis of silver nanoparticles using Syzygium aromaticum (clove) extract: Catalytic and antimicrobial effectsApplied Organometallic Chemistry, 33(5)https://doi.org/10.1002/aoc.4867
Akcan, T., Estévez, M., & Serdaroğlu, M. (2017). Antioxidant protection of cooked meatballs during frozen storage by whey protein edible films with phytochemicals from Laurus nobilis L. and Salvia officinalisLWT - Food Science and Technology, 77, 323–331https://doi.org/10.1016/j.lwt.2016.11.051
Akhlaghi, F., Rajaei, Z., Hadjzadeh, M. A. R., Iranshahi, M., & Alizadeh, M. (2012). Antihyperglycemic effect of asafoetida (Ferula assafoetida oleo-gum-resin) in streptozotocin-induced diabetic ratsWorld Applied Sciences Journal, 17(2), 157–162
Akhtar, M. S., Khan, M. A., & Malik, M. T. (2002). Hypoglycaemic activity of Alpinia galanga rhizome and its extracts in rabbitsFitoterapia, 73(7–8), 623–628https://doi.org/10.1016/S0367-326X(02)00235-6
Akinola, A. A., Ahmad, S., & Maziah, M. (2014). Total anti-oxidant capacity, flavonoid, phenolic acid and polyphenol content in ten selected species of Zingiberaceae rhizomesAfrican Journal of Traditional Complementary Alternative Medicine, 11(3), 7–13
Aksoy, L. (2013). Oxidant/antioxidant equilibrium in rats supplemented with diesel fuel or with opium poppy (Papaver somniferum L.) seed oil biodieselRevue de Medecine Veterinaire, 164(1), 34–38
Al-Asmari, A. K., Athar, M. T., & Kadasah, S. G. (2017). An updated phytopharmacological review on medicinal plant of Arab region: Apium graveolens LinnPharmacognosy Reviews, 11(21), 13–18https://doi.org/10.4103/phrev.phrev_35_16
Al-Ghamdi, A. Y. (2019). Antimicrobial and catalytic activities of green synthesized silver nanoparticles using bay laurel (Laurus nobilis) leaves extractJournal of Biomaterials and Nanobiotechnology, 10(01), 26–39https://doi.org/10.4236/jbnb.2019.101003
Al-Hadid, K. J. (2017). Quantitative analysis of antimicrobial activity of Foeniculum vulgare. A reviewPlant OMICS, 10(1), 28–36https://doi.org/10.21475/poj.10.01.17.322
Al-Ma’adhedi, S. H. F. (2012). Phytochemical screening, estimation of some heavy metals concentrations, and specific extraction of bioactive components from Iraqi Anethum graveolens l. seeds and studying their AntibacterialAl-Anbar Journal of Veterinary Sciences, 5(2), 28–36
Al-Mariri, A., Ismail, R., Allaham, A., Alobeid, B., & Alhallab, L. (2021). Inhibitory effects of essential oils of Cinnamon zeylanicum and Myristica fragrans against Brucella abortus 544 inoculated in fresh baladi cheeseJournal of Food Quality and Hazards Control, 8(1), 34–40https://doi.org/10.18502/JFQHC.8.1.5461
Al-Numair, K. S., Ahmad, D., Ahmed, S. B., & Al-Assaf, A. H. (2007). Nutritive value, levels of polyphenols and anti-nutritional factors in Sri Lankan cinnamon (Cinnamomum Zeyalnicum) and chinese cinnamon (Cinnamomum cassia)Food Science & Agriculture Research Center, 154(154), 5–21
Al-Saif, S. S. A. L., Awad, M. A., & Siddiqui, M. I. (2018). Formation, characterization and pathogen activities of green synthesis of curcuma silver nanoparticlesJournal of Computational and Theoretical Nanoscience, 15(4), 1300–1306https://doi.org/10.1166/jctn.2018.7306
Al-Samydai, A., Al-Mamoori, F., Shehadeh, M., & Hudaib, M. (2018). Anti-diabetic activity of cinnamon : A reviewInternational Research Journal of Pharmacy and Medical Sciences, 1(5), 43–45
Al-Snafi, A. E. (2015). Therapeutic properties of medicinal plants: a review of their immunological effects (part 1)Asian Journal of Pharmaceutical Research, 5(3), 208–216
Al-Snafi, P. D. A. E. (2016). A review on chemical constituents and pharmacological activities of Coriandrum sativumIOSR Journal of Pharmacy (IOSRPHR), 06(07), 17–42https://doi.org/10.9790/3013-067031742
Al-Zuhair, H., El-Sayeh, B., Ameen, H. A., & Al-Shoora, H. (1996). Pharmacological studies of cardamom oil in animalsPharmacological Research, 34(1–2), 79–82https://doi.org/10.1006/phrs.1996.0067
Al-Yahya, M. A., Rafatullah, S., Mossa, J. S., Ageel, A. M., Al-Said, M. S., & Tariq, M. (1990). Gastric antisecretory, antiulcer and cytoprotective properties of ethanolic extract of Alpinia galanga willd in ratsPhytotherapy Research, 4(3), 112–114https://doi.org/10.1002/ptr.2650040308
Alam, T., Akbar, F., Ali, M., Munis, M. F. H., & Khan, J. (2019). Biosynthesis of iron oxide nanoparticles via Crocus sativus and their antifungal efficacy against verticillium wilt pathogen verticillium dahliaeBioRxiv, 861401
Alejandro Celis Toledo, O., Sharifi-Rad, J., Sufiyan Fazal, S., & Singla, R. K. (2012). Review on the pharmacognostical & pharmacological characterization of Apium graveolens linn related papers Apium graveoleons a healt h boon Ravi kant Apium plant s: beyond simple food and phyt opharmacological applicat ions review on the pharmacognostical. In Indo Global Journal of Pharmaceutical Sciences (Vol. 2, Issue 1)
Alejo-Armijo, A., Altarejos, J., & Salido, S. (2017). Phytochemicals and biological activities of laurel tree (Laurus nobilis)Natural Product Communications, 12(5), 743–757https://doi.org/10.1177/1934578x1701200519
Alghuthaymi, M. A., Diab, A. M., Elzahy, A. F., Mazrou, K. E., Tayel, A. A., & Moussa, S. H. (2021). Green biosynthesized selenium nanoparticles by cinnamon extract and their antimicrobial activity and application as edible coatings with nano-chitosanJournal of Food Quality, 2021https://doi.org/10.1155/2021/6670709
Alhumaydhi, F. A., Khan, I., Rauf, A., Qureshi, M. N., Aljohani, A. S. M., Khan, S. A., Khalil, A. A., El-Esawi, M. A., & Muhammad, N. (2021). Synthesis, characterization, biological activities, and catalytic applications of alcoholic extract of saffron (Crocus sativus) flower stigma-based gold nanoparticlesGreen Processing and Synthesis, 10(1), 230–245https://doi.org/10.1515/gps-2021-0024
Aliakbari-Baydokhty, M., Marziyeh Saghebjoo, H. S., & Hedayati, M. (2019). The effect of endurance training and hydroalcoholic extract of Anethum Graveolens L. (dill) on biochemical cardiovascular risk factors in obese male ratsJournal of Basic Research in Medical Science, 6(4), 1–11
Alquraidi, A. O., Mosa, K. A., & Ramamoorthy, K. (2019). Phytotoxic and genotoxic effects of copper nanoparticles in coriander (Coriandrum sativum—apiaceae)Plants, 8(1), 19https://doi.org/10.3390/plants8010019
Alsalhi, M. S., Devanesan, S., Atif, M., Alqahtani, W. S., Nicoletti, M., & Del Serrone, P. (2020). Therapeutic potential assessment of green synthesized zinc oxide nanoparticles derived from fennel seeds extractInternational Journal of Nanomedicine, 15, 8045–8057https://doi.org/10.2147/IJN.S272734
Alsammarraie, F. K., Wang, W., Zhou, P., Mustapha, A., & Lin, M. (2018). Green synthesis of silver nanoparticles using turmeric extracts and investigation of their antibacterial activitiesColloids and Surfaces B: Biointerfaces, 171, 398–405https://doi.org/10.1016/j.colsurfb.2018.07.059
Alshehri, A. A., & Malik, M. A. (2019). Biogenic fabrication of znonps using trigonella foenum-graecum for proficient photocatalytic degredation of methylene blue under uv irradiationJournal of Materials Science Materials in Electronics, 30, 16156–16173
Altaf, M., Manoharadas, S., & Zeyad, M. T. (2021). Green synthesis of cerium oxide nanoparticles using Acorus calamus extract and their antibiofilm activity against bacterial pathogensMicroscopy Research and Technique, 84(8), 1638–1648https://doi.org/10.1002/jemt.23724
Althomali, R. H., Alamry, K. A., Hussein, M. A., Khan, A., & Alosaimi, A. M. (2021). A green nanocomposite based modified cellulose/TiO2/Cinnamon bark for the reduction of toxic organic compounds using spectrophotometric techniqueJournal of Materials Research and Technology, 12, 947–966https://doi.org/10.1016/j.jmrt.2021.03.002
Altinkaynak, C., Ildiz, N., Baldemir, A., Ozdemir, N., Yilmaz, V., & Ocsoy, I. (2019). Synthesis of organic-inorganic hybrid nanoflowers using Trigonella foenum-graecum seed extract and investigation of their anti-microbial activityDerim, 36(2), 159–167
Alves de Figueiredo Sousa, H., Gonçalves de Oliveira Filho, J., Egea, M. B., Rosada Silva, E., Macagnan, D., Pires, M., & Peixoto, J. (2019). Active film incorporated with clove essential oil on storage of banana varietiesNutrition and Food Science, 49(5), 911–924https://doi.org/10.1108/NFS-09-2018-0262
Alves, P. I. C., Radünz, M., Borges, C. D., Bastos, C. P., Timm, C. D., & Gandra, E. A. (2021). Antimicrobial potential of a bioactive coating based on chitosan incorporated with clove essential oil in hamburger-like meat productResearch, Society and Development, 10(11), e73101119373https://doi.org/10.33448/rsd-v10i11.19373
Alwhibi, M. S., Soliman, D. A., Awad, M. A., Rizwana, H., & Marraiki, N. A. (2018). Biosynthesis of silver nanoparticles using fenugreek seed extract and evaluation of their antifungal and antibacterial activitiesJournal of Computational and Theoretical Nanoscience, 15(4), 1255–1260https://doi.org/10.1166/jctn.2018.7301
Amalraj, A., & Gopi, S. (2017). Biological activities and medicinal properties of Asafoetida: A reviewJournal of Traditional and Complementary Medicine, 7(3), 347–359https://doi.org/10.1016/j.jtcme.2016.11.004
Aman, A. K., Singh, R. K., Kumar, R., & Ghosh, A. K. (2018). Effect of high energy ball milling grinding on physico-chemical, morphological and optical properties of Curcuma longa nanoparticles powdersInternational Journal of Pharmaceutical Sciences and Research, 9(2), 672–677https://doi.org/10.13040/IJPSR.0975-8232.9(2).672-77
Ambhore, S. S., Padghan, P. V., Thombre, B. M., & Jamadar, K. S. (2020). Studies on turmeric powder ( Curcuma Longa L. ) added gheeThe Pharma Innovation Journal, 9(12), 9–14
Amenta, V., Aschberger, K., Arena, M., Bouwmeester, H., Botelho Moniz, F., Brandhoff, P., Gottardo, S., Marvin, H. J. P., Mech, A., Quiros Pesudo, L., Rauscher, H., Schoonjans, R., Vettori, M. V., Weigel, S., & Peters, R. J. (2015). Regulatory aspects of nanotechnology in the agri/feed/food sector in EU and non-EU countriesRegulatory Toxicology and Pharmacology, 73(1), 463–476https://doi.org/10.1016/j.yrtph.2015.06.016
Amer, S. A., & Rizk, A. E. (2022). Production and evaluation of novel functional extruded corn snacks fortified with ginger, bay leaves and turmeric powderFood Production, Processing and Nutrition, 4(1)https://doi.org/10.1186/s43014-022-00083-3
Aminzare, M., Hashemi, M., Hassanzadazar, H., Amiri, E., & Abbasi, Z. (2017). Antibacterial activity of corn starch films incorporated with Zataria multiflora and Bonium persicum essential oilsAnnual Research and Review in Biology, 19(1)https://doi.org/10.9734/ARRB/2017/37103
Anand, P., Murali, K. Y., Tandon, V., Chandra, R., & Murthy, P. S. (2007). Preliminary studies on antihyperglycemic effect of aqueous extract of Brassica nigra (L.) Koch in streptozotocin induced diabetic ratsIndian Journal of Experimental Biology, 45(8), 696–701
Angelita, A. (2016). Characterization of edible films prepared from base formulations and cinnamon extract on anise oil as natural antimicrobial and application as edible coating to strawberryUniversitas Pelita Harapan
Anitha, M. L., Jose, R., Rinita, J., Jothi, N. S. N. (2020). Green synthesis of trigonella foenum graecum mediated iron nanoparticles by co precipitation methodThe Journal of Chemical Physics
Anitha, M. L., Riya, J., Rinita, J., Eunice, P. C., & Jothi, N. S. N. (2021). Facile green synthesis and characterisation of gold nanoparticles using fenugreek seeds and honeyJournal of Physics: Conference Series, 2070(1)https://doi.org/10.1088/1742-6596/2070/1/012048
Anjana, G., Roy, A., Rajeshkumar, S., & Ezhilarasan, D. (2020). Cassia oleoresin mediated synthesis of magnesium oxide nanoparticles and brine shrimp lethality assayJournal of Pharmaceutical Research International, August, 75–82https://doi.org/10.9734/jpri/2020/v32i1530628
Antala, B. V., Patel, M. S., Bhuva, S. V., Gupta, S., Rabadiya, S., & Lahkar, M. (2012). Protective effect of methanolic extract of Garcinia indica fruits in 6-OHDA rat model of Parkinson’s diseaseIndian Journal of Pharmacology, 44(6), 683–687https://doi.org/10.4103/0253-7613.103242
Anvarinezhad, M., Javadi, A., & Jafarizadeh-Malmiri, H. (2020). Green approach in fabrication of photocatalytic, antimicrobial, and antioxidant zinc oxide nanoparticles - Hydrothermal synthesis using clove hydroalcoholic extract and optimization of the processGreen Processing and Synthesis, 9(1), 375–385https://doi.org/10.1515/gps-2020-0040
Araújo, C., & Leon, L. L. (2001). Biological Activities of Curcuma longa L. In Mem Inst Oswaldo Cruz (Vol. 96, Issue 5)
Arif, A., Bhatti, A., & John, P. (2019). Therapeutic potential of Foeniculum vulgare mill. Derived selenium nanoparticles in arthritic Balb/c miceInternational Journal of Nanomedicine, 14, 8561–8572https://doi.org/10.2147/IJN.S226674
Armellini, R., Peinado, I., Pittia, P., Scampicchio, M., Heredia, A., & Andres, A. (2018). Effect of saffron (Crocus sativus L.) enrichment on antioxidant and sensorial properties of wheat flour pastaFood Chemistry, 254, 55–63https://doi.org/10.1016/j.foodchem.2018.01.174
Aruna, G., & Baskaran, V. (2010). Comparative study on the levels of carotenoids lutein, zeaxanthin and β-carotene in Indian spices of nutritional and medicinal importanceFood Chemistry, 123(2), 404–409https://doi.org/10.1016/j.foodchem.2010.04.056
Asgarpanah, J. (2012). Phytochemistry, pharmacology and medicinal properties of Coriandrum sativum LAfrican Journal of Pharmacy and Pharmacology, 6(31), 2340–2345https://doi.org/10.5897/ajpp12.901
Ashokkumar, K., Murugan, M., Dhanya, M. K., Pandian, A., & Warkentin, T. D. (2021). Phytochemistry and therapeutic potential of black pepper [Piper nigrum (L.)] essential oil and piperine: a reviewClinical Phytoscience, 7(1)https://doi.org/10.1186/s40816-021-00292-2
Ashokkumar, K., Murugan, M., Dhanya, M. K., & Warkentin, T. D. (2020). Botany, traditional uses, phytochemistry and biological activities of cardamom [Elettaria cardamomum (L.) Maton] – A critical review. In Journal of Ethnopharmacology (Vol. 246). Elsevier Ireland Ltdhttps://doi.org/10.1016/j.jep.2019.112244
Ashrafuzzaman Zahid, M., Seo, J. K., Parvin, R., Ko, J., & Yang, H. S. (2019). Comparison of butylated hydroxytoluene, ascorbic acid, and clove extract as antioxidants in fresh beef patties at refrigerated storageFood Science of Animal Resources, 39(5), 768–779https://doi.org/10.5851/kosfa.2019.e67
Asif, M., Yehya, A. H. S., Al-Mansoub, M. A., Revadigar, V., Ezzat, M. O., Khadeer Ahamed, M. B., Oon, C. E., Murugaiyah, V., Abdul Majid, A. S., & Abdul Majid, A. M. S. (2016). Anticancer attributes of Illicium verum essential oils against colon cancerSouth African Journal of Botany, 103, 156–161https://doi.org/10.1016/j.sajb.2015.08.017
Aslam Bhatti, H., Khan, S., Faizi, S., Abbas, G., Ali, I., Jawaid, S., Naushir Akbar Ali, A., Jamy, R., Shahid, F., Ali Versiani, M., & Dar, A. (2017). Protocatecheuic acid underlies the antioxidant activity exhibited by Illicium verum fruitJournal of Analytical & Pharmaceutical Research, 6(3)https://doi.org/10.15406/japlr.2017.06.00177
Assadpour, E., Jafari, S. M., & Maghsoudlou, Y. (2017). Evaluation of folic acid release from spray dried powder particles of pectin-whey protein nano-capsulesInternational Journal of Biological Macromolecules, 95, 238–247https://doi.org/10.1016/j.ijbiomac.2016.11.023
Assiry, A. A., Karobari, M. I., Bhavikatti, S. K., & Marya, A. (2021). Crossover analysis of the astringent, antimicrobial, and anti-inflammatory effects of Illicium verum/star anise in the oral cavityBioMed Research International, 2021, 3–8https://doi.org/10.1155/2021/5510174
Aswathy Aromal, S., & Philip, D. (2012). Green synthesis of gold nanoparticles using Trigonella foenum-graecum and its size-dependent catalytic activitySpectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 97, 1–5https://doi.org/10.1016/j.saa.2012.05.083
Athira, G. K., & Jyothi, A. N. (2014). Preparation and characterization of curcumin loaded cassava starch nanoparticles with improved cellular absorptionInternational Journal of Pharmacy and Pharmaceutical Sciences, 6(10), 171–176
Attia, A. A., Ramdan, H. S., Al-Eisa, R. A., Adle Fadle, B. O. A., & El-Shenawy, N. S. (2021). Effect of saffron extract on the hepatotoxicity induced by copper nanoparticles in male miceMolecules, 26(10)https://doi.org/10.3390/molecules26103045
Attila, B., Muste, S., Pop, A., & Ucean, A. P. Ă. (2021). Valorization Of tomato pomace in innovative food products and evaluation of synergetic effect with Mentha piperita l. and Anethum graveolens l -a comprehensive reviewHop and Medicinal Plants, 1, 164–172
Atwaa, E. S. H., Shahein, M. R., El-Sattar, E. S. A., Hijazy, H. H. A., Albrakati, A., & Elmahallawy, E. K. (2022). Bioactivity, physicochemical and sensory properties of probiotic yoghurt made from whole milk powder reconstituted in aqueous fennel extractFermentation, 8(2), 52https://doi.org/10.3390/fermentation8020052
Awad, M. A. A., Hendi, A., Ortashi, K. M., Alzahrani, B., Soliman, D., Alanazi, A., Alenazi, W., Taha, R. M., Ramadan, R., El-Tohamy, M., AlMasoud, N., & Alomar, T. S. (2021). Biogenic synthesis of silver nanoparticles using Trigonella foenum-graecum seed extract: Characterization, photocatalytic and antibacterial activitiesSensors and Actuators A: Physical, 323, 112670https://doi.org/10.1016/j.sna.2021.112670
Aydemir, T., & Becerik, S. (2011). Phenolic content and antioxidant activity of different extracts from ocimum basilicum, apium graveolens and lepidium sativum seedsJournal of Food Biochemistry, 35(1), 62–79https://doi.org/10.1111/j.1745-4514.2010.00366.x
Ayelén Vélez, M., Cristina Perotti, M., Santiago, L., María Gennaro, A., & Hynes, E. (2017). Bioactive compounds delivery using nanotechnology: Design and applications in dairy foodNutrient Delivery, 221–250https://doi.org/10.1016/b978-0-12-804304-2.00006-8
Ayışığı, M., Yalçın, T., & Yıldız Aktaş, L. (2019). Antimicrobial potentials of phyto-synthesized silver nanoparticles from Laurus nobilis LCelal Bayar Üniversitesi Fen Bilimleri Dergisi, 15(3), 317–321https://doi.org/10.18466/cbayarfbe.582161
Azad, R., Delwar, A., Surya, B., Michael, T., Tieneke, T., & Sanjaya, T. (2019)Market analysis of cumin seed. 1–14https://crcna.com.au/resources/publications/market-analysis-cumin-seed
Azizian-Shermeh, O., Valizadeh, M., Taherizadeh, M., & Beigomi, M. (2020). Phytochemical investigation and phytosynthesis of eco-friendly stable bioactive gold and silver nanoparticles using petal extract of saffron (Crocus sativus L.) and study of their antimicrobial activitiesApplied Nanoscience (Switzerland), 10(8), 2907–2920https://doi.org/10.1007/s13204-019-01059-5
Azizian, H., Rezvani, M. E., Esmaeili, D. M., & Bagheri, S. M. (2012). Anti-obesity, fat lowering and liver steatosis protective effects of ferula asafoetida gum in type 2 diabetic rats posiible involvement of leptinIranian Journal of Diabetes and Obesity, 4(3), 120–126
Azlan, A., Sultana, S., Huei, C. S., & Razman, M. R. (2022). Antioxidant, anti-obesity, nutritional and other beneficial effects of different chili pepper: A reviewMolecules, 27(3), 1–11https://doi.org/10.3390/molecules27030898
Babapour, H., Jalali, H., Nafchi, A. M., & Jokar, M. (2022). Effects of active packaging based on potato starch / nano zinc oxide / fennel ( Foeniculum vulgare miller ) essential oil on fresh pistachio during cold storageJournal of Nuts, 13(February)https://doi.org/10.22034/jon.2022.1941353.1129
Badami, R. C., Razdan, M. K. (1972). Isolation and identification of L- leucine as DNP-L- leucine hydrochloride in the leaves of garcinia indicaIndian Chem Soc Journal
Badgujar, S. B., Patel, V. V., & Bandivdekar, A. H. (2014). Foeniculum vulgare mill: A review of its botany, phytochemistry, pharmacology, contemporary application, and toxicologyBioMed Research Internationalhttps://doi.org/10.1155/2014/842674
Badihi, L., Gerami, M., Akbarinodeh, D., Shokrzadeh, M., & Ramezani, M. (2021). Physio-chemical responses of exogenous calcium nanoparticle and putrescine polyamine in Saffron (Crocus sativus L.)Physiology and Molecular Biology of Plants, 27(1), 119–133https://doi.org/10.1007/s12298-020-00923-x
Badola, R., Danish, M., Kumar, S., Fahad, M., Kanade, P. P., Upadhayay, S., Kohli, D., & Rautela, I. (2018). Effect of incorporation of black pepper and cardamom on quality characteristics of paneerInternational Journal of Applied Science and Engineering, 6(2), 121–127https://doi.org/10.30954/2322-0465.2.2018.4
Bagavan, A., Rahuman, A. A., Kamaraj, C., Elango, G., Zahir, A. A., Jayaseelan, C., Santhoshkumar, T., & Marimuthu, S. (2011). Contact and fumigant toxicity of hexane flower bud extract of Syzygium aromaticum and its compounds against Pediculus humanus capitis (Phthiraptera: Pediculidae)Parasitology Research, 109(5), 1329–1340https://doi.org/10.1007/s00436-011-2425-1
Bagheri, S. M., Hedesh, S. T., Mirjalili, A., & Dashti-R, M. H. (2016). Evaluation of anti-inflammatory and some possible mechanisms of antinociceptive effect of Ferula assa foetida oleo gum resinJournal of Evidence-Based Complementary and Alternative Medicine, 21(4), 271–276https://doi.org/10.1177/2156587215605903
Bagherzade, G., Tavakoli, M. M., & Namaei, M. H. (2017). Green synthesis of silver nanoparticles using aqueous extract of saffron (Crocus sativus L.) wastages and its antibacterial activity against six bacteriaAsian Pacific Journal of Tropical Biomedicine, 7(3), 227–233https://doi.org/10.1016/j.apjtb.2016.12.014
Bagyalakshmi, B., Priyadarshini, S. L., & Balamurugan, A. (2019). Anticancer activity of bee venom against lung cancer cell line ( A549 Cells ) enhanced by iron oxide nanoparticles synthesized from syzygium aromaticumJournal of Drug Delivery and Therapeutics Open, 9, 248–254
Bahattab, O., Khan, I., Bawazeer, S., Rauf, A., Qureshi, M. N., Al-Awthan, Y. S., Muhammad, N., Khan, A., Akram, M., Islam, M. N., & Bin Emran, T. (2021). Synthesis and biological activities of alcohol extract of black cumin seeds (Bunium persicum)-based gold nanoparticles and their catalytic applicationsGreen Processing and Synthesis, 10(1), 440–445https://doi.org/10.1515/gps-2021-0041
Bahmid, N. A., Dekker, M., Fogliano, V., & Heising, J. (2021). Development of a moisture-activated antimicrobial film containing ground mustard seeds and its application on meat in active packaging systemFood Packaging and Shelf Life, 30(August), 100753https://doi.org/10.1016/j.fpsl.2021.100753
Bährle-Rapp, M. (2007). Syzygium aromaticumSpringer Lexikon Kosmetik Und Körperpflege, 541–541https://doi.org/10.1007/978-3-540-71095-0_10277
Balakrishnan, S., Sivaji, I., Kandasamy, S., Duraisamy, S., Kumar, N. S., & Gurusubramanian, G. (2017). Biosynthesis of silver nanoparticles using myristica fragrans seed extract and its antibacterial activity against multidrug resistant salmonella enterica serovarEnvironmental Science and Pollution Research, 24, 14758–14769
Balakumbahan, R., Rajamani, K., & Kumanan, K. (2010). Acorus calamus: an overviewJournal of Medicinal Plants Research, 4(25), 2740–2745http://www.academicjournals.org/JMPR
Baldo, D. E. B., Serrano, J. E., Diomerl, C., & Baldo, E. B. (2016). Screening for intestinal anti-inflammatory activity of Alpinia galanga against acetic acid-induced colitis in Mice (Mus musculus). ~ 72 ~Journal of Medicinal Plants Studies, 4(1), 72–77
Balfour, H. (1857)The Plants of the Bible. Trees and Shrubs
Mounyt,B., Moulay, S., & Saad, I. (2016). Methods for in vitro evaluating antimicrobial activity: A reviewJournal of Pharmaceutical Analysis, 6(6), 17–79https://ac.els-cdn.com/S2095177915300150/1-s2.0-S2095177915300150-main.pdf?_tid=98fc0310-a3c9-45ad-a705-f4789eae18fd&acdnat=1552489821_3bebd92b334682aa98528a548985b3fd
Bano, F., Ahmed, A., Ahmed, M., & Parveen, T. (2015). Anethum graveolens seeds aqueous extract stimulates whole brain 5-hydroxytryptamine metabolism and reduces feeding behavior and body weight in obese ratsPakistan Journal of Pharmaceutical Sciences, 28(1), 221–225
Bansal, S., Sharma, K., Gautam, V., Lone, A. A., Malhotra, E. V., Kumar, S., & Singh, R. (2021). A comprehensive review of Bunium persicum: A valuable medicinal spiceFood Reviews International, 00(00), 1–20https://doi.org/10.1080/87559129.2021.1929305
Barakat, A. (2019). Ameliorating role of Foeniculum vulgare (fennel) and Pimpinella anisum (anise) against Zinc oxide nanoparticles induced hepatotoxicity in male albino ratsJournal of Bioscience and Applied Research, 5(3), 262–277https://doi.org/10.21608/jbaar.2019.146878
Barbinta-Patrascu, M. E., Gorshkova, Y., Ungureanu, C., Badea, N., Bokuchava, G., Lazea-Stoyanova, A., Bacalum, M., Zhigunov, A., & Petrovič, S. (2021). Characterization and antitumoral activity of biohybrids based on turmeric and silver/silver chloride nanoparticlesMaterials, 14(16), 4726https://doi.org/10.3390/ma14164726
Barla, A., Topçu, G., Öksüz, S., Tümen, G., & Kingston, D. G. I. (2007). Identification of cytotoxic sesquiterpenes from Laurus nobilis LFood Chemistry, 104(4), 1478–1484https://doi.org/10.1016/j.foodchem.2007.02.019
Barros, L., Carvalho, A. M., & Ferreira, I. C. F. R. (2010). The nutritional composition of fennel (Foeniculum vulgare): Shoots, leaves, stems and inflorescencesLWT - Food Science and Technology, 43(5), 814–818https://doi.org/10.1016/j.lwt.2010.01.010
Barua, C. C., Haloi, A., Sen, S., & Barua, I. (2015). Evaluation of gastric ulcer protective activity of Acorus calamus linn. in laboratory animalsMedicinal Plants: Phytochemistry, Pharmacology and Therapeutics, May
Baskararaj, S., & Kunjiappan, S. (2019). Biogenic synthesis of Garcinia indica mediated gold nanoparticles for enhanced anticancer activity on human hepatoma cell lines Biogenic synthesis of Garcinia indica mediated gold nanoparticles for enhanced anticancer activity on human hepatoma cell linesIPMN, February
Basri, A. M., Taha, H., & Ahmad, N. (2017). A review on the pharmacological activities and phytochemicals of Alpinia officinarum (Galangal) extracts derived from bioassay-guided fractionation and isolationPharmacognosy Reviews, 11(21), 43–56https://doi.org/10.4103/phrev.phrev_55_16
Batiha, G. E. S., Alkazmi, L. M., Wasef, L. G., Beshbishy, A. M., Nadwa, E. H., & Rashwan, E. K. (2020). Syzygium aromaticum l. (myrtaceae): traditional uses, bioactive chemical constituents, pharmacological and toxicological activitiesBiomolecules, 10(2), 202https://doi.org/10.3390/biom10020202
Batool, S., Khera, R. A., Hanif, M. A., & Ayub, M. A. (2020). Bay leafMedicinal Plants of South Asia, January
Bawazeer, S., Khan, I., Rauf, A., Aljohani, A. S. M., Alhumaydhi, F. A., Khalil, A. A., Qureshi, M. N., Ahmad, L., & Khan, S. A. (2022). Black pepper (Piper nigrum) fruit-based gold nanoparticles (BP-AuNPs): Synthesis, characterization, biological activities, and catalytic applications - A green approachGreen Processing and Synthesis, 11(1), 11–28https://doi.org/10.1515/gps-2022-0002
Behbahani, B. A., Shahidi, F., Yazdi, F. T., Mortazavi, S. A., & Mohebbi, M. (2017). Use of Plantago major seed mucilage as a novel edible coating incorporated with Anethum graveolens essential oil on shelf life extension of beef in refrigerated storageInternational Journal of Biological Macromolecules, 94, 515–526https://doi.org/10.1016/j.ijbiomac.2016.10.055
Ben- Nun, L. (2022). Health effects of dillMedical Research in Biblical Times
Ben Abdesslem, S., Ben Moussa, O., Boulares, M., Elbaz, M., Chouaibi, M., Ayachi, S., & Hassouna, M. (2020). Evaluation of the effect of fennel (Foeniculum vulgare Mill) essential oil addition on the quality parameters and shelf-life prediction of yoghurtInternational Journal of Dairy Technology, 73(2), 403–410https://doi.org/10.1111/1471-0307.12667
Benítez, V., Mollá, E., Martín-Cabrejas, M. A., Aguilera, Y., López-Andréu, F. J., Cools, K., Terry, L. A., & Esteban, R. M. (2011). Characterization of industrial onion wastes (Allium cepa L.): dietary fibre and bioactive compoundsPlant Foods for Human Nutrition, 66(1), 48–57https://doi.org/10.1007/s11130-011-0212-x
Benkeblia, N. (2004). Antimicrobial activity of essential oil extracts of various onions (Allium cepa) and garlic (Allium sativum)LWT - Food Science and Technology, 37(2), 263–268https://doi.org/10.1016/j.lwt.2003.09.001
Bhanger, M. I., Bukhari, S. B., & Memon, S. (2008). Antioxidative activity of extracts from a fenugreek seedsPakistan Journal of Analytical and Environmental Chemistry, 9(2), 6
Bhat, A. A., Kumar, A., & Kaur, M. (2016). Effect of clove oil on the oxidative stability and microbial quality of almond and walnut enriched chevon nuggetsJournal of Pure and Applied Microbiology, 10, 1341+https://link.gale.com/apps/doc/A481650224/AONE?u=anon~11b2e98a&sid=googleScholar&xid=feea037b
Bhat, N. A., Hamdani, A. M., & Masoodi, F. A. (2018). Development of functional cookies using saffron extractJournal of Food Science and Technology, 55(12), 4918–4927https://doi.org/10.1007/s13197-018-3426-1
Bhat, S. (2013). Nutrient composition of coriander leaf and seeds as per usdaNational Nutrition Data Base
Bhat, S. P., Rizvi, W., & Kumar, P. A. (2021). Analgesic and anti-inflammatory activity of Brassica nigra l. seed analgesic and anti-inflammatory activity of Brassica nigra l. seedInternational Journal of Drug Formulation and Research, 5(5)
Bhattacharya, E., Pal, U., Dutta, R., Bhowmik, P. C., & Mandal Biswas, S. (2022). Antioxidant, antimicrobial and DNA damage protecting potential of hot taste spices: A comparative approach to validate their utilization as functional foodsJournal of Food Science and Technology, 59(3), 1173–1184https://doi.org/10.1007/s13197-021-05122-4
Bhatti, H. N., Zafar, F., & Jamal, M. A. (2010). Evaluation of phenolic contents and antioxidant potential of methanolic extracts of green cardamom (Elettaria cardamomum)Asian Journal of Chemistry, 22(6), 4787–4794
Bhatti, S., Ali Shah, S. A., Ahmed, T., & Zahid, S. (2018). Neuroprotective effects of Foeniculum vulgare seeds extract on lead-induced neurotoxicity in mice brainDrug and Chemical Toxicology, 41(4), 399–407https://doi.org/10.1080/01480545.2018.1459669
Bhawana, Basniwal, R. K., Buttar, H. S., Jain, V. K., & Jain, N. (2011). Curcumin nanoparticles: preparation, characterization, and antimicrobial studyJournal of Agricultural and Food Chemistry, 59(5), 2056–2061https://doi.org/10.1021/jf104402t
Bhowmik, D., Sampath Kumar, K. P., Yadav, A., Srivastava, S., Paswan, S., & Dutta, A. S. (2012). Recent trends in Indian traditional herbs Syzygium aromaticum and its health benefitsJournal of Pharmacognosy and Phytochemistry, 1(1)www.phytojournal.comwww.phytojournal.com
Bhutta, Z. A., Ashar, A., Mahfooz, A., Khan, J. A., Saleem, M. I., Rashid, A., Aqib, A. I., Kulyar, MFe. A., Sarwar, I., Shoaib, M., Nawaz, S., & Yao, W. (2021). Enhanced wound healing activity of nano ZnO and nano Curcuma longa in third-degree burnApplied Nanoscience (Switzerland), 11(4), 1267–1278https://doi.org/10.1007/s13204-020-01661-y
Bisht, S., Mizuma, M., Feldmann, G., Ottenhof, N., Hong, S.-M., Pramanik, D., Chenna, V., Karikari, C., Sharma, R., Goggins, M. G., Rudek, M. A., Ravi, R., Maitra, A., & Maitra, A. (2010). Systemic administration of polymeric nanoparticles encapsulated curcumin blocks tumor growth and metastases in preclinical models of pancreatic cancerMolecular Cancer Therapeutics, 9(8), 2255–2264
Bisht, S., Feldmann, G., Soni, S., Ravi, R., Karikar, C., Maitra, A., & Maitra, A. (2007). Polymeric nanoparticle-encapsulated curcumin (“nanocurcumin”): A novel strategy for human cancer therapyJournal of Nanobiotechnology, 5, 1–18https://doi.org/10.1186/1477-3155-5-3
Bojorges, H., Ríos-Corripio, M. A., Hernández-Cázares, A. S., Hidalgo-Contreras, J. V., & Contreras-Oliva, A. (2020). Effect of the application of an edible film with turmeric (Curcuma longa L.) on the oxidative stability of meatFood Science and Nutrition, 8(8), 4308–4319https://doi.org/10.1002/fsn3.1728
Bora, K., & Sharma, A. (2009). Phytoconstituents and therapeutic potential of allium cepa linn.- A ReviewPharmacognosy Reviews, 3(5), 170–180
Borjoeifar, M., Nabieyan, S., Saadatfar, A., & Mehrjerdi, M. R. Z. (2021). Development of Operational Strategies for Branding Ferula assa-foetida L. Medicinal Plant (Case study: Rangelands of Kerman Province, Iran)Journal of Rangeland Science, 11(2), 224–240
Borrin, T. R., Georges, E. L., Brito-Oliveira, T. C., Moraes, I. C. F., & Pinho, S. C. (2018). Technological and sensory evaluation of pineapple ice creams incorporating curcumin-loaded nanoemulsions obtained by the emulsion inversion point methodInternational Journal of Dairy Technology, 71(2), 491–500https://doi.org/10.1111/1471-0307.12451
Bostoglou, E., Govaris, A., Giannenas, I., & Botsoglou, N. (2010). Use of saffron (Crocus sativus L.) as a feed additive for improving growth and meat or egg quality in poultryFunctionnal Plant Science and Biotechnology, 4(2), 98–107
