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The use of Hormonal Therapy to Augment Radiation Therapy in Prostate Cancer: An Update

  • Prostate Cancer (S Prasad, Section Editor)
  • Published:
Current Urology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Androgen deprivation therapy (ADT) is an important adjunctive therapy to external beam radiation therapy (RT) for the definitive management of prostate cancer. The role of ADT is well-established for locally advanced or high-risk disease in conjunction with standard doses of RT, but less defined for intermediate-risk disease or with dose-escalated RT. The goal of this review is to summarize evidence evaluating the combination of ADT/RT, focusing on recent trials and current controversies as they pertain to the practicing clinician.

Recent Findings

The benefit of ADT on biochemical control is maintained with dose-escalated RT according to recently reported phase III studies. Furthermore, there is now prospective, randomized evidence to support the addition of ADT to RT in the post-prostatectomy setting.

Summary

ADT continues to play an important role for prostate cancer patients receiving dose-escalated RT. Future research is needed to identify subgroups most likely to benefit from this combination.

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  1. Department of Radiation and Cellular Oncology, University of Chicago, 5758 South Maryland Avenue MC 9006, Chicago, IL, 60637, USA

    Greg Kauffmann & Stanley L. Liauw

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Greg Kauffmann and Stanley L. Liauw each declare no potential conflicts of interest.

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This article is part of the Topical Collection on Prostate Cancer

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Kauffmann, G., Liauw, S.L. The use of Hormonal Therapy to Augment Radiation Therapy in Prostate Cancer: An Update. Curr Urol Rep 18, 50 (2017). https://doi.org/10.1007/s11934-017-0698-3

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