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Microphthalmos: Clinical and Ultrasonographic Findings

  • Original Article
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Annals of Ophthalmology

Abstract

We analyzed ocular and ultrasonographic findings of microphthalmos and associated ocular and systemic pathologies in 27 microphthalmic eyes. A high incidence of consanguinous marriages (26%) was present among the parents of patients. Associated systemic abnormalities were growth retardation, congenital rubella, cleft lip and palate, facial hemangioma, inguinal hernia, clinodactyly, Hurler syndrome, Goltz–Gorlin syndrome and Hallermann–Streiff syndrome. A variety of ocular/systemic abnormalities were encountered. Early ultrasonographic diagnosis and description of other ocular and systemic pathologies are essential.

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References

  1. Weiss AH, Kousseff BG, Ross EA et al. Simple microphthalmos. Arch Ophthalmol 1989;107:1625–1630

    PubMed  CAS  Google Scholar 

  2. Weiss AH, Kousseff BG, Ross EA et al. Complex microphthalmos. Arch Ophthalmol 1989;107:1619–1624

    PubMed  CAS  Google Scholar 

  3. Bakır M, Sarıalioğlu F, Bilgiç S et al. Microphthalmos with bilateral colobomatous orbital cyst accompanied by polycystic kidney disease and vacuolisation of myeloid progenitor cells. Acta Paediatr 1992;81:1054–1057

    PubMed  Google Scholar 

  4. Ulman İ, Herek Ö, Genç AK et al. Microphthalmos associated with esophageal atresia. J Pediatr Surg 1996;3:433–434

    Article  Google Scholar 

  5. François J, Goes F Ultrasonographic study of 100 emmetropic eyes. Ophthalmologica 1977;175:321–327

    Article  PubMed  Google Scholar 

  6. Warburg M Classification of microphthalmos and coloboma. J Med Genet 1993;30:664–669

    Article  PubMed  CAS  Google Scholar 

  7. Byrne SF, Green RL. Ultrasound of the Eye and Orbit. 1st Ed. St Louis, MO: Mosby; 1992

    Google Scholar 

  8. Khairallah M, Messaoud R, Zaouali S et al. Posterior segment changes associated with posterior microphthalmos. Ophthalmology 2002;109:569–574

    Article  PubMed  Google Scholar 

  9. Auffarth GU, Blum M, Faller U et al. Relative anterior microphthalmos-morphometric analysis and its implications for cataract surgery. Ophthalmology 2000;107:1555–1560

    Article  PubMed  CAS  Google Scholar 

  10. Zeiter HJ. Congenital microphthalmos. Am J Ophthalmol 1963;55:910–923

    PubMed  CAS  Google Scholar 

  11. Rahi JS, Dezateux C. British Congenital Cataract Interest Group. Congenital and infantile cataract in the United Kingdom: underlying or associated factors. Invest Ophthalmol Vis Sci 2000;41:2108–2114

    Google Scholar 

  12. Francis PJ, Berry V, Moore AT et al. Lens biology: development and human cataractogenesis. Trends Genet 1999;15:191–196

    Article  PubMed  CAS  Google Scholar 

  13. Givens KT, Lee DA, Jones T et al. Congenital rubella syndrome: ophthalmic manifestations and associated systemic disorders. Br J Ophthalmol 1993;77:358–363

    Article  PubMed  CAS  Google Scholar 

  14. Harch C, Chase HB, Gonsalves NI Studies on an anophthalmic strain of mice. Dev Biol 1978;63:352–357

    Article  PubMed  CAS  Google Scholar 

  15. Elder MJ Aetiology of severe visual impairment and blindness in microphthalmos. Br J Ophthalmol 1994;78:332–334

    Article  PubMed  CAS  Google Scholar 

  16. Basic and Clinical Science Course Section 2: Fundamentals and Principles of Ophthalmology. San Francisco: American Academy of Ophthalmology; 2001

  17. Weiss AH, Martinez C Microphthalmos with cyst. Clinical presentations and computed tomographic findings. J Pediatr Ophthalmol Strabismus 1985;22:6

    PubMed  CAS  Google Scholar 

  18. Hornby SJ, Dandona L, Jones RB et al. The familial contribution to non-syndromic ocular coloboma in south India. Br J Ophthalmol 2003;87:336–340

    Article  PubMed  CAS  Google Scholar 

  19. Porges Y, Gershoni-Baruch R, Leibu R et al. Hereditary microphthalmia with colobomatous cyst. Am J Ophthalmol 1992;114:30–34

    PubMed  CAS  Google Scholar 

  20. Hornby SJ, Adolph S, Gilbert CE et al. Visual acuity in children with coloboma clinical features and a new phenotypic classification system. Ophthalmology 2000;10:511–520

    Article  Google Scholar 

  21. Lloyd IC, Colley A, Tullo AB et al. Dominantly inherited unilateral retinal dysplasia. Br J Ophthalmol 1993;77:378–380

    Article  PubMed  CAS  Google Scholar 

  22. Basic and Clinical Science Course Section 6: Pediatric Ophthalmology and Strabismus. San Francisco: American Academy of Ophthalmology; 2001, pp. 267

  23. Tucker S, Jones B, Collin R Systemic anomalies in 77 patients with congenital anophthalmos or microphthalmos. Eye 1996;10:310–314

    PubMed  Google Scholar 

  24. Warburg M An update on microphthalmos and coloboma. Ophthalmol Paediatr Genet 1991;12:57–63

    CAS  Google Scholar 

  25. Goltz RW, Henderson RR, Hitch JM et al. Focal dermal hypoplasia: a review of the literature and report of two cases. Arch Dermatol 1970;101:1–11

    Article  PubMed  CAS  Google Scholar 

  26. Jacquemin C, Mullaney PB, Bosley TM Ophthalmological and intracranial anomalies in patients with clinical anophthalmos. Eye 2000;14:82–87

    PubMed  Google Scholar 

  27. Ulusoy M, Tunçbilek E Türkiye’de 1988’de akraba evlilikleri. Nüfusbilim dergisi 1989;11:35–46

    PubMed  Google Scholar 

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Authors and Affiliations

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Correspondence to Suat Hayri Ugurbas MD.

Additional information

Drs. Ugurbas and Kargi are from the Department of Ophthalmology, Zonguldak Karaelmas University Faculty of Medicine, Zonguldak, Turkey. Drs. Zilelioglu and Günalp are from the Department of Ophthalmology, Ankara University Faculty of Medicine, Ankara, Turkey.

The authors have stated that they do not have a significant financial interest or other relationship with any product manufacturer or provider of services discussed in this article. The authors also do not discuss the use of off-label products, which includes unlabeled, unapproved, or investigative products or devices.

The authors analyzed ocular and ultrasonographic findings of microphthalmos and associated ocular and systemic pathologies.

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Ugurbas, S.H., Zilelioglu, G., Günalp, I. et al. Microphthalmos: Clinical and Ultrasonographic Findings. Ann Ophthalmol 39, 112–122 (2007). https://doi.org/10.1007/s12009-007-0005-x

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  • DOI: https://doi.org/10.1007/s12009-007-0005-x

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