Bota, V., Sumalan, R. M., Obistioiu, D., Negrea, M., Cocan, I., Popescu, I., & Alexa, E. (2022). Study on the sustainability potential of thyme, oregano, and coriander essential oils used as vapours for antifungal protection of wheat and wheat productsSustainability, 14(7), 4298
Boukhechem, S., Bougherara, H., Mimoune, N., Redouane, R., Nia, N., & Kaidi, R. (2021). Effect of sprouted Trigonella foenum graecum L. incorporation into the diet on milk production of rabbit does and growth of young rabbits in the Northeast of AlgeriaBulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Veterinary Medicine, 78(1), 48https://doi.org/10.15835/buasvmcn-vm:2020.0047
Bouras., Mesbahi, Y., Amine, A. (2021)In vitro and in vivo antifungal effect of silver oxide and syzygium aromaticum in wistars ratsApplied Biochemistry
Bozan, B., & Karakaplan, U. (2007). Antioxidants from laurel (Laurus nobilis L.) berries: Influence of extraction procedure on yield and antioxidant activity of extractsActa Alimentaria, 36(3), 321–328https://doi.org/10.1556/AAlim.36.2007.3.4
Britto, G. C. S. de, Bécker, G., Soares, W. P., Nascimento, E., Rodrigues, E. C., Picanço, N. F. M., Faria, R. A. P. G. de, & Scabora, M. H. (2020). Bioactive compounds and physicochemical properties of dairy products supplemented with plantain and turmericJournal of Food Processing and Preservation, 44(9)https://doi.org/10.1111/jfpp.14720
Budiman, I., Tjokropranoto, R., Widowati, W., Fauziah, N., & Erawijantari, P. (2015). Potency of tumeric (Curcuma longa L.) extract and curcumin as anti-obesity by inhibiting the cholesterol and triglycerides synthesis in HepG2 cellsInternational Journal of Research in Medical Sciences, 3(5), 1165https://doi.org/10.5455/2320-6012.ijrms20150525
Bulut Kocabas, B., Attar, A., Peksel, A., & Altikatoglu Yapaoz, M. (2021). Phytosynthesis of CuONPs via Laurus nobilis: Determination of antioxidant content, antibacterial activity, and dye decolorization potentialBiotechnology and Applied Biochemistry, 68(4), 889–895https://doi.org/10.1002/bab.2010
Busari, Z. A., Dauda, K. A., Morenikeji, O. A., Afolayan, F., Oyeyemi, O. T., Meena, J., Sahu, D., & Panda, A. K. (2017). Antiplasmodial activity and toxicological assessment of curcumin PLGA-encapsulated nanoparticlesFrontiers in Pharmacology, 8(SEP)https://doi.org/10.3389/fphar.2017.00622
Busquets, R. (2017). Emerging nanotechnologies in food scienceEmerging Nanotechnologies in Food Science, 1–222
Caleja, C., Barros, L., Antonio, A. L., Ciric, A., Soković, M., Oliveira, M. B. P. P., Santos-Buelga, C., & Ferreira, I. C. F. R. (2015). Foeniculum vulgare mill. as natural conservation enhancer and health promoter by incorporation in cottage cheeseJournal of Functional Foods, 12, 428–438https://doi.org/10.1016/j.jff.2014.12.016
Calixto, J. B., Beirith, A., Ferreira, J., Santos, A. R. S., Filho, V. C., & Yunes, R. A. (2000). Naturally occurring antinociceptive substances from plantsPhytotherapy Research, 14(6), 401–418https://doi.org/10.1002/1099-1573(200009)14:6%3c401::AID-PTR762%3e3.0.CO;2-H
Campo Velasco, J. A., Vanegas Mahecha, P., & Andrade-Mahecha, M. M. (2017). Essential oil turmeric (Curcuma longa) antifungal agent as in edible coatings applied to pumpkin minimally processedRevista de Ciências Agrárias, 40(3), 641–654
Caputo, L., Nazzaro, F., Souza, L. F., Aliberti, L., De Martino, L., Fratianni, F., Coppola, R., & De Feo, V. (2017). Laurus nobilis: composition of essential oil and its biological activitiesMolecules, 22(6)https://doi.org/10.3390/molecules22060930
Caputo, L., Souza, L. F., Alloisio, S., Cornara, L., & De Feo, V. (2016). Coriandrum sativum and Lavandula angustifolia essential oils: Chemical composition and activity on central nervous systemInternational Journal of Molecular Sciences, 17(12), 1999https://doi.org/10.3390/ijms17121999
Careaga, M., Fernández, E., Dorantes, L., Mota, L., Jaramillo, M. E., & Hernandez-Sanchez, H. (2003). Antibacterial activity of capsicum extract against Salmonella typhimurium and Pseudomonas aeruginosa inoculated in raw beef meatInternational Journal of Food Microbiology, 83(3), 331–335https://doi.org/10.1016/S0168-1605(02)00382-3
Carrubba, A., Torre, R, L., Prima, A, D., Saiano, F., Alonzo, G. (2002)Statistical analyses on the essential oil of Italian coriander (Coriandrum sativum l.) fruits of different ages
Casado-Hidalgo, G., Pérez-Quintanilla, D., Morante-Zarcero, S., & Sierra, I. (2021). Mesostructured silica-coated magnetic nanoparticles to extract six opium alkaloids in poppy seeds prior to ultra-high-performance liquid chromatography-tandem mass spectrometry analysisFoods, 10(7), 1587https://doi.org/10.3390/foods10071587
Casillas-figueroa, F., Arellano-garcía, M. E., Leyva-aguilera, C., Ruíz-ruíz, B., Vázquez-gómez, R. L., Radilla-chávez, P., Chávez-santoscoy, R. A., Pestryakov, A., Toledano-magaña, Y., García-ramos, J. C., & Bogdanchikova, N. (2020). Argovit™ silver nanoparticles effects on allium cepa: Plant growth promotion without cyto genotoxic damageNanomaterials, 10(7), 1–20https://doi.org/10.3390/nano10071386
Cavaliere, A., De Marchi, E., & Banterle, A. (2017). Investigation on the role of consumer health orientation in the use of food labelsPublic Health, 147, 119–127https://doi.org/10.1016/j.puhe.2017.02.011
Cerqueira, M. Â., Pinheiro, A. C., Ramos, O. L., Silva, H., Bourbon, A. I., & Vicente, A. A. (2017). Advances in food nanotechnologyEmerging Nanotechnologies in Food Science, 11–38https://doi.org/10.1016/B978-0-323-42980-1.00002-9
Chahal, K., Kaur, R., Kumar, A., & Bhardwaj, U. (2017). Chemistry and biological activities of Anethum graveolens L. (dill) essential oil: A reviewJournal of Pharmacognosy and Phytochemistry, 6(2), 295–306https://www.phytojournal.com/archives/2017/vol6issue2/PartF/6-2-67-817.pdf
Chainani-Wu, N. (2003). Safety and anti-inflammatory activity of curcumin: A component of tumeric (Curcuma longa)Journal of Alternative and Complementary Medicine, 9(1), 161–168https://doi.org/10.1089/107555303321223035
Chakrabarty, S., Islam, A. K. M. M., & Islam, A. K. M. A. (2021). Nutritional benefits and pharmaceutical potentialities of chili : A reviewFundamental and Applied Agriculture, 2, 227–232
Chakraborty, A. J., Uddin, T. M., Matin Zidan, B. M. R., Mitra, S., Das, R., Nainu, F., Dhama, K., Roy, A., Hossain, M. J., Khusro, A., & Emran, T. B. (2022). Allium cepa: A treasure of bioactive phytochemicals with prospective health benefitsEvidence-Based Complementary and Alternative Medicine, 2022https://doi.org/10.1155/2022/4586318
Chakraborty, P., Dam, D., & Abraham, J. (2016). Bioactivity of lanthanum nanoparticle synthesized using Trigonella foenum-graecum seed extractJournal of Pharmaceutical Sciences and Research, 8(11), 1253–1257
Chakraborty, R., Sen, S., Ali Ahmed, F., & Barakoti, H. (2020). Evaluation of in vitro anti-diabetic and anti-oxidant potential of Acorus calamus rhizomeIndo Global Journal of Pharmaceutical Sciences, 10(03), 35–40https://doi.org/10.35652/igjps.2020.10304
Chanda, N., Shukla, R., Zambre, A., Mekapothula, S., Kulkarni, R. R., Katti, K., Bhattacharyya, K., Fent, G. M., Casteel, S. W., Boote, E. J., Viator, J. A., Upendran, A., Kannan, R., & Katti, K. V. (2011). An effective strategy for the synthesis of biocompatible gold nanoparticles using cinnamon phytochemicals for phantom CT imaging and photoacoustic detection of cancerous cellsPharmaceutical Research, 28(2), 279–291https://doi.org/10.1007/s11095-010-0276-6
Chanda, S., & Ramachandra, T. V. (2019). Phytochemical and pharmacological importance of turmeric (Curcuma longa): a reviewResearch & Reviews: A Journal of Pharmacology, 16–23www.stmjournals.com
Chang, S. T., Chen, P. F., & Chang, S. C. (2001). Antibacterial activity of leaf essential oils and their constituents from Cinnamomum osmophloeumJournal of Ethnopharmacology, 77(1), 123–127https://doi.org/10.1016/S0378-8741(01)00273-2
Chao, I. C., Wang, C. M., Li, S. P., Lin, L. G., Ye, W. C., & Zhang, Q. W. (2018). Simultaneous quantification of three curcuminoids and three volatile components of curcuma longa using pressurized liquid extraction and high-performance liquid chromatographyMolecules, 23(7), 1568https://doi.org/10.3390/molecules23071568
Chatterjee, D., & Bhattacharjee, P. (2015). Use of eugenol-lean clove extract as a flavoring agent and natural antioxidant in mayonnaise: Product characterization and storage studyJournal of Food Science and Technology, 52(8), 4945–4954https://doi.org/10.1007/s13197-014-1573-6
Chau, T. P., Kandasamy, S., Chinnathambi, A., Alahmadi, T. A., & Brindhadevi, K. (2021). Synthesis of zirconia nanoparticles using Laurus nobilis for use as an antimicrobial agentApplied Nanoscience (Switzerland)https://doi.org/10.1007/s13204-021-02041-w
Chemingui, H., Smiri, M., Missaoui, T., & Hafiane, A. (2019). Zinc oxide nanoparticles induced oxidative stress and changes in the photosynthetic apparatus in fenugreek (Trigonella foenum graecum L.)Bulletin of Environmental Contamination and Toxicology, 102(4), 477–485https://doi.org/10.1007/s00128-019-02590-5
Chen, B., He, Y., Xiao, Y., Guo, D., Liu, P., He, Y., Sun, Q., Jiang, P., Liu, Z., & Liu, Q. (2020). Heated fennel therapy promotes the recovery of gastrointestinal function in patients after complex abdominal surgery: A single-center prospective randomized controlled trial in ChinaSurgery (United States), 168(5), 793–799https://doi.org/10.1016/j.surg.2020.05.040
Chen, J., Ding, J., Li, D., Wang, Y., Wu, Y., Yang, X., Chinnathambi, A., Salmen, S. H., & Ali Alharbi, S. (2022). Facile preparation of Au nanoparticles mediated by Foeniculum Vulgare aqueous extract and investigation of the anti-human breast carcinoma effectsArabian Journal of Chemistry, 15(1), 103479https://doi.org/10.1016/j.arabjc.2021.103479
Chen, X., Zou, L. Q., Niu, J., Liu, W., Peng, S. F., & Liu, C. M. (2015). The stability, sustained release and cellular antioxidant activity of curcumin nanoliposomesMolecules, 20(8), 14293–14311https://doi.org/10.3390/molecules200814293
Cheng, C.-Y., Yang, A.-J., Ekambaranellore, P., Huang, K.-C., & Lin, W.-W. (2018). Antiobesity action of INDUS810, a natural compound from trigonella foenum graecum AMPK dependent lipolysis effect in adipocytesObesity Research & Clinical Practice, 12(6), 562–569
Cheshmeh, S., Elahi, N., Ghayyem, M., Moradi, S., Pasdar, Y., & Tahmasebi, S. (2021). Effects of green cardamom supplementation on obesity and diabetes gene expression among obese women with polycystic ovary syndrome; a double blind randomized controlled trialResearch Square, PREPRINT(version 1), 1–12
Chin, S. F., Mohd Yazid, S. N. A., & Pang, S. C. (2014). Preparation and characterization of starch nanoparticles for controlled release of curcuminInternational Journal of Polymer Science, 2014https://doi.org/10.1155/2014/340121
Choi, H.-Y. (2009). Antioxidant activity of Curcuma longa l., novel foodstuff. In Molecular and Cellular Toxicology (Vol. 5, Issue 3, pp. 237–242)
Choudhary, M. K., Kataria, J., & Sharma, S. (2017). A biomimetic synthesis of stable gold nanoparticles derived from aqueous extract of Foeniculum vulgare seeds and evaluation of their catalytic activityApplied Nanoscience (Switzerland), 7(7), 439–447https://doi.org/10.1007/s13204-017-0589-4
Chouksey, D., Sharma, P., & Pawar, R. S. (2010). Biological activities and chemical constituents of Illicium verum hook fruits (chinese star anise)Der Pharmacia Sinica, 1(3), 1–10http://www.imedpub.com/articles/biological-activities-and-chemical-constituents-of-illicium-verum-hook-fruits-chinese-star-anise.pdf
Chouksey, D., Upmanyu, N., & Pawar, R. S. (2013). Central nervous system activity of Illicium verum fruit extractsAsian Pacific Journal of Tropical Medicine, 6(11), 869–875https://doi.org/10.1016/S1995-7645(13)60155-8
Chouni, A., & Paul, S. (2018). A review on phytochemical and pharmacological potential of Alpinia galangaPharmacognosy Journal, 10(1), 9–15https://doi.org/10.5530/pj.2018.1.2
Chowdhury, S., & Kumar, S. (2020). Alpha-terpinyl acetate: A natural monoterpenoid from Elettaria cardamomum as multi-target directed ligand in Alzheimer’s diseaseJournal of Functional Foods, 68(February), 103892https://doi.org/10.1016/j.jff.2020.103892
Chudiwal, A. K., Jain, D. P., & Somani, R. S. (2010). Alpinia galanga willd.- an overview on phyto-pharmacological propertiesIndian Journal of Natural Products and Resources, 1(2), 143–149
Chun, S., Muthu, M., Gansukh, E., Thalappil, P., & Gopal, J. (2016). The ethanopharmacological aspect of carbon nanodots in turmeric smokeScientific Reports, 6(November), 1–12https://doi.org/10.1038/srep35586
Cicero, N., Gervasi, T., Durazzo, A., Lucarini, M., Macrì, A., Nava, V., Giarratana, F., Tardugno, R., Vadalà, R., & Santini, A. (2022). Mineral and microbiological analysis of spices and aromatic herbsFoods, 11(4), 1–12https://doi.org/10.3390/foods11040548
Clemente, I., Aznar, M., & Nerín, C. (2019). Synergistic properties of mustard and cinnamon essential oils for the inactivation of foodborne moulds in vitro and on Spanish breadInternational Journal of Food Microbiology, 298, 44–50https://doi.org/10.1016/j.ijfoodmicro.2019.03.012
Cortez, M. V., Perovic, N. R., Soria, E. A., & Defagó, M. D. (2020). Effect of heat and microwave treatments on phenolic compounds and fatty acids of turmeric (curcuma longa l.) and saffron (crocus sativus l.)Brazilian Journal of Food Technology, 23, 1–7https://doi.org/10.1590/1981-6723.20519
Courrol, D. dos S., Teixeira, B. H., & Pereira, C. B. P. (2016). Pegylated curcumin with gold nanoparticles: antimicrobial agent evaluationJournal of Biomedical Engineering and Biosciences, 3https://doi.org/10.11159/jbeb.2016.008
Cusano, E., Consonni, R., Petrakis, E. A., Astraka, K., Cagliani, L. R., & Polissiou, M. G. (2018). Integrated analytical methodology to investigate bioactive compounds in Crocus sativus L. flowersPhytochemical Analysis, 29(5), 476–486https://doi.org/10.1002/pca.2753
Da Silveira, S. M., Luciano, F. B., Fronza, N., Cunha, A., Scheuermann, G. N., & Vieira, C. R. W. (2014). Chemical composition and antibacterial activity of Laurus nobilis essential oil towards foodborne pathogens and its application in fresh Tuscan sausage stored at 7°CLWT - Food Science and Technology, 59(1), 86–93https://doi.org/10.1016/j.lwt.2014.05.032
Dager, A., Baliyan, A., Kurosu, S., Maekawa, T., & Tachibana, M. (2020). Ultrafast synthesis of carbon quantum dots from fenugreek seeds using microwave plasma enhanced decomposition: Application of C-QDs to grow fluorescent protein crystalsScientific Reports, 10(1), 1–15https://doi.org/10.1038/s41598-020-69264-9
Dager, A., Uchida, T., Maekawa, T., & Tachibana, M. (2019). Synthesis and characterization of Mono-disperse Carbon Quantum Dots from Fennel Seeds: Photoluminescence analysis using Machine LearningScientific Reports, 9(1), 1–10https://doi.org/10.1038/s41598-019-50397-5
Daisy, E., Angelina, R., Bavyaa, R., & Rajagopal, R. (2013). Green synthesis and characterization of silver nanoparticles using fenugreek seed extractInternational Journal of Scientific and Research Publications, 3(7), 2250–3153www.ijsrp.org
Dall’Acqua, S., Cervellati, R., Speroni, E., Costa, S., Guerra, M. C., Stella, L., Greco, E., & Innocenti, G. (2009). Phytochemical composition and antioxidant activity of Laurus nobilis L. leaf infusionJournal of Medicinal Food, 12(4), 869–876https://doi.org/10.1089/jmf.2008.0119
Dall’Acqua, S., Viola, G., Giorgetti, M., Loi, M. C., & Innocenti, G. (2006). Two new sesquiterpene lactones from the leaves of Laurus nobilisChemical and Pharmaceutical Bulletin, 54(8), 1187–1189https://doi.org/10.1248/cpb.54.1187
Dalvandi, F., Almasi, H., Ghanbarzadeh, B., Hosseini, H., & Karimian, N. (2020). Effect of vacuum packaging and edible coating containing black pepper seeds and turmeric extracts on shelf life extension of chicken breast filletsJournal of Food and Bioprocess Engineering, 3(1), 69–78
Dam, D., Banerjee, K., & Mukhopadhyay, A. (2016). 519P Lanthanum nanoparticles synthesized from fenugreek seed extract as targeted therapy for osteosarcomaAnnals of Oncology, 27, ix168https://doi.org/10.1016/s0923-7534(21)00677-3
Damanhouri, Z. A. (2014). A review on therapeutic potential of Piper nigrum l. (black pepper): the king of spicesMedicinal & Aromatic Plants, 03(03)https://doi.org/10.4172/2167-0412.1000161
Daneshi-Maskooni, M., Keshavarz, S. A., Qorbani, M., Mansouri, S., Alavian, S. M., Badri-Fariman, M., Jazayeri-Tehrani, S. A., & Sotoudeh, G. (2018). Green cardamom increases Sirtuin-1 and reduces inflammation in overweight or obese patients with non-alcoholic fatty liver disease: A double-blind randomized placebo-controlled clinical trialNutrition and Metabolism, 15(1)https://doi.org/10.1186/s12986-018-0297-4
Daru, M. (2021). Partnership expansion between farmers and the herbal medicine industry for community economic developmentE3S Web of Conferences, 306, 02006https://doi.org/10.1051/e3sconf/202130602006
Das, A., Roy, A., Rajeshkumar, S., & Lakshmi, T. (2019). Anti-inflammatory activity of turmeric oil mediated silver nanoparticlesResearch Journal of Pharmacy and Technology, 12(7), 3507–3510https://doi.org/10.5958/0974-360X.2019.00596.1
Das, G., Patra, J. K., Gonçalves, S., Romano, A., Gutiérrez-Grijalva, E. P., Heredia, J. B., Talukdar, A. D., Shome, S., & Shin, H. S. (2020). Galangal, the multipotent super spices: A comprehensive reviewTrends in Food Science and Technology, 101(May), 50–62https://doi.org/10.1016/j.tifs.2020.04.032
Das, R. K., Kasoju, N., & Bora, U. (2010). Encapsulation of curcumin in alginate-chitosan-pluronic composite nanoparticles for delivery to cancer cellsNanomedicine: Nanotechnology, Biology and Medicine, 6(1), 153–160https://doi.org/10.1016/j.nano.2009.05.009
Das, S., Singh, V. K., Dwivedy, A. K., Chaudhari, A. K., & Dubey, N. K. (2021). Anethum graveolens essential oil encapsulation in chitosan nanomatrix: investigations on in vitro release behavior, organoleptic attributes, and efficacy as potential delivery vehicles against biodeterioration of rice (Oryza sativa l.)Food and Bioprocess Technology, 14(5), 831–853https://doi.org/10.1007/s11947-021-02589-z
Das, S., Singh, V. K., Dwivedy, A. K., Chaudhari, A. K., Upadhyay, N., Singh, A., Deepika, & Dubey, N. K. (2020). Fabrication, characterization and practical efficacy of Myristica fragrans essential oil nanoemulsion delivery system against postharvest biodeteriorationEcotoxicology and Environmental Safety, 189, 110000https://doi.org/10.1016/j.ecoenv.2019.110000
Database, U. S. nutrition. (2021)Galangal: health benefits, nutrition, uses in ayurveda, recipes, side effects
de Araujo, C. I. M., Bonato, L. B., Mangucci, C. B., Malpass, G. R. P., Okura, M. H., & Granato, A. C. (2022). Comparison of biopolymer-based edible coatings incorporating Piper nigrum and Schinus terebinthifolia applied on minimally processed pineappleBritish Food Journal, 124(4), 1274–1284https://doi.org/10.1108/BFJ-04-2021-0453
De, M., De, A. K., & Banerjee, A. B. (1999). Antimicrobial screening of some Indian spicesPhytotherapy Research, 13(7), 616–618https://doi.org/10.1002/(SICI)1099-1573(199911)13:7%3c616::AID-PTR475%3e3.0.CO;2-V
De, M., De, A. K., Sen, P., & Banerjee, A. B. (2002). Antimicrobial properties of Star anise (Illicium verum Hook f)Phytotherapy Research, 16(1), 94–95https://doi.org/10.1002/ptr.989
De Sousa Leite, A., Dantas, A. F., Da Silva Oliveira, G. L., Gomes Júnior, A. L., De Lima, S. G., Das Graças Lopes Citó, A. M., De Freitas, R. M., Melo-Cavalcante, A. A. D. C., & Lopes, J. A. D. (2015). Evaluation of toxic, cytotoxic, mutagenic, and antimutagenic activities of natural and technical cashew nut shell liquids using the allium cepa and artemia salina bioassaysBioMed Research International, 2015https://doi.org/10.1155/2015/626835
Debnath, P., Mondal, A., Hajra, A., Das, C., & Mondal, N. K. (2018). Cytogenetic effects of silver and gold nanoparticles on Allium cepa rootsJournal of Genetic Engineering and Biotechnology, 16(2), 519–526https://doi.org/10.1016/j.jgeb.2018.07.007
Deepa, B., & Anuradha, C. V. (2011). Antioxidant potential of Coriandrum sativum l. seed extractIndian Journal of Experimental Biology, 49(1), 30–38
Dehpour, A. A., Ebrahimzadeh, M. A., Fazel, N. S., & Mohammad, N. S. (2009). Antioxidant activity of the methanol extract of Ferula assafoetida and its essential oil compositionGrasas y Aceites, 60(4), 405–412https://doi.org/10.3989/gya.010109
Deka, C., Aidew, L., Devi, N., Buragohain, A. K., & Kakati, D. K. (2016). Synthesis of curcumin-loaded chitosan phosphate nanoparticle and study of its cytotoxicity and antimicrobial activityJournal of Biomaterials Science, Polymer Edition, 27(16), 1659–1673https://doi.org/10.1080/09205063.2016.1226051
Demir, E., Kaya, N., & Kaya, B. (2014). Genotoxic effects of zinc oxide and titanium dioxide nanoparticles on root meristem cells of allium cepa by comet assayTurkish Journal of Biology, 38(1), 31–39https://doi.org/10.3906/biy-1306-11
Deng, M., Wen, J., Zhu, H., & Zou, X. (2009). The hottest pepper variety in ChinaGenetic Resources and Crop Evolution, 56(5), 605–608https://doi.org/10.1007/s10722-009-9445-z
Derwich, E., Benziane, Z., & Boukir, A. (2009). Chemical composition and antibacterial activity of Leaves essential oil of laurus nobilis from MoroccoAustralian Journal of Basic and Applied Sciences, 3(4), 3818–3824
Desai, M. P., Sangaokar, G. M., & Pawar, K. D. (2018). Kokum fruit mediated biogenic gold nanoparticles with photoluminescent, photocatalytic and antioxidant activitiesProcess Biochemistry, 70, 188–197https://doi.org/10.1016/j.procbio.2018.03.027
Deshmukh, A. R., Gupta, A., & Kim, B. S. (2019). Ultrasound assisted green synthesis of silver and iron oxide nanoparticles using fenugreek seed extract and their enhanced antibacterial and antioxidant activitiesBioMed Research International, 2019https://doi.org/10.1155/2019/1714358
Dev, M., Ghosh, M., & Bhattacharyya, Dkumar. (2021). Physico-chemical, antimicrobial, and organoleptic properties of roasted aromatic spice (clove bud) in baked productApplied Biochemistry and Biotechnology, 193(6), 1813–1835https://doi.org/10.1007/s12010-021-03504-0
Dewi, K., Widyarto, B., Erawijantari, P., & Widowati, W. (2015)In vitro study of Myristica fragrans seed (Nutmeg) ethanolic extract and quercetin compound as anti-inflammatory agentInternational Journal of Research in Medical Sciences, 2303–2310https://doi.org/10.18203/2320-6012.ijrms20150621
Dey, T., Ghosh, A., Mishra, S., Pal, P. K., Chattopadhyay, A., Pattari, S. K., & Bandyopadhyay, D. (2020). Attenuation of arsenic induced high fat diet exacerbated oxidative stress mediated hepatic and cardiac injuries in male Wistar rats by piperine involved antioxidative mechanismsFood and Chemical Toxicology, 142https://doi.org/10.1016/j.fct.2020.111477
Dhanya, N. P. (2017). Non linear optical investigations of silver nanoparticles synthesised by curcumin reductionOptical Materials, 73, 384–387https://doi.org/10.1016/j.optmat.2017.08.026
Dhanyaraj, D., & Thomas, A. (2021). Phyto-assisted synthesis of gold nanoparticles by aqueous extract of curcuma longa and the evaluation of total phenolic and flavonoid contentsUttar Pradesh Journal of Zoology, 42(18), 82–88
Dhanyaraj, D., Shine, F., Shibu, J, S, T., Akhila, T, A. (2019). Gold nanoparticles synthesis in extract of curcuma longa, evaluation of its total phenolic contentBISFAA
Dharmadasa, R. M., Abeysinghe, D. C., Abeywardhane, K. W., Dissanayake, M. N., & Fernando, N. S. (2015). Leaf essential oil composition, antioxidant activity, total phenolic content and total flavonoid content of Pimenta dioica (l.)merr (myrtaceae): a superior quality spice grown in Sri LankaUniversal Journal of Agricultural Research, 3(2), 49–52https://doi.org/10.13189/ujar.2015.030203
Dharman, S., Maragathavalli, Rajeshkumar, & Shanmugasundaram, K. (2021). Ecofriendly synthesis, characterisation and antibacterial activity of curcumin mediated silver nanoparticlesInternational Journal of Dentistry and Oral Science, 8(4), 2314–2318https://doi.org/10.19070/2377-8075-21000457
Dhawi, F., El-Beltagi, H. S., Aly, E., & Hamed, A. M. (2020). Antioxidant, antibacterial activities and mineral content of buffalo yoghurt fortified with fenugreek and Moringa oleifera seed floursFoods, 9(9), 1157https://doi.org/10.3390/foods9091157
Dhillon, G. K., & Amarjeet, K. (2013). Quality evaluation of bread incorporated with different levels cinnamon powderInternational Journal of Food Science, Nutrition and Dietetics, 2(7), 70–74https://doi.org/10.19070/2326-3350-1300013
Dhull, S. B., Punia, S., Sandhu, K. S., Chawla, P., Kaur, R., Singh, A. (2020). Effect of debittered fenugreek flour addition on physical, nutritional, antioxidant and sensory properties of wheat flour ruskLegume Science, 2(1)
Dhull, S. B., Bangar, S. P., Deswal, R., Dhandhi, P., Kumar, M., Trif, M., & Rusu, A. (2021). Development and characterization of active native and cross-linked pearl millet starch-based film loaded with fenugreek oilFoods, 10(12), 3097https://doi.org/10.3390/foods10123097
Din, Z. U., Shad, A. A., Bakht, J., Ullah, I., & Jan, S. (2015)In vitro antimicrobial, antioxidant activity and phytochemical screening of Apium graveolensPakistan Journal of Pharmaceutical Sciences, 28(5), 1699–1704
Divya, K. S., Harshitha, B. S., Kumar, R. D., & Bala, C. J. (2019)In vitro investigation of antioxidant potentiality of methanol and silver nanoparticles extract from Trigonella foenum-graecumJournal of Pharmacognosy and Phytochemistry, 8(3), 2213–2221
Dobroslavic, E., Repajic, M., Dragovic- Uzelac, V., & Garofulic, I. E. (2022). Isolation of laurus nobilis leaf polyphenols: A review on current techniques and future perspectivesFoods, 11, 235
Dossa, F. (2018). Onion (Allium Cepa) production in urban and peri-urban areas: financial performance and importance of this activity for market gardeners in southern beninCurrent Investigations in Agriculture and Current Research, 3(2)https://doi.org/10.32474/ciacr.2018.03.000159
Dougnon, T. J., Kiki, P., Dougnon, T. V., & Youssao, I. (2014). Evaluation of Capsicum frutescens powder effects on the growth performances, biochemical and hematological parameters in Hubbard broilerJournal of Applied Pharmaceutical Science, 4(10), 38–43https://doi.org/10.7324/JAPS.2014.40107
Doweidar, M. M., Amer, A. M., & Tawfek, A. (2016). Preparation and evaluation of healthy cinnamon cakeEgyptian Journal of Nutrition, XXXI(4), 157–195
Driscoll, J. A., Brody, S. L., & Kollef, M. H. (2007). The epidemiology, pathogenesis and treatment of Pseudomonas aeruginosa infectionsDrugs, 67(3), 351–368https://doi.org/10.2165/00003495-200767030-00003
Du, W. X., Olsen, C. W., Avena-Bustillos, R. J., McHugh, T. H., Levin, C. E., Mandrell, R., & Friedman, M. (2009). Antibacterial effects of allspice, garlic, and oregano essential oils in tomato films determined by overlay and vapor-phase methodsJournal of Food Science, 74(7), 390–397https://doi.org/10.1111/j.1750-3841.2009.01289.x
Duan, J., Zhang, Y., Han, S., Chen, Y., Li, B., Liao, M., Chen, W., Deng, X., Zhao, J., & Huang, B. (2010). Synthesis and in vitro/in vivo anti-cancer evaluation of curcumin-loaded chitosan/poly(butyl cyanoacrylate) nanoparticlesInternational Journal of Pharmaceutics, 400(1–2), 211–220https://doi.org/10.1016/j.ijpharm.2010.08.033
Dwivedi, P. (2020). Curcuma longa aided Ag/CS nanocomposite coating of surfaces as SARS-CoV-2 contamination minimizing measure towards containment of COVID-19: a perspectiveLetters in Applied NanoBioScience, 9(4), 1485–1493https://doi.org/10.33263/lianbs94.14851493
Echegoyen, Y., & Nerín, C. (2015). Performance of an active paper based on cinnamon essential oil in mushrooms qualityFood Chemistry, 170, 30–36https://doi.org/10.1016/j.foodchem.2014.08.032
EFSA Scientific Commitee. (2011). Guidance for risk assessment of engineered nanomaterialsEFSA Journal, 9(5), 2–36
Ehsani, A., Hashemi, M., Naghibi, S. S., Mohammadi, S., & Khalili Sadaghiani, S. (2016). Properties of Bunium persicum essential oil and its application in Iranian white cheese against Listeria monocytogenes and Escherichia coli O157:H7Journal of Food Safety, 36(4), 563–570https://doi.org/10.1111/jfs.12277
El-Batal, A. I., Ahmed, N. H., Barakat, L. A. A., & Khirallah, S. M. (2019). Tumoricidal effect of Trigonella foenum-graceum extract and selenium nanoparticles on ehrlich carcinoma bearing miceAsian Journal of Research in Biochemistry, March, 1–16https://doi.org/10.9734/ajrb/2019/v4i130059
El-Naggar, E. A. (2019). Influence of fenugreek seeds flour on the rheological characteristics of wheat flour and biscuit qualityZagazig Journal of Agricultural Research, 46(3), 721–738https://doi.org/10.21608/zjar.2019.40961
El-Soud, N. A., El-Laithy, N., El-Saeed, G., Wahby, M. S., Khalil, M., Morsy, F., & Shaffie, N. (2011). Antidiabetic activities of foeniculum vulgare mill. essential oil in streptozotocin-induced diabetic ratsMacedonian Journal of Medical Sciences, 4(2), 139–146https://doi.org/10.3889/MJMS.1857-5773.2011.0173
El Gizawy, H. A., Boshra, S. A., Mostafa, A., Mahmoud, S. H., Ismail, M. I., Alsfouk, A. A., Taher, A. T., & Al-Karmalawy, A. A. (2021). Pimenta dioica (L.) merr. bioactive constituents exert anti-sars-cov-2 and anti-inflammatory activities: Molecular docking and dynamics, in vitro, and in vivo studiesMolecules, 26(19)https://doi.org/10.3390/molecules26195844
El Gohary, E. G. E., Farag, S. M., El-Sayed, A. A., Khattab, R. R., & Mahmoud, D. M. (2021). Insecticidal activity and biochemical study of the clove oil (Syzygium aromaticum) nano-formulation on culex pipiens l. (diptera: Culicidae)Egyptian Journal of Aquatic Biology and Fisheries, 25(1), 227–239https://doi.org/10.21608/ejabf.2021.137233
El Khoury, E., Abiad, M., Kassaify, Z. G., & Patra, D. (2015). Green synthesis of curcumin conjugated nanosilver for the applications in nucleic acid sensing and anti-bacterial activityColloids and Surfaces B: Biointerfaces, 127, 274–280https://doi.org/10.1016/j.colsurfb.2015.01.050
Elbialy, N. S., Abdelfatah, E. A., & Khalil, W. A. (2019). Antitumor activity of curcumin-green synthesized gold nanoparticles: In vitro studyBioNanoScience, 9(4), 813–820https://doi.org/10.1007/s12668-019-00660-w
Elmasry, T. A., Al-Shaalan, N. H., Tousson, E., El-Morshedy, K., & Al-Ghadeer, A. (2018). Star anise extracts modulation of reproductive parameters, fertility potential and DNA fragmentation induced by growth promoter equigan in rat testesBrazilian Journal of Pharmaceutical Sciences, 54(1)https://doi.org/10.1590/s2175-97902018000117261
ElMitwalli, O. S., Barakat, O. A., Daoud, R. M., Akhtar, S., & Henari, F. Z. (2020). Green synthesis of gold nanoparticles using cinnamon bark extract, characterization, and fluorescence activity in Au/eosin Y assembliesJournal of Nanoparticle Research, 22(10)https://doi.org/10.1007/s11051-020-04983-8
Elsayid, M. A., Mohamed, H. A., Hassan, S. A., Khidi, A. M., & Shaddad, S. A. (2018). Antifungal effect of gold as nanoparticle synthesis by fenugreek seed extractWorld Journal of Pharmaceutical Research, 8(1), 1–9
Elsiddig, E. S. E. H. (2022). Green synthesis of silver nano-particles by using fenugreek seeds extract and application as antifungal agentSUST Repository
Embuscado, M. E. (2015). Spices and herbs: natural sources of antioxidants - a mini review. In Journal of Functional Foods (Vol. 18, pp. 811–819). Elsevier Ltdhttps://doi.org/10.1016/j.jff.2015.03.005
Eram, S., Mujahid, M., Bagga, P., Ansari, V. A., Ahmad, M. A., Kumar, A., Ahsan, F., & Akhter, M. S. (2019). A review on phytopharmacological activity of Alpinia galangaInternational Journal of Pharmacy and Pharmaceutical Sciences, 6–11https://doi.org/10.22159/ijpps.2019v11i3.31352
Ercin, E., Kecel-Gunduz, S., Gok, B., Aydin, T., Budama-Kilinc, Y., & Kartal, M. (2022). Laurus nobilis L. essential oil-loaded PLGA as a nanoformulation candidate for cancer treatmentMolecules, 27(6), 1–20https://doi.org/10.3390/molecules27061899
Ereifej, K. I., Feng, H., Rababah, T. M., Tashtoush, S. H., Al-U’datt, M. H., Al-Rabadi, G. J., Torley, P., & Alkasrawi, M. (2015). Microbiological status and nutritional composition of spices used in food preparationFood and Nutrition Sciences, 06(12), 1134–1140https://doi.org/10.4236/fns.2015.612118
Eresam, E. K. K., Pinto, S., & Aparnathi, K. D. (2015). Concise and informative title: Evaluation of selected spices in extending shelf life of paneerJournal of Food Science and Technology, 52(4), 2043–2052https://doi.org/10.1007/s13197-013-1226-1
Erna, K. H., Felicia, W. X. L., Rovina, K., Vonnie, J. M., & Huda, N. (2022). Development of curcumin/rice starch films for sensitive detection of hypoxanthine in chicken and fish meatCarbohydrate Polymer Technologies and Applications, 3, 100189https://doi.org/10.1016/j.carpta.2022.100189
Eskin, N. A. M., Raju, J., & Bird, R. P. (2007). Novel mucilage fraction of Sinapis alba L. (mustard) reduces azoxymethane-induced colonic aberrant crypt foci formation in F344 and Zucker obese ratsPhytomedicine, 14(7–8), 479–485https://doi.org/10.1016/j.phymed.2006.09.016
