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In Vitro Release Kinetics and Transferrin Saturation Study of Intravenous Iron Sucrose Entrapped in Poly(ethylene glycol)-Assisted Silica Xerogel

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Abstract

The presence of labile iron fractions in intravenous iron supplements compromises their safety. Poly(ethylene glycol) (PEG)-assisted silica xerogel was evaluated as a potential drug carrier for iron sucrose with the purpose of limiting labile iron available for in vitro uptake by transferrin. The drug entrapped xerogels were synthesized by the sol–gel process with varying amounts of PEG. In vitro release studies were conducted in simulated body fluid (SBF) at 37 ± 0.02 °C (pH 7.4). The results indicated that the cumulative release percentage increased with the increase in the amount of PEG in the matrix. The biphasic release profile followed first-order kinetics for the first 6 h and Higuchi model for the remaining time (up to 168 h). The sample showing highest percentage of cumulative release (the xerogel with 16 % PEG) was used for in vitro transferrin saturation studies in contrast with the plain drug. The xerogel formulation exhibited 7.25 ± 0.4 % transferrin saturation in 180 min as compared to 12.89 ± 0.2 % for the raw drug. These results indicate that encapsulation of iron sucrose in PEG-assisted silica xerogel and subsequent sustained release from the matrix can improve the safety of the drug when presence of labile iron is a major concern.

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Authors and Affiliations

  1. School of Materials Science and Nanotechnology, Jadavpur University, Kolkata, 700032, India

    Jahnavi Jha, Suparna Chakraborty & Mahua Ghosh Chaudhuri

  2. Department of Metallurgical and Material Engineering, Jadavpur University, Kolkata, 700032, India

    Rajib Dey

  3. 3, Lake Gardens, Kolkata, 700045, West Bengal, India

    Jahnavi Jha

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  1. Jahnavi Jha
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  2. Suparna Chakraborty
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  4. Rajib Dey
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Correspondence to Jahnavi Jha.

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Jha, J., Chakraborty, S., Chaudhuri, M.G. et al. In Vitro Release Kinetics and Transferrin Saturation Study of Intravenous Iron Sucrose Entrapped in Poly(ethylene glycol)-Assisted Silica Xerogel. Appl Biochem Biotechnol 178, 1351–1362 (2016). https://doi.org/10.1007/s12010-015-1951-1

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