Esmaeili, H., Hafezimoghadam, Z., Esmailidehaj, M., Rezvani, M. E., & Hafizibarjin, Z. (2018). The effect of asafoetida essential oil on myocardial ischemic-reperfusion injury in isolated rat heartsAvicenna Journal of Phytomedicine (Ajp), 8(4), 338–349https://doi.org/10.22038/ajp.2018.10315
Etikala, A., Thamburaj, S., Johnson, A. M., Sarma, C., Mummaleti, G., & Kalakandan, S. K. (2022). Incidence, toxin gene profile, antibiotic resistance and antibacterial activity of Allium parvum and Allium cepa extracts on Bacillus cereus isolated from fermented millet-based foodLwt, 160(August 2021), 113314https://doi.org/10.1016/j.lwt.2022.113314
Đorđević, B. S., Todorović, Z. B., Troter, D. Z., Stanojević, L, P., Stojanović, G. S., Đalović, I. G., Mitrović, P. M., & Veljković V. B. (2021). Extraction of phenolic compounds from black mustard (Brassica nigra L.) seed by deep eutectic solventsJournal of Food Measurement and Characterization, 15(2), 1931–1938
Fadaka, A., Aluko, O., Awawu, S., & Theledi, K. (2021). Green synthesis of gold nanoparticles using Pimenta dioica leaves aqueous extract and their application as photocatalyst, antioxidant, and antibacterial agentsJournal of Multidisciplinary Applied Natural Science, 1(2), 78–88https://doi.org/10.47352/jmans.v1i2.81
Faisal, S., Al-Radadi, N. S., Jan, H., Abdullah, Shah, S. A., Shah, S., Rizwan, M., Afsheen, Z., Hussain, Z., Uddin, M. N., Idrees, M., & Bibi, N. (2021). Curcuma longa mediated synthesis of copper oxide, nickel oxide and Cu-Ni bimetallic hybrid nanoparticles: Characterization and evaluation for antimicrobial, anti-parasitic and cytotoxic potentialsCoatings, 11(7), 1–22https://doi.org/10.3390/coatings11070849
Faizal, P., Suresh, S., Satheesh Kumar, R., & Augusti, K. T. (2009). A study on the hypoglycemic and hypolipidemic effects of an ayurvedic drug Rajanyamalakadi in diabetic patientsIndian Journal of Clinical Biochemistry, 24(1), 82–87https://doi.org/10.1007/s12291-009-0014-1
Fathima, R., & Mujeeb, A. (2021). Plasmon enhanced linear and nonlinear optical properties of natural curcumin dye with silver nanoparticlesDyes and Pigments, 189, 109256https://doi.org/10.1016/j.dyepig.2021.109256
Fatima, M., Zaidi, N. S. S., Amraiz, D., & Afzal, F. (2015)In vitro antiviral activity of Cinnamomum cassia and its nanoparticles against H7N3 influenza a virusJournal of Microbiology and Biotechnology, 26(1), 151–159https://doi.org/10.4014/jmb.1508.08024
Fazal, S., & Singla, R. (2012). Review on the pharmacognostical & pharmacological characterization of Apium graveolens linnIndo Global Journal of Pharmaceutical Sciences, 2(1), 36–42http://iglobaljournal.com/wp-content/uploads/2012/05/3.-Fazal-Singla-2012.pdf
Feretti, D., Zerbini, I., Zani, C., Ceretti, E., Moretti, M., & Monarca, S. (2007). Allium cepa chromosome aberration and micronucleus tests applied to study genotoxicity of extracts from pesticide-treated vegetables and grapesFood Additives and Contaminants, 24(6), 561–572https://doi.org/10.1080/02652030601113602
Ferfera-Harrar, H., Berdous, D., & Benhalima, T. (2018). Hydrogel nanocomposites based on chitosan-g-polyacrylamide and silver nanoparticles synthesized using Curcuma longa for antibacterial applicationsPolymer Bulletin, 75(7), 2819–2846https://doi.org/10.1007/s00289-017-2183-z
Ferreira, L. S., Chaves, M. A., Dacanal, G. C., & Pinho, S. C. (2018). Wet agglomeration by high shear of binary mixtures of curcumin-loaded lyophilized liposomes and cornstarch: Powder characterization and incorporation in cakesFood Bioscience, 25, 74–82https://doi.org/10.1016/j.fbio.2018.08.003
Ferreira, M. I., Magro, M., Ming, L. C., da Silva, M. B., Ormond Sobreira Rodrigues, L. F., Zanoni do Prado, D., Bonaiuto, E., Baratella, D., De Almeida Roger, J., Pace Pereira Lima, G., Rossetto, M., Zennaro, L., & Vianello, F. (2017). Sustainable production of high purity curcuminoids from Curcuma longa by magnetic nanoparticles: A case study in BrazilJournal of Cleaner Production, 154, 233–241https://doi.org/10.1016/j.jclepro.2017.03.218
Fidan, H., Stefanova, G., Kostova, I., Stankov, S., Damyanova, S., Stoyanova, A., & Zheljazkov, V. D. (2019). Chemical composition and antimicrobial activity of Laurus nobilis l essential oils from bulgariaMolecules, 24(4), 1–10https://doi.org/10.3390/molecules24040804
Firdhouse, M. J., & Lalitha, P. (2018). Formulations of sunscreen lotions using Acorus calamus and zinc oxide nanoparticles and their in vitro evaluation of sun protection factor ( Spf )World Journal of Pharmaceutical Research, 7(9), 510–515https://doi.org/10.20959/wjpr20189-11562
Fouad, A. S., & Hafez, R. M. (2018). The effects of silver ions and silver nanoparticles on cell division and expression of cdc2 gene in Allium cepa root tipsBiologia Plantarum, 62(1), 166–172https://doi.org/10.1007/s10535-017-0751-6
Fragoon, A., Frah, L., & Mamoun, A. (2016). Biosynthesis of gold nanoparticles by fenugreek (Trigonella foenum-graecum) extractAdvances in Science, Technology and Engineering Systems, 1(5), 50–55https://doi.org/10.25046/aj010509
Fragoon, A., Mamoun, A., Frah, L., & Abd Alwahab, S. (2016). Biosynthesis of gold nanoparticle by fenugreek seed (trigonella foenum) extractProceedings - 2015 International Conference on Computing, Control, Networking, Electronics and Embedded Systems Engineering, ICCNEEE 2015, 388–391https://doi.org/10.1109/ICCNEEE.2015.7381397
Frangopoulos, T. (2021). Incorporation of Trigonella Foenum-Graecum seed powder in meat emulsion systems with olive oil: Effects on physicochemical, texture, and color characteristicsJournal of Food Science and Technologyhttps://doi.org/10.1007/s13197-021-05220-3
Freitas, R. M. (2009). Investigation of oxidative stress involvement in hippocampus in epilepsy model induced by pilocarpineNeuroscience Letters, 462(3), 225–229https://doi.org/10.1016/j.neulet.2009.07.037
Galeano, Y. L., Torres, O. V., & Garcia, A. S. (2018). Evaluation of nutmeg as active component during storage of bovine loinsRevista de Ciencias Agricolas, 35(1), 48–57
Gandapu, U., Chaitanya, R. K., Kishore, G., Reddy, R. C., & Kondapi, A. K. (2011). Curcumin-loaded apotransferrin nanoparticles provide efficient cellular uptake and effectively inhibit HIV-1 replication In vitroPLoS ONE, 6(8)https://doi.org/10.1371/journal.pone.0023388
Ganesan, R. M., & Gurumallesh Prabu, H. (2019). Synthesis of gold nanoparticles using herbal Acorus calamus rhizome extract and coating on cotton fabric for antibacterial and UV blocking applicationsArabian Journal of Chemistry, 12(8), 2166–2174https://doi.org/10.1016/j.arabjc.2014.12.017
Ganesan, S., Mehalingam, P., & Selvam, G. S. (2019). Green synthesis of silver nanoparticles from de-oiled rhizomes of Curcuma longa L. and its biomedical potentialSpringer Proceedings in Materials, 94–106https://doi.org/10.1007/978-3-030-25135-2_10
Gao, H., Cheng, C., Fang, S., McClements, D. J., Ma, L., Chen, X., Zou, L., Liang, R., & Liu, W. (2022). Study on curcumin encapsulated in whole nutritional food model milk: Effect of fat content, and partitioning situationJournal of Functional Foods, 90https://doi.org/10.1016/j.jff.2022.104990
Garcia-Amezquita, L. E., Tejada-Ortigoza, V., Campanella, O. H., & Welti-Chanes, J. (2018). Influence of drying method on the composition, physicochemical properties, and prebiotic potential of dietary fibre concentrates from fruit peelsJournal of Food Qualityhttps://doi.org/10.1155/2018/9105237
García-González, C. A., & Silvar, C. (2020). Phytochemical assessment of native ecuadorian peppers (Capsicum spp.) and correlation analysis to fruit phenomicsPlants, 9(8), 1–25https://doi.org/10.3390/plants9080986
Garg, S. (2012). Rapid biogenic synthesis of silver nanoparticles using black pepper (Piper nigrum) corn extract Indo-Hungarian project View project Nanoparticle, wound healing, anti-cancer studies View projectInternational Journal of Innovations in Biological and Chemical Sciences, 3(July), 5–10https://www.researchgate.net/publication/280007266
Garg, S., & Garg, A. (2018). Encapsulation of curcumin in silver nanoparticle for enhancement of anticancer drug deliveryInternational Journal of Pharmaceutical Sciences and Research, 9(3), 1160https://doi.org/10.13040/IJPSR.0975-8232.9(3).1160-66
Gaur, G. K., Rani, R., & Dharaiya, C. N. (2019). Development of herbal milk using tulsi juice, ginger juice and turmeric powderInternational Journal of Chemical Studies, 7(2), 1150–1157
Gaurav, I., & Tanuja. (2021). Green synthesis and characterization of silver nanoparticles with Rhizome extract of Curcuma longa (AgNPs-RECL) for Antimicrobial activity towards Xanthomonas and Erwinia speciesResearch Journal of Pharmacy and Technology, 14(1), 325–330https://doi.org/10.5958/0974-360x.2021.00060.3
Gazwi, H. S. S., Mahmoud, M. E., & Toson, E. M. A. (2022). Analysis of the phytochemicals of Coriandrum sativum and Cichorium intybus aqueous extracts and their biological effects on broiler chickensScientific Reports, 12(1), 1–11https://doi.org/10.1038/s41598-022-10329-2
Geetha, A. R., George, E., Srinivasan, A., & Shaik, J. (2013). Optimization of green synthesis of silver nanoparticles from leaf extracts of pimenta dioica (Allspice)The Scientific World Journal, 2013(i)https://doi.org/10.1155/2013/362890
George, J. M., & Mathew, B. (2019)Curcuma longa rhizome extract mediated unmodified silver nanoparticles as multisensing probe for Hg(II) ionsMaterials Research Express, 6(11), 1150h5https://doi.org/10.1088/2053-1591/ab5240
George, R., Roy, A., Rajeshkumar, S., & Lakshmi, T. (2020). Coriander oleoresin assisted synthesis and characterization of silver nanoparticles and its antioxidant activityBiomedicine (India), 40(3), 309–312https://doi.org/10.51248/.v40i3.15
Ghafari, S., Esmaeili, S., Naghibi, F., & Mosaddegh, M. (2013). Plants used to treat “tabe rebá” (malaria like fever) in Iranian Traditional MedicineInternational Journal of Traditional and Herbal Medicine, 1(6), 168–176http://www.ijthmjournal.com
Ghaffari, S., & Roshanravan, N. (2019). Saffron; an updated review on biological properties with special focus on cardiovascular effectsBiomedicine and Pharmacotherapy, 109(May 2018), 21–27https://doi.org/10.1016/j.biopha.2018.10.031
Ghannadi, A., Fattahian, K., Shokoohinia, Y., Behbahani, M., & Shahnoush, A. (2014). Anti-viral evaluation of sesquiterpene coumarins from ferula assa-foetida against HSV-1Iranian Journal of Pharmaceutical Research, 13(2), 523–530
Ghinny, D. A., Alsafi, M. Y., Al-Bashir, R. M., Elsammani, T. O., Alshreef, A. M., El-hadiyah, T. M. H., & Saeed, A. A. (2019). Investigation of anti-obesity activity of ethanolic extract of Foeniculum vulgare seeds, in vivo and in silico modelsWorld Journal of Pharmacy and Pharmaceutical Sciences, 8(11), 111–124https://doi.org/10.20959/wjpps201911-14880
Ghosh, S., Sengupta, J., Datta, P., & Gomes, A. (2014). Hematopoietic and antioxidant activities of gold nanoparticles synthesized by aqueous extract of fenugreek ( Trigonella foenum-graecum ) seedAdvanced Science, Engineering and Medicine, 6(5), 546–552https://doi.org/10.1166/asem.2014.1511
Gingasu, D., MÎNdru, I., Patron, L., Marinescu, G., Ianculescu, A., Surdu, V. A., Somacescu, S., Preda, S., & Oprea, O. (2018). Synthesis of cobalt aluminate nanoparticles by combustion methods using cinnamon bark extractRevue Roumaine de Chimie, 63(5–6), 459–466
Gnanajobitha, G., Annadurai, G., & Kannan, C. (2012). Green synthesis of silver nanoparticle using Elettaria cardamomom and assesment of its antimicrobial activityInternational Journal of Pharmaceutical Sciences and Research (IJPSR), 3(3), 323–330http://www.ijpsr.info/docs/IJPSR12-03-03-011.pdf
Godebo, D. D., Dessalegn, E., & Niguse, G. (2019). Nutritional composition, microbial load and sensory properties of fenugreek (Trigonella foenum-graecum l.) flour substituted InjeraJournal of Food Processing & Technology, 10(7), 1–7https://doi.org/10.4172/2157-7110.1000799
Goel, A., Ajaikumar, B., Kunnumakkara, B., Bharat, B., & Aggarwal, B. (2007). Curcumin as ‘“curecumin”’: From kitchen to clinicBiochemical Pharmacology, 75, 787–809
Goel, B., & Mishra, S. (2020). Medicinal and nutritional perspective of cinnamon: a mini-reviewEuropean Journal of Medicinal Plants, March, 10–16https://doi.org/10.9734/ejmp/2020/v31i330218
Gök, V. (2015). Effect of replacing beef fat with poppy seed oil on quality of Turkish sucukKorean Journal for Food Science of Animal Resources, 35(2), 240–247https://doi.org/10.5851/kosfa.2015.35.2.240
Golmohammadi, F. (2013). Medical plant of Ferula assa-foetida and its cultivating , main characteristics and economical importance in South khorasan province - east of IranGlobal Health, 2334–2346
Golubkina, N. A., Nadezhkin, S. M., Agafonov, A. F., Kosheleva, O. V., Molchanova, A. V., Russo, G., Cuciniello, A., & Caruso, G. (2015). Seed oil content, fatty acids composition and antioxidant properties as affected by genotype in Allium cepa L. and perennial onion speciesAdvances in Horticultural Science, 29(4), 199–206https://doi.org/10.13128/ahs-22738
Goodarzi, M. T., Khodadadi, I., Tavilani, H., & Abbasi Oshaghi, E. (2016). The role of Anethum graveolens l. (dill) in the management of diabetesJournal of Tropical Medicine, 2016https://doi.org/10.1155/2016/1098916
Goswami, M., Sharma, B. D., Mendiratta, S. K., & Pathak, V. (2018). Evaluation of quality characteristics low fat buffalo meat cookies incorporated with poppy seeds (Papaver somniferum)Buffalo Bulletin, 37(4), 535–544
Goswami, N., & Chatterjee, S. (2014). Assessment of free radical scavenging potential and oxidative DNA damage preventive activity of Trachyspermum ammi l. (carom) and Foeniculum vulgare mill. (fennel) seed extractsBioMed Research International, 2014https://doi.org/10.1155/2014/582767
Gottesman, R., Shukla, S., Perkas, N., Solovyov, L. A., Nitzan, Y., & Gedanken, A. (2011). Sonochemical coating of paper by microbiocidal silver nanoparticlesLangmuir, 27(2), 720–726https://doi.org/10.1021/la103401z
Goyal, D., Saini, A., Saini, G. S. S., & Kumar, R. (2019). Green synthesis of anisotropic gold nanoparticles using cinnamon with superior antibacterial activityMaterials Research Express, 6(7)https://doi.org/10.1088/2053-1591/ab15a6
Goyal, S., Gupta, N., & Chatterjee, S. (2016). Investigating therapeutic potential of trigonella foenum-graecum L. As our defense mechanism against several human diseasesJournal of Toxicology, 2016https://doi.org/10.1155/2016/1250387
Goyal, V., Singh, A., Singh, J., Kaur, H., Kumar, S., & Rawat, M. (2022). Biogenically structural and morphological engineering of Trigonella foenum-graecum mediated SnO2 nanoparticles with enhanced photocatalytic and antimicrobial activitiesMaterials Chemistry and Physics, 282, 125946https://doi.org/10.1016/j.matchemphys.2022.125946
Granja Alvear, L. A. (2019). Evaluation of the reducing and capping agent of garlic and cinnamon bark extracts In the synthesis of silver nanoparticlesQuimica
Guerra, A. S., Hoyos, C. G., Velásquez-Cock, J., Vélez, L., Gañán, P., & Zuluaga, R. (2022). The effects of adding a gel-alike Curcuma longa l. suspension as color agent on some quality and sensory properties of yogurtMolecules, 27(3)https://doi.org/10.3390/molecules27030946
Gunasekera, N., Wijeratnam, S. W., Perera, S., Hewajulige, I., Gunathilaka, S., Paliyath, G., & Subramanian, J. (2018). Extending storage life of mango (Mangifera indica L.) using a new edible wax formulation incorporated with hexanal and cinnamon bark oilTropical Agriculture, 95(1), 97–110
Gunes-Bayir, A., Bilgin, M. G., Kutlu, S. S., Demirci, D., & Gölgeci, F. N. (2020). Microbiological, chemical and sensory analyzes of produced probiotic yoghurts added clove and propolisIcontech International Journal, 4(2), 1–14https://doi.org/10.46291/icontechvol4iss2pp1-14
Gupta, J., Gupta, R., & Mathur, K. (2019). Pharmacognostical, pharmacological and traditional perspectives of apium graveolens an ethnomedicinal plantInternational Journal of Life Science and Pharma Research, 9(3), 38–47
Gupta, A., Mahajan, S., & Sharma, R. (2015). Evaluation of antimicrobial activity of Curcuma longa rhizome extract against Staphylococcus aureusBiotechnology Reports, 6, 51–55https://doi.org/10.1016/j.btre.2015.02.001
Gupta, E. (2020). Elucidating the phytochemical and pharmacological potential of Myristica fragrans (nutmeg)Ethnopharmacological Investigation of Indian Spices, January, 52–61https://doi.org/10.4018/978-1-7998-2524-1.ch004
Güzel, Y., & Özyazıcı, G. (2021). Adoption of promising fenugreek (Trigonella foenum-graceum L.) genotypes for yield and quality characteristics in the semiarid climate of TurkeyAtmosphere, 12(9)https://doi.org/10.3390/atmos12091199
Ha, P. T., Le, M. H., Hoang, T. M. N., Le, T. T. H., Duong, T. Q., Tran, T. H. H., Tran, D. L., & Nguyen, X. P. (2012). Preparation and anti-cancer activity of polymer-encapsulated curcumin nanoparticlesAdvances in Natural Sciences: Nanoscience and Nanotechnology, 3(3)https://doi.org/10.1088/2043-6262/3/3/035002
Hadi, S. M., Etheb, A. M., Omran, A. H., & Hassan, S. H. (2022). Characterization, biofilm and plasmid curing effect of silver nanoparticles synthesis by aqueous extract of Myristica fragrans seedsJordan Journal of Biological Sciences, 15(1), 149–158https://doi.org/10.54319/jjbs/150120
Hafez, R. M., & Fouad, A. S. (2020). Mitigation of genotoxic and cytotoxic effects of silver nanoparticles on onion root tips using some antioxidant scavengersEgyptian Journal of Botany, 60(1), 133–145https://doi.org/10.21608/ejbo.2019.13390.1321
Hajalizadeh, Z., Dayani, O., Khezri, A., & Tahmasbi, R. (2020). Digestibility, ruminal characteristics, and meat quality of fattening lambs fed different levels of fennel (Foeniculum vulgare) seed powderJournal of Livestock Science and Technologies, 8(1), 37–46https://doi.org/10.22103/jlst.2020.15855.1319
Hajhashemi, V., Sajjadi, S. E., & Zomorodkia, M. (2011). Antinociceptive and anti-inflammatory activities of Bunium persicum essential oil, hydroalcoholic and polyphenolic extracts in animal modelsPharmaceutical Biology, 49(2), 146–151https://doi.org/10.3109/13880209.2010.504966
Hajji, M., Falcimaigne-Gordin, A., Ksouda, G., Merlier, F., Thomasset, B., & Nasri, M. (2021). A water soluble polysaccharide from anethum graveolens seeds structural characterization, antioxidant activity and potential use as meat preservativeInternational Journal of Biological Macromolecules, 167(15), 516–527
Hameed, I. H., Hamza, L. F., & Kamal, S. A. (2015). Analysis of bioactive chemical compounds of Aspergillus niger by using gas chromatography-mass spectrometry and fourier-transform infrared spectroscopyJournal of Pharmacognosy and Phytotherapy, 7(8), 132–163https://doi.org/10.5897/JPP2015.0354
Handharyani, E., Sutardi, L. N., Mustika, A. A., Andriani, A., & Yuliani, S. (2020). Antibacterial activity of Curcuma longa (turmeric), Curcuma zedoaria (zedoary), and Allium sativum (garlic) nanoparticle extract on chicken with chronic respiratory disease complex: in vivo studyE3S Web of Conferences, 151, 1–5https://doi.org/10.1051/e3sconf/202015101054
Hariri, A., & Ouis, N. (2020). Effect of volatile oils from Petroselinum crispum and Foeniculum vulgare on the quality and shelf-life of steamed yoghurtsAlgerian Journal of Natural Products, 1, 723–731
Harlina, P. W., Ma, M., Shahzad, R., Gouda, M. M., & Qiu, N. (2018). Effect of clove extract on lipid oxidation, antioxidant activity, volatile compounds and fatty acid composition of salted duck eggsJournal of Food Science and Technology, 55(12), 4719–4734https://doi.org/10.1007/s13197-018-3367-8
Hasan, A. A., Abdullah, R. M., & Hameed, H. Q. (2020). Effect of trigonellafoenum extract and TiO2 nanoparticles against acinetobacter baumanniiAnnals of Tropical Medicine and Public Health, 23(18)https://doi.org/10.36295/ASRO.2020.231814
Hashemi, S. M. B., & Jafarpour, D. (2020). The efficacy of edible film from Konjac glucomannan and saffron petal extract to improve shelf life of fresh-cut cucumberFood Science and Nutrition, 8(7), 3128–3137https://doi.org/10.1002/fsn3.1544
Hassanzadazar, H., Taami, B., Aminzare, M., & Daneshamooz, S. (2018). Bunium persicum (boiss.) b. fedtsch: an overview on phytochemistry, therapeutic uses and its application in the food industryJournal of Applied Pharmaceutical Science, 8(10), 150–158https://doi.org/10.7324/JAPS.2018.81019
He, X., & Hwang, H. M. (2016). Nanotechnology in food science: Functionality, applicability, and safety assessment. In Journal of Food and Drug Analysis (Vol. 24, Issue 4, pp. 671–681). Elsevier Taiwan LLChttps://doi.org/10.1016/j.jfda.2016.06.001
Hefnawy, H. T., El-Shourbagy, G. A., & Ramadan, M. F. (2016). Phenolic extracts of carrot, grape leaf and turmeric powder antioxidant potential and application in biscuitsJournal of Food Measurement and Characterization, 10, 576–583
Hegazy, A., & Hegazy, A. I. (2011). Influence of using fenugreek seed flour as antioxidant and antimicrobial agent in the manufacturing of beef burger with emphasis on frozen storage stabilityWorld Journal of Agricultural Sciences, 7(4), 391–399
Heikal, Y. M., Şuţan, N. A., Rizwan, M., & Elsayed, A. (2020). Green synthesized silver nanoparticles induced cytogenotoxic and genotoxic changes in Allium cepa L. varies with nanoparticles doses and duration of exposureChemosphere, 243, 125430https://doi.org/10.1016/j.chemosphere.2019.125430
Hemalatha, P., & Premnath, A. (2016). Study on silver nanoparticle encapsulated curcumin for anticancer activityHemalatha et Al World Journal of Pharmaceutical Research, 5(October1), 958https://doi.org/10.20959/wjpr201610-7170
Hendrayady, A., & Audi Ghaffari, M. (2011). Application of Garcinia indica as a colorant and antioxidant in rice extrudatesJurnal Fisip Umrah, Vol 1 No(1), 287–295http://e-journal.usd.ac.id/index.php/LLT; http://jurnal.untan.ac.id/index.php/jpdpb/article/viewFile/11345/10753; https://doi.org/10.1016/j.sbspro.2015.04.758;www.iosrjournals.org
Herbst, R., & Herbst, S. T. (2015)The deluxe food lover’s companion. 854https://books.google.com/books?id=e8BoCwAAQBAJ&pg=PT901
Hettiarachchi, S. S., Dunuweera, S. P., Dunuweera, A. N., & Rajapakse, R. M. G. (2021). Synthesis of curcumin nanoparticles from raw turmeric rhizomeACS Omega, 6(12), 8246–8252https://doi.org/10.1021/acsomega.0c06314
Hettiarachchy, N. S., Glenn, K. C., Gnanasambandam, R., & Johnson, M. G. (1996). Natural antioxidant extract from Fenugreek (Trigonella foenumgraecum) for ground beef pattiesJournal of Food Science, 61(3), 516–519https://doi.org/10.1111/j.1365-2621.1996.tb13146.x
Ho, K. K. H. Y., Schroën, K., San Martín-González, M. F., & Berton-Carabin, C. C. (2017). Physicochemical stability of lycopene-loaded emulsions stabilized by plant or dairy proteinsFood Structure, 12, 34–42https://doi.org/10.1016/j.foostr.2016.12.001
Homayouni Moghadam, F., Dehghan, M., Zarepur, E., Dehlavi, R., Ghaseminia, F., Ehsani, S., Mohammadzadeh, G., & Barzegar, K. (2014). Oleo gum resin of Ferula assa-foetida L. ameliorates peripheral neuropathy in miceJournal of Ethnopharmacology, 154(1), 183–189https://doi.org/10.1016/j.jep.2014.03.069
Hooda, S., & Jood, S. (2005). Organoleptic and nutritional evaluation of wheat biscuits supplemented with untreated and treated fenugreek flourFood Chemistry, 90(3), 427–435https://doi.org/10.1016/j.foodchem.2004.05.006
Hossain, M. M., Das Aka, T., Rahman, M. S., Uddin, A. H. M. M., Rahman, N., & Rashid, M. M. O. (2019). Neuropharmacological activity of the crude ethanolic extract of Syzygium aromaticum flowering budDiscovery Phytomedicine, 6(4)https://doi.org/10.15562/phytomedicine.2019.109
Howard, L. A., Wong, A. D., Perry, A. K., & Klein, B. P. (1999). β-Carotene and ascorbic acid retention in fresh and processed vegetablesJournal of Food Science, 64(5), 929–936https://doi.org/10.1111/j.1365-2621.1999.tb15943.x
Hu, K., Huang, X., Gao, Y., Huang, X., Xiao, H., & McClements, D. J. (2015). Core–shell biopolymer nanoparticle delivery systems: Synthesis and characterization of curcumin fortified zein–pectin nanoparticlesFood Chemistry, 182, 275–281https://doi.org/10.1016/j.foodchem.2015.03.009
Hu, Y., Fu, A., Miao, Z., Zhang, X., Wang, T., Kang, A., Shan, J., Zhu, D., & Li, W. (2018). Fluorescent ligand fishing combination with in-situ imaging and characterizing to screen Hsp 90 inhibitors from Curcuma longa L. based on InP/ZnS quantum dots embedded mesoporous nanoparticlesTalanta, 178, 258–267https://doi.org/10.1016/j.talanta.2017.09.035
Hu, Y., Luo, J., Kong, W., Zhang, J., Logrieco, A. F., Wang, X., & Yang, M. (2015). Uncovering the antifungal components from turmeric (Curcuma longa L.) essential oil as Aspergillus flavus fumigants by partial least squaresRSC Advances, 5(52), 41967–41976https://doi.org/10.1039/c5ra01725d
Huda, J. A., Hameed, I. H., & Hamza, L. F. (2017). Anethum graveolens: physicochemical properties, medicinal uses, antimicrobial effects, antioxidant effect, anti-inflammatory and analgesic effects: a reviewInternational Journal of Pharmaceutical Quality Assurance, 8(3), 88–91https://doi.org/10.25258/ijpqa.v8i03.9569
Hussain, J., Khan, A. L., ur Rehman, N., Zainullah, Khan, F., Hussain, S. T., & Shinwari, Z. K. (2009). Proximate and nutrient investigations of selected medicinal plants species of PakistanPakistan Journal of Nutrition, 8(5), 620–624https://doi.org/10.3923/pjn.2009.620.624
Hussein, N. H., Shaarawy, H. H., Hawash, S. I., & Abdel-Kader, A. E. (2018). Green synthesis of silver nanoparticle using fenugreek seeds extractARPN Journal of Engineering and Applied Sciences, 13(2), 1–5
Hussein, H. J., Hadi, M. Y., & Hameed, I. H. (2016). Study of chemical composition of Foeniculum vulgare using Fourier transform infrared spectrophotometer and gas chromatography - mass spectrometryJournal of Pharmacognosy and Phytotherapy, 8(3), 60–89https://doi.org/10.5897/JPP2015.0372
Ibrahim, F. M., Ibrahim, A. Y., El Gohary, A. E., Hussein, M. S., & Ahmed, K. A. (2016). Illicium verum extracts anti-gastro ulcerogenic potential on experimentally rat modelsInternational Journal of PharmTech Research, 9(5), 65–80
Ikpeama, A., Onwuka, G. I., & Nwankwo, C. (2014). Nutritional composition of tumeric (Curcuma longa) and its antimicrobial propertiesInternational Journal of Scientific & Engineering Research, 5(10), 1085–1089
Imchen, P., Ziekhrü, M., Zhimomi, B. K., & Phucho, T. (2022). Biosynthesis of silver nanoparticles using the extract of Alpinia galanga rhizome and Rhus semialata fruit and their antibacterial activityInorganic Chemistry Communications, 142, 109599https://doi.org/10.1016/j.inoche.2022.109599
Indu Rawat, N. V., & K. J. (2020). Cinnamon (Cinnamomum zeylanicum)Medicinal Plants in India: Importance and Cultivation, 164–177
Iqbal, S., Jabeen, F., Peng, C., Ijaz, M. U., & Chaudhry, A. S. (2020). Cinnamomum cassia ameliorates Ni-NPs-induced liver and kidney damage in male Sprague Dawley ratsHuman and Experimental Toxicology, 39(11), 1565–1581https://doi.org/10.1177/0960327120930125
Iranshahy, M., & Iranshahi, M. (2011). Traditional uses, phytochemistry and pharmacology of asafoetida (Ferula assa-foetida oleo-gum-resin) - A reviewJournal of Ethnopharmacology, 134(1), 1–10https://doi.org/10.1016/j.jep.2010.11.067
Ishtiaque, S., Naz, S., Siddiqi, R., Jabeen, S., & Ahmed, J. (2015). Antioxidant activity and phenolic contents of ajwain, mustard, fenugreek and poppy seedRecent Innovations in Chemical Engineering (Formerly Recent Patents on Chemical Engineering), 7(2), 119–127https://doi.org/10.2174/2405520407666150425004125
Ismail, M. A., Darwish, A. Z. M., Hussein, N. A., & Darwish, S. M. (2014)In vivo effect of essential oils from Laurus nobilis, Anethum graveolens and Mentha piperita on mycobiota associated with domiati cheese during storageFood and Public Health, 4(3), 110–122https://doi.org/10.5923/j.fph.20140403.07
Istúriz-Zapata, M. A., Hernández-López, M., Correa-Pacheco, Z. N., & Barrera-Necha, L. L. (2020). Quality of cold-stored cucumber as affected by nanostructured coatings of chitosan with cinnamon essential oil and cinnamaldehydeLwt, 123(September 2019), 109089https://doi.org/10.1016/j.lwt.2020.109089
Ituen, E., Singh, A., Yuanhua, L., & Akaranta, O. (2021). Green synthesis and anticorrosion effect of Allium cepa peels extract-silver nanoparticles composite in simulated oilfield pickling solutionSN Applied Sciences, 3(6)https://doi.org/10.1007/s42452-021-04670-w
Jacob, V., & P, R. (2019)In vitro analysis: the antimicrobial and antioxidant activity of zinc oxide nanoparticles from Curcuma longaAsian Journal of Pharmaceutical and Clinical Research, 12(1), 200https://doi.org/10.22159/ajpcr.2018.v12i1.28808
Jacob, V., Rajiv, P., & Dhanasekaran, S. (2020). Antioxidant and anticancerous activities of biologically synthesized zinc oxide nanoparticles (Zno nps) from the rhizomes of curcuma longaInternational Journal of Pharmaceutical Research, 12(September), 2304–2313https://doi.org/10.31838/ijpr/2020.SP1.283
Jadouali, S. M., Atifi, H., Mamouni, R., Majourhat, K., Bouzoubaâ, Z., Laknifli, A., & Faouzi, A. (2019). Chemical characterization and antioxidant compounds of flower parts of Moroccan crocus sativus LJournal of the Saudi Society of Agricultural Sciences, 18(4), 476–480https://doi.org/10.1016/j.jssas.2018.03.007
Jagtap, P., Bhise, K., & Prakya, V. (2015). A Phytopharmacological Review on Garcinia indica~ 2 ~ International Journal of Herbal Medicine, 3(4)
Jahromi, M. A. M., Al-Musawi, S., Pirestani, M., Ramandi, M. F., Ahmadi, K., Rajayi, H., Hassan, Z. M., Kamali, M., & Mirnejad, R. (2014). Curcumin-loaded chitosan tripolyphosphate nanoparticles as a safe, natural and effective antibiotic inhibits the infection of staphylococcus aureus and pseudomonas aeruginosa in vivoIranian Journal of Biotechnology, 12(3)https://doi.org/10.15171/ijb.1012
Jain, A., Wadhawan, S., & Mehta, S. K. (2021). Biogenic synthesis of non-toxic iron oxide NPs via Syzygium aromaticum for the removal of methylene blueEnvironmental Nanotechnology, Monitoring & Management, 16, 100464https://doi.org/10.1016/j.enmm.2021.100464
Jain, S., Buttar, H. S., Chintameneni, M., & Kaur, G. (2018). Prevention of cardiovascular diseases with anti-inflammatory and anti- oxidant nutraceuticals and herbal products: An overview of pre-clinical and clinical studiesRecent Patents on Inflammation & Allergy Drug Discovery, 12(2), 145–157https://doi.org/10.2174/1872213x12666180815144803
Jaiswal, P., Kumar, P., Singh, V. K., & Singh, D. K. (2009). Biological effects of Myristica fragransAnnual Review of Biomedical Sciences, 11, 21–29https://doi.org/10.5016/1806-8774.2009v11p21
Jamal, A., Javed, K., Aslam, M., & Jafri, M. A. (2006). Gastroprotective effect of cardamom, Elettaria cardamomum Maton. fruits in ratsJournal of Ethnopharmacology, 103(2), 149–153https://doi.org/10.1016/j.jep.2005.07.016
Jamzad, M., & Kamari Bidkorpeh, M. (2020). Green synthesis of iron oxide nanoparticles by the aqueous extract of Laurus nobilis L. leaves and evaluation of the antimicrobial activityJournal of Nanostructure in Chemistry, 10(3), 193–201https://doi.org/10.1007/s40097-020-00341-1
Jana, S., & Shekhawat, G. (2010). Anethum graveolens: An Indian traditional medicinal herb and spicePharmacognosy Reviews, 4(8), 179–184https://doi.org/10.4103/0973-7847.70915
Jana, S., & Shekhawat, G. (2010). Anethum graveolens: An Indian traditional medicinal herb and spicePharmacognosy Reviews, 4(8), 179–184https://doi.org/10.4103/0973-7847.70915
Jasim, B., Thomas, R., Mathew, J., & Radhakrishnan, E. K. (2017). Plant growth and diosgenin enhancement effect of silver nanoparticles in Fenugreek (Trigonella foenum-graecum L.)Saudi Pharmaceutical Journal, 25(3), 443–447https://doi.org/10.1016/j.jsps.2016.09.012
Javad, S. (2017). Antibacterial activity of plant extract and zinc nanoparticles obtained from Syzigium aromaticum LPure and Applied Biology, 6(4), 1079–1087https://doi.org/10.19045/bspab.2017.600115
Jayaprakash, N., Judith Vijaya, J., John Kennedy, L., Priadharsini, K., & Palani, P. (2014). One step phytosynthesis of highly stabilized silver nanoparticles using Piper nigrum extract and their antibacterial activityMaterials Letters, 137, 358–361https://doi.org/10.1016/j.matlet.2014.09.027
Jayathilake, A. L., Jayasinghe, M. A., & Walpita, J. (2022). Development of ginger, turmeric oleoresins and pomegranate peel extracts incorporated pasteurized milk with pharmacologically important active compoundsApplied Food Research, 2(1), 100063https://doi.org/10.1016/j.afres.2022.100063
Jelin, F. J., Kumar, S. S., Malini, M., Vanaja, M., & Annadurai, G. (2015). Environment -assisted green approach agnps by nutmeg inhibition potential accustomed to pharmaceuticalsEuropean Journal of Biomedical AND Pharmaceutical Sciences, 2(3), 258–274
Jerlin Showmya, J., Harini, K., Pradeepa, M., Thiyagarajan, M., Manikandan, R., Venkatachalam, P., & Geetha, N. (2012). Rapid green synthesis of silver nanoparticles using seed extracts of Foeniculum vulgare and screening of its antibacterial activityPlant Cell Biotechnology and Molecular Biology, 13(1–2), 29–34
Jeyaratnam, N., Nour, A. H., Kanthasamy, R., Nour, A. H., Yuvaraj, A. R., & Akindoyo, J. O. (2016). Essential oil from Cinnamomum cassia bark through hydrodistillation and advanced microwave assisted hydrodistillationIndustrial Crops and Products, 92, 57–66https://doi.org/10.1016/j.indcrop.2016.07.049
Jin, H., Xia, F., Jiang, C., Zhao, Y., & He, L. (2009). Nanoencapsulation of lutein with hydroxypropylmethyl cellulose phthalate by supercritical antisolventChinese Journal of Chemical Engineering, 17(4), 672–677https://doi.org/10.1016/S1004-9541(08)60262-1
Asgarpanah,J. (2012). Phytochemistry and pharmacologic properties of Myristica fragrans Hoyutt.: A reviewAfrican Journal of Biotechnology, 11(65)https://doi.org/10.5897/ajb12.1043
Jolayemi, A. T., & Ojewole, J. A. O. (2013). Comparative anti-inflammatory properties of Capsaicin and ethyl-aAcetate extract of Capsicum frutescens linn [Solanaceae] in ratsAfrican Health Sciences, 13(2), 357–361https://doi.org/10.4314/ahs.v13i2.23
Jung, C. H., Ahn, J., Jeon, T. I., Kim, T. W., & Ha, T. Y. (2012). Syzygium aromaticum ethanol extract reduces high-fat diet-induced obesity in mice through downregulation of adipogenic and lipogenic gene expressionExperimental and Therapeutic Medicine, 4(3), 409–414https://doi.org/10.3892/etm.2012.609
Kaashmeera, N. K., Krupavaram, B., Singh, J. C. H., Anandarajagopal, K., Aasminerjiit, K., & Shopana, P. (2020). Evaluation of ethanolic root extract of Allium cepa. l for analgesic and anti-inflammatory activities in animal modelsWorld Journal of Current Medical and Pharmaceutical Research, 02(01), 67–73https://doi.org/10.37022/wjcmpr.2020.02017
Kabrah, A. (2015). The Antibacterial Activity of Onion on MSSA and MRSA Isolates of Staphylococcus aureusProQuest Dissertations and Theses, 198https://search.proquest.com/docview/1718551102?accountid=26642;http://link.periodicos.capes.gov.br/sfxlcl41?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&genre=dissertations+%26+theses&sid=ProQ:ProQuest+Dissertations+%26+Theses+Globa
Kačániová, M., Mellen, M., Vukovic, N. L., Kluz, M., Puchalski, C., Haščík, P., & Kunová, S. (2019). Combined effect of vacuum packaging, fennel and savory essential oil treatment on the quality of chicken thighsMicroorganisms, 7(5), 2–11https://doi.org/10.3390/microorganisms7050134
Kailey, R., Dhawan, K., Rasane, P., Singh, J., Kaur, S., Singh, B. P., Kaur, N., & Kaur, D. (2019). Utilization of Foeniculum vulgare in herbal candy preparation and analysing its effect on the physico-chemical and sensory propertiesCurrent Science, 116(12), 2013–2019https://doi.org/10.18520/cs/v116/i12/2013-2019
Kalam, M. A. (2020). An Overview of Myristica fragrans (Nutmeg) -Its benefits and adverse effects to HumansIndian Journal of Integrated Medicine, 2, 45–50
Kaltsa, O., Yanniotis, S., Polissiou, M., & Mandala, I. (2018). Stability, physical properties and acceptance of salad dressings containing saffron (Crocus sativus) or pomegranate juice powder as affected by high shear (HS) and ultrasonication (US) processLwt, 97(January), 404–413https://doi.org/10.1016/j.lwt.2018.07.015
Kamal, S. B., Kumar, A., & Tanwar, T. (2017). Physico-chemical, proximate, sensory and storage quality attributes analysis of Papaver somniferum (poppy) fortified chevon nuggetsJournal of Applied and Natural Science, 9(1), 114–120https://doi.org/10.31018/jans.v9i1.1158
Kamatou, G. P., Vermaak, I., & Viljoen, A. M. (2012). Eugenol - from the remote Maluku islands to the international market place: a review of a remarkable and versatile moleculeMolecules, 17(6), 6953–6981https://doi.org/10.3390/molecules17066953
Kamel, K. M., Khalil, I. A., Rateb, M. E., Elgendy, H., & Elhawary, S. (2017). Chitosan-coated cinnamon/oregano-loaded solid lipid nanoparticles to augment 5-fluorouracil cytotoxicity for colorectal cancer: Extract standardization, nanoparticle optimization, and cytotoxicity evaluationJournal of Agricultural and Food Chemistry, 65(36), 7966–7981https://doi.org/10.1021/acs.jafc.7b03093
Kamel Moawad, R., Saleh, O., Mohamed, S., & Abdelmaguid, N. M. (2020). Shelf-life evaluation of raw chicken sausage incorporated with green tea and clove powder extracts at refrigerated storagePlant Archives, 20(2), 8821–8830
Kamkar, A., Khanjari, A. O. M., & Aghaee, E, M. (2017). Effect of packaging with chitosan film containing Bunium persicum L. essential oil on chemical and microbial properties of chicken filletJournal of Fasa University of Medical Science, 7(1)
Kamoun, J., Krichen, F., Koubaa, I., Zouari, N., Bougatef, A., Abousalham, A., & Aloulou, A. (2021)In vitro lipolysis and physicochemical characterization of unconventional star anise oil towards the development of new lipid-based drug delivery systemsHeliyon, 7(4), e06717https://doi.org/10.1016/j.heliyon.2021.e06717
Kanniah, P., Chelliah, P., Thangapandi, J. R., Gnanadhas, G., Mahendran, V., & Robert, M. (2021). Green synthesis of antibacterial and cytotoxic silver nanoparticles by Piper nigrum seed extract and development of antibacterial silver based chitosan nanocompositeInternational Journal of Biological Macromolecules, 189, 18–33https://doi.org/10.1016/j.ijbiomac.2021.08.056
Karadağoğlu, Ö., Şahin, T., Ölmez, M., Ahsan, U., Özsoy, B., & Önk, K. (2019). Fatty acid composition of liver and breast meat of quails fed diets containing black cumin (Nigella sativa L.) and/or coriander (Coriandrum sativum L.) seeds as unsaturated fatty acid sourcesLivestock Science, 223, 164–171https://doi.org/10.1016/j.livsci.2019.03.015
Kareem, M. A., Krushna, G. S., Hussain, S. A., & Devi, K. L. (2009). Effect of aqueous extract of nutmeg on hyperglycaemia, hyperlipidaemia and cardiac histology associated with isoproterenol-induced myocardial infarction in ratsTropical Journal of Pharmaceutical Research, 8(4), 337–344https://doi.org/10.4314/tjpr.v8i4.45227
Kargozari, M., Hamedi, H., Amirnia, S. A., Montazeri, A., & Abbaszadeh, S. (2018). Effect of bioactive edible coating based on sodium alginate and coriander ( Coriandrum sativum L. ) essential oil on the quality of refrigerated chicken filletFood & Health, 1(6), 30–38
Karimi, M., Sekhavatizadeh, S. S., & Hosseinzadeh, S. (2021). milk dessert containing lactobacillus reuteri encapsulated with sodium alginate, ferula asafoetida and zedo gum as three layers of wall materialsFood and Bioproducts Processing, 127, 244–254
Karimi, E., Oskoueian, E., Hendra, R., & Jaafar, H. Z. E. (2010). Evaluation of Crocus sativus L. stigma phenolic and flavonoid compounds and its antioxidant activityMolecules, 15(9), 6244–6256https://doi.org/10.3390/molecules15096244
Kashkouli, S., Jamzad, M., & Nouri, A. (2018). Total phenolic and flavonoids contents, radical scavenging activity and green synthesis of silver nanoparticles by Laurus nobilis L. leaves aqueous extractJournal of Medicinal Plants and By-Products, 1, 25–32. moz-extension://0074b4dd-988d-4d53–9b16-bec6dea4bf70/enhanced-reader.html?openApp&pdf https://jmpb.areeo.ac.ir/article_116725_dac1a5ad6a5cc68538510268c5c720dc.pdf
Kaur, N., Kaur, C. K., & Singh, R. U. (2018). Phytochemical screening and antioxidant activity of Anethum graveolens L. seed extracts. ~ 324 ~The Pharma Innovation Journal, 7(6), 324–329
Kaur, G., Kaur, R., & Kaur, S. (2021). Studies on physiochemical properties of oil extracted from Brassica nigra and Brassica rapa toriaMaterials Today: Proceedings, 48(October), 1645–1651https://doi.org/10.1016/j.matpr.2021.09.527
Kaur, P., Gupta, S., Kaur, K., Kaur, N., Kumar, R., & Bhullar, M. S. (2021). Nanoemulsion of Foeniculum vulgare essential oil: A propitious striver against weeds of Triticum aestivumIndustrial Crops and Products, 168, 113601https://doi.org/10.1016/j.indcrop.2021.113601
Kavas, N., & Kavas, G. (2017). Use of turmeric (Curcuma longa l.) essential oil added to an egg white protein powder-based film in the storage of Çökelek cheeseJournal of Food Chemistry and Nanotechnology, 3(3), 105–110https://doi.org/10.17756/jfcn.2017-045
Kavoosi, G., & Rowshan, V. (2013). Chemical composition, antioxidant and antimicrobial activities of essential oil obtained from Ferula assa-foetida oleo-gum-resin: Effect of collection timeFood Chemistry, 138(4), 2180–2187https://doi.org/10.1016/j.foodchem.2012.11.131
Keshavarz, A., Minaiyan, M., Ghannadi, A., & Mahzouni, P. (2013). Effects of carum carvi L. (Caraway) extract and essential oil on TNBS-induced colitis in ratsResearch in Pharmaceutical Sciences, 8(1), 1–8
Kestwal, R. M., Bagal-Kestwal, D., & Chiang, B.-H. (2015). Fenugreek hydrogel–agarose composite entrapped gold nanoparticles for acetylcholinesterase based biosensor for carbamates detectionAnalytica Chimica Acta, 886, 143–150https://doi.org/10.1016/j.aca.2015.06.004
Keykhosravy, K., Khanzadi, S., Hashemi, M., & Azizzadeh, M. (2020). Chitosan-loaded nanoemulsion containing Zataria Multiflora Boiss and Bunium persicum Boiss essential oils as edible coatings: Its impact on microbial quality of turkey meat and fate of inoculated pathogensInternational Journal of Biological Macromolecules, 150, 904–913https://doi.org/10.1016/j.ijbiomac.2020.02.092
Khadka, G. (2018). Preparation and shelf life study of cinnamon oleoresin incorporated yoghurtFood Technology Thesishttp://202.45.146.37:8080/jspui/handle/123456789/89
Khairullah, A. R., Solikhah, T. I., Ansori, A. N. M., Hidayatullah, A. R., Hartadi, E. B., Ramandinianto, S. C., & Fadholly, A. (2021). Review on the pharmacological and health aspects of apium graveolens or celery: An updateSystematic Reviews in Pharmacy, 12(1), 606–612https://doi.org/10.31838/srp.2021.1.87
Khajeh, M., Yamini, Y., Bahramifar, N., Sefidkon, F., & Reza Pirmoradei, M. (2005). Comparison of essential oils compositions of Ferula assa-foetida obtained by supercritical carbon dioxide extraction and hydrodistillation methodsFood Chemistry, 91(4), 639–644https://doi.org/10.1016/j.foodchem.2004.06.033
Khaliq, T., Sarfraz, M., & Ashraf, M. A. (2015). Recent progress for the utilization of Curcuma longa, Piper nigrum and Phoenix dactylifera Seeds against type 2 diabetesWest Indian Medical Journal, 64(5), 527–532https://doi.org/10.7727/wimj.2016.176
Khamisabadi, H., & Ahmadpanah, J. (2020). The effect of diets supplemented with coriandrum sativum seeds on carcass performance, immune system, blood metabolites, rumen parameters and meat quality of lambsActa Scientiarum - Animal Sciences, 43(1), 1–13https://doi.org/10.4025/actascianimsci.v43i1.52048
Khan, I., Bawazeer, S., Rauf, A., Qureshi, M. N., Muhammad, N., Al-Awthan, Y., Bahattab, O., Maalik, A., & Rengasamy, K. R. R. (2022). synthesis, biological investigation and catalytic application using the alcoholic extract of black cumin seeds based silver nanoparticlesJournal of Nanostructure in Chemistry, 12, 59–77
Khan, H. N., Rasheed, S., Choudhary, M. I., Ahmed, N., & Adem, A. (2022). Anti-glycation properties of Illicium verum Hook. f. fruit in-vitro and in a diabetic rat modelBMC Complementary Medicine and Therapies, 22(1), 1–15https://doi.org/10.1186/s12906-022-03550-z
Khan, I., Ahmad, H., & Ahmad, B. (2014). Anti-glycationand anti-oxidation properties of Capsicum frutescens and Curcuma longa fruits: Possible role in prevention of diabetic complicationPakistan Journal of Pharmaceutical Sciences, 27(5), 1359–1362
Khan, I., Shah, S., Ahmad, J., Abdullah, A., & Johnson, S. K. (2017). Effect of incorporating bay leaves in cookies on postprandial glycemia, appetite, palatability, and gastrointestinal well-BeingJournal of the American College of Nutrition, 36(7), 514–519https://doi.org/10.1080/07315724.2017.1326324
Khan, M. A., Moghul, N. B., Butt, M. A., Kiyani, M. M., Zafar, I., & Bukhari, A. I. (2021). Assessment of antibacterial and antifungal potential of Curcuma longa and synthesized nanoparticles: A comparative studyJournal of Basic Microbiology, 61(7), 603–611https://doi.org/10.1002/jobm.202100010
Khan, M. J., Shameli, K., Sazili, A. Q., Selamat, J., & Kumari, S. (2019). Rapid green synthesis and characterization of silver nanoparticles arbitrated by curcumin in an alkaline mediumMolecules, 24(4)https://doi.org/10.3390/molecules24040719
Khan, M., & Siddiqui, M. (2007). Antimicrobial activity of piper fruitsIndian Journal of Natural Products and Resources, 6(2), 111–113
Khan, M. T., Ahmed, S., Shah, A. A., Shah, A. N., Tanveer, M., El-Sheikh, M. A., & Siddiqui, M. H. (2021). Influence of zinc oxide nanoparticles to regulate the antioxidants enzymes, some osmolytes and agronomic attributes in coriandrum sativum l. Grown under water stressAgronomy, 11(10)https://doi.org/10.3390/agronomy11102004
Khan, R. U., Fatima, A., Naz, S., Ragni, M., Tarricone, S., & Tufarelli, V. (2022). Perspective, opportunities and challenges in using fennel (Foeniculum vulgare) in poultry health and production as an eco-friendly alternative to antibiotics: a reviewAntibiotics, 11(2)https://doi.org/10.3390/antibiotics11020278
Khare, A. K., Abraham, R. J. J., Rao, V. A., & Babu, R. N. (2016). Utilization of carrageenan, citric acid and cinnamon oil as an edible coating of chicken fillets to prolong its shelf life under refrigeration conditionsVeterinary World, 9(2), 166–175https://doi.org/10.14202/vetworld.2016.166-175
Kharey, P., Dutta, S. B., Gorey, A., Manikandan, M., Kumari, A., Vasudevan, S., Palani, I. A., Majumder, S. K., & Gupta, S. (2020). Pimenta dioica mediated biosynthesis of gold nanoparticles and evaluation of its potential for theranostic applicationsChemistrySelect, 5(26), 7901–7908https://doi.org/10.1002/slct.202001230
Khater, M. S., & Osman, Y. A. H. (2015). Influence of TiO2 nanoparticles on growth, chemical constituents and toxicity of fennel plantArab Journal of Nuclear Sciences and Applications, 48(4), 178–186
Khazdair, M. R., Anaeigoudari, A., Hashemzehi, M., & Mohebbati, R. (2019). Neuroprotective potency of some spice herbs, a literature reviewJournal of Traditional and Complementary Medicine, 9(2), 98–105https://doi.org/10.1016/j.jtcme.2018.01.002
Kheeree, N., Sangvanich, P., Puthong, S., & Karnchanatat, A. (2010). Antifungal and antiproliferative activities of lectin from the rhizomes of Curcuma amarissima RoscoeApplied Biochemistry and Biotechnology, 162(3), 912–925https://doi.org/10.1007/s12010-009-8804-8
Khobragade, S. P., Padghan, P. V., & Deshmukh, A. P. (2021). textural properties of paneer prepared from blends of raw turmeric extract and buffalo milkJournal of Pharmacognosy and Phytochemistry, 10(1), 149–152
Khorasani, S., Ghandehari Yazdi, A. P., Saadatfar, A., Kamali Rousta, L., Nejatian, M., Abarian, M., & Jafari, S. M. (2022). Valorization of saffron tepals for the green synthesis of silver nanoparticles and evaluation of their efficiency against foodborne pathogensWaste and Biomass Valorizationhttps://doi.org/10.1007/s12649-022-01791-0
Khorram, F., & Ramezanian, A. (2020). Cinnamon essential oil incorporated in shellac, a novel bio-product to maintain quality of ‘Thomson navel’ orange fruitJournal of Food Science and Technologyhttps://doi.org/10.1007/s13197-020-04798-4
Khorshidi, S., Mehdizadeh, T., & Ghorbani, M. (2021). The effect of chitosan coatings enriched with the extracts and essential oils of Elettaria Cardamomum on the shelf-life of chicken drumsticks vacuum-packaged at 4 °CJournal of Food Science and Technology, 58(8), 2924–2935https://doi.org/10.1007/s13197-020-04794-8
Khoso, S., Mehar, S., Anam, I., Naheed, N., Saeed, F., Khan, N., & Abbasi, B. H. (2022). Green synthesis of ZnO nanoparticles from Foeniculum vulgare, its characterization and biological potential against bacteriaJournal of Animal and Plant Sciences, 32(1), 229–237https://doi.org/10.36899/JAPS.2022.1.0418
Khosropanah, M. H., Dinarvand, A., Nezhadhosseini, A., Haghighi, A., Hashemi, S., Nirouzad, F., Khatamsaz, S., Entezari, M., Hashemi, M., & Dehghani, H. (2016). Analysis of the antiproliferative effects of curcumin and nanocurcumin in MDA-MB231 as a breast cancer cell lineIranian Journal of Pharmaceutical Research, 15(1), 231–239
Khumkomgool, A., Saneluksana, T., & Harnkarnsujarit, N. (2020). Active meat packaging from thermoplastic cassava starch containing sappan and cinnamon herbal extracts via LLDPE blown-film extrusionFood Packaging and Shelf Life, 26, 100557https://doi.org/10.1016/j.fpsl.2020.100557
Kiarsi, Z., Hojjati, M., Behbahani, B. A., & Noshad, M. (2020)In vitro antimicrobial effects of Myristica fragrans essential oil on foodborne pathogens and its influence on beef quality during refrigerated storageJournal of Food Safety, 40(3)https://doi.org/10.1111/jfs.12782
Kiasalari, Z., Khalili, M., Roghani, M., Heidari, H., & Azizi, Y. (2013). Antiepileptic and antioxidant effect of hydroalcoholic extract of ferula assa foetida gum on pentylentetrazoleinduced kindling in male miceBasic and Clinical Neuroscience, 4(4), 21–28
Kiasalari, Z., Khalili, M., Roghani, M., & Sadeghian, A. (2012). Antiepileptic and antioxidant effect of Brassica nigra on pentylenetetrazol-induced kindling in miceIranian Journal of Pharmaceutical Research, 11(4), 1209–1217https://doi.org/10.22037/ijpr.2012.1212
Kikuzaki, H., Sato, A., Mayahara, Y., & Nakatani, N. (2000). Galloylglucosides from berries of Pimenta dioicaJournal of Natural Products, 63(6), 749–752https://doi.org/10.1021/np9906121
Kilic, S., Oz, E., & Oz, F. (2021). Effect of turmeric on the reduction of heterocyclic aromatic amines and quality of chicken meatballsFood Control, 128https://doi.org/10.1016/j.foodcont.2021.108189
Kim, S., Kim, D. B., Jin, W., Park, J., Yoon, W., Lee, Y., Kim, S., Lee, S., Kim, S., Lee, O. H., Shin, D., & Yoo, M. (2018). Comparative studies of bioactive organosulphur compounds and antioxidant activities in garlic (Allium sativum L.), elephant garlic (Allium ampeloprasum L.) and onion (Allium cepa L.)Natural Product Research, 32(10), 1193–1197https://doi.org/10.1080/14786419.2017.1323211
Kim, Y. K., Nam, M. S., & Bae, H. C. (2017). Characteristics of gouda cheese supplemented with chili pepper extract microcapsulesKorean Journal for Food Science of Animal Resources, 37(6), 833–839https://doi.org/10.5851/kosfa.2017.37.6.833
Kivrak, Ş, Gokturk, T., & Kivrak, İ. (2017). Assessment of volatile oil composition, phenolics and antioxidant activity of bay (Laurus nobilis) leaf and usage in cosmetic applicationsInternational Journal of Secondary Metabolite, 4(2), 148–148https://doi.org/10.21448/ijsm.323800
Kocaadam, B., & Şanlier, N. (2017). Curcumin, an active component of turmeric (Curcuma longa), and its effects on healthCritical Reviews in Food Science and Nutrition, 57(13), 2889–2895https://doi.org/10.1080/10408398.2015.1077195
Koffi-Nevry, R., Kouassi, K. C., Nanga, Z. Y., Koussémon, M., & Loukou, G. Y. (2012). Antibacterial activity of two bell pepper extracts: Capsicum annuum L. and Capsicum frutescensInternational Journal of Food Properties 15, (5), 961–971https://doi.org/10.1080/10942912.2010.509896
Konwarh, R., Saikia, J. P., Karak, N., & Konwar, B. K. (2010). ‘Poly(ethylene glycol)-magnetic nanoparticles-curcumin’ trio: Directed morphogenesis and synergistic free-radical scavengingColloids and Surfaces B: Biointerfaces, 81(2), 578–586https://doi.org/10.1016/j.colsurfb.2010.07.062
Kooti, W., Ali-Akbari, S., Asadi-Samani, M., Ghadery, H., & Ashtary-Larky, D. (2015). A review on medicinal plant of Apium graveolensAdvanced Herbal Medicine, 1(1), 48–59
Kooti, W., & Daraei, N. (2017). A review of the antioxidant activity of celery (Apium graveolens l)Journal of Evidence-Based Complementary and Alternative Medicine, 22(4), 1029–1034https://doi.org/10.1177/2156587217717415
Korikanthimath, V. S., Prasath, D., Govardhan, R. (2001). Medicinal properties of cardamom elettaria cardamomumICAR IISR
Kos, I., Bedekovic, D., Siric, I., Vnucec, I., Pecina, M., Glumpak, A., & Stanko, K. C. (2017). Technological characterization and consumer perception of dry fermented game sausages with bay leaf (Laurus nobilis L.) essential oilJournal of Central European Agriculture, 18(4), 794–805https://doi.org/10.5513/jcea01/18.4.1961
Kouame, K., Peter, A. I., Akang, E. N., Adana, M., Moodley, R., Naidu, E. C., & Azu, O. O. (2018). Effect of long-term administration of cinnamomum cassia silver nanoparticles on organs (Kidneys and liver) of sprague-dawley ratsTurkish Journal of Biology, 42(6), 498–505https://doi.org/10.3906/biy-1805-103
Kouame, K., Peter, A. I., Akang, E. N., Moodley, R., Naidu, E. C., & Azu, O. O. (2019). Histological and biochemical effects of Cinnamomum cassia nanoparticles in kidneys of diabetic Sprague-Dawley ratsBosnian Journal of Basic Medical Sciences, 19(2), 138–145https://doi.org/10.17305/bjbms.2019.3481
Krishnamurthy, N., Lewis, Y. S., & Ravindranath, B. (1982). Chemical constituents of kokam fruit rindJournal of Food Science and Technology, 19(3), 97–100http://ir.cftri.com/id/eprint/8578
Krishnan, V., Bupesh, G., Manikandan, E., Thanigai, A. K., Magesh, S., Kalyanaraman, R., Maaza, M. (2016). Green synthesis of silver nanoparticles using Piper nigrum concoction and its anticancer activity against MCF-7 and Hep-2 cell linesJournal of Antimicrobial Agents, 2(3)https://doi.org/10.4172/2472-1212.1000123
Krishnan, V., Kalyanaraman, R., & Fathima, G. (2015). Green biosynthesis of silver nanoparticles from Elettaria cardamomum ( Seed ) and its in vitro cytotoxic activityWorld Journal of Pharmacy and Pharmaceutical Sciences, 4(04), 723–733
Krishnaprabha, M., & Pattabi, M. (2016a). Synthesis of gold nanoparticles using garcinia indica fruit rind extractInternational Journal of Nanoscience, 15(5–6)https://doi.org/10.1142/S0219581X16600152
Krishnaprabha, M., & Pattabi, M. (2016b). Synthesis of gold nanostructures using fruit extract of Garcinia IndicaAIP Conference Proceedings, 1731https://doi.org/10.1063/1.4947776
Ktari, N., Feki, A., Trabelsi, I., Triki, M., Maalej, H., Slima, S. B., Nasri, M., Amara, I. B., & Salah, R. B. (2017). Structure, functional and antioxidant properties in tunisian beef sausage of a novel polysaccharide from trigonella foenum-graecum seedsInternational Journal of Biological Macromolecules, 98, 169–181
Kulkarni, C. P., Bodhankar, S. L., Ghule, A. E., Mohan, V., & Thakurdesai, P. A. (2012). Antidiabetic activity of Trigonella foenumgraecum L. seeds extract (IND01) in neonatal streptozotocin-induced (n-STZ) ratsDiabetologia Croatica, 41(1), 29–40
Kulkarni, P. (2004). The ayurvedic plantsSri Satguru Publications, 98
Kumar, S. J. T., Akshay, V. R., Vasundhara, M., & Arumugam, M. (2020). Biosynthesis of multiphase iron nanoparticles using Syzygium aromaticum and their magnetic propertiesColloids and Surfaces A: Physicochemical and Engineering Aspects, 603, 125241https://doi.org/10.1016/j.colsurfa.2020.125241
Kumar, S., & Kumari, R. (2021). Traditional, phytochemical and biological activities of Elettaria cardamomum (L.) maton-a reviewInternational Journal of Pharmaceutical Sciences and Research, 12(8), 4122https://doi.org/10.13040/IJPSR.0975-8232.12(8).4122-31
Kumar, A., Bankoti, K., Kumar, T., & Dhara, S. (2022)Hydrothermal synthesis of clove bud-derived multifunctional carbon dots passivated with PVP- antioxidant , catalysis , and bioimaging applications
Kumar, A., Dora, J., & Singh, A. (2011). A review on spice of life Curcuma longa (Turmeric)International Journal Applied Biological Pharmaceutical Technology, 2, 371–379www.ijabpt.com
Kumar, A., Pratap Singh, P., & Prakash, B. (2020). Unravelling the antifungal and anti-aflatoxin B1 mechanism of chitosan nanocomposite incorporated with Foeniculum vulgare essential oilCarbohydrate Polymers, 236, 116050https://doi.org/10.1016/j.carbpol.2020.116050
Kumar, D., Kumar, P., Vikram, K., & Singh, H. (2022). Fabrication and characterization of noble crystalline silver nanoparticles from Pimenta dioica leave extract and analysis of chemical constituents for larvicidal applicationsSaudi Journal of Biological Sciences, 29(2), 1134–1146https://doi.org/10.1016/j.sjbs.2021.09.052
Kumar, D., Rajeshwari, A., Jadon, P. S., Chaudhuri, G., Mukherjee, A., Chandrasekaran, N., & Mukherjee, A. (2015). Cytogenetic studies of chromium (III) oxide nanoparticles on Allium cepa root tip cellsJournal of Environmental Sciences, 38, 150–157https://doi.org/10.1016/j.jes.2015.03.038
Kumar Dey, B., Sanyal Mukherjee Professor, S., Author, C., & Sanyal Mukherjee, S. (2021). Potential of clove and its nutritional benefits in physiological perspective: A review~ 103 ~ International Journal of Physiology, 6(1), 103–106www.journalofsports.com
Kumare, K. D., Londhe, G. K., & Anarthe, N. K. (2022). Effect of black pepper ( Piper nigrum ) and turmeric ( Curcuma longa ) powder on sensory and rheological quality of burfiThe Pharma Innovation Journal, 11(1), 539–543
Kumari, M., Khan, S. S., Pakrashi, S., Mukherjee, A., & Chandrasekaran, N. (2011). Cytogenetic and genotoxic effects of zinc oxide nanoparticles on root cells of Allium cepaJournal of Hazardous Materials, 190(1), 613–621https://doi.org/10.1016/j.jhazmat.2011.03.095
Kumari, P. (2013). Development of semolina based upma incorporated with fenugreek and chickenpea seeds flour and evaluation of its sensory and nutritional attributes along with its glycemic indexTrends in Biosciences Journal
Kumari, V., Tyagi, P., & Sangal, A. (2022). In-vitro kinetic release study of illicium verum (Chakraphool) polymeric nanoparticlesMaterials Today: Proceedings, 60, 14–20https://doi.org/10.1016/j.matpr.2021.11.014
Kurian, M., Varghese, B., Athira, T. S., & Krishna, S. (2016). Novel and efficient synthesis of silver nanoparticles using Curcuma longa and Zingiber officinale rhizome extractsInternational Journal of Nanoscience and Nanotechnology, 12(3), 175–181
Kyriaki, H., Eleni, K., George, L. I., Kostas, B., Petros, T. A. (2019). Antioxidant properties of crocus Sativus L. and its constituents and relevance to neurodegenerative diseases; Focus on Alzheimer’s and Parkinson’s DiseaseCurrent Neuropharmacology, 17(4), 377–402http://www.eurekaselect.com/603/journal/current-neuropharmacology
Laczkowski, M. S., Baqueta, M. R., de Oliveira, V. M. A. T., Gonçalves, T. R., Gomes, S. T. M., Março, P. H., Matsushita, M., & Valderrama, P. (2021). Application of chemometric tools in the development and sensory evaluation of gluten-free cracknel biscuits with the addition of chia seeds and turmeric powderJournal of Food Science and Technology, 58(11), 4118–4126https://doi.org/10.1007/s13197-020-04874-9
Lagua, E. B., & Ampode, K. M. B. (2021). Turmeric powder: potential alternative to antibiotics in broiler chicken dietsJournal of Animal Health and Production, 9(3), 243–253https://doi.org/10.17582/journal.jahp/2021/9.3.243.253
Lahmass, I., Sabouni, A., Elyoubi, M., Benabbes, R., Mokhtari, S., & Saalaoui, E. (2017). Anti-diabetic effect of aqueous extract Crocus sativus L. in tartrazine induced diabetic male ratsPhysiology and Pharmacology (Iran), 21(4), 312–321
Lakhan, M. N., Chen, R., Shar, A. H., Chandio, M. B., Shah, A. H., Ahmed, R., & Wang, J. (2020). Illicium verum as a green source for the synthesis of silver nanoparticles and investigation of antidiatom activity against Paeodactylum TricornutumSukkur IBA Journal of Emerging Technologies, 3(1), 23–30https://doi.org/10.30537/sjet.v3i1.495
Lakshmeesha, T. R., Kalagatur, N. K., Mudili, V., Mohan, C. D., Rangappa, S., Prasad, B. D., Ashwini, B. S., Hashem, A., Alqarawi, A. A., Malik, J. A., Abd-Allah, E. F., Gupta, V. K., Siddaiah, C. N., & Niranjana, S. R. (2019). Biofabrication of zinc oxide nanoparticles with Syzygium aromaticum flower buds extract and finding its novel application in controlling the growth and mycotoxins of Fusarium graminearumFrontiers in Microbiology, 10(JUN)https://doi.org/10.3389/fmicb.2019.01244
Lal, G., Saran, P. L., Devi, G., & Bijarniya, D. (2020). Production technology of fennel (Foeniculum vulgare Mill)Advances in Vegetable Agronomy, 232–243
Lampe, J. W. (2003). Spicing up a vegetarian diet: Chemopreventive effects of phytochemicalsAmerican Journal of Clinical Nutrition, 78(3 SUPPL.)https://doi.org/10.1093/ajcn/78.3.579s
Lane, K. E., Li, W., Smith, C. J., & Derbyshire, E. J. (2016). The development of vegetarian omega-3 oil in water nanoemulsions suitable for integration into functional food productsJournal of Functional Foods, 23, 306–314https://doi.org/10.1016/j.jff.2016.02.043
Lans, C. A. (2006). Ethnomedicines used in Trinidad and Tobago for urinary problems and diabetes mellitusJournal of Ethnobiology and Ethnomedicine, 2https://doi.org/10.1186/1746-4269-2-45
Laokuldilok, N., Thakeow, P., Kopermsub, P., & Utama-ang, N. (2017). Quality and antioxidant properties of extruded breakfast cereal containing encapsulated turmeric extractChiang Mai Journal of Science, 44(3), 946–955
Lashkarizadeh, M. R., Asgaripour, K., Saedi Dezaki, E., & Fasihi Harandi, M. (2015). Comparison of scolicidal effects of amphotricin B, silver nanoparticles, and Foeniculum vulgare mill on hydatid cysts protoscolecesIranian Journal of Parasitology, 10(2), 206–212
Lee, K. A., Kim, K.-T., Kim, H. J., Chung, M. S., Chang, P. S., Park, H., & Pai, H. D. (2014). Antioxidant activities of onion (Allium cepa L.) peel extracts produced by ethanol, hot water, and subcritical water extractionFood Science and Biotechnology, 23(2), 615–621https://doi.org/10.1007/s10068-014-0084-6
Lee, E. L. (2009). Genotype X environment impact on selected bioactive compound content of fenugreek (Trigonella foenum-graecum L.)ProQuest Dissertations and Theses, 166https://search.proquest.com/docview/193686920?accountid=27575
Lee, J. H., Won, M., & Song, K. B. (2015). Physical properties and antimicrobial activities of porcine meat and bone meal protein films containing coriander oilLwt, 63(1), 700–705https://doi.org/10.1016/j.lwt.2015.03.043
Lee, M. K. H., Yang, H. B. S., Jae, H., & Kim, L. M. (2021). Metabolite analysis and anti-obesity effects of celery seed in 3T3- L1 adipocytesFood Science and Biotechnology, 30(2), 277–286https://doi.org/10.1007/s10068-020-00866-9
Lee, S., & Lee, J. H. (2013). Quality of sponge cakes supplemented with cinnamonJournal of the Korean Society of Food Science and Nutrition, 42(4), 650–654https://doi.org/10.3746/jkfn.2013.42.4.650
Lee, Y. S., & Ryu, M. J. (2019). Antioxidant effects of Cinnamomum cassia bark extract and its effectiveness as a cosmetics ingredientAsian Journal of Beauty and Cosmetology, 17(1), 69–80https://doi.org/10.20402/ajbc.2018.0262
Lewis, D. A., Tharib, S. M., & Veitch, G. B. A. (1985). The anti-inflammatory activity of celery apium graveolens L. (Fam. Umbelliferae)Pharmaceutical Biology, 23(1), 27–32https://doi.org/10.3109/13880208509070685
Li, C. W., Chu, Y. C., Huang, C. Y., Fu, S. L., & Chen, J. J. (2020). Evaluation of antioxidant and anti-α-glucosidase activities of various solvent extracts and major bioactive components from the seeds of Myristica fragransMolecules (Basel, Switzerland), 25(21)https://doi.org/10.3390/molecules25215198
Lian, T., Peng, M., Vermorken, A. J. M., Jin, Y., Luo, Z., Van De Ven, W. J. M., Wan, Y., Hou, P., & Cui, Y. (2016). Synthesis and characterization of curcumin-functionalized hp-β-cd-modified goldmag nanoparticles as drug delivery agentsJournal of Nanoscience and Nanotechnology, 16(6), 6258–6264https://doi.org/10.1166/jnn.2016.11370
Liao, J. C., Deng, J. S., Chiu, C. S., Hou, W. C., Huang, S. S., Shie, P. H., & Huang, G. J. (2012). Anti-inflammatory activities of Cinnamomum cassia constituents in vitro and in vivoEvidence-Based Complementary and Alternative Medicine, 2012https://doi.org/10.1155/2012/429320
Licón, C. C., Carmona, M., Rubio, R., Molina, A., & Berruga, M. I. (2012). Preliminary study of saffron (Crocus sativus L. stigmas) color extraction in a dairy matrixDyes and Pigments, 92(3), 1355–1360https://doi.org/10.1016/j.dyepig.2011.09.022
Lietzow, J. (2021). Biologically active compounds in mustard seeds: A toxicological perspectiveFoods, 10(9), 2089https://doi.org/10.3390/foods10092089
Lim, H. S., Kashif, G., Park, S. H., Hwang, S. Y., & Park, J. (2010). quality and antioxidant properties of yellow layer cack containing korean turmeric powderJournal of Food and Nutrition Research, 49(3), 123–133
Lim, H. S., Park, S. H., Ghafoor, K., Hwang, S. Y., & Park, J. (2011). Quality and antioxidant properties of bread containing turmeric (Curcuma longa L.) cultivated in South KoreaFood Chemistry, 124(4), 1577–1582https://doi.org/10.1016/j.foodchem.2010.08.016
Lim, S. H., Lee, H. S., Lee, C. H., & Choi, C. I. (2021). Pharmacological Activity of Garcinia indica (Kokum): An Updated ReviewPharmaceuticals, 14(12), 1–13https://doi.org/10.3390/ph14121338
Lim, T. K. (2016). Edible medicinal and non-medicinal plants. In Edible Medicinal and Non-Medicinal Plants (Vol. 10)https://doi.org/10.1007/978-94-017-7276-1
Lima, E. P., Gonçalves, O. H., Ames, F. Q., Castro-Hoshino, L. V., Leimann, F. V., Cuman, R. K. N., Comar, J. F., & Bersani-Amado, C. A. (2021). Anti-inflammatory and antioxidant activity of nanoencapsulated curcuminoids extracted from Curcuma longa L. in a model of cutaneous inflammationInflammation, 44(2), 604–616https://doi.org/10.1007/s10753-020-01360-4
Liman, R., Başbuğ, B., Ali, M. M., Acikbas, Y., & Ciğerci, İH. (2021). Cytotoxic and genotoxic assessment of tungsten oxide nanoparticles in Allium cepa cells by Allium ana-telophase and comet assaysJournal of Applied Genetics, 62(1), 85–92https://doi.org/10.1007/s13353-020-00608-x
Lisanti, A., Formica, V., Ianni, F., Albertini, B., Marinozzi, M., Sardella, R., & Natalini, B. (2016). Antioxidant activity of phenolic extracts from different cultivars of Italian onion (Allium cepa) and relative human immune cell proliferative inductionPharmaceutical Biology, 54(5), 799–806https://doi.org/10.3109/13880209.2015.1080733
Liu, Q., Zhang, M., Bhandari, B., Xu, J., & Yang, C. (2020). Effects of nanoemulsion-based active coatings with composite mixture of star anise essential oil, polylysine, and nisin on the quality and shelf life of ready-to-eat Yao meat productsFood Control, 107https://doi.org/10.1016/j.foodcont.2019.106771
Liu, X. C., Zhou, L. G., Liu, Z. L., & Du, S. S. (2013). Identification of insecticidal constituents of the essential oil of Acorus calamus rhizomes against Liposcelis bostrychophila badonnelMolecules, 18(5), 5684–5696https://doi.org/10.3390/molecules18055684
Llavata, B., Albors, A., & Martin-Esparza, M. E. (2020). High fibre gluten-free fresh pasta with tiger nut, chickpea and fenugreek: Technofunctional, sensory and nutritional propertiesFoods, 9(1), 11https://doi.org/10.3390/foods9010011
Lorenzo-Leal, A. C., Palou, E., López-Malo, A., & Bach, H. (2019). Antimicrobial, cytotoxic, and anti-inflammatory activities of Pimenta dioica and Rosmarinus officinalis essential oilsBioMed Research International, 2019https://doi.org/10.1155/2019/1639726
Losso, J. N., Holliday, D. L., Finley, J. W., Martin, R. J., Rood, J. C., Yu, Y., & Greenway, F. L. (2009). Fenugreek bread: a treatment for diabetes mellitusJournal of Medicinal Food, 12(5), 1046–1049
Luhmer, K., Schulze-Kaysers, N., Feuereisen, M., Wirth, L., Maretzky, F., Wüst, M., Blum, H., Dörr, E., & Pude, R. (2021). Fatty acid composition, tocopherols, volatile compounds, and sensory evaluation of low morphine yielding varieties of poppy (Papaver somniferum l.) seeds and oilsJournal of Agricultural and Food Chemistry, 69(11), 3439–3451https://doi.org/10.1021/acs.jafc.0c07183
Luna, C., Barriga-Castro, E. D., Gómez-Treviño, A., Núñez, N. O., & Mendoza-Reséndez, R. (2016). Microstructural, spectroscopic, and antibacterial properties of silver-based hybrid nanostructures biosynthesized using extracts of coriander leaves and seedsInternational Journal of Nanomedicine, 11, 4787–4798https://doi.org/10.2147/IJN.S105166
Luna, C., Chávez, V. H. G., Barriga-Castro, E. D., Núñez, N. O., & Mendoza-Reséndez, R. (2015). Biosynthesis of silver fine particles and particles decorated with nanoparticles using the extract of Illicium verum (star anise) seedsSpectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 141, 43–50https://doi.org/10.1016/j.saa.2014.12.076
Luthra, P. M., Singh, R., & Chandra, R. (2001). Therapeutic uses of curcuma longa (Turmeric)Indian Journal of Clinical Biochemistry, 16(2), 153–160https://doi.org/10.1007/BF02864854
Ma’Mani, L., Nikzad, S., Kheiri-Manjili, H., Al-Musawi, S., Saeedi, M., Askarlou, S., Foroumadi, A., & Shafiee, A. (2014). Curcumin-loaded guanidine functionalized PEGylated I3ad mesoporous silica nanoparticles KIT-6: Practical strategy for the breast cancer therapyEuropean Journal of Medicinal Chemistry, 83(March 2018), 646–654https://doi.org/10.1016/j.ejmech.2014.06.069
Mafakheri, S., Niri Dehghan, F., & Mirhosseini, M. (2017). Study the biological production and antibacterial and antifungal effects of silver nanoparticles synthesized by the methanolic extract of clove (Syzygium aromaticum)Journal of Biotechnology, 8(2), 11http://biot.modares.ac.ir/article-22-3170-en.html
Maggi, L., Carmona, M., Kelly, S. D., Marigheto, N., & Alonso, G. L. (2011). Geographical origin differentiation of saffron spice (Crocus sativus L. stigmas) - Preliminary investigation using chemical and multi-element (H, C, N) stable isotope analysisFood Chemistry, 128(2), 543–548https://doi.org/10.1016/j.foodchem.2011.03.063
Maghami, M., Motalebi, A. A., & Anvar, S. A. A. (2019). Influence of chitosan nanoparticles and fennel essential oils (Foeniculum vulgare) on the shelf life of Huso huso fish fillets during the storageFood Science and Nutrition, 7(9), 3030–3041https://doi.org/10.1002/fsn3.1161
Magro, M., Campos, R., Baratella, D., Ferreira, M. I., Bonaiuto, E., Corraducci, V., Uliana, M. R., Lima, G. P. P., Santagata, S., Sambo, P., & Vianello, F. (2015). Magnetic purification of curcumin from Curcuma longa rhizome by novel naked maghemite nanoparticlesJournal of Agricultural and Food Chemistry, 63(3), 912–920https://doi.org/10.1021/jf504624u
Mahae, N., & Chaiseri, S. (2009a). Antioxidant activities and antioxidative components in extracts of Alpinia galanga (l.) swKasetsart Journal - Natural Science, 43(2), 358–369
Mahae, N., & Chaiseri, S. (2009b). Antioxidant activities and antioxidative components in extracts of Alpinia galanga (L.) SwKasetsart Journal - Natural Science, 43(2), 358–369
Mahboubi, M. (2022). The beneficial effects of Ferula asafoetida oleo-gum resin in gastrointestinal disordersBulletin of Faculty of Pharmacy Cairo University, 59(1), 50–63https://doi.org/10.54634/2090-9101.1025
Mahendra, P., & Bisht, S. (2012). Ferula asafoetida : Traditional uses and pharmacological activityPharmacognosy Reviews, 6(12), 141–146https://doi.org/10.4103/0973-7847.99948
Mahendra, R., Rofik, A., Salim, H. M., Ulfa, M., & Awwaliyah, E. S. (2021). Neuroprotective activity of extract of celery (Apium graveolens) in insilico studyMedical and Health Science Journal, 5(2), 27–31https://doi.org/10.33086/mhsj.v5i2.2362
Maheshwari, B., & Yella Reddy, S. (2005). Application of kokum (Garcinia indica) fat as cocoa butter improver in chocolateJournal of the Science of Food and Agriculture, 85(1), 135–140https://doi.org/10.1002/jsfa.1967
Majeed, M., Majeed, S., Nagabhushanam, K., Lawrence, L., & Mundkur, L. (2020). Garcinia indica extract standardized for 20% Garcinol reduces adipogenesis and high fat diet-induced obesity in mice by alleviating endoplasmic reticulum stressJournal of Functional Foods, 67https://doi.org/10.1016/j.jff.2020.103863
Maji, S., Ray, P. R., Ghatak, P. K., & Chakraborty, C. (2018). Total phenolic content (TPC) and quality of herbal lassi fortified with Turmeric (Curcuma longa) extractAsian Journal of Dairy and Food Research, 37(of), 273–277https://doi.org/10.18805/ajdfr.dr-1391
Majidi, Z., Bina, F., Kahkeshani, N., & Rahimi, R. (2020). Bunium persicum: A Review of Ethnopharmacology, Phy-tochemistry, and Biological Activities. In Traditional & Integrative Medicine (Vol. 5, Issue 3)http://jtim.tums.ac.irhttp//jtim.tums.ac.ir
Majumdar, M. (2012)Fenugreek - health benefits, uses, and side effectshttp://www.medindia.net/patients/lifestyleandwellness/fenugreek-reference.htm
Makhlouf, H., Saksouk, M., Habib, J., & Chahine, R. (2011). Determination of antioxidant activity of saffron taken from the flower of Crocus sativus grown in LebanonAfrican Journal of Biotechnology, 10(41), 8093–8100https://doi.org/10.5897/ajb11.406
Maleki, M., & Mohsenzadeh, M. (2022). Optimization of a biodegradable packaging film based on carboxymethyl cellulose and Persian gum containing titanium dioxide nanoparticles and Foeniculum vulgare essential oil using response surface methodologyJournal of Food Processing and Preservation, 46(4)https://doi.org/10.1111/jfpp.16424
Malhotra, S. K., & Welfare, F. (2021)Spices statistics at a glance 2021 (Issue December)
Malini, P. S. G., Premalatha, V., & Rani, S. (2019). Green synthesis and characterization of silver nanoparticles using ethanol extract of Myristica fragrans (Nutmeg) and its biological applicationsJournal of Nanoscience and Technology, 5(3), 738–740https://doi.org/10.30799/jnst.s02.19050309
Mallikarjuna, K., Bathula, C., Buruga, K., Shrestha, N. K., Noh, Y.-Y., & Kim, H. (2017). Green synthesis of palladium nanoparticles using fenugreek tea and their catalytic applications in organic reactionsMaterials Letters, 205, 138–141https://doi.org/10.1016/j.matlet.2017.06.081
Mallikarjuna, K., Bathula, C., Dinneswara Reddy, G., Shrestha, N. K., Kim, H., & Noh, Y.-Y. (2019). Au-Pd bimetallic nanoparticles embedded highly porous Fenugreek polysaccharide based micro networks for catalytic applicationsInternational Journal of Biological Macromolecules, 126, 352–358https://doi.org/10.1016/j.ijbiomac.2018.12.137
Mamgain, P., & Singh, R. H. (1994). Controlled clinical trial of the lekhaniya drugvaca (Acorus calamus) in cases of Ischaemic heart diseasesJournal of Research in Ayurveda and Siddha, 15(1), 35–51
Man, S. M., Pǎucean, A., Cǎlian, I. D., Murean, V., Chi, M. S., Pop, A., Murean, A. E., Bota, M., & Muste, S. (2019). Influence of fenugreek flour (Trigonella foenum-graecum l.) addition on the technofunctional properties of dark wheat flourJournal of Food Quality, 2019https://doi.org/10.1155/2019/8635806
Manap, A. S. A., Tan, A. C. W., Leong, W. H., Chia, A. Y. Y., Vijayabalan, S., Arya, A., Wong, E. H., Rizwan, F., Bindal, U., Koshy, S., & Madhavan, P. (2019). Synergistic effects of curcumin and piperine as potent acetylcholine and amyloidogenic inhibitors with significant neuroprotective activity in sh-sy5y cells via computational molecular modeling and in vitro assayFrontiers in Aging Neuroscience, 10(JUL)https://doi.org/10.3389/fnagi.2019.00206
Mandal, S., & Mandal, M. (2015). Coriander (Coriandrum sativum L.) essential oil: Chemistry and biological activityAsian Pacific Journal of Tropical Biomedicine, 5(6), 421–428https://doi.org/10.1016/j.apjtb.2015.04.001
Mangalampalli, B., Dumala, N., & Grover, P. (2018). Allium cepa root tip assay in assessment of toxicity of magnesium oxide nanoparticles and microparticlesJournal of Environmental Sciences (China), 66(May), 125–137https://doi.org/10.1016/j.jes.2017.05.012
Mani, D., & Dhawan, S. S. (2014). Scientific basis of therapeutic uses of opium poppy (Papaver somniferum) in AyurvedaActa Horticulturae, 1036, 175–180https://doi.org/10.17660/ActaHortic.2014.1036.20
Manikandan, S., & Devi, R. S. (2005). Antioxidant property of α-asarone against noise-stress-induced changes in different regions of rat brainPharmacological Research, 52(6), 467–474https://doi.org/10.1016/j.phrs.2005.07.007
Manisha, D. R., Merugu, R., Vijay Babu, A. R., & Pratap Rudra, M. P. (2014). Microwave assisted biogenic synthesis of silver nanoparticles using dried seed extract of Coriandrum sativum, Characterization and antimicrobial activityInternational Journal of ChemTech Research, 6(7), 3957–3961
Manjunath, N., Nayar, R., Akkara, S. S., Sathu, T., Vasudevan, V. N., & Rajkumar, S. R. (2019). Effect of carrageenan edible film with oleoresins of Piper nigrum ( black pepper ) on quality of buffalo meat steaks Effect of carrageenan edible film with oleoresins of Piper nigrum ( black pepper ) on quality of buffalo meat steaksThe Pharma Innovation Journal, 8(9), 397–400
Mans, K., & Aburjai, T. (2019). Accessing the hypoglycemic effects of seed extract from celery (Apium graveolens) in alloxan-induced diabetic ratsJournal of Pharmaceutical Research International, April, 1–10https://doi.org/10.9734/jpri/2019/v26i630152
Mansha Rafiq, S., & Ghosh, C. B. (2021). Fennel (Foeniculum vulgare) and Ajwain (Trachyspermum ammi) extracts as potential preservatives in processed cheese foodsIndian Journal of Dairy Science, 74(3), 199–207https://doi.org/10.33785/ijds.2021.v74i03.002
Marand, S. A., Alizadeh Khaledabad, M., & Almasi, H. (2021). Optimization and characterization of plantago major seed gum/nanoclay/Foeniculum vulgare essential oil active nanocomposite films and their application in preservation of local butterFood and Bioprocess Technology, 14(12), 2302–2322https://doi.org/10.1007/s11947-021-02724-w
Marrelli, M., Amodeo, V., Statti, G., & Conforti, F. (2019). Biological properties and bioactive components of allium cepa L.: Focus on potential benefits in the treatment of obesity and related comorbiditiesMolecules, 24(1)https://doi.org/10.3390/molecules24010119
Martina, E. C., Oludayo, A. K., Linda, N. C., Chinasa, O. P., Ambrose, O. C., & Muoneme, O. T. (2020). Effect of the incorporation of graded levels of turmeric ( Curcuma longa ) on different qualities of stirred yoghurtAfrican Journal of Food Science, 14(April), 71–85https://doi.org/10.5897/AJFS2020.1903
Mashmoul, M., Azlan, A., Khaza’Ai, H., Yusof, B. N. M., & Noor, S. M. (2013). Saffron: a natural potent antioxidant as a promising anti-obesity drugAntioxidants, 2(4), 293–308https://doi.org/10.3390/antiox2040293
Masihuddin, M., Jafri, M., Siddiqui, A., & Chaudhary, S. (2018). Traditional uses, phytochemistry and pharmacological activities of papaver somniferum with special reference of unani medicine an updated reviewJournal of Drug Delivery and Therapeutics, 8(5-s), 110–114https://doi.org/10.22270/jddt.v8i5-s.2069
Matacchione, G., Gurău, F., Silvestrini, A., Tiboni, M., Mancini, L., Valli, D., Rippo, M. R., Recchioni, R., Marcheselli, F., Carnevali, O., Procopio, A. D., Casettari, L., & Olivieri, F. (2021). Anti-SASP and anti-inflammatory activity of resveratrol, curcumin and β-caryophyllene association on human endothelial and monocytic cellsBiogerontology, 22(3), 297–313https://doi.org/10.1007/s10522-021-09915-0
Matsuda, H., Shimoda, H., Ninomiya, K., & Yoshikawa, M. (2002). Inhibitory mechanism of costunolide, a sesquiterpene lactone isolated from Laurus nobilis, on blood-ethanol elevation in rats: Involvement of inhibition of gastric emptying and increase in gastric juice secretionAlcohol and Alcoholism, 37(2), 121–127https://doi.org/10.1093/alcalc/37.2.121
Matulyte, I., Jekabsone, A., Jankauskaite, L., Zavistanaviciute, P., Sakiene, V., Bartkiene, E., Ruzauskas, M., Kopustinskiene, D. M., Santini, A., & Bernatoniene, J. (2020). The essential oil and hydrolats from myristica fragrans seeds with magnesium aluminometasilicateFoods, 9(37), 1–12https://doi.org/10.3390/foods9010037
Mechchate, H., Es-Safi, I., Amaghnouje, A., Boukhira, S., Alotaibi, A. A., Al-Zharani, M., Nasr, F. A., Noman, O. M., Conte, R., Amal, E. H. E. Y., Bekkari, H., & Bousta, D. (2021). Antioxidant, anti-inflammatory and antidiabetic proprieties of LC-MS/MS identified polyphenols from coriander seedsMolecules, 26(2)https://doi.org/10.3390/molecules26020487
Medhin, D. G., Bakos, P., & Hadhazy, P. (1986). Inhibitory effects of extracts of Lupinus termis and Coriandrum sativum on electrically induced contraction of the rabbit ear artery. In Acta Pharmaceutica Hungarica (Vol. 56, Issue 3, pp. 109–113)
Meena, R. K., & Chouhan, N. (2015). Biosynthesis of silver nanoparticles from plant ( Fenugreek Seeds ) reducing method and their optical propertiesResearch Journal of Recent Sciences Res. J. Recent. Sci, 4(January), 47–52http://www.isca.in/rjrs/archive/v4/iIVC-2015/10.ISCA-IVC-2015-04CS-004.pdf
Meghwal, M. (2012). A review on the functional properties, nutritional content, medicinal utilization and potential application of fenugreekJournal of Food Processing & Technology, 03(09)https://doi.org/10.4172/2157-7110.1000181
Mehdizadeh, T., Langroodi, A, M., Shakouri, R., Khorshidi, S. (2019). physicochemical,microbial and sensory characteristics of probiotic yoghurt enhanced with anethum graveolens essential oilJournal of Food Safety, 39(5)
Mehmood, M. H., & Gilani, A. H. (2010). Pharmacological basis for the medicinal use of black pepper and piperine in gastrointestinal disordersJournal of Medicinal Food, 13(5), 1086–1096https://doi.org/10.1089/jmf.2010.1065
Mehmood, Y., Farooq, U., Yousaf, H., Riaz, H., Mahmood, R. K., Nawaz, A., Abid, Z., Gondal, M., Malik, N. S., Barkat, K., & Khalid, I. (2020). Antiviral activity of green silver nanoparticles produced using aqueous buds extract of Syzygium aromaticumPakistan Journal of Pharmaceutical Sciences, 33(2), 839–845https://doi.org/10.36721/PJPS.2020.33.2.SUP.839-845.1
Mehra, N., Tamta, G., & Nand, V. (2021). A review on nutritional value, phytochemical and pharmacological attributes of Foeniculum vulgare MillJournal of Pharmacognosy and Phytochemistry, 10(2), 1255–1263https://doi.org/10.22271/phyto.2021.v10.i2q.13983
Melnyk, J. P., Wang, S., & Marcone, M. F. (2010). Chemical and biological properties of the world’s most expensive spice: SaffronFood Research International, 43(8), 1981–1989https://doi.org/10.1016/j.foodres.2010.07.033
Menaga, S., Kripa, K., & Sangeetha, R. (2017). Evaluation of in vitro inhibition of proton-pump by nanosilver particles synthesized using seeds of anethum graveolensAsian Journal of Pharmaceutical and Clinical Research, 10(6), 363–366https://doi.org/10.22159/ajpcr.2017.v10i6.16896
Michalak-Majewska, M., Teterycz, D., Muszyński, S., Radzki, W., & Sykut-Domańska, E. (2020). Influence of onion skin powder on nutritional and quality attributes of wheat pastaPLoS ONE, 15(1), 1–15https://doi.org/10.1371/journal.pone.0227942
Mileriene, J., Serniene, L., Henriques, M., Gomes, D., Pereira, C., Kondrotiene, K., Kasetiene, N., Lauciene, L., Sekmokiene, D., & Malakauskas, M. (2021). Effect of liquid whey protein concentrate–based edible coating enriched with cinnamon carbon dioxide extract on the quality and shelf life of Eastern European curd cheeseJournal of Dairy Science, 104(2), 1504–1517https://doi.org/10.3168/jds.2020-18732
Minh, N. P. (2021). effectiveness of chili powder incorporation to microbial loads,physicochemical and sensory characteristics of vietnamese fermented pork rollJournal of Pure and Applied Microbiology, 15(1)
Mishra, S., & Pathak, V. (2021). Phytochemical study and antimicrobial activity of khus khus seedsWorld Journal of Pharmaceutical Research, 10(11), 1663–1681
Missaoui, T., Smiri, M., Chemingui, H., Jbira, E., & Hafiane, A. (2018). Regulation of mitochondrial and cytosol antioxidant systems of fenugreek (Trigonella foenum graecum L.) exposed to nanosized titanium dioxideBulletin of Environmental Contamination and Toxicology, 101(3), 326–337https://doi.org/10.1007/s00128-018-2414-5
Missaoui, T., Smiri, M., Chmingui, H., & Hafiane, A. (2017). Effects of nanosized titanium dioxide on the photosynthetic metabolism of fenugreek (Trigonella foenum-graecum L.)Comptes Rendus - Biologies, 340(11–12), 499–511https://doi.org/10.1016/j.crvi.2017.09.004
Mittal, L., Camarillo, I. G., Varadarajan, G. S., Srinivasan, H., Aryal, U. K., & Sundararajan, R. (2020). High-throughput, label-free quantitative proteomic studies of the anticancer effects of electrical pulses with turmeric silver nanoparticles: An in vitro model studyScientific Reports, 10(1), 1–18https://doi.org/10.1038/s41598-020-64128-8
Mobeen, S. A., & Riazunnisa, K. (2019). Methylene blue dye degradation by silver nanoparticles biosynthesized using seed extracts of Foeniculum vulgareZero Waste, 219–225https://doi.org/10.1201/9780429059247-14
Modi, S., Yadav, V. K., Choudhary, N., Alswieleh, A. M., Sharma, A. K., Bhardwaj, A. K., Khan, S. H., Yadav, K. K., Cheon, J.-K., & Jeon, B. H. (2022). Onion peel waste mediated-green synthesis of zinc oxide nanoparticles and their phytotoxicity on mung bean and wheat plant growthMaterials, 15, 2393
Mohammed, G. J., Omran, A. M., & Hussein, H. M. (2016). Antibacterial and phytochemical analysis of piper nigrum using gas chromatography – mass spectrum and fourier-transform infrared spectroscopyInternational Journal of Pharmacognosy and Phytochemical Research, 8(6), 977–996
Mohammed, K. A. K., Abdulkadhim, H. M., & Noori, S. I. (2016). Chemical composition and anti-bacterial effects of clove (Syzygium aromaticum) flowersInternational Journal of Current Microbiology and Applied Sciences, 5(2), 483–489https://doi.org/10.20546/ijcmas.2016.502.054
Mohammed, G. J., Omran, A. M., & Hussein, H. M. (2016). Antibacterial and phytochemical analysis of piper nigrum using gas chromatography – mass spectrum and fourier-transform infrared spectroscopyInternational Journal of Pharmacognosy and Phytochemical Research, 8(6), 977–996
Mohammed, N. A. (2019)In vitro study of antimicrobial activity of silver nanoparticles usage (Curcuma longa L.) rhizomes against HelicobacterpyloriPlant Archives, 19(1), 1102–1106
Mohammed, R. R., Omer, A. K., Yener, Z., Uyar, A., & Ahmed, A. K. (2021). Biomedical effects of Laurus nobilis L. leaf extract on vital organs in streptozotocin-induced diabetic rats: Experimental researchAnnals of Medicine and Surgery, 61(October 2020), 188–197https://doi.org/10.1016/j.amsu.2020.11.051
Mok, J.-S., Song, K.-C., Chol, N.-J., & Yang, H.-S. (2001). antibacterial effect of cinnamon bark extract against fish pathogenic bacteriaKorean Journal of Fisheries and Aquatic Sciences, 34(5), 545–549
Momin, A. H., Acharya, S. S., & Gajjar, A. V. (2012). coriandrum sativum- review of advances in phytopharmacologyInternational Journal of Pharmaceutical Sciences and Research, 3(5), 1233–1239
Mondal, M. A., Yeasmin, T., Karim, R., Siddiqui, M. N., Nabi, S. R., Sayed, M. A., & Siddiky, M. N. A. (2015). Effect of dietary supplementation of turmeric (Curcuma longa) powder on the growth performance and carcass traits of broiler chicks. SAARC Journal of Agriculture, 13(1), 188–199
Montalbán, M. G., Coburn, J. M., Lozano-Pérez, A. A., Cenis, J. L., Víllora, G., & Kaplan, D. L. (2018). Production of curcumin-loaded silk fibroin nanoparticles for cancer therapyNanomaterials, 8(2), 7–13https://doi.org/10.3390/nano8020126
Moradi, M. T., Karimi, A., Alidadi, S., & Hashemi, L. (2017). Anti-adenovirus activity, antioxidant potential, and phenolic content of dried flower buds of Syzygium aromaticum extract in HEp2 cell lineMarmara Pharmaceutical Journal, 21(4), 852–859https://doi.org/10.12991/mpj.2017.4
Moratalla-López, N., Bagur, M. J., Lorenzo, C., Martínez-Navarro, M. E., Rosario Salinas, M., & Alonso, G. L. (2019). Bioactivity and bioavailability of the major metabolites of Crocus sativus l. flowerMolecules, 24(15)https://doi.org/10.3390/molecules24152827
Mostafa, D. M., Abd El-Alim, S. H., Asfour, M. H., Al-Okbi, S. Y., Mohamed, D. A., & Awad, G. (2015). Transdermal nanoemulsions of Foeniculum vulgare Mill. essential oil: Preparation, characterization and evaluation of antidiabetic potentialJournal of Drug Delivery Science and Technology, 29, 99–106https://doi.org/10.1016/j.jddst.2015.06.021
Mozafarian, V. (2018)Identification of medicinal and aromatic plants of Iran. 1350
Mtibaa, A. C., Smaoui, S., Ben Hlima, H., Sellem, I., Ennouri, K., & Mellouli, L. (2019). Enterocin BacFL31 from a Safety Enterococcus faecium FL31: Natural Preservative Agent Used Alone and in Combination with Aqueous Peel Onion (Allium cepa) Extract in Ground Beef Meat StorageBioMed Research International, 2019https://doi.org/10.1155/2019/4094890
Muche, B. M., & Rupasinghe, H. P. V. (2011). Natural antimicrobial agents of cinnamon ( Cinnamomum zeylanicum L. and C. cassia ) and vanilla ( Vanilla planifola, V. fresh-cut fruitsEthiop. Journal of Applied Science and Technology, 2(1), 1–13
Muckensturm, B., Foechterlen, D., Reduron, J. P., Danton, P., & Hildenbrand, M. (1997). Phytochemical and chemotaxonomic studies of Foeniculum vulgareBiochemical Systematics and Ecology, 25(4), 353–358https://doi.org/10.1016/S0305-1978(96)00106-8
Muhammad, A., Akhtar, A., Aslam, S., Khan, R. S., Ahmed, Z., & Khalid, N. (2021). Review on physicochemical, medicinal and nutraceutical properties of poppy seeds: a potential functional food ingredientFunctional Foods in Health and Disease, 11(10), 522–547https://doi.org/10.31989/ffhd.v11i10.836
Muhammad, D. R. A., Saputro, A. D., Rottiers, H., Van de Walle, D., & Dewettinck, K. (2018). Physicochemical properties and antioxidant activities of chocolates enriched with engineered cinnamon nanoparticlesEuropean Food Research and Technology, 244(7), 1185–1202https://doi.org/10.1007/s00217-018-3035-2
Muhammad, D. R. A., Sedaghat Doost, A., Gupta, V., bin Sintang, M. D., Van de Walle, D., Van der Meeren, P., & Dewettinck, K. (2020). Stability and functionality of xanthan gum–shellac nanoparticles for the encapsulation of cinnamon bark extractFood Hydrocolloids, 100(August 2019), 105377https://doi.org/10.1016/j.foodhyd.2019.105377
Muhammad, W., As, S., Sumaira, S., Muhammad, N., Safia, H., & Muhammad, J. (2017). Green synthesis of gold nanoparticles and their characterizations using plant extract of Papaver somniferumNano Science & Nano Technology: An Indian Journal, 11(2), 1–8https://www.tsijournals.com/articles/green-synthesis-of-gold-nanoparticles-and-their-characterizations-using-plant-extract-of-papaver-somniferum-13484.html%0Awww.tsijournals.com
Muhammad, W., Khan, M. A., Nazir, M., Siddiquah, A., Mushtaq, S., Hashmi, S. S., & Abbasi, B. H. (2019). Papaver somniferum L. mediated novel bioinspired lead oxide (PbO) and iron oxide (Fe2O3) nanoparticles: In-vitro biological applications, biocompatibility and their potential towards HepG2 cell lineMaterials Science and Engineering C, 103(April), 109740https://doi.org/10.1016/j.msec.2019.109740
Mukherjee, P. K., Kumar, V., Mal, M., & Houghton, P. J. (2007). Acorus calamus: Scientific validation of ayurvedic tradition from natural resourcesPharmaceutical Biology, 45(8), 651–666https://doi.org/10.1080/13880200701538724
Mukthamba, P., & Srinivasan, K. (2017). Dietary fenugreek (Trigonella foenum-graecum) seeds and garlic (Allium sativum) alleviates oxidative stress in experimental myocardial infarctionFood Science and Human Wellness, 6(2), 77–87https://doi.org/10.1016/j.fshw.2017.04.001
Mulla, M., Ahmed, J., Al-Attar, H., Castro-Aguirre, E., Arfat, Y. A., & Auras, R. (2017). Antimicrobial efficacy of clove essential oil infused into chemically modified LLDPE film for chicken meat packagingFood Control, 73, 663–671https://doi.org/10.1016/j.foodcont.2016.09.018
Murugesan, K., Koroth, J., Srinivasan, P. P., Singh, A., Mukundan, S., Karki, S. S., Choudhary, B., & Gupta, C. M. (2019). Effects of green synthesised silver nanoparticles (ST06-AgNPs) using curcumin derivative (ST06) on human cervical cancer cells (HeLa) in vitro and EAC tumor bearing mice modelsInternational Journal of Nanomedicine, 14, 5257–5270https://doi.org/10.2147/IJN.S202404
Musa Özcan, M., & Atalay, Ç. (2006). Determination of seed and oil properties of some poppy (Papaver somniferum L.) varietiesGrasas y Aceites, 57(2), 169–174https://doi.org/10.3989/gya.2006.v57.i2.33
Mustafa, R. A. (2021). Phytochemicals analysis and minerals present in the dried used as spices: health risk implication in Northern of IraqPakistan Journal of Medical and Health Sciences, 15(7), 2006–2013https://doi.org/10.53350/pjmhs211572006
Muthukumaran, P., Kumaravel, S., & Nimia, N. (2019). Phytochemical, GC-MS and FT-IR Analysis of Papaver somniferum LJournal of Pharmaceutical and Biological Sciences, 7(1), 1–8https://doi.org/10.18231/j.jpbs.2019.001
Mzabri, I., Addi, M., & Berrichi, A. (2019). Traditional and modern uses of saffron (Crocus sativus). In Cosmetics (Vol. 6, Issue 4, pp. 1–11). MDPI AGhttps://doi.org/10.3390/COSMETICS6040063
Nadeem, M., Anjum, F. M., Khan, M. I., Tehseen, S., El-Ghorab, A., & Sultan, J. I. (2013). Nutritional and medicinal aspects of coriander (Coriandrum sativum L.): A reviewBritish Food Journal, 115(5), 743–755https://doi.org/10.1108/00070701311331526
Nagaonkar, D., Shende, S., & Rai, M. (2015). Biosynthesis of copper nanoparticles and its effect on actively dividing cells of mitosis in Allium cepaBiotechnology Progress, 31(2), 557–565https://doi.org/10.1002/btpr.2040
Nagdeve, M. (2021). 11 benefits that prove why mustard is good for healthOrganic Facts
Nakkala, J. R., Mata, R., Gupta, A. K., & Sadras, S. R. (2014). Biological activities of green silver nanoparticles synthesized with Acorous calamus rhizome extractEuropean Journal of Medicinal Chemistry, 85, 784–794https://doi.org/10.1016/j.ejmech.2014.08.024
Namjoyan, F., Jahangiri, A., Azemi, M. E., Arkian, E., & Mousavi, H. (2015). Inhibitory effects of physalis alkekengi l., Alcea rosea l., Bunium persicum b. fedtsch. and Marrubium vulgare l. on mushroom tyrosinaseJundishapur Journal of Natural Pharmaceutical Products, 10(1), 1–6https://doi.org/10.17795/jjnpp-23356
Naseri, M., Mojab, F., Khodadoost, M., Kamalinejad, M., Davati, A., Choopani, R., Hasheminejad, A., Bararpoor, Z., Shariatpanahi, S., & Emtiazy, M. (2012). The study of anti-infammatory activity of oil-based dill (Anethum graveolens L.) extract used topically in formalin-induced infammation male rat pawIranian Journal of Pharmaceutical Research, 11(4), 1169–1174
Nassiri-Asl, M., & Hosseinzadeh, H. (2015). chapter 3-neuropharmacology effects of saffron and its active constituentsBioactive Neutraceuticals and Dietary Supplements in Neurological and Brain Disease, 29–39
Natarajan, B., Muralidharan, A., Satish, R., & Dhananjayan, R. (2007). Neuropharmacological activity of Trigonella foenum graecum Linn. seedsJournal of Natural Remedies, 7(1), 160–165
Nauman, S. M., & Mohammad, I. (2015). Role of khardal (Brassica Nigra) in non-communicable diseases: An overviewInternational Journal of Drug Development and Research, 7(1), 137–144
Nawaz, H., Shad, M. A., & Muzaffar, S. (2018). Phytochemical composition and antioxidant potential of BrassicaBrassica Germplasm - Characterization, Breeding and Utilization, 1, 7–26https://doi.org/10.5772/intechopen.76120
Nayak, C. A., Rastogi, N. K., & Raghavarao, K. S. M. S. (2010). Bioactive constituents present in garcinia indica choisy and its potential food applications: A reviewInternational Journal of Food Properties 13, (3), 441–453https://doi.org/10.1080/10942910802626754
Nayak, N. K., & Pathak, V. (2017). Development of low fat chevon patties using poppy seed as fat replacerIndian Journal of Small Ruminants (The), 23(2), 236https://doi.org/10.5958/0973-9718.2017.00038.1
Nayaka, S., Chakraborty, B., Bhat, M. P., Nagaraja, S. K., Airodagi, D., Swamy, P. S., Rudrappa, M., Hiremath, H., Basavarajappa, D. S., & Kanakannanavar, B. (2020). Biosynthesis, characterization, and in vitro assessment on cytotoxicity of actinomycete-synthesized silver nanoparticles on Allium cepa root tip cellsBeni-Suef University Journal of Basic and Applied Sciences, 9(1)https://doi.org/10.1186/s43088-020-00074-8
Nazari, E., Khanavi, M., Amani, L., Sharifzadeh, M., Vazirian, M., Saeedi, M., Sanati, M., & Lamardi, S. N. S. (2020). Beneficial effect of Brassica nigra fixed oil on the changes in memory caused by Β-amyloid in an animal modelPharmaceutical Sciences, 26(3), 261–269https://doi.org/10.34172/PS.2020.19
Nazeruddin, G. M., Prasad, N. R., Prasad, S. R., Shaikh, Y. I., Waghmare, S. R., & Adhyapak, P. (2014). Coriandrum sativum seed extract assisted in situ green synthesis of silver nanoparticle and its anti-microbial activityIndustrial Crops and Products, 60, 212–216https://doi.org/10.1016/j.indcrop.2014.05.040
Nejat, H., Rabiee, M., Varshochian, R., Tahriri, M., Jazayeri, H. E., Rajadas, J., Ye, H., Cui, Z., & Tayebi, L. (2017). Preparation and characterization of cardamom extract-loaded gelatin nanoparticles as effective targeted drug delivery system to treat glioblastomaReactive and Functional Polymers, 120, 46–56https://doi.org/10.1016/j.reactfunctpolym.2017.09.008
Nellore, J., Pauline, C., Amarnath, K., & Shilpa, P. N. (2012). Antioxidant effect of gold nanoparticles synthesised from Curcuma Longa restrains 1-methyl-2-phenyl pyridinium ion induced stress in PC12 cellsJournal of Nanoneuroscience, 2(1), 63–74https://doi.org/10.1166/jns.2012.1018
Nguyen, H. N., Ha, P. T., Nguyen, A. S., Nguyen, D. T., Do, H. D., Thi, Q. N., & Hoang, T. M. N. (2016). Curcumin as fluorescent probe for directly monitoring in vitro uptake of curcumin combined paclitaxel loaded PLA-TPGS nanoparticlesAdvances in Natural Sciences: Nanoscience and Nanotechnology, 7(2)https://doi.org/10.1088/2043-6262/7/2/025001
Nguyen, P. H., Le, T. V. T., Kang, H. W., Chae, J., Kim, S. K., Kwon, Ki. I., Seo, D. B., Lee, S. J., & Oh, W. K. (2010). AMP-activated protein kinase (AMPK) activators from Myristica fragrans (nutmeg) and their anti-obesity effectBioorganic and Medicinal Chemistry Letters, 20(14), 4128–4131https://doi.org/10.1016/j.bmcl.2010.05.067
Nguyen, Q. H., Talou, T., Cerny, M., Evon, P., & Merah, O. (2015). Oil and fatty acid accumulation during coriander (Coriandrum sativum L.) fruit ripening under organic cultivationCrop Journal, 3(4), 366–369https://doi.org/10.1016/j.cj.2015.05.002
Nile, S. H., & Park, S. W. (2013). Total phenolics, antioxidant and xanthine oxidase inhibitory activity of three colored onions (Allium cepa L.)Frontiers in Life Science, 7(3–4), 224–228https://doi.org/10.1080/21553769.2014.901926
Nisar, T., Iqbal, M., Raza, A., Iftikhar, F., Safdar, M., & Waheed, M. (2015). Estimation of total phenolics and free radical scavenging of turmeric (Curcuma longa)Journal of Agricultural & Environmental Sciences, 15(7), 1272–1277https://doi.org/10.5829/idosi.aejaes.2015.15.7.9527
Noumi, E., Snoussi, M., Alreshidi, M. M., Rekha, P. D., Saptami, K., Caputo, L., De Martino, L., Souza, L. F., Msaada, K., Mancini, E., Flamini, G., Al-Sieni, A., & De Feo, V. (2018). Chemical and biological evaluation of essential oils from cardamom speciesMolecules, 23(11)https://doi.org/10.3390/molecules23112818
Ntohogian, S., Gavriliadou, V., Christodoulou, E., Nanaki, S., Lykidou, S., Naidis, P., Mischopoulou, L., Barmpalexis, P., Nikolaidis, N., & Bikiaris, D. N. (2018). Chitosan nanoparticles with encapsulated natural and Uf-purified annatto and saffron for the preparation of UV protective cosmetic emulsionsMolecules, 23(9)https://doi.org/10.3390/molecules23092107
Nur Manik, M. I., Ali, M. H., Nath Ray, M., Islam, M. M., Zobayed, A., Hossain, M. T., Md, A., Fahad, T. M., & Khan, A. (2022). A comprehensive review on medicinal values and health benefits of spices and condiments commonly used in the Indian sub-continentResearch Journal of Pharmacognosy and Phytochemistry, 14(01), 11–18https://doi.org/10.5271/0975-4385.2022.00003
Obeid, M. A., Khadra, I., Albaloushi, A., Mullin, M., Alyamani, H., & Ferro, V. A. (2019). Microfluidic manufacturing of different niosomes nanoparticles for curcumin encapsulation: Physical characteristics, encapsulation efficacy, and drug releaseBeilstein Journal of Nanotechnology, 10, 1826–1832https://doi.org/10.3762/bjnano.10.177
Odimegwu, N. E., Ubbaonu, C. N., Ofoedu, C. E., Akajiaku, L. O., Njoku, N. E., Agunwah, L. M., Alagbaoso, S. O., & Iwuh, G. E. (2019). comparative study on the proximate composition, functional and sensory properties of turmeric and pawpaw custard productsCurrent Journal of Applied Science and Technology, 33(4), 1–11
Ogunruku, O. O., Oboh, G., & Ogunsuyi, O. B. (2018). Neuroprotective potential of phenolic extracts of Capsicum frutescens as an inhibitor of monoamine oxidase and cholinesterase activitiesIfe Journal of Science, 20(2), 403https://doi.org/10.4314/ijs.v20i2.20
Ogwaro, B. A., O’gara, E. A., Hill, D. J., & Gibson, H. (2021). A study of the antimicrobial activity of combined black pepper and cinnamon essential oils against escherichia fergusonii in traditional african yoghurtFoods, 10(11), 2847https://doi.org/10.3390/foods10112847
Okunade, O. A., Ghawi, S. K., Methven, L., & Niranjan, K. (2015). Thermal and pressure stability of myrosinase enzymes from black mustard, brown mustard and yellow mustard seedsFood Chemistry, 187, 485–490
Olaleye, M. T., Akinmoladun, A. C., & Akindahunsi, A. A. (2006). Antioxidant properties of Myristica fragrans (Houtt) and its effect on selected organs of albino ratsAfrican Journal of Biotechnology, 5(13), 1274–1278http://www.academicjournals.org/AJB
Olatunji, T. L., & Afolayan, A. J. (2019). Comparative quantitative study on phytochemical contents and antioxidant activities of capsicum annuum L. and Capsicum frutescens LScientific World Journal, 2019https://doi.org/10.1155/2019/4705140
Oliveira, A. R., Ribeiro, A. E. C., Oliveira, E. R., Ribeiro, K. O., Garcia, M. C., Careli-Gondim, I., Junior, M. S. S., & Caliari, M. (2020). physicochemical, microbiological and sensory characteristics of snacks developed from broken rice grains and turmeric powderInternational Journal of Food Science + Technology, 55(7), 2719–2729
Omar, A. E., Al-Khalaifah, H. S., Mohamed, W. A. M., Gharib, H. S. A., Osman, A., Al-Gabri, N. A., & Amer, S. A. (2020). Effects of phenolic-rich onion (Allium cepa L.) extract on the growth performance, behavior, intestinal histology, amino acid digestibility, antioxidant activity, and the immune status of broiler chickensFrontiers in Veterinary Science, 7https://doi.org/10.3389/fvets.2020.582612
Otunola, G, A., Afolayan, A, J., Ajayi, E, O., Odeyemi, S, W. (2017). Characterization, antibacterial and antioxidant properties of silver nanoparticles synthesized from aqueous extracts of allium sativum,zingiber officinale and capsicum frutescensA Multifaceted Peer Reviewed Journal in the Field of Pharmacognosy and Natural Products
Otunola, G. A., Oloyede, O. B., Oladiji, A. T., & Afolayan, A. J. (2010). Comparative analysis of the chemical composition of three spices - Allium sativum L. Zingiber officinale Rosc. and Capsicum frutescens L. commonly consumed in NigeriaAfrican Journal of Biotechnology, 9(41), 6927–6931https://doi.org/10.5897/ajb10.183
Oudjedi, K., Manso, S., Nerin, C., Hassissen, N., & Zaidi, F. (2019). New active antioxidant multilayer food packaging films containing Algerian Sage and Bay leaves extracts and their application for oxidative stability of fried potatoesFood Control, 98, 216–226https://doi.org/10.1016/j.foodcont.2018.11.018
Oyemitan, I. A., Elusiyan, C. A., Onifade, A. O., Akanmu, M. A., Oyedeji, A. O., & McDonald, A. G. (2017). Neuropharmacological profile and chemical analysis of fresh rhizome essential oil of Curcuma longa (turmeric) cultivated in Southwest NigeriaToxicology Reports, 4(February), 391–398https://doi.org/10.1016/j.toxrep.2017.07.001
Ozbek, H. (2005). The anti-inflammatory activity of the Foeniculum vulgare l. essential oil and investigation of its median lethal dose in rats and miceInternational Journal of Pharmacology, 1(4), 329–331https://doi.org/10.3923/ijp.2005.329.331
Özkutlu, F., Kara, S. M., & Sekeroglu, N. (2007). Determination of mineral and trace elements in some spices cultivated in TurkeyActa Horticulturae, 756, 321–327https://doi.org/10.17660/actahortic.2007.756.34
Pakrashi, S., Jain, N., Dalai, S., Jayakumar, J., Chandrasekaran, P. T., Raichur, A. M., Chandrasekaran, N., & Mukherjee, A. (2014)In vivo genotoxicity assessment of titanium dioxide nanoparticles by Allium cepa root tip assay at high exposure concentrationsPLoS ONE, 9(2)https://doi.org/10.1371/journal.pone.0087789
Pal, M., Srivastava, M., Soni, D. K., Kumar, A., & Tewari, S. K. (2011). Composition and anti-microbial activity of essential oil of Myristica fragrans from Andaman Nicobar IslandInernational Journal of Pharmacy & L Ife Sciences, 2(10), 1115–1117
Pal, S., Pal, K., Mukherjee, S., Bera, D., Karmakar, P., & Sukhen, D. (2020). Green cardamom mediated phytosynthesis of ZnONPs and validation of its antibacterial and anticancerous potentialMaterials Research Express, 7(1)https://doi.org/10.1088/2053-1591/ab69c8
Panda, V. S., & Islam, A. (2013)In vivo anti-inflammatory activity of Garcinia indica fruit rind (Kokum) in ratsThe Journal of Phytopharmacology, 2(5), 8–14https://doi.org/10.31254/phyto.2013.2502
Panda, V. S., & Khambat, P. D. (2014). Antiulcer activity of Garcinia indica fruit rind (kokum berry) in ratsBiomedicine and Aging Pathology, 4(4), 309–316https://doi.org/10.1016/j.biomag.2014.07.008
Pandey, H., & Awasthi, P. (2015). Effect of processing techniques on nutritional composition and antioxidant activity of fenugreek (Trigonella foenum-graecum) seed flourJournal of Food Science and Technology, 52(2), 1054–1060https://doi.org/10.1007/s13197-013-1057-0
Pandit, R. (1970). Green synthesis of silver nanoparticles from seed extract of Brassica nigra and its antibacterial activityNusantara Bioscience, 7(1), 15–19https://doi.org/10.13057/nusbiosci/n070103
Pandya, K. K., Patel, R. B., & Chakravarthy, B. K. (1990). Antibacterial activity of some Indian medicinal plantsIndian Drugs, 27(8), 415–417
Parida, U. K., Bindhani, B. K., & Nayak, P. (2011). Green synthesis and characterization of gold nanoparticles using onion (Allium cepa) extractWorld Journal of Nano Science and Engineering, 01(04), 93–98https://doi.org/10.4236/wjnse.2011.14015
Park, S. H., Lim, H. S., & Hwang, S. Y. (2012). Evaluation of antioxidant, rheological, physical and sensorial properties of wheat flour dough and cake containing turmeric powderFood Science and Technology International, 18(5), 435–443https://doi.org/10.1177/1082013211428220
Parki, A., Chaubey, P., Prakash, O., Kumar, R., & Pant, A. K. (2017). Seasonal variation in essential oil compositions and antioxidant properties of Acorus calamus l. accessionsMedicines, 4(4), 81https://doi.org/10.3390/medicines4040081
Parvandi, M., Rezadoost, H., & Farzaneh, M. (2021). Introducing Alternaria tenuissima SBUp1, as an endophytic fungus of Ferula assa-foetida from Iran, which is a rich source of rosmarinic acidLetters in Applied Microbiology, 73(5), 569–578https://doi.org/10.1111/lam.13542
Pashapoor, A., Mashhadyrafie, S., & Mortazavi, P. (2020). The antioxidant potential and antihyperlipidemic activity of Myristica fragrans seed (nutmeg) extract in diabetic ratsJournal of Human, Environment, and Health Promotion, 6(2), 91–96https://doi.org/10.29252/jhehp.6.2.7
Passano, P. (1995). The many uses of methiManushi, 2, 31–34
Patel, S., Shende, S., Arora, S., & Singh, A. K. (2013). An assessment of the antioxidant potential of coriander extracts in ghee when stored at high temperature and during deep fat fryingInternational Journal of Dairy Technology, 66(2), 207–213https://doi.org/10.1111/1471-0307.12023
Pathak, P., Srivastava, S., & Grover, S. (2000). Development of food products based on millets, legumes and fenugreek seeds and their suitability in the diabetic dietInternational Journal of Food Sciences and Nutrition, 51(5), 409–414https://doi.org/10.1080/096374800427019
Patil, S. D., Shinde, S., Kandpile, P., & Jain, A. S. (2015). Evaluation of antimicrobial activity of asafoetidaInternational Journal of Pharmaceutical Science and Research, 6(2), 722–727https://doi.org/10.13040/IJPSR.0975-8232.6(2).722-27
Patra, D., & Moussawi, R. N. (2015). Curcumin conjugated gold nanoparticles for nucleic acid sensingIEEE-NANO 2015 - 15th International Conference on Nanotechnology, 401–404https://doi.org/10.1109/NANO.2015.7388621
Patra, D., & Sleem, F. (2013). A new method for pH triggered curcumin release by applying poly(l-lysine) mediated nanoparticle-congregationAnalytica Chimica Acta, 795, 60–68https://doi.org/10.1016/j.aca.2013.07.063
Patra, J. K., Das, G., Bose, S., Banerjee, S., Vishnuprasad, C. N., del Pilar Rodriguez-Torres, M., & Shin, H. S. (2020). Star anise (Illicium verum): Chemical compounds, antiviral properties, and clinical relevancePhytotherapy Research, 34(6), 1248–1267https://doi.org/10.1002/ptr.6614
Pattanayak, M., Muralikrishnan, T., & Nayak, P. L. (2013). Green synthesis of gold nanoparticles using Elettaria cardamomum ( ELAICHI ) aqueous extractWorld Journal of Nano Science & Technology, 2(2), 52–58https://doi.org/10.5829/idosi.wjnst.2013.2.1.21131
Paul, R., Roy, A., Rajeshkumar, S., & Thangavelu, L. (2020). Cytotoxic effect and antibacterial activity of coriander oleoresin mediated zinc oxide nanoparticlesInternational Journal of Pharmaceutical Research, 12(October), 3057–3062https://doi.org/10.31838/ijpr/2020.SP1.411
Pavalakumar, D., Jayasinghe, M., Edirisinghe, M., Wijesekara, I., & Senadheera, S. (2021). Cinnamomum zeylanicum and Curcuma longa incorporated dairy yoghurts with hindered glycaemic properties for healthy peopleJournal of Future Foods, 1(1), 104–112https://doi.org/10.1016/j.jfutfo.2021.09.006
Pellegrini, M., Rossi, C., Palmieri, S., Maggio, F., Chaves-López, C., Lo Sterzo, C., Paparella, A., De Medici, D., Ricci, A., & Serio, A. (2020). Salmonella enterica control in stick carrots through incorporation of coriander seeds essential oil in sustainable washing treatmentsFrontiers in Sustainable Food Systems, 4https://doi.org/10.3389/fsufs.2020.00014
Perumalsamy, R., & Krishnadhas, L. (2022). Anti-diabetic activity of silver nanoparticles synthesized from the hydroethanolic extract of Myristica fragrans seedsApplied Biochemistry and Biotechnology, 194(3), 1136–1148https://doi.org/10.1007/s12010-022-03825-8
Pesnya, D. S. (2013). Cytogenetic effects of chitosan-capped silver nanoparticles in the Allium cepa testCaryologia, 66(3), 275–281https://doi.org/10.1080/00087114.2013.852342
Peters, R., Kramer, E., Oomen, A. G., Herrera Rivera, Z. E., Oegema, G., Tromp, P. C., Fokkink, R., Rietveld, A., Marvin, H. J. P., Weigel, S., Peijnenburg, A. A. C. M., & Bouwmeester, H. (2012). Presence of nano-sized silica during in vitro digestion of foods containing silica as a food additiveACS Nano, 6(3), 2441–2451https://doi.org/10.1021/nn204728k
Pgs, M. (2020). Seed production technology of coriander (Coriandrum sativum)In Advances in Vegetable Agronomy, 214–222
Pilar Santamarina, M., Roselló, J., Giménez, S., & Amparo Blázquez, M. (2016). Commercial Laurus nobilis L. and Syzygium aromaticum L. Merr. & Perry essential oils against post-harvest phytopathogenic fungi on riceLWT - Food Science and Technology, 65, 325–332https://doi.org/10.1016/j.lwt.2015.08.040
Pillai, R. R., Sreelekshmi, P. B., & Meera, A. P. (2022). Enhanced biological performance of green sythesized copper oxide nanoparticles using Pimenta dioica leaf extractMaterials Today: Proceedings, 50, 163–172https://doi.org/10.1016/j.matpr.2021.11.547
Pipriya, S. (2019). Evaluation of antibacterial potential & phytochemical screening by the medicinal plant of Acorus calamus & Agaricus bisporus & their synthesis of herbal silver nanoparticles with different solventsInternational Journal of Engineering Research and Technology (IJERT), 8(05), 158–169
Pipriya, S., Kundu, N., & Tiwari, U. (2018). Green synthesis, characterization and antioxidant activity of silver nanoparticles in extracts of Acorus calamus and Agaricus bisporusInternational Journal of Biochemistry Research & Review, 21(4), 1–15https://doi.org/10.9734/ijbcrr/2018/41615
Plangar, A. F., Anaeigoudari, A., Khajavirad, A., & Shafei, M. N. (2019). Beneficial cardiovascular effects of hydroalcoholic extract from crocus sativus in hypertension induced by angiotensin IIJournal of Pharmacopuncture, 22(2), 95–101https://doi.org/10.3831/KPI.2019.22.012
Pongkorpsakol, P., Wongkrasant, P., Kumpun, S., Chatsudthipong, V., & Muanprasat, C. (2015). Inhibition of intestinal chloride secretion by piperine as a cellular basis for the anti-secretory effect of black peppersPharmacological Research, 100, 271–280https://doi.org/10.1016/j.phrs.2015.08.012
Pooloth, J. (2013). Biosynthesis of silver nanoparticles using Trigonella foenum graecum and the determination of their antimicrobial activityInternational Journal of Science and Research (IJSR), 2(5), 287–290https://www.ijsr.net/archive/v2i5/IJSRON2013955.pdf
Prabhu, S., & Poulose, E. K. (2012). Silver nanoparticles: mechanism of antimicrobial action, synthesis, medical applications, and toxicity effectsInternational Nano Letters, 2(1)https://doi.org/10.1186/2228-5326-2-32
Pradeep, K. U., Geervani, P., & Eggum, B. O. (1993). common indian spices:nutrient composition, consumption and contribution to dietary valuePlant Foods for Human Nutrition, 44(2), 137–148
Pradeep, S., Jain, A. S., Dharmashekara, C., Prasad, S. K., Akshatha, N., Pruthvish, R., Amachawadi, R. G., Srinivasa, C., Syed, A., Elgorban, A. M., Kheraif, A. A. A., Ortega-Castro, J., Frau, J., Flores-Holguin, N., Shivamallu, C., Kollur, S. P., Glossm, D. (2021). Synthesis, computational pharmacokinetics report, conceptual DFT-based calculations and anti-acetylcholinesterase activity of hydroxyapatite nanoparticles derived from Acorus calamus plant extractMedicinal and Pharmaceutical Chemistry
Pramanik, A., Datta, A. K., Das, D., Kumbhakar, D. V., Ghosh, B., Mandal, A., Gupta, S., Saha, A., & Sengupta, S. (2018). Assessment of nanotoxicity (Cadmium Sulphide and Copper Oxide) using cytogenetical parameters in Coriandrum sativum L. (Apiaceae)Cytology and Genetics, 52(4), 299–308https://doi.org/10.3103/S0095452718040084
Pramanik, A., Datta, A. K., Gupta, S., Ghosh, B., Das, D., & Kumbhakar, D. V. (2017). Assessment of genotoxicity of engineered nanoparticles (cadmium sulphide – CdS and copper oxide - CuO) using plant model (Coriandrum sativum L.)International Journal of Research in Pharmaceutical Sciences, 8(4), 741–753
Prasad, S., & Aggarwal , B, B. (2011). chapter 13: turmeric, the golden spiceHerbal Medicine: Biomolecular and Clinical Aspects
Premkumar, J., Sudhakar, T., Dhakal, A., Shrestha, J. B., Krishnakumar, S., & Balashanmugam, P. (2018). Synthesis of silver nanoparticles (AgNPs) from cinnamon against bacterial pathogensBiocatalysis and Agricultural Biotechnology, 15, 311–316https://doi.org/10.1016/j.bcab.2018.06.005
Pundarikakshudu, K., Shah, D. H., Panchal, A. H., & Bhavsar, G. C. (2016). Anti-inflammatory activity of fenugreek (Trigonella foenum-graecum Linn) seed petroleum ether extractIndian Journal of Pharmacology, 48(4), 441–444https://doi.org/10.4103/0253-7613.186195
Puthur, S., Raj, K. K., Anoopkumar, A. N., Rebello, S., & Aneesh, E. M. (2020). Acorus calamus mediated green synthesis of ZnONPs: A novel nano antioxidant to future perspectiveAdvanced Powder Technology, 31(12), 4679–4682https://doi.org/10.1016/j.apt.2020.10.016
Puvača, N., Kostadinović, L., Popović, S., Lević, J., Ljubojević, D., Tufarelli, V., Jovanović, R., Tasić, T., Ikonić, P., & Lukač, D. (2016). Proximate composition, cholesterol concentration and lipid oxidation of meat from chickens fed dietary spice addition (Allium sativum, Piper nigrum, Capsicum annuum)Animal Production Science, 56(11), 1920–1927https://doi.org/10.1071/AN15115
Qiao, G. H., Wexxin, D., Zhigang, X., Sami, R., Khojah, E., & Amanullah, S. (2020). Antioxidant and anti-inflammatory capacities of pepper tissuesItalian Journal of Food Science, 32(2), 265–274https://doi.org/10.14674/IJFS-1700
Qureshi, A. I., Sheikh, R. A., Tahir, N., Pal, M. A., Asif, H. S., Mir, R., & Heena, J. (2018). Efficacy of fenugreek seed powder for the development of functional spent hen meat pattiesJournal of Entomology and Zoology Studies, 6(5), 353–356
Rabadia, J., Hirani, U., Kardani, D., Kaneria, A., & Rabadia, J. (2014). Cardioprotective effect of methanolic extract of Syzygium aromaticum on isoproterenol induced myocardial infarction in ratAsian Journal of Phamacology and Toxicology, 02(04), 1–6
Radini, I. A., Hasan, N., Malik, M. A., & Khan, Z. (2018). Biosynthesis of iron nanoparticles using Trigonella foenum-graecum seed extract for photocatalytic methyl orange dye degradation and antibacterial applicationsJournal of Photochemistry and Photobiology B: Biology, 183, 154–163https://doi.org/10.1016/j.jphotobiol.2018.04.014
Radwan, A. M., Aboelfetoh, E. F., Kimura, T., Mohamed, T. M., & El-Keiy, M. M. (2021). Fenugreek-mediated synthesis of zinc oxide nanoparticles and evaluation of its in vitro and in vivo antitumor potencyBiomedical Research and Therapy, 8(8), 4483–4496https://doi.org/10.15419/bmrat.v8i8.687
Raeisi, M., Hashemi, M., Afshari, A., Tabarraei, A., Aminzare, M., & Jannat, B. (2019). Cinnamon and rosemary essential oils incorporated into alginate coating improve chemical and sensorial quality of chicken meatIranian Journal of Chemistry and Chemical Engineering, 38(5), 293–304https://doi.org/10.2139/ssrn.3627606
Rahaiee, S., Moini, S., Hashemi, M., & Shojaosadati, S. A. (2015). Evaluation of antioxidant activities of bioactive compounds and various extracts obtained from saffron (Crocus sativus L.): a reviewJournal of Food Science and Technology, 52(4), 1881–1888https://doi.org/10.1007/s13197-013-1238-x
Rahman, A. (2021). Effects of lettuce and foeniculum vulgare powder as a natural source of nitrate on the physical, chemical and microbiological properties and sensory evaluation of vacuum packed sausageIranian Food Science and Technology Research Journal
Rahman, R. T., Lou, Z., Zhang, J., Yu, F., Timilsena, Y. P., Zhang, C., Zhang, Y., & Bakry, A. M. (2017). Star anise (Illicium verum hook. f.) as quorum sensing and biofilm formation inhibitor on foodborne bacteria: study in milkJournal of Food Protection, 80(4), 645–653https://doi.org/10.4315/0362-028X.JFP-16-294
Rahnama, F., Mohammadzadeh Milani, J., & Gohari Ardabili, A. (2017). Improved quality attributes of brabari and lavash flat breads with wheat doughs incorporated with fenugreek seed (Trigonella foenum graecum) gumJournal of Food Processing and Preservation, 41(1)https://doi.org/10.1111/jfpp.12741
Rai, P. K., Jaiswal, D., Mehta, S., Rai, D. K., Sharma, B., & Watal, G. (2010). Effect of Curcuma longa freeze dried rhizome powder with milk in STZ induced diabetic ratsIndian Journal of Clinical Biochemistry, 25(2), 175–181https://doi.org/10.1007/s12291-010-0032-z
Rai, P. D., Dambal, A. A., Khatri, S., & Khadabadi, S. S. (2015). Development of an anti-obesity polyherbal formulation containing Terminalia arjuna, Lagenaria siceraria and Piper nigrumThe Pharma Innovation, 3(11), 33–37
Rajabi, H., Jafari, S. M., Rajabzadeh, G., Sarfarazi, M., & Sedaghati, S. (2019). Chitosan-gum arabic complex nanocarriers for encapsulation of saffron bioactive componentsColloids and Surfaces A: Physicochemical and Engineering Aspects, 578, 123644https://doi.org/10.1016/j.colsurfa.2019.123644
Rajamurugan, R., Suyavaran, A., Selvaganabathy, N., Ramamurthy, C. H., Reddy, G. P., Sujatha, V., & Thirunavukkarasu, C. (2012). Brassica nigra plays a remedy role in hepatic and renal damagePharmaceutical Biology, 50(12), 1488–1497https://doi.org/10.3109/13880209.2012.685129
Rajan, A., Rajan, A. R., & Philip, D. (2017). Elettaria cardamomum seed mediated rapid synthesis of gold nanoparticles and its biological activitiesOpenNano, 2(November 2016), 1–8https://doi.org/10.1016/j.onano.2016.11.002
Rajeshwari, A., Kavitha, S., Alex, S. A., Kumar, D., Mukherjee, A., Chandrasekaran, N., & Mukherjee, A. (2015). Cytotoxicity of aluminum oxide nanoparticles on Allium cepa root tip—effects of oxidative stress generation and biouptakeEnvironmental Science and Pollution Research, 22(14), 11057–11066https://doi.org/10.1007/s11356-015-4355-4
Rajeshwari, A., Roy, B., Chandrasekaran, N., & Mukherjee, A. (2016). Cytogenetic evaluation of gold nanorods using Allium cepa testPlant Physiology and Biochemistry, 109, 209–219https://doi.org/10.1016/j.plaphy.2016.10.003
Rajeshwari, A., Suresh, S., Chandrasekaran, N., & Mukherjee, A. (2016). Toxicity evaluation of gold nanoparticles using an Allium cepa bioassayRSC Advances, 6(29), 24000–24009https://doi.org/10.1039/c6ra04712b
Rajeshwari, U., & Andallu, B. (2011). Medicinal benefits of coriander(Coriandrum Sativum L)Spatula DD - Peer Reviewed Journal on Complementary Medicine and Drug Discovery, 1(1), 51https://doi.org/10.5455/spatula.20110106123153
Rajeswari, V. D., Eed, E. M., Elfasakhany, A., Badruddin, I. A., Kamangar, S., & Brindhadevi, K. (2021). Green synthesis of titanium dioxide nanoparticles using Laurus nobilis (bay leaf): Antioxidant and antimicrobial activitiesApplied Nanoscience (Switzerland)https://doi.org/10.1007/s13204-021-02065-2
Rajkumar, V., Gunasekaran, C., Dharmaraj, J., Chinnaraj, P., Paul, C. A., & Kanithachristy, I. (2020). Structural characterization of chitosan nanoparticle loaded with Piper nigrum essential oil for biological efficacy against the stored grain pest controlPesticide Biochemistry and Physiology, 166, 104566https://doi.org/10.1016/j.pestbp.2020.104566
Rajoriya, P., Misra, P., Shukla, P. K., & Ramteke, P. W. (2016). Light-regulatory effect on the phytosynthesis of silver nanoparticles using aqueous extract of garlic (Allium sativum) and onion (Allium cepa) bulbCurrent Science, 111(8), 1364–1368https://doi.org/10.18520/cs/v111/i8/1364-1368
Rajput, S. B., Tonge, M. B., & Karuppayil, S. M. (2014). An overview on traditional uses and pharmacological profile of Acorus calamus Linn. (Sweet flag) and other Acorus species. In Phytomedicine (Vol. 21, Issue 3, pp. 268–276). Urban und Fischer Verlag Jenahttps://doi.org/10.1016/j.phymed.2013.09.020
Ramezani, M., Nasri, S., & Yassa, N. (2009). Antinociceptive and anti-inflammatory effects of isolated fractions from Apium graveolens seeds in micePharmaceutical Biology, 47(8), 740–743https://doi.org/10.1080/13880200902939283
Ramírez-Tortosa, M. C., Mesa, M. D., Aguilera, M. C., Quiles, J. L., Baró, L., Ramirez-Tortosa, C. L., Martinez-Victoria, E., & Gil, A. (1999). Oral administration of a turmeric extract inhibits LDL oxidation and has hypocholesterolemic effects in rabbits with experimental atherosclerosisAtherosclerosis, 147(2), 371–378https://doi.org/10.1016/S0021-9150(99)00207-5
Rao, K., Ch, B., Narasu, L. M., & Giri, A. (2010). Antibacterial activity of Alpinia galanga (L) willd crude extractsApplied Biochemistry and Biotechnology, 162(3), 871–884https://doi.org/10.1007/s12010-009-8900-9
Rao, P. S., Navinchandra, S., & Jayaveera, K. (2012). An important spice, Pimenta dioica (Linn.) Merill: A ReviewInternational Current Pharmaceutical Journal, 1(8), 221–225https://doi.org/10.3329/icpj.v1i8.112555
Rao, P. V., & Gan, S. H. (2014). Cinnamon: A multifaceted medicinal plantEvidence-Based Complementary and Alternative Medicine, 2014https://doi.org/10.1155/2014/642942
Rao, S., & Ramakrishna, A. (2020). Indian medicinal plantsIndian Medicinal Plantshttps://doi.org/10.1201/9781003001898
Rashid, M. A., & Zuberi, R. H. (2016). Pharmacognostical studies for standardisation of a medicinal spice, the fruit of Illicium Verum hook. fPharmaTutor, 4(8), 36–41
Rather, M. A., Dar, B. A., Sofi, S. N., Bhat, B. A., & Qurishi, M. A. (2016). Foeniculum vulgare: a comprehensive review of its traditional use, phytochemistry, pharmacology, and safety. In Arabian Journal of Chemistry (Vol. 9, pp. S1574–S1583). Elsevier B.Vhttps://doi.org/10.1016/j.arabjc.2012.04.011
Rathour, M., Malav, O. P., Kumar, P., Chatli, M. K., & Mehta, N. (2017). Storage stability of chevon rolls incorporated with ethanolic extracts of Aloe vera and Cinnamon bark at refrigeration temperature (4±1°C)Journal of Animal Research, 7(1), 183https://doi.org/10.5958/2277-940x.2017.00025.0
Raut, V. R. A., & Ghotankar, A. M. (2019). Review of khuskhus ( khaskhas ) ( seeds of Papaver somniferum linn. ) with special reference of ayurveda medicineJournal of Ayurveda and Integrated Medical Sciences, 4(06), 228–231
Ravichandra, V., Hanumantharayappa, B., & Madhava Reddy Papasani, V. (2014). Evaluation of cardio protective activity of Galangin against doxorubicin induced cardiomyopathyInternational Journal of Pharmacy and Pharmaceutical Sciences, 6(9), 86–90
Razavi, M. S., Golmohammadi, A., Nematollahzadeh, A., Fiori, F., Rovera, C., & Farris, S. (2020). Preparation of cinnamon essential oil emulsion by bacterial cellulose nanocrystals and fish gelatinFood Hydrocolloids, 109, 106111https://doi.org/10.1016/j.foodhyd.2020.106111
Ražná, K., Khasanova, N., Ivanišová, E., Qahramon, D., & Habán, M. (2018). Antioxidant properties of cumin (Bunium persicum Boiss.) extract and its protective role against ultrasound-induced oxidative stress tested by microrna based markersPotravinarstvo Slovak Journal of Food Sciences, 12(1), 11–19https://doi.org/10.5219/838
Reddy, S. Y., & Prabhakar, J. V. (1994). cocoa butter extenders from kokum and phulwara butterJournal of the American Oil Chemists’ Society, 71(2), 217–219
Reddy, G. C., & Raghuveer, S. (2018)Non-traditional products from kokum: Inland and global opportunities5(6), 102–104
Reddy, L. H., Arias, J. L., Nicolas, J., & Couvreur, P. (2012). Magnetic nanoparticles: Design and characterization, toxicity and biocompatibility, pharmaceutical and biomedical applicationsChemical Reviews, 112(11), 5818–5878https://doi.org/10.1021/cr300068p
Reddy Pullagurala, V. L., Adisa, I. O., Rawat, S., Kalagara, S., Hernandez-Viezcas, J. A., Peralta-Videa, J. R., & Gardea-Torresdey, J. L. (2018). ZnO nanoparticles increase photosynthetic pigments and decrease lipid peroxidation in soil grown cilantro (Coriandrum sativum)Plant Physiology and Biochemistry, 132, 120–127https://doi.org/10.1016/j.plaphy.2018.08.037
Remani, K. C., & Binitha, N. N. (2022). Fluorescence sensing of picric acid by ceria nanostructures prepared using fenugreek extractJournal of the Iranian Chemical Society, 19(2), 619–633https://doi.org/10.1007/s13738-021-02327-4
Repajić, M., Ekić, S., Kruk, V., & Dragović Uzelac, V. (2021). Effect of accelerated solvent extraction conditions on the isolation of bioactive compounds from fennel (Foeniculum vulgare Mill.) seedsHrvatski Časopis Za Prehrambenu Tehnologiju, Biotehnologiju i Nutricionizam, 15(3–4), 102–106https://doi.org/10.31895/hcptbn.15.3-4.7
Restrepo-Osorio, J., Nobile-Correa, D. P., Zuñiga, O., & Sánchez-Andica, R. A. (2020). Determination of nutritional value of turmeric flour and the antioxidant activity of Curcuma longa rhizome extracts from agroecological and conventional crops of Valle del Cauca-ColombiaRevista Colombiana de Quimica, 49(1), 26–32https://doi.org/10.15446/rev.colomb.quim.v1n49.79334
Rezaei-Chiyaneh, E., Amirnia, R., Amani Machiani, M., Javanmard, A., Maggi, F., & Morshedloo, M. R. (2020). Intercropping fennel (Foeniculum vulgare L.) with common bean (Phaseolus vulgaris L.) as affected by PGPR inoculation: A strategy for improving yield, essential oil and fatty acid compositionScientia Horticulturae, 261(September), 108951https://doi.org/10.1016/j.scienta.2019.108951
Rezaei, S., Mohammadi, M., Najafpour, G. D., Moghadamnia, A., Kazemi, S., & Nikzad, M. (2018). Separation of curcumin from Curcuma longa L. and its conjugation with silica nanoparticles for anti-cancer activitiesInternational Journal of Engineering, Transactions B: Applications, 31(11), 1803–1809https://doi.org/10.5829/ije.2018.31.11b.01
Ring, L. C., Yenn, T. W., Wen-Nee, T., Tumin, N. D., Yusof, F. A. M., Yacob, L. S., Rosli, M. I. H. B., & Taher, M. A. (2020). Synthesis of curcumin quantum dots and their antimicrobial activity on necrotizing fasciitis causing bacteriaMaterials Today: Proceedings, 31(January), 31–35https://doi.org/10.1016/j.matpr.2020.01.082
Rinita, J., Jose, R., & Jothi, N. S. N. (2021). Acclimated growth and characterization of manganese oxide nanospheres using natural extract from trigonella foenum-graecumMaterials Technology, 36(7), 412–419https://doi.org/10.1080/10667857.2020.1761660
Rizwana, H., Bokahri, N. A., Alkhattaf, F. S., Albasher, G., & Aldehaish, H. A. (2021). Antifungal, antibacterial, and cytotoxic activities of silver nanoparticles synthesized from aqueous extracts of mace-arils of myristica fragransMolecules, 26(24)https://doi.org/10.3390/molecules26247709
Robert, S. D., Ismail, AAsafi, & Rosli, W. I. W. (2016). Reduction of postprandial blood glucose in healthy subjects by buns and flatbreads incorporated with fenugreek seed powderEuropean Journal of Nutrition, 55(7), 2275–2280https://doi.org/10.1007/s00394-015-1037-4
Rodrigues, A. S., Almeida, D. P., Gandara, J. S., & Gregorio, M. R. P. (2017). Onions : a source of flavonoids world ’ s largest science, technology & medicine open access book publisherBiosynthesis Hum Health, 23(September), 439
Rostami-Vartooni, A., Nasrollahzadeh, M., & Alizadeh, M. (2016). Green synthesis of seashell supported silver nanoparticles using Bunium persicum seeds extract: Application of the particles for catalytic reduction of organic dyesJournal of Colloid and Interface Science, 470, 268–275https://doi.org/10.1016/j.jcis.2016.02.060
Ru, Q., Hu, Q., Dai, C., Zhang, X., & Wang, Y. (2022). Formulation of Laurus nobilis essential oil nanoemulsion system and its application in fresh-cut muskmelonsCoatings, 12(2)https://doi.org/10.3390/coatings12020159
Ruiz-Torres, N., Flores-Naveda, A., Barriga-Castro, E. D., Camposeco-Montejo, N., Ramírez-Barrón, S., Borrego-Escalante, F., Niño-Medina, G., Hernández-Juárez, A., Garza-Alonso, C., Rodríguez-Salinas, P., & García-López, J. I. (2021). Zinc oxide nanoparticles and zinc sulfate impact physiological parameters and boosts lipid peroxidation in soil grown coriander plants (Coriandrum sativum)Molecules, 26(7), 1–14https://doi.org/10.3390/molecules26071998
Sabir, S., Arshad, M., & Chaudhari, S. K. (2014). Zinc oxide nanoparticles for revolutionizing agriculture: Synthesis and applications. In Scientific World Journal (Vol. 2014). Hindawi Limitedhttps://doi.org/10.1155/2014/925494
Sachdeva, C., & Kaushik, N, K. (2021). Spices reservoir of health benefitsNatural Medicinal Plants
Sadadekar, A. S., Shruthy, R., Preetha, R., Kumar, N., Pande, K. R., & Nagamaniammai, G. (2022). Enhanced antimicrobial and antioxidant properties of Nano chitosan and pectin based biodegradable active packaging films incorporated with fennel (Foeniculum vulgare) essential oil and potato (Solanum tuberosum) peel extractsJournal of Food Science and Technologyhttps://doi.org/10.1007/s13197-021-05333-9
Sadeghzadeh, H., Pilehvar-Soltanahmadi, Y., Akbarzadeh, A., Dariushnejad, H., Sanjarian, F., & Zarghami, N. (2017). The effects of nanoencapsulated curcumin-Fe3O4 on proliferation and hTERT gene expression in lung cancer cellsAnti-Cancer Agents in Medicinal Chemistry, 17(10)https://doi.org/10.2174/1871520617666170213115756
Sagadevan, S., Anita Lett, J., Vennila, S., Varun Prasath, P., Saravanan Kaliaraj, G., Fatimah, I., Léonard, E., Mohammad, F., Al-Lohedan, H. A., Alshahateet, S. F., & Lee, C. T. (2021). Photocatalytic activity and antibacterial efficacy of titanium dioxide nanoparticles mediated by Myristica fragrans seed extractChemical Physics Letters, 771, 138527https://doi.org/10.1016/j.cplett.2021.138527
Saha, N., & Dutta Gupta, S. (2017). Low-dose toxicity of biogenic silver nanoparticles fabricated by Swertia chirata on root tips and flower buds of Allium cepaJournal of Hazardous Materials, 330, 18–28https://doi.org/10.1016/j.jhazmat.2017.01.021
Sahib, A. S. (2016). Anti-diabetic and antioxidant effect of cinnamon in poorly controlled type-2 diabetic Iraqi patients: A randomized, placebo-controlled clinical trialJournal of Intercultural Ethnopharmacology, 5(2), 108–113https://doi.org/10.5455/jice.20160217044511
Saikia, T., Lalhlenmawia, H., Laldinchhana, Roy, P. K., & Thanzami, K. (2020). Effect of polymeric nanoparticles of curcumin on a549 cell lineInternational Journal of Current Pharmaceutical Research, 12(5), 50–53https://doi.org/10.22159/ijcpr.2020v12i5.39765
Sakhare, S. D., & Prabhasankar, P. (2017). Effect of roller milled fenugreek fiber incorporation on functional, thermal and rheological characteristics of whole wheat flourJournal of Food Measurement and Characterization, 11(3), 1315–1325https://doi.org/10.1007/s11694-017-9509-2
Saleem, A., Naureen, I., Naeem, M., Tasleem, G., Ahmed, H., & Farooq, U. (2022). Therapeutic role of piper nigrum L (Black Pepper) and pharmacological activitiesScholars International Journal of Biochemistry, 5(1), 15–21https://doi.org/10.36348/sijb.2022.v05i01.003
Saleh, A. M., Selim, S., Jaouni, S. Al, & AbdElgawad, H. (2018). CO 2 enrichment can enhance the nutritional and health benefits of parsley (Petroselinum crispum L.) and dill (Anethum graveolens L.). In Food Chemistry (Vol. 269)https://doi.org/10.1016/j.foodchem.2018.07.046
Saleh, S. R., Salam, H. S. H., & Hassan, A. H. A. (2021). Antibacterial activity of origanum majorana and Curcuma longa extracts against multiple drug-resistant pathogenic E. coli and methicillin-resistant Staphylococcus aureus isolates recovered from meat productsJournal of Advanced Veterinary Research, 11(4), 221–229
Salehi, B., Hernández-Álvarez, A. J., Contreras, M. D. M., Martorell, M., Ramírez-Alarcón, K., Melgar-Lalanne, G., Matthews, K. R., Sharifi-Rad, M., Setzer, W. N., Nadeem, M., Yousaf, Z., & Sharifi-Rad, J. (2018). Potential phytopharmacy and food applications of capsicum spp.: A comprehensive reviewNatural Product Communications, 13(11), 1543–1556https://doi.org/10.1177/1934578x1801301133
Salim, A. A., Bakhtiar, H., Bidin, N., & Ghoshal, S. K. (2018). Unique attributes of spherical cinnamon nanoparticles produced via PLAL technique: Synergy between methanol media and ablating laser wavelengthOptical Materials, 85, 100–105https://doi.org/10.1016/j.optmat.2018.08.054
Salim, A. A., & Bidin, N. (2017). Pulse Q-switched Nd:YAG laser ablation grown cinnamon nanomorphologies: Influence of different liquid mediumJournal of Molecular Structure, 1149, 694–700https://doi.org/10.1016/j.molstruc.2017.08.055
Salim, A. A., Bidin, N., & Ghoshal, S. K. (2018). Growth and characterization of spherical cinnamon nanoparticles: Evaluation of antibacterial efficacyLWT - Food Science and Technology, 90(September 2017), 346–353https://doi.org/10.1016/j.lwt.2017.12.047
Salim, A. A., Bidin, N., Ghoshal, S. K., Islam, S., & Bakhtiar, H. (2018). Synthesis of truncated tetrahedral cinnamon nanoparticles in citric acid media via PLAL techniqueMaterials Letters, 217, 267–270https://doi.org/10.1016/j.matlet.2018.01.103
Salim, A. A., Bidin, N., Lafi, A. S., & Huyop, F. Z. (2017). Antibacterial activity of PLAL synthesized nanocinnamonMaterials and Design, 132, 486–495https://doi.org/10.1016/j.matdes.2017.07.014
Salim, A. A., Ghoshal, S. K., & Bakhtiar, H. (2021). Growth mechanism and optical characteristics of Nd:YAG laser ablated amorphous cinnamon nanoparticles produced in ethanol: Influence of accumulative pulse irradiation time variationPhotonics and Nanostructures - Fundamentals and Applications, 43, 100889https://doi.org/10.1016/j.photonics.2020.100889
Salman, A. S., Al-Shaikh, T. M., Hamza, Z. K., El-Nekeety, A., Bawazir, S. S., Hassan, N. S., & Abdel-Wahhab, M. A. (2021). maltodextrin-cinnamon essential oil nanoformulation as a potent protective against titanium nanoparticles induced oxidative stress, genotoxicity, and reproductive disturbancesEnvironmental Science and Pollution Research, 28, 39035–39051
Sangaonkar, G. M., & Pawar, K. D. (2018). Garcinia indica mediated biogenic synthesis of silver nanoparticles with antibacterial and antioxidant activitiesColloids and Surfaces B: Biointerfaces, 164, 210–217https://doi.org/10.1016/j.colsurfb.2018.01.044
Sangeetha, J., Sandhya, J., & Philip, J. (2014). Biosynthesis and functionalization of silver nanoparticles using Nigella sativa, Dioscorea alata and Ferula asafoetidaScience of Advanced Materials, 6(8), 1681–1690https://doi.org/10.1166/sam.2014.1991
Sani, A. M., Kakhki, A. H., & Moradi, E. (2013). Chemical composition and nutritional value of saffron’s pollen (Crocus sativus L.)Nutrition and Food Science, 43(5), 490–495https://doi.org/10.1108/NFS-04-2012-0040
Sankar, R., Rahman, P. K. S. M., Varunkumar, K., Anusha, C., Kalaiarasi, A., Shivashangari, K. S., & Ravikumar, V. (2017). Facile synthesis of Curcuma longa tuber powder engineered metal nanoparticles for bioimaging applicationsJournal of Molecular Structure, 1129, 8–16https://doi.org/10.1016/j.molstruc.2016.09.054
Santhosh, A., Theertha, V., Prakash, P., & Smitha Chandran, S. (2019). From waste to a value added product: Green synthesis of silver nanoparticles from onion peels together with its diverse applicationsMaterials Today: Proceedings, 46, 4460–4463https://doi.org/10.1016/j.matpr.2020.09.680
Santin, J. R., Lemos, M., Júnior, L. C. K., Niero, R., & de Andrade, S. F. (2010). Antiulcer effects of Achyrocline satureoides (Lam) DC (Asteraceae) (Marcela), a folk medicine plant, in different experimental modelsJournal of Ethnopharmacology, 130(2), 334–339https://doi.org/10.1016/j.jep.2010.05.014
Santin, J. R., Lemos, M., Klein-Júnior, L. C., Machado, I. D., Costa, P., De Oliveira, A. P., Tilia, C., De Souza, J. P., De Sousa, J. P. B., Bastos, J. K., & De Andrade, S. F. (2011). Gastroprotective activity of essential oil of the Syzygium aromaticum and its major component eugenol in different animal modelsNaunyn-Schmiedeberg’s Archives of Pharmacology, 383(2), 149–158https://doi.org/10.1007/s00210-010-0582-x
Santos, A. J., Pina, L. T. S., Galvão, J. G., Trindade, G. G. G., Nunes, R. K. V., Santos, J. S., Santos, C. P., Gonsalves, J. K. M. C., Lira, A. A. M., Cavalcanti, S. C. H., Santos, R. L. C., Sarmento, V. H. V., & Nunes, R. S. (2020). Clay/PVP nanocomposites enriched with Syzygium aromaticum essential oil as a safe formulation against Aedes aegypti larvaeApplied Clay Science, 185, 105394https://doi.org/10.1016/j.clay.2019.105394
DosSantos, S. M., Malpass, G. R. P., Okura, M. H., & Granato, A. C. (2018). Edible active coatings incorporated with cinnamomum cassia and myristica fragrans essential oils to improve shelf-life of minimally processed applesCiencia Rural, 48(12)https://doi.org/10.1590/0103-8478cr20180447
Sanwo, K. A., Adegoke, A. V., Akinola, O. S., Njoku, C. P., Okolo, S. O., Oladipo, N. A., & Oladejo, A. S. (2020). Meat quality characteristics Of improved indigenous chickens (funaab-alpha) fed turmeric (Curcuma longa) or clove (Syzygium aromaticum) as feed additivesJournal of Agricultural Science and Environment, 19(1), 102–112https://doi.org/10.51406/jagse.v19i1.2018
Sanwo, K. A., Adegoke, A. V., Egbeyale, L. T., Abiona, J. A., Sobayo, R. A., Obajuluwa, O. V., & Abdulazeez, A. O. (2020). Meat quality and lipid profile of broiler chickens fed diets containing turmeric (Curcuma Longa) powder and cayenne pepper (Capsicum Frutescens) powder as antioxidantsJournal of Agricultural Science and Environment, 19(1), 73–91https://doi.org/10.51406/jagse.v19i1.2016
Sarac, H. (2021). Bioactive components and biological activities of the cardamom ( Elettaria cardamomum L. ) plantResearch and Reviews in Science and Mathematics, 91
Saranyadevi, S., Suresh, K., Mathiyazhagan, N., Muthusamy, R., & Thirumalaisamy, R. (2021). Silver nanoparticles synthesized using asafoetida resin, characterization of their broad spectrum and larvicidal activityAnnals of the Romanian Society for Cell Biology, 25(4), 15035–15049
Saravanakumar, P., Muthukumar, M., Muthuchudarkodi, R. R., & Ramkumar, P. (2018). Charecterization of undoped cobalt oxide and cerium ion doped cobalt oxide nanoparticlesInternational Journal of Recent Research Aspects, August, 918–923
Saravani, M., Ehsani, A., Aliakbarlu, J., & Ghasempour, Z. (2019). Gouda cheese spoilage prevention: Biodegradable coating induced by Bunium persicum essential oil and lactoperoxidase systemFood Science and Nutrition, 7(3), 959–968https://doi.org/10.1002/fsn3.888
Sardiñas-Valdés, M., Hernández-Becerra, J. A., García, H. S., Chay-Canul, A. J., Velázquez-Martínez, J. R., & Ochoa-Flores, A. A. (2021). Physicochemical and sensory properties of manchego-type cheese fortified with nanoemulsified curcuminInternational Food Research Journal, 28(2), 326–336
Saricaoglu, F. T., & Turhan, S. (2019). Performance of mechanically deboned chicken meat protein coatings containing thyme or clove essential oil for storage quality improvement of beef sucuksMeat Science, 158, 107912https://doi.org/10.1016/j.meatsci.2019.107912
Sarkar, T., Salauddin, M., & Chakraborty, R. (2020). In-depth pharmacological and nutritional properties of bael (Aegle marmelos): A critical reviewJournal of Agriculture and Food Research, 2(October), 100081https://doi.org/10.1016/j.jafr.2020.100081
Sarkar, T., Salauddin, M., Roy, A., Sharma, N., Sharma, A., Yadav, S., Jha, V., Rebezov, M., Khayrullin, M., Thiruvengadam, M., Chung, I. M., Shariati, M. A., & Simal-Gandara, J. (2022). Minor tropical fruits as a potential source of bioactive and functional foodsCritical Reviews in Food Science and Nutritionhttps://doi.org/10.1080/10408398.2022.2033953
Sathiyabama, M., Indhumathi, M., & Amutha, T. (2020). Preparation and characterization of curcumin functionalized copper nanoparticles and their application enhances disease resistance in chickpea against wilt pathogenBiocatalysis and Agricultural Biotechnology, 29, 101823https://doi.org/10.1016/j.bcab.2020.101823
Sattar, A., Abdo, A., Mushtaq, M. N., Anjum, I., & Anjum, A. (2019). Evaluation of gastro-protective activity of myristica fragrans on ethanol-induced ulcer in albino ratsAnais Da Academia Brasileira de Ciencias, 91(2), 1–8https://doi.org/10.1590/0001-3765201920181044
Saygi, K. O., Kacmaz, B., & Gul, S. (2021). Antimicrobial activities of coriander seed essential oil and silver nanoparticlesResearch Squarhttps://doi.org/10.21203/rs.3.rs-526332/v1
Scherer, M. D., Sposito, J. C. V., Falco, W. F., Grisolia, A. B., Andrade, L. H. C., Lima, S. M., Machado, G., Nascimento, V. A., Gonçalves, D. A., Wender, H., Oliveira, S. L., & Caires, A. R. L. (2019). Cytotoxic and genotoxic effects of silver nanoparticles on meristematic cells of Allium cepa roots: A close analysis of particle size dependenceScience of The Total Environment, 660, 459–467https://doi.org/10.1016/j.scitotenv.2018.12.444
Sebai, H., Rtibi, K., Selmi, S., Jridi, M., Balti, R., & Marzouki, L. (2019). Modulating and opposite actions of two aqueous extracts prepared from: Cinnamomum cassia L. bark and Quercus ilex L. on the gastrointestinal tract in ratsRSC Advances, 9(38), 21695–21706https://doi.org/10.1039/c9ra02429h
Selles, S. M. A., Kouidri, M., Belhamiti, B. T., & Ait Amrane, A. (2020). Chemical composition, in-vitro antibacterial and antioxidant activities of Syzygium aromaticum essential oilJournal of Food Measurement and Characterization, 14(4), 2352–2358https://doi.org/10.1007/s11694-020-00482-5
Senaratne, R., & Pathirana, R. (2020)Cinnamon - botany, agronomy, chemistry and industrial applicationshttps://www.springer.com/gp/book/9783030544256
Senthilkumar, N., Aravindhan, V., Ruckmani, K., & Potheher, I. V. (2018). Coriandrum sativum mediated synthesis of silver nanoparticles and evaluation of their biological characteristicsMaterials Research Express, 5(5), 55032https://doi.org/10.1088/2053-1591/aac312
Šeregelj, V., Tumbas Šaponjac, V., Lević, S., Kalušević, A., Ćetković, G., Čanadanović-Brunet, J., Nedović, V., Stajčić, S., Vulić, J., & Vidaković, A. (2019). Application of encapsulated natural bioactive compounds from red pepper waste in yogurtJournal of Microencapsulation, 36(8), 704–714https://doi.org/10.1080/02652048.2019.1668488
Sethumadhavan, S. C., & Pottail, L. (2019). Acorus calamus gold nanoparticles as enhanced anti-microbial agents for transdermal patchesMicro and Nano Letters, 14(4), 367–372https://doi.org/10.1049/mnl.2018.5512
Sg, A., Ah, M., & Av, G. (2012). Review of piperine as a bio-enhancerAmerican Journal of PharmTech Research, 2(February), 32–44
Shad, A. A., Shah, H. U., Bakht, J., Choudhary, M. I., & Ullah, J. (2011). Nutraceutical potential and bioassay of Apium graveolens L. grown in Khyber Pakhtunkhwa-PakistanJournal of Medicinal Plant Research, 5(20), 5160–5166
Shafiee, M., Akbari, M. R., Asadi-Khoshoei, E., Bahadoran, S., & Hassanpour, H. (2020). Growth performance, nutrients digestibility, immune system, and blood parameters in broiler chickens fed on diets supplemented with cumin (Cuminum cyminum) or black cumin (bunium persicum) seed powdersPoultry Science Journal, 8(2), 223–231https://doi.org/10.22069/psj.2020.18155.1601
Shah, Z., Ali, T., & Shafi, S. (2019). Phytopharmacological review of Bunium persicum (Boiss)B. fedtschJournal of Drug Delivery and Therapeutics, 9(2), 458–460https://doi.org/10.22270/jddt.v9i2.2509
Shah, R., Pathan, A., Vaghela, H., Ameta, S. C., & Parmar, K. (2019). Green synthesis and characterization of copper nanoparticles using mixture (Zingiber officinale, Piper nigrum and Piper longum) extract and its antimicrobial activityChemical Science Transactions, 8(1), 63–69https://doi.org/10.7598/cst2019.1517
Shahbandeh, M. (2019). Saffron: leading producers worldwide 2019Statistahttps://www.statista.com/statistics/1135621/leading-saffron-producers-worldwide/
Shahi, Z., Sayyed-Alangi, S. Z., & Najafian, L. (2020). Effects of enzyme type and process time on hydrolysis degree, electrophoresis bands and antioxidant properties of hydrolyzed proteins derived from defatted Bunium persicum Bioss. press cakeHeliyon, 6(2)https://doi.org/10.1016/j.heliyon.2020.e03365
Shahid, S., Chand, N., Khan, R. U., Suhail, S. M., & Khan, N. A. (2015). Alternations in cholesterol and fatty acids composition in egg yolk of Rhode island red x fyoumi hens fed with hemp seeds (Cannabis sativa l.)Journal of Chemistryhttps://doi.org/10.1155/2015/362936
Shahidullah, M., Janarthan, M., & Khan, S. (2017). Evaluation of cardioprotective activity of maceration extract of Elettaria cardamomum in doxorubicin induced cardiotoxicity in ratsIndian Journal of Research in Pharmacy and Biotechnology, 5(6), 366–370www.ijrpb.comjournalhomepage: http://www.ijrpb.com
Shahrajabian, M. H., Sun, W., & Cheng, Q. (2019). Chinese star anise and anise, magic herbs in traditional Chinese medicine and modern pharmaceutical scienceAsian Journal of Medical and Biological Research, 5(3), 162–179https://doi.org/10.3329/ajmbr.v5i3.43584
Shahrajabian, M. H., Sun, W., & Cheng, Q. (2020). Chinese star anise (Illicium verum) and pyrethrum (Chrysanthemum cinerariifolium) as natural alternatives for organic farming and health care-A reviewAustralian Journal of Crop Science, 14(3), 517–523https://doi.org/10.21475/ajcs.20.14.03.p2209
Shahrajabian, M. H., Sun, W., & Cheng, Q. (2021). Survey on chemical constituent, traditional and modern pharmaceutical and health benefits of chinese star anise, a treasure from the EastPharmacognosy Communications, 11(1), 31–35https://doi.org/10.5530/pc.2021.1.7
Shailendiran, D., Pawar, N., Chanchal, A., Pandey, R. P., Bohidar, H. B., & Verma, A. K. (2011). Characterization and antimicrobial activity of nanocurcumin and curcumin2011 International Conference on Nanoscience, Technology and Societal Implications, NSTSI11, February 2021https://doi.org/10.1109/NSTSI.2011.6111984
Shanmugam, J., Dhayalan, M., Savaas Umar, M. R., Gopal, M., AliKhan, M., Simal-Gandara, J., & Cid-Samamed, A. (2022). Green synthesis of silver nanoparticles using Allium cepa var aggregatum natural extract: antibacterial and cytotoxic propertiesNanomaterials, 12(10), 1725https://doi.org/10.3390/nano12101725
Sharada, S. O. V. (2015a). Green synthesis and characterization of silver nanoparticles and evaluation of their antibacterial activity using Elettaria cardamom seedsJournal of Nanomedicine & Nanotechnology, 06(02), 2–5https://doi.org/10.4172/2157-7439.1000266
Sharada, S. O. V. (2015b). Green Synthesis and Characterization of Silver Nanoparticles and Evaluation of their Antibacterial Activity using Elettaria Cardamom SeedsJournal of Nanomedicine & Nanotechnology, 06(02)https://doi.org/10.4172/2157-7439.1000266
Sharafati-Chaleshtori, F., & Sharafati-Chaleshtori, R. (2017)In vitro antibacterial and antioxidant properties of elettaria cardamomum maton extract and its effects, incorporated with chitosan, on storage time of lamb meatVeterinarski Arhiv, 87(3), 301–315https://doi.org/10.24099/vet.arhiv.160117
Sharara, M. S. (2017). Effect of germination and heat treatment on chemical composition and bioactive components of fenugreek seedsWorld Journal of Diary and Food Sciences, 12(1), 33–41https://doi.org/10.5829/idosi.wjdfs.2017.33.41
Sharififar, F., Yassa, N., & Mozaffarian, V. (2010). Bioactivity of major components from the seeds of Bunium persicum (Boiss.) FEDTCHPakistan Journal of Pharmaceutical Sciences, 23(3), 300–304
Sharma, V., Singh, P., Rani, A. (2017). Antimicrobial activity of Trigonella foenum-graecum l. (fenugreek)European Journal of Experimental Biology, 07(01)https://doi.org/10.21767/2248-9215.100004
Sharma, C., Ansari, S., Ansari, M. S., & Satsangee, S. P. (2022). Phyto-mediated synthesis of Pt and Au/Pt bimetallic nanoparticles using Syzygium aromaticum bud-extract: Study of their catalytic, antibacterial, and antioxidant activitiesJournal of Industrial and Engineering Chemistryhttps://doi.org/10.1016/j.jiec.2022.04.031
Sharma, G., Sharma, A. R., Kurian, M., Bhavesh, R., Nam, J. S., & Lee, S. S. (2014). Green synthesis of silver nanoparticle using Myristica fragrans (nutmeg) seed extract and its biological activityDigest Journal of Nanomaterials and Biostructures, 9(1), 325–332
Sharma, M., Inbaraj, B. S., Dikkala, P. K., Sridhar, K., Mude, A. N., & Narsaiah, K. (2022). Preparation of curcumin hydrogel beads for the development of functional kulfi, a tailoring delivery systemFoods, 11(2), 182https://doi.org/10.3390/foods11020182
Sharma, M., Monika, Thakur, P., Saini, R. V., Kumar, R., & Torino, E. (2020). Unveiling antimicrobial and anticancerous behavior of AuNPs and AgNPs moderated by rhizome extracts of Curcuma longa from diverse altitudes of HimalayaScientific Reports, 10(1), 1–11https://doi.org/10.1038/s41598-020-67673-4
Sharma, V., Sharma, R., Gautam, D. N. S., Kuca, K., Nepovimova, E., & Martins, N. (2020). Role of vacha (Acorus calamus Linn.) in neurological and metabolic disorders: Evidence from ethnopharmacology, phytochemistry, pharmacology and clinical studyJournal of Clinical Medicine, 9(4)https://doi.org/10.3390/jcm9041176
Shashanka, R. (2021). Investigation of optical and thermal properties of CuO and ZnO nanoparticles prepared by Crocus Sativus (Saffron) flower extractJournal of the Iranian Chemical Society, 18(2), 415–427https://doi.org/10.1007/s13738-020-02037-3
Sheikh, E., Bhatt, M. L. B., & Tripathi, M. (2018). Bio-based synthesised and characterized monodispersed Curcuma longa silver nanoparticles induces targeted anticancer activity in breast cancer cellsPharmacognosy Magazine, 14(57), S340–S345https://doi.org/10.4103/pm.pm_71_18
Shi, Y., Li, C., Liu, S., Liu, Z., Zhu, J., Yang, J., & Hu, X. (2015). Facile synthesis of fluorescent carbon dots for determination of curcumin based on fluorescence resonance energy transferRSC Advances, 5(79), 64790–64796https://doi.org/10.1039/c5ra13404h
Shirani, G., & Ganesharanee, R. (2009). Extruded products with Fenugreek (Trigonella foenum-graecium) chickpea and rice: Physical properties, sensory acceptability and glycaemic indexJournal of Food Engineering, 90(1), 44–52https://doi.org/10.1016/j.jfoodeng.2008.06.004
Kumar, S., & Alagawadi, K. R. (2010). Influence Of Alpinia galanga rhizomes on cafeteria diet induced obesity in ratsPharmacologyonline, 3, 84–91
Shome, S., Talukdar, A. Das, & Upadhyaya, H. (2021). Antibacterial activity of curcumin and its essential nanoformulations against some clinically important bacterial pathogens: A comprehensive reviewBiotechnology and Applied Biochemistry, August, 1–30https://doi.org/10.1002/bab.2289
Shuaib, M., Ullah, N., Hafeez, A., Alhidary, I. A., Abdelrahman, M. M., & Khan, R. U. (2020). Effect of dietary supplementation of wildCumin (Bunium persicum) seeds on performance, nutrient digestibility and circulating metabolites in broiler chicks during the finisher phaseAnimal Biotechnology, 1–5https://doi.org/10.1080/10495398.2020.1844222
Shukla, R., Rai, N., Singhai, M., & Singhai, A. K. (2018). a magical medicinal fruit of piper nigrumWorld Journal of Pharmaceutical Research, 7(8), 418–425
Shyu, Y. S., Lin, J. T., Chang, Y. T., Chiang, C. J., & Yang, D. J. (2009). Evaluation of antioxidant ability of ethanolic extract from dill (Anethum graveolens L.) flowerFood Chemistry, 115(2), 515–521https://doi.org/10.1016/j.foodchem.2008.12.039
Siani, N. G., & Rostamnejadi, A. (2016). Evaluation of inhibition effect of ZnO nanoparticles concentration regarding seed germination and seedling growth of fenugreek ( Trigonella foenum-graecum L.)Journal of Medicinal Plants and By-Products, 2, 235–243
da Silva, B. M., Vieira, LGdeF., Beltrami, J. M., Serenini, G. D. F., dos Santos, N. S., Soares, A. A., & Alves, G. (2020). Physical-Chemical characterization of fresh shanklish cheese with kefir and turmeric extract (Curcuma longa l.)Arquivos de Ciências Veterinárias e Zoologia Da UNIPAR, 23(2cont), 23–27https://doi.org/10.25110/arqvet.v23i2cont.2020.8265
Singh, P., Bajpai, V., Gond, V., Kumar, A., Tadigoppula, N., Kumar, B. (2020). determination of bioactive compound of fenugreek seeds using lc-ms techniquesLegume Genomics, 377–393
Singh, T. P., Chauhan, G., Mendiratta, S. K., Agarwal, R. K., Arora, S., Verma, A. K., & Rajkumar, V. (2022)In vitro antioxidant and antimicrobial activities of clove extract and its effectiveness in bio-composite film on storage stability of goat meat ballsJournal of Food Science, 87(5), 2083–2095
Singh, A. K. (2017). Spices and condimentsWild Relatives of Cultivated Plants in India, 137–154https://doi.org/10.1007/978-981-10-5116-6_11
Singh, A. K., Prakash, P., Singh, R., Nandy, N., Firdaus, Z., Bansal, M., Singh, R. K., Srivastava, A., Roy, J. K., Mishra, B., & Singh, R. K. (2017). Curcumin quantum dots mediated degradation of bacterial biofilmsFrontiers in Microbiology, 8(AUG)https://doi.org/10.3389/fmicb.2017.01517
Singh, A., Singh, S., & Sharma, R. (2020). Nutritional potentials and nutrient profile of fenugreek (Trigonella foenum-graecum l.): review articleInternational Journal of Current Microbiology and Applied Sciences, 9(10), 3606–3615https://doi.org/10.20546/ijcmas.2020.910.417
Singh, L. M., Chakraborty, B., Pal, R., Nath, A., Pal, S., Rahman, D. S., Ghosh, S. K., & Sengupta, M. (2017). A comparative study on the antioxidant and immunomodulatory properties of curcumin conjugated gold nanospheres and free curcuminJournal of Applied Pharmaceutical Science, 7(11), 56–63https://doi.org/10.7324/JAPS.2017.71108
Singh, P. K., Kumar, S., Bhat, Z. F., & Kumar, P. (2015). Effect of sorghum bicolour and clove oil on the quality characteristics and storage quality of aerobically packaged chevon cutletsNutrition and Food Science, 45(1), 145–163https://doi.org/10.1108/NFS-02-2014-0017
Singh, P., Roy, T. K., Kanupriya, C., Tripathi, P. C., Kumar, P., & Shivashankara, K. S. (2022). Evaluation of bioactive constituents of Garcinia indica (kokum) as a potential source of hydroxycitric acid, anthocyanin, and phenolic compoundsLwt, 156https://doi.org/10.1016/j.lwt.2021.112999
Singh, R., Kumar Sharma, P., & Malviya, R. (2011). Pharmacological properties and ayurvedic value of Indian buch plant (Acorus calamus): A short reviewAdvances in Biological Research, 5(3), 145–154
Sinu, P. A., & Shivanna, K. R. (2007). Pollination biology of large cardamom (Amomum subulatum)Current Science, 93(4), 548–552
Siregar, T. M., Cahyana, A. H., & Gunawan, R. J. (2017). Characteristics and free radical scavenging activity of zinc oxide (ZnO) nanoparticles derived from extract of coriander (Coriandrum sativum L.)Reaktor, 17(3), 145https://doi.org/10.14710/reaktor.17.3.145-151
Siriken, B., Yavuz, C., & Guler, A. (2018). Antibacterial activity of Laurus nobilis: a review of literatureMedical Science and Discovery, 374–379https://doi.org/10.17546/msd.482929
Sivakumar, C., Rajan, A. P., & Kousalya, G. N. (2019). Roots extract mediated green synthesis of copper nano particles using Acorus calamus and its characterizationWorld Journal of Pharmaceutical Research, 8(9), 975–983https://doi.org/10.20959/wjpr20199-15432
Slimestad, R., Fossen, T., & Vågen, I. M. (2007). Onions: A source of unique dietary flavonoidsJournal of Agricultural and Food Chemistry, 55(25), 10067–10080https://doi.org/10.1021/jf0712503
Snehlata, H. S., & Payal, D. R. (2012). Fenugreek (Trigonella foenum-graecum l.): an overview. In Available online on www.ijcpr.com International Journal of Current Pharmaceutical Review and Research (Vol. 2, Issue 4)www.ijcpr.com
Soares, K. S., Souza, M. P., Silva-Filho, E. C., Barud, H. S., Ribeiro, C. A., Santos, D. D., Rocha, K. N. S., de Moura, J. F. P., Oliveira, R. L., & Bezerra, L. R. (2021). Effect of edible onion (Allium cepa L.) film on quality, sensory properties and shelf life of beef burger pattiesMolecules, 26(23), 1–13https://doi.org/10.3390/molecules26237202
Soleimani Far, M., Niyazmand, R., & Shahdi Noghabi, M. (2017). Evaluation and comparison of physicochemical properties, fatty acid, oxidative stability of coriander and dill seeds TT - ارزیابی و مقایسه خصوصیات فیزیکوشیمیایی، ساختار اسید چرب و پایداری اکسایشی روغن بذر گشنیز و شویدMdrsjrns, 14(62), 123–133http://fsct.modares.ac.ir/article-7-8010-en.html
Soliman, M., Qari, S. H., Abu-Elsaoud, A., El-Esawi, M., Alhaithloul, H., & Elkelish, A. (2020). Rapid green synthesis of silver nanoparticles from blue gum augment growth and performance of maize, fenugreek, and onion by modulating plants cellular antioxidant machinery and genes expressionActa Physiologiae Plantarum, 42(9)https://doi.org/10.1007/s11738-020-03131-y
Soltaninezhad, B., Khanzadi, S., Hashemi, M., & Azizzadeh, M. (2020). The Inhibition of Escherichia coli O157:H7 Inoculated in Hamburger Using a Chitosan/Cellulose Nanofiber Film Containing the Nanoemulsion of Trachyspermum ammi and Bunium persicum Essential OilsJournal of Human, Environment, and Health Promotion, 6(1), 30–34https://doi.org/10.29252/jhehp.6.1.6
Soman, M., Ramachandran Nair, P. C., Vinod, V. M., & Kesavamongalam, S. P. (2014). Nutritional and anti nutritional status of Acorus calamus l. rhizomeAnnals: Food Science & Technology, 15(1), 51–59http://search.ebscohost.com/login.aspx?direct=true&db=fsr&AN=101022536&site=ehost-live
Somanawat, K., Thong-Ngam, D., & Klaikeaw, N. (2013). Curcumin attenuated paracetamol overdose induced hepatitisWorld Journal of Gastroenterology, 19(12), 1962–1967https://doi.org/10.3748/wjg.v19.i12.1962
Somani, R. S., & Singhai, A K. (2008). Hypoglycaemic and antidiabetic activities of seeds of Myristica fragrans in normoglycaemic and alloxan-induced diabetic ratsAsian Journal of Experimental Sciences, 22(1), 95–102http://www.ajes.in/PDFs/08-1/11. Hypoglycaemic and Antidiabetic Activity.pdf
Song, J. H., Lim, J. A., & Lee, J. H. (2014). Quality and antioxidant properties of cookies supplemented with cinnamon powderJournal of the Korean Society of Food Science and Nutrition, 43(9), 1457–1461https://doi.org/10.3746/jkfn.2014.43.9.1457
Soshnikova, V., Kim, Y. J., Singh, P., Huo, Y., Markus, J., Ahn, S., Castro-Aceituno, V., Kang, J., Chokkalingam, M., Mathiyalagan, R., & Yang, D. C. (2018). Cardamom fruits as a green resource for facile synthesis of gold and silver nanoparticles and their biological applicationsArtificial Cells, Nanomedicine and Biotechnology, 46(1), 108–117https://doi.org/10.1080/21691401.2017.1296849
Sotomayor-Gerding, D., Oomah, B. D., Acevedo, F., Morales, E., Bustamante, M., Shene, C., & Rubilar, M. (2016). High carotenoid bioaccessibility through linseed oil nanoemulsions with enhanced physical and oxidative stabilityFood Chemistry, 199, 463–470https://doi.org/10.1016/j.foodchem.2015.12.004
Sowbhagya, H. B., Mahadevamma, S., Indrani, D., & Srinivas, P. (2011). Physicochemical and microstructural characteristics of celery seed spent residue and influence of its addition on quality of biscuitsJournal of Texture Studies, 42(5), 369–376https://doi.org/10.1111/j.1745-4603.2011.00294.x
Sowmiya Rajalakshmi, B., Ancy Jenifer, A., Ahila, K. G., Vasanthy, M., & Thamaraiselvi, C. (2019). Effective removal of TDS and COD from sugar effluent using green synthesized magnetic iron nanoparticle with Trigonella foenum-graecum seed mucilageWaste Management and Resource Efficiency, 961–973https://doi.org/10.1007/978-981-10-7290-1_80
Sp, K., Pv, P., At, S., & Ambhore, S. (2020). Studies on process standardization and sensory properties of buffalo milk paneer blended with raw turmeric extract ( Curcuma longa L. )The Pharma Innovation Journal, 9(11), 34–40
Speroni, E., Cervellati, R., Dall’Acqua, S., Guerra, M. C., Greco, E., Govoni, P., & Innocenti, G. (2011). Gastroprotective effect and antioxidant properties of different laurus nobilis L. Leaf extractsJournal of Medicinal Food, 14(5), 499–504https://doi.org/10.1089/jmf.2010.0084
Sreelakshmi, C., Goel, N., Datta, K. K. R., Addlagatta, A., Ummanni, R., & Reddy, B. V. S. (2013). Green synthesis of curcumin capped gold nanoparticles and evaluation of their cytotoxicityNanoscience and Nanotechnology Letters, 5(12), 1258–1265https://doi.org/10.1166/nnl.2013.1678
Chatterjee, S., & Nandini Goswami, P. B. (2012). Estimation of phenolic components and in vitro antioxidant activity of fennel (Foeniculum vulgare) and ajwain (Trachyspermum ammi) seedsAdvances in Bioresearch, 3(June), 109–118
Srinivasan, K. (2006). Fenugreek (Trigonella foenum-graecum): A review of health beneficial physiological effectsFood Reviews International, 22(2), 203–224https://doi.org/10.1080/87559120600586315
Srivastava, D., Rajiv, J. M., Naidu, M. M., Puranaik, J., & Srinivas, P. (2012). Effect of fenugreek seed husk on the rheology and quality characteristics of muffinsFood and Nutrition Sciences, 03(11), 1473–1479https://doi.org/10.4236/fns.2012.311191
Stati, G., Rossi, F., Trakoolwilaiwan, T., Tung, L. D., Mourdikoudis, S., Thanh, N. T. K., & Di Pietro, R. (2022). Development and characterization of curcumin-silver nanoparticles as a promising formulation to test on human pterygium-derived keratinocytesMolecules, 27(1), 1–11https://doi.org/10.3390/molecules27010282
Statistica. (2020)Main countries for opium poppy cultivation based on acreage in 2019https://www.statista.com/statistics/264744/top-countries-for-oppium-cultivation-based-on-acreage/
Staughton, J. (2021). 7 impressive benefits of allspiceOrganic Facts
Suárez, A., Ulate, G., & Ciccio, J. F. (1997). Cardiovascular effects of ethanolic and aqueous extracts of Pimenta dioica in Sprague-Dawley ratsJournal of Ethnopharmacology, 55(2), 107–111https://doi.org/10.1016/S0378-8741(96)01485-7
Subbaiah, K. P. V., Ramanjaneyulu, G., & Savithramma, N. (2013). Synthesis of silver nanoparticles and validation from rhizome powder of Curcuma longa L. – an ethnobotanical plant for skin diseaseIndian Streams Research Journal, 3(May), 1–7
Subham, K., Kaur, J., Chakroborty, M., Manuel, S. G. A., & Pradeep, N. (2020). Green synthesis of zinc oxide nanoparticles using the extracts of Calotropis gigantea, Foeniculum vulgare and Murraya koenigii and their antimicrobial propertiesJournal of Advanced Scientific Research, 11(3), 183–188https://ezproxy.lib.swin.edu.au/login?url=http://search.ebscohost.com/login.aspx?direct=true&db=a9h&AN=145639198&site=ehost-live&scope=site
Subhapriya, S., & Gomathipriya, P. (2018). Green synthesis of titanium dioxide (TiO2) nanoparticles by Trigonella foenum-graecum extract and its antimicrobial propertiesMicrobial Pathogenesis, 116, 215–220https://doi.org/10.1016/j.micpath.2018.01.027
Suleria, H. A. R., Butt, M. S., Anjum, F. M., Saeed, F., & Khalid, N. (2015). Onion: Nature protection against physiological threatsCritical Reviews in Food Science and Nutrition, 55(1), 50–66https://doi.org/10.1080/10408398.2011.646364
Sulieman, A. M. E., Ali, A. O., & Hemavathy, J. (2008). Lipid content and fatty acid composition of fenugreek (Trigonellafoenum- graecum L.) seeds grown in SudanInternational Journal of Food Science and Technology, 43(2), 380–382https://doi.org/10.1111/j.1365-2621.2006.01446.x
Suliman, G. M., Alowaimer, A. N., Al-Mufarrej, S. I., Hussein, E. O. S., Fazea, E. H., Naiel, M. A. E., Alhotan, R. A., & Swelum, A. A. (2021). The effects of clove seed (Syzygium aromaticum) dietary administration on carcass characteristics, meat quality, and sensory attributes of broiler chickensPoultry Science, 100(3), 100904https://doi.org/10.1016/j.psj.2020.12.009
Sun, Z., Xiong, T., Zhang, T., Wang, N., Chen, D., & Li, S. (2019). Influences of zinc oxide nanoparticles on Allium cepa root cells and the primary cause of phytotoxicityEcotoxicology, 28(2), 175–188https://doi.org/10.1007/s10646-018-2010-9
Susanah, R. W., Retno, K., & Made Dira, S. I. (2018). Total phenolic and flavonoid contents and antimicrobial activity of acorus calamus L Rhizome ethanol extractResearch Journal of Chemistry and Environment, 22(Special issue II), 65–70
Swamibhut. (2017). allspice/pimenta dioicaNturalherbssite
Swamy, M. K., Akhtar, M. S., & Sinniah, U. R. (2016). Antimicrobial properties of plant essential oils against human pathogens and their mode of action: An updated reviewEvidence-Based Complementary and Alternative Medicine, 2016https://doi.org/10.1155/2016/3012462
Swapna, T. S., Binitha, M., & Manju, T. S. (2004)In vitro multiplication in Kaempferia galanga LinnApplied Biochemistry and Biotechnology - Part A Enzyme Engineering and Biotechnology, 118(1–3), 233–241https://doi.org/10.1385/ABAB:118:1-3:233
Syed, B., Bhat, P. S., Bisht, N., Karthik, R. N., Farangis-Rakhimova, D., Devi, A. T., Prasad, A., Satish, S., Nanjundaswamy, S., & Nagendra Prasad, M. N. (2018). Phytobiological mediated production of silver nanoparticles from Garcinia indica and their bactericidal potentialJournal of Biologically Active Products from Nature, 8(3), 154–161https://doi.org/10.1080/22311866.2018.1486227
Taami, B., Rostami Zadeh, K., Aminzare, M., & Hassanzad Azar, H. (2021). Antioxidant efficacy of biodegradable starch film containing of bunium persicum essential oil nanoemulsion fortified with cinnamaldehydeSSRN Electronic Journalhttps://doi.org/10.2139/ssrn.3972558
Tahir, H. U., Sarfraz, R. A., Ashraf, A., & Adil, S. (2016). Chemical composition and antidiabetic activity of essential oils obtained from two spices (Syzygium aromaticum and Cuminum cyminum)International Journal of Food Properties 19, (10), 2156–2164https://doi.org/10.1080/10942912.2015.1110166
Tajik, H., Farhangfar, A., Moradi, M., & Razavi Rohani, S. M. (2014). Effectiveness of clove essential oil and grape seed extract combination on microbial and lipid oxidation characteristics of raw buffalo patty during storage at abuse refrigeration temperatureJournal of Food Processing and Preservation, 38(1), 31–38https://doi.org/10.1111/j.1745-4549.2012.00736.x
Tajkarimi, M. M., Ibrahim, S. A., & Cliver, D. O. (2010). Antimicrobial herb and spice compounds in foodFood Control, 21(9), 1199–1218https://doi.org/10.1016/j.foodcont.2010.02.003
Takooree, H., Aumeeruddy, M. Z., Rengasamy, K. R., Venugopala, K. N., Jeewon, R., Zengin, G., & Mahomoodally, M. F. (2019). a systematic review on black pepper (piper nigrum L) from folk uses to pharmacological applicationsCritical Reviews in Food Science and Nutrition, 59, S210–S243
Talebi, F., Misaghi, A., Khanjari, A., Kamkar, A., Gandomi, H., & Rezaeigolestani, M. (2018). Incorporation of spice essential oils into poly-lactic acid film matrix with the aim of extending microbiological and sensorial shelf life of ground beefLWT, 96, 482–490https://doi.org/10.1016/j.lwt.2018.05.067
Talebi, F., MIsaghi, A., Khanjari, A., Kamkar, A., Gandomi, H., & Saeedi, M. (2017). Evaluation of antimicrobial activity of Poly Lactic Acid (PLA) films containing cellulose nanoparticle and Bunium persicum and Mentha pepperita essential oils (EOs)Iranian Journal of Veterinary Medicine, 11(4), 289–298https://doi.org/10.22059/ijvm.2017.223435.1004783
Talodthaisong, C., Plaeyao, K., Mongseetong, C., Boonta, W., Srichaiyapol, O., Patramanon, R., Kayunkid, N., & Kulchat, S. (2021). The decoration of ZnO nanoparticles by gamma aminobutyric acid, curcumin derivative and silver nanoparticles: Synthesis, characterization and antibacterial evaluationNanomaterials, 11(2), 1–19https://doi.org/10.3390/nano11020442
Tamilarasi, R., Sivanesan, D., Kanimozhi, P., & College, S. T. E. T. W. (2012). Hepatoprotective and antioxidant efficacy of Anethum graveolens linn in carbon tetrachloride induced hepatotoxicity in albino ratsJournal of Chemical and Pharmaceutical Research, 4(4), 1885–1888
Tamiru Kasaye, A. (2015). Evaluation of composite blends of fermented fenugreek and wheat flour to assess its suitability for bread and biscuitInternational Journal of Nutrition and Food Sciences, 4(1), 29https://doi.org/10.11648/j.ijnfs.20150401.15
Tang, X., Yu, H., Bui, B., Wang, L., Xing, C., Wang, S., Chen, M., Hu, Z., & Chen, W. (2021). Nitrogen-doped fluorescence carbon dots as multi-mechanism detection for iodide and curcumin in biological and food samplesBioactive Materials, 6(6), 1541–1554https://doi.org/10.1016/j.bioactmat.2020.11.006
Tanko, Y., Mohammed, A., Okasha, M. A., Umar, A. H., & Magaji, R. A. (2008). Anti-nociceptive and anti-inflammatory activities of ethanol extract of Syzygium aromaticum flower bud in Wistar rats and miceAfrican Journal of Traditional, Complementary and Alternative Medicines, 5(2), 209–212https://doi.org/10.4314/ajtcam.v5i2.31275
Tanruean, K., Kaewnarin, K., & Rakariyatham, N. (2014). Antibacterial and antioxidant activities of Anethum graveolens L. dried fruit extractsChiang Mai Journal of Science, 41(3), 649–660
Tasleem, F., Azhar, I., Ali, S. N., Perveen, S., & Mahmood, Z. A. (2014). Analgesic and anti-inflammatory activities of Piper nigrum LAsian Pacific Journal of Tropical Medicine, 7(S1), S461–S468https://doi.org/10.1016/S1995-7645(14)60275-3
Tavakoli, F., Rafieiolhossaini, M., & Ravash, R. (2021). Effects of PEG and nano-silica elicitors on secondary metabolites production in Crocus sativus LRussian Journal of Plant Physiology, 68(5), 931–940https://doi.org/10.1134/S1021443721050216
Tawfek, M. A. E. M., & Ali, A. R. M. (2022). Effectiveness of cardamom or bay leaf powder in improving the quality of labnehACTA, 21(1), 39–52
Tekeli, A., Kop-Bozbay, C., Atan, H., Karamik, S. (2020). Nutritional values of cold pres poppy ( Papaver somniferum L. ) and sesame ( Sesamum indicum L. ) meal as alternative protein sourceInternational Agriculture Congress, January
Tenne, P. C. R. K., & Karunaratne, M. M. S. C. (2018a). Phytochemical profile and bioactivity of essential oil from Pimenta dioica leaves on Cowpea beetle, Callosobruchus maculatus (f.) (coleoptera: bruchidae): a farmer friendly solution for postharvest pest managementOpen Agriculture, 3(1), 301–309https://doi.org/10.1515/opag-2018-0033
Tenne, P. C. R. K., & Karunaratne, M. M. S. C. (2018b). Phytochemical profile and bioactivity of essential oil from Pimenta dioica leaves on Cowpea beetle, Callosobruchus maculatus (F) (Coleoptera: Bruchidae): a farmer friendly solution for postharvest pest managementOpen Agriculture, 3(1), 301–309https://doi.org/10.1515/opag-2018-0033
Teshika, J. D., Zakariyyah, A. M., Zaynab, T., Zengin, G., Rengasamy, K. R., Pandian, S. K., & Fawzi, M. M. (2019). Traditional and modern uses of onion bulb (Allium cepa L.): A systematic reviewCritical Reviews in Food Science and Nutrition, 59, S39–S70https://doi.org/10.1080/10408398.2018.1499074
Tétényi, P. (2010). Opium poppy ( Papaver somniferum ): Botany and horticultureHorticultural Reviews, 373–408https://doi.org/10.1002/9780470650622.ch7
Thadakapally, R., Aafreen, A., Aukunuru, J., Habibuddin, M., & Jogala, S. (2016). Preparation and characterization of PEG-albumin-curcumin nanoparticles intended to treat breast cancerIndian Journal of Pharmaceutical Sciences, 78(1), 65–72https://doi.org/10.4103/0250-474X.180250
Thakur, A., Sharma, N., Bhatti, M., Sharma, M., Trukhanov, A. V., Trukhanov, S. V., Panina, L. V., Astapovich, K. A., & Thakur, P. (2020). Synthesis of barium ferrite nanoparticles using rhizome extract of Acorus Calamus: Characterization and its efficacy against different plant phytopathogenic fungiNano-Structures and Nano-Objects, 24, 100599https://doi.org/10.1016/j.nanoso.2020.100599
Thanh, V, N, T. (2014). Synthesis and evaluation of gold nanoparticle conjugated with curcuminBachelor Thesis - Biotechnology & Related Fields
Tharachand, C., Immanuel Selvaraj, C., & Abraham, Z. (2015). Comparative evaluation of anthelmintic and antibacterial activities in leaves and fruits of Garcinia cambogia (gaertn.) desr. and Garcinia indica (dupetit-thouars) choisyBrazilian Archives of Biology and Technology, 58(3), 379–386https://doi.org/10.1590/S1516-8913201500062
Tharun, G., Ramana, G., Sandhya, R., & Shravani, M. (2017a). Phytochemical and pharmacological review on Laurus nobilisJournal of Pharmacy Research, 11(3), 249–256http://jprsolutions.info
Tharun, G., Ramana, G., Sandhya, R., & Shravani, M. (2017b). Phytochemical and Pharmacological Review on Laurus NobilisJournal of Pharmacy Research, 11(3), 249–256http://jprsolutions.info
Thomas, R. A., & Krishnakumari, S. (2015). Phytochemical profiling of Myristica fragrans seed extract with different organic solventsAsian Journal of Pharmaceutical and Clinical Research, 8(1), 303–307
Thong-Ngam, D., Choochuai, S., Patumraj, S., Chayanupatkul, M., & Klaikeaw, N. (2012). Curcumin prevents indomethacin-induced gastropathy in ratsWorld Journal of Gastroenterology, 18(13), 1479–1484https://doi.org/10.3748/wjg.v18.i13.1479
Thummaneni, C., Surya Prakash, D. V, Golli, R., & Vangalapati, M. (2022). Green synthesis of silver nanoparticles and characterization of caffeic acid from Myristica fragrans (Nutmeg) against antibacterial activityMaterials Today: Proceedingshttps://doi.org/10.1016/j.matpr.2022.04.586
Tinca, A. L., Iurian, S., Rus, L. M., Porfire, A., & Tefas, L. R. (2020). Development and characterization of curcumin-loaded polycaprolactone nanoparticles by Design of ExperimentsRomanian Journal of Pharmaceutical Practice, 13(3), 127–138https://doi.org/10.37897/rjphp.2020.3.3
Tiyagi, S. A., Mahmood, I., & Rizvi, R. (2010). application of organic additives for the management of plant parasitic nematodes and soil pathogenic fungi on fenugreek and mungbeanJournal of Medicinal and Aromatic Plant Sciences, 32(4), 420–431
Tizghadam, P., Roufegari-nejad, L., Asefi, N., & Jafarian Asl, P. (2021). Physicochemical characteristics and antioxidant capacity of set yogurt fortified with dill (Anethume graveolens) extractJournal of Food Measurement and Characterization, 15(4), 3088–3095https://doi.org/10.1007/s11694-021-00881-2
Tomar, R. S., & Shrivastava, V. (2014). Efficacy evaluation of ethanolic extract of Brassica nigra as potential anitmicrobial agent against selcted microorganismsInternational Journal of Pahramaceutical Acience and Health Care., 3(4), 117–123
Tometri, S. S., Ahmady, M., Ariaii, P., & Soltani, M. S. (2020). Extraction and encapsulation of Laurus nobilis leaf extract with nano-liposome and its effect on oxidative, microbial, bacterial and sensory properties of minced beefJournal of Food Measurement and Characterization, 14(6), 3333–3344https://doi.org/10.1007/s11694-020-00578-y
Tosati, J. V., de Oliveira, E. F., Oliveira, J. V., Nitin, N., & Monteiro, A. R. (2018). Light-activated antimicrobial activity of turmeric residue edible coatings against cross-contamination of Listeria innocua on sausagesFood Control, 84, 177–185https://doi.org/10.1016/j.foodcont.2017.07.026
Toshima, N., & Yonezawa, T. (1998). Bimetallic nanoparticles - novel materials for chemical and physical applicationsNew Journal of Chemistry, 22(11), 1179–1201https://doi.org/10.1039/a805753b
Trung, D., Nhuan, T., Van, T. C., Minh, V., & Anh, P. (2020). Biofabrication of silver nanoparticles using Curcuma longa extract : Effects of extraction and synthesis conditions, characteristics, and its antibacterial activityJ Biochem Tech, 11(1), 57–66
Tungmunnithum, D., Tanaka, N., Uehara, A., & Iwashina, T. (2020). Flavonoids profile, taxonomic data, history of cosmetic uses, anti-oxidant and anti-aging potential of alpinia galanga (L.) willdCosmetics, 7(4), 1–8https://doi.org/10.3390/cosmetics7040089
Umaraw, P., Chauhan, G., Mendiratta, S. K., Verma, A. K., & Arya, A. (2020). Effect of oregano and bay as natural preservatives in meat bread for extension of storage stability at ambient temperatureJournal of Food Processing and Preservation, 44(4)https://doi.org/10.1111/jfpp.14375
Upadhyay, P. K., Singh, S., Agrawal, G., & Vishwakarma, V. K. (2017). Pharmacological activities and therapeutic uses of resins obtained from Ferula asafoetida Linn.: A ReviewInternational Journal of Green Pharmacy, 11(2), S240–S247
Upadhyay, R. K. (2016). Nutraceutical, pharmaceutical and therapeutic uses of Allium cepa: A reviewInternational Journal of Green Pharmacy, 10(1), S46–S64
USDA. (2019a). spices, anise seedFood Data Central
USDA. (2019b). spices, caraway seedFood Data Central
USDA. (2019c). spices, cloves, groundFood Data Central
USDA. (2019d). spices, turmeric, groundFood Data Central
USDA. (2019e)Spices , caraway seed02005
Utami, R., Khasanah, L. U., Manuhara, G. J., & Ayuningrum, Z. K. (2019). Effects of cinnamon bark essential oil (cinnamomum burmannii) on characteristics of edible film and quality of fresh beefPertanika Journal of Tropical Agricultural Science, 42(4), 1173–1184
Vakayil, R., Muruganantham, S., Kabeerdass, N., Rajendran, M., Mahadeo Palve, A., Ramasamy, S., Awad Alahmadi, T. S., Almoallim, H., Manikandan, V., & Mathanmohun, M. (2021). Acorus calamus-zinc oxide nanoparticle coated cotton fabrics shows antimicrobial and cytotoxic activities against skin cancer cellsProcess Biochemistry, 111(P1), 1–8https://doi.org/10.1016/j.procbio.2021.08.024
Vakili, S., Savardashtaki, A., Moghaddam, M. A. M., Nowrouzi, P., Shirazi, M. K., & Ebrahimi, G. (2017). The effects of saffron consumption on lipid profile, liver enzymes, and oxidative stress in male hamsters with high fat dietTrends in Pharmaceutical Sciences, 3(3), 201–208
Valdés, A., Mellinas, A. C., Ramos, M., Burgos, N., Jiménez, A., & Garrigós, M. C. (2015). Use of herbs, spices and their bioactive compounds in active food packagingRSC Advances, 5(50), 40324–40335https://doi.org/10.1039/c4ra17286h
Valsaraj, R., Pushpangadan, P., Smitt, U. W., Adsersen, A., & Nyman, U. (1997). Antimicrobial screening of selected medicinal plants from IndiaJournal of Ethnopharmacology, 58(2), 75–83https://doi.org/10.1016/S0378-8741(97)00085-8
Vardavas, C. I., Majchrzak, D., Wagner, K. H., Elmadfa, I., & Kafatos, A. (2006). Lipid concentrations of wild edible greens in CreteFood Chemistry, 99(4), 822–834https://doi.org/10.1016/j.foodchem.2005.08.058
Varghese, B., Kurian, M., Krishna, S., & Athira, T. S. (2020). Biochemical synthesis of copper nanoparticles using Zingiber officinalis and Curcuma longa: Characterization and antibacterial activity studyMaterials Today: Proceedings, 25, 302–306https://doi.org/10.1016/j.matpr.2020.01.476
Varuna, K. J. B., & Madhusudhan, B. (2015). Synthesis, characterization and hemocompatibility evaluation of curcumin encapsulated chitosan nanoparticles for oral deliveryInternational Journal of Advanced Research, 3(4), 604–611
Vasavda, K., Hegde, P., & Harini, A. (2013). Pharmacological activities of turmeric: A reviewJournal of Traditional Medicinal and Clinical Nuropathy, 2, 133
Vecchio, M. G., Gulati, A., Minto, C., & Lorenzoni, G. (2016). Pimpinella anisum and Illicium verum: The multifaceted role of anise plantsThe Open Agriculture Journal, 10(1), 81–86https://doi.org/10.2174/1874331501610010084
Venkatadri, B., Shanparvish, E., Rameshkumar, M. R., Arasu, M. V., Al-Dhabi, N. A., Ponnusamy, V. K., & Agastian, P. (2020). Green synthesis of silver nanoparticles using aqueous rhizome extract of Zingiber officinale and Curcuma longa: In-vitro anti-cancer potential on human colon carcinoma HT-29 cellsSaudi Journal of Biological Sciences, 27(11), 2980–2986https://doi.org/10.1016/j.sjbs.2020.09.021
Venugopal, K., Rather, H. A., Rajagopal, K., Shanthi, M. P., Sheriff, K., Illiyas, M., Rather, R. A., Manikandan, E., Uvarajan, S., Bhaskar, M., & Maaza, M. (2017). Synthesis of silver nanoparticles (Ag NPs) for anticancer activities (MCF 7 breast and A549 lung cell lines) of the crude extract of Syzygium aromaticumJournal of Photochemistry and Photobiology B: Biology, 167, 282–289https://doi.org/10.1016/j.jphotobiol.2016.12.013
Verma, R. K., Mishra, G., Singh, P., Jha, K. K., & Khosa, R. L. (2011). Alpinia galanga – an important medicinal plant : A reviewDer Pharmacia Sinica, 2(1), 142–154
Vidanagamage, S. A., Pathiraje, P. M. H. D., & Perera, O. D. A. N. (2016). Effects of Cinnamon (Cinnamomum Verum) Extract on Functional Properties of ButterProcedia Food Science, 6(Icsusl 2015), 136–142https://doi.org/10.1016/j.profoo.2016.02.033
Vigyan Kendra, K., Preeti Kumari, I., Kumar Maurya Scholar, R., Kumar, V., Kumar Verma, R., Kumari, P., Kumar Maurya, R., Verma, R., & Kumar Singh, R. (2018). Medicinal properties of turmeric (Curcuma longa L.): A review. ~ 1354 ~International Journal of Chemical Studies, 6(4), 1354–1357
Vijayakumar, S., Vaseeharan, B., Malaikozhundan, B., & Shobiya, M. (2016). Laurus nobilis leaf extract mediated green synthesis of ZnO nanoparticles: Characterization and biomedical applicationsBiomedicine & Pharmacotherapy, 84, 1213–1222https://doi.org/10.1016/j.biopha.2016.10.038
Vijayasteltar, L., Jismy, I. J., Joseph, A., Maliakel, B., Kuttan, R., & Krishnakumar, I. M. (2017). Beyond the flavor: A green formulation of Ferula asafoetida oleo-gum-resin with fenugreek dietary fibre and its gut health potentialToxicology Reports, 4(June), 382–390https://doi.org/10.1016/j.toxrep.2017.06.012
Vilela, J., Martins, D., Monteiro-Silva, F., González-Aguilar, G., de Almeida, J. M. M. M., & Saraiva, C. (2016). Antimicrobial effect of essential oils of Laurus nobilis L. and Rosmarinus officinallis L. on shelf-life of minced “Maronesa” beef stored under different packaging conditionsFood Packaging and Shelf Life, 8, 71–80https://doi.org/10.1016/j.fpsl.2016.04.002
Vinod, K., & Aditi, S. (2019). Synthesis, characterization, antimicrobial activity and release study of cinnamon loaded poly nanoparticlesResearch Journal of Pharmacy and Technology, 12(4), 1529–1535
Vinotha, V., Yazhiniprabha, M., Raj, D. S., Mahboob, S., Al-Ghanim, K. A., Al-Misned, F., Govindarajan, M., & Vaseeharan, B. (2020). Biogenic synthesis of aromatic cardamom-wrapped zinc oxide nanoparticles and their potential antibacterial and mosquito larvicidal activity: An effective eco-friendly approachJournal of Environmental Chemical Engineering, 8(6), 104466https://doi.org/10.1016/j.jece.2020.104466
Vinothini, P., & Suthacini, V. (2021). Cardamom crop production and harvesting: A reviewShanlax International Journal of Economics, 9(3), 31–37
Virk, P. (2018). Antidiabetic activity of green gold-silver nanocomposite with trigonella foenum graecum L. seeds extract on streptozotocin- induced diabetic ratsPakistan Journal of Zoology, 50(2), 711–718https://doi.org/10.17582/JOURNAL.PJZ/2018.2.711.718
Vispute, M. M., Sharma, D., Biswas, A. K., Rokade, J. J., Chaple, A. R., Biswas, A., Gopi, M., & Kapgate, M. G. (2021). Dietary hemp ( Cannabis sativa l.) and dill seed ( Anethum graveolens ) improve physicochemical properties, oxidative stability, and sensory attributes of broiler meatACS Food Science & Technology, 1(3), 453–461https://doi.org/10.1021/acsfoodscitech.0c00049
Vohra, S. B., Shah, S. A., Sharma, K., Naqvi, S. A. H., & Dandiya, P. C. (1989). Antibacterial, antipyretic, analgesic and anti-inflammatory studies on Acorus calamus LinnAnnals of National Academy of Medical Sciences, 25, 13–20
Vutakuri, N., & Somara, S. (2018). Natural and herbal medicine for breast cancer using Elettaria cardamomum (L.) MatonInternational Journal of Herbal Medicine, 6(2), 91–96
Waghmare, R. D., Gunjal, D. B., Naik, V. M., Gore, A. H., Nimbalkar, M. S., Anbhule, P. V., Bhosale, S. V., Sohn, D., & Kolekar, G. B. (2021). Carbon nanodots derived from kitchen waste biomass as a growth accelerator for fenugreek plantJournal of Nanoscience and Nanotechnology, 21(4), 2234–2245https://doi.org/10.1166/jnn.2021.19028
Wagner, K.-H., & Elmadfa, I. (2003). Biological relevance of terpenoidsAnnals of Nutrition and Metabolism, 47(3–4), 95–106https://doi.org/10.1159/000070030
Wang, D., Zhang, L., Huang, J., Himabindu, K., Tewari, D., Horbanczuk, J. O., Xu, S., Chen, Z., Atanasov, A. G. (2021). Cardiovascular protective effect of black pepper (Piper nigrum L.) and its major bioactive constituent piperineTrends in Food Science and Technology, 117, 34–45https://inpst.net/cardiovascular-protective-effect-of-black-pepper-piper-nigrum-l-and-its-major-bioactive-constituent-piperine/
Wang, G. W., Hu, W. T., Huang, B. K., & Qin, L. P. (2011). Illicium verum: A review on its botany, traditional use, chemistry and pharmacologyJournal of Ethnopharmacology, 136(1), 10–20https://doi.org/10.1016/j.jep.2011.04.051
Wang, N., Xu, Y., Chao, H., Zhang, M., Zhou, Y., & Wang, M. (2020). Effects of celery powder on wheat dough properties and textural, antioxidant and starch digestibility properties of breadJournal of Food Science and Technology, 57(5), 1710–1718https://doi.org/10.1007/s13197-019-04204-8
Wang, Y. H., Avula, B., Nanayakkara, N. P. D., Zhao, J., & Khan, I. A. (2013). Cassia cinnamon as a source of coumarin in cinnamon-flavored food and food SUPPL.ements in the United StatesJournal of Agricultural and Food Chemistry, 61(18), 4470–4476https://doi.org/10.1021/jf4005862
Wang, Y., Han, T., Zhu, Y., Zheng, C. J., Ming, Q. L., Rahman, K., & Qin, L. P. (2010). Antidepressant properties of bioactive fractions from the extract of crocus sativus LJournal of Natural Medicines, 64(1), 24–30https://doi.org/10.1007/s11418-009-0360-6
Wani, S. A., & Kumar, P. (2016). Development and parameter optimization of health promising extrudate based on fenugreek oat and peaFood Bioscience, 14, 34–40https://doi.org/10.1016/j.fbio.2016.02.002
Wani, S., Solanke, N., & Kumar, P. (2015). Extruded product based on oat and fenugreek and their storage stabilityCurrent Nutrition & Food Science, 11(1), 78–84https://doi.org/10.2174/1573401311666150304235616
Wójcik, M., Różyło, R., Schönlechner, R., Matwijczuk, A., & Dziki, D. (2022). Low-Carbohydrate, High-Protein, and Gluten-Free Bread Supplemented with Poppy Seed Flour: Physicochemical, Sensory, and Spectroscopic PropertiesMolecules, 27(5)https://doi.org/10.3390/molecules27051574
Wu, F., Chen, Y., Li, G., Zhu, D., Wang, L., & Wang, J. (2019). Zinc oxide nanoparticles synthesized from Allium cepa prevents UVB radiation mediated inflammation in human epidermal keratinocytes (HaCaT cells)Artificial Cells, Nanomedicine and Biotechnology, 47(1), 3548–3558https://doi.org/10.1080/21691401.2019.1642905
Yadav, V. R., Suresh, S., Devi, K., & Yadav, S. (2009). Effect of cyclodextrin complexation of curcumin on its solubility and antiangiogenic and anti-inflammatory activity in rat colitis modelAAPS PharmSciTech, 10(3), 752–762https://doi.org/10.1208/s12249-009-9264-8
Yadav, A., Kujur, A., Kumar, A., Singh, P. P., Gupta, V., & Prakash, B. (2020). Encapsulation of Bunium persicum essential oil using chitosan nanopolymer: Preparation, characterization, antifungal assessment, and thermal stabilityInternational Journal of Biological Macromolecules, 142, 172–180https://doi.org/10.1016/j.ijbiomac.2019.09.089
Yadav, U. C. S., & Baquer, N. Z. (2014). Pharmacological effects of Trigonella foenum-graecum L. in health and diseasePharmaceutical Biology, 52(2), 243–254https://doi.org/10.3109/13880209.2013.826247
Yahyazadeh, R., Rahbardar, M. G., Razavi, B. M., Karimi, G., & Hosseinzadeh, H. (2021). The effect of elettaria cardamomum (cardamom) on the metabolic syndrome: narrative reviewIranian Journal of Basic Medical Sciences, 24(11), 1462–1469https://doi.org/10.22038/IJBMS.2021.54417.12228
Yang, C. H., Li, R. X., & Chuang, L. Y. (2012). Antioxidant activity of various parts of Cinnamomum cassia extracted with different extraction methodsMolecules, 17(6), 7294–7304https://doi.org/10.3390/molecules17067294
Yang, J. F., Yang, C. H., Chang, H. W., Yang, C. S., Wang, S. M., Hsieh, M. C., & Chuang, L. Y. (2010). Chemical composition and antibacterial activities of Illicium verum against antibiotic-resistant pathogensJournal of Medicinal Food, 13(5), 1254–1262https://doi.org/10.1089/jmf.2010.1086
Yang, M., Lu, F., Zhou, T., Zhao, J., Ding, C., Fakhri, A., & Gupta, V. K. (2020). Biosynthesis of nano bimetallic Ag/Pt alloy from Crocus sativus L. extract: Biological efficacy and catalytic activityJournal of Photochemistry and Photobiology B: Biology, 212, 112025https://doi.org/10.1016/j.jphotobiol.2020.112025
Yang, X. X., Li, C. M., & Huang, C. Z. (2016). Curcumin modified silver nanoparticles for highly efficient inhibition of respiratory syncytial virus infectionNanoscale, 8(5), 3040–3048https://doi.org/10.1039/c5nr07918g
Yazdanparast, R., & Bahramikia, S. (2008). Evaluation of the effect of Anethum graveolens L. crude extracts on serum lipids and lipoproteins profiles in hypercholesterolaemic ratsDaru, 16(2), 88–94
Yekeen, T. A., Azeez, M. A., Lateef, A., Asafa, T. B., Oladipo, I. C., Badmus, J. A., Adejumo, S. A., & Ajibola, A. A. (2017). Cytogenotoxicity potentials of cocoa pod and bean-mediated green synthesized silver nanoparticles on Allium cepa cellsCaryologia, 70(4), 366–377https://doi.org/10.1080/00087114.2017.1370260
Yili, A., Yimamu, H., Maksimov, V. V., Aisa, H. A., Veshkurova, O. N., & Salikhov, S. I. (2006). Chemical composition of essential oil from seeds of Anethum graveolens cultivated in ChinaChemistry of Natural Compounds, 42(4), 491–492https://doi.org/10.1007/s10600-006-0190-7
Younis, F. A. I., Abdelbagi, H., Ahmed, M., Ahmed, F., & Mohmmed, R. (2018). Green synthesis and characterization of gold nanoparticles (AuNPs) using fenugreek seeds extract (Trigonella foenum - gracum)European Journal of Biomedical and Pharmaceutical Sciences, 5(4), 100–107
Zaazaa, L., Naceiri Mrabti, H., Ed-Dra, A., Bendahbia, K., Hami, H., Soulaymani, A., & Ibriz, M. (2021). Determination of mineral composition and phenolic content and investigation of antioxidant, antidiabetic, and antibacterial activities of Crocus sativus l. aqueous stigmas extractsAdvances in Pharmacological and Pharmaceutical Sciences, 2021https://doi.org/10.1155/2021/7533938
Zahid, M. A., Choi, J. Y., Seo, J.-K., Parvin, R., Ko, J., & Yang, H.-S. (2020). Effects of clove extract on oxidative stability and sensory attributes in cooked beef patties at refrigerated storageMeat Science, 161, 107972https://doi.org/10.1016/j.meatsci.2019.107972
Zahid, M. A., Eom, J. U., Parvin, R., Seo, J. K., & Yang, H. S. (2022). Changes in quality traits and oxidation stability of Syzygium aromaticum extract-added cooked ground beef during frozen storageAntioxidants, 11(3)https://doi.org/10.3390/antiox11030534
Zahid, Z., Rezgui, M., Nisar, S., & Azeem, M. W. (2016). Phytochemistry and medicinal uses of underutilized tree Garcinia indica: A detailed reviewIjcbs, 10(September), 40–45www.iscientific.org/Journal.html
Zaidi, S. F., Aziz, M., Muhammad, J. S., & Kadowaki, M. (2015). Diverse pharmacological properties of Cinnamomum cassia: A reviewPakistan Journal of Pharmaceutical Sciences, 28(4), 1433–1438
Zaki, F. E. (2018). Incorporation of fenugreek seed powder in the manufacturing of rabbit sausage and its effects on the quality properties during frozen storageJournal of Advances in Food Science & Technology, 5(1), 8–14
Zambre, D., Raut, N., Raut, S., Zode, R., & Umekar, M. (2022). Effect of green synthesized fenugreek metal-ion nanoparticles on resistant microorganismMultidisciplinary International Research Journal of Gujarat Technological University, 4(1), 113–119
Zanariah, J., Rehan, A. N., & Rosnah, O. (1997). Nutritional composition of common Zingiberaceae species used in traditional medicines and cookingJ. Trop. Agric. and Fd. Sc., 25(2), 225–229
Zara, S., Petretto, G. L., Mannu, A., Zara, G., Budroni, M., Mannazzu, I., Multineddu, C., Pintore, G., & Fancello, F. (2021). Antimicrobial activity and chemical characterization of a non-polar extract of saffron stamens in food matrixFoods, 10(4)https://doi.org/10.3390/foods10040703
Zay, K., & Gere, A. (2019). Sensory acceptance of poppy seed-flavored white chocolates using just-about-right methodLWT, 103, 162–168https://doi.org/10.1016/j.lwt.2018.12.069
Zeka, K., Marrazzo, P., Micucci, M., Ruparelia, K. C., Arroo, R. R. J., Macchiarelli, G., Nottola, S. A., Continenza, M. A., Chiarini, A., Angeloni, C., Hrelia, S., & Budriesi, R. (2020). Activity of antioxidants from crocus sativus l. Petals: Potential preventive effects towards cardiovascular systemAntioxidants, 9(11), 1–18https://doi.org/10.3390/antiox9111102
Zhang, C., Fan, L., Fan, S., Wang, J., Luo, T., Tang, Y., Chen, Z., & Yu, L. (2019). Cinnamomum cassia presl: a review of its traditional uses, phytochemistry, pharmacology and toxicologyMolecules, 24(19)https://doi.org/10.3390/molecules24193473
Zhang, H., Peng, X., Li, X., Wu, J., & Guo, X. (2017). The application of clove extract protects chinesestyle sausages against oxidation and quality deteriorationKorean Journal for Food Science of Animal Resources, 37(1), 114–122https://doi.org/10.5851/kosfa.2017.37.1.114
Zhang, M., Luo, W., Yang, K., & Li, C. (2022). Effects of sodium alginate edible coating with cinnamon essential oil nanocapsules and Nisin on quality and shelf life of beef slices during refrigerationJournal of Food Protectionhttps://doi.org/10.4315/jfp-21-380
Zhao, X. X., Lin, F. J., Li, H., Li, H. Bin, Wu, D. T., Geng, F., Ma, W., Wang, Y., Miao, B. H., & Gan, R. Y. (2021). Recent advances in bioactive compounds, health functions, and safety concerns of onion (Allium cepa l.)Frontiers in Nutrition, 8(July)https://doi.org/10.3389/fnut.2021.669805
Zheng, C. J., Yoo, J. S., Lee, T. G., Cho, H. Y., Kim, Y. H., & Kim, W. G. (2005). Fatty acid synthesis is a target for antibacterial activity of unsaturated fatty acidsFEBS Letters, 579(23), 5157–5162https://doi.org/10.1016/j.febslet.2005.08.028
Zhou, W., Liang, Z., Li, P., Zhao, Z., & Chen, J. (2018). Tissue-specific chemical profiling and quantitative analysis of bioactive components of Cinnamomum cassia by combining laser-microdissection with UPLC-Q/TOF–MSChemistry Central Journal, 12(1), 1–9https://doi.org/10.1186/s13065-018-0438-x
Zia, I., Mirza, S., Jolly, R., Rehman, A., Ullah, R., & Shakir, M. (2019). Trigonella foenum graecum seed polysaccharide coupled nano hydroxyapatite-chitosan: A ternary nanocomposite for bone tissue engineeringInternational Journal of Biological Macromolecules, 124, 88–101https://doi.org/10.1016/j.ijbiomac.2018.11.059
Ziadi, S. A., & Mahmood, H. R. (2017). The effect of silver bio-nanoparticles synthesized by Curcuma longa L. on pathogenic fungiInternational Journal of ChemTech Research, 10(3), 508–514
Zinatloo-Ajabshir, Z., & Zinatloo-Ajabshir, S. (2019). Preparation and characterization of curcumin niosomal nanoparticles via a simple and eco-friendly routeJournal of Nanostructures, 9(4), 784–790https://doi.org/10.22052/JNS.2019.04.020
Zivyar, N., Bagherzade, G., … M. M.-J. of H., & 2021, undefined. (2021). Evaluation of the green synthesis, characterization and antibacterial activity of silver nanoparticles from corm extract of Crocus sativus var. HaussknechtiiJhpr.Birjand.Ac.Ir, 4, 19–32https://doi.org/10.22077/jhpr.2021.3812.1177
Zubor, Á. A., Surányi, G., Győri, Z., Borbély, G., & Prokisch, J. (2003). Molecular biological approach of the systematics of Crocus sativus l. and its allies. In I International Symposium on Saffron Biology and Biotechnology (Vol. 650, pp. 85–93)
Żuk-Gołaszewska, K., & Wierzbowska, J. (2017). Fenugreek: Productivity, nutritional value and usesJournal of Elementology, 22(3), 1067–1080https://doi.org/10.5601/jelem.2017.22.1.1396
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Mandal, D., Sarkar, T. & Chakraborty, R. Critical Review on Nutritional, Bioactive, and Medicinal Potential of Spices and Herbs and Their Application in Food Fortification and Nanotechnology. Appl Biochem Biotechnol 195, 1319–1513 (2023). https://doi.org/10.1007/s12010-022-04132-y
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DOI: https://doi.org/10.1007/s12010-022-04132